Diabetes Drug Pipeline

Part I: Target Pipelines

Chapter 1: Insulin

• Insulin Market: Sales of Major Products in 2007
• Rec Human Insulin for Injection (2nd Generation)
• Biosimilar Rec Human Insulin for Injection (2nd Generation)
• Rhu Insulin (2nd Generation) in Off-Patent Countries: China
• Rhu Insulin (2nd Generation) in Off-Patent Countries: Russia
• Rhu Insulin (2nd Generation) in Off-Patent Countries: India
• Rhu Insulin (2nd Generation) in Off-Patent Countries: Others
• Modern Insulin Analogs (3rd Generation) for Injection
• Biosimilar Modern Insulin Analogs (3rd Generation)
• Tailored Insulin Analogs (4th Generation) for Injection
• Human Insulin with Drug Delivery for Injection
• Other Long-Acting Insulin for Injection
• Transgenic Human Insulin for Injection
• Inhaled Insulin
• Oral Insulin
• Transdermal Insulin
• Rectal Insulin
• Intranasal Insulin
  

Chapter 2: Peroxisome Proliferator-Activated Receptor (PPAR) Agonists

• PPAR alpha Agonists
• PPAR gamma Agonists / Insulin Sensitizer
• PPAR alpha and gamma Agonists
• PPAR delta Agonists
• PPAR gamma and delta Agonists
• PPAR pan Agonists (alpha, gamma and delta)
• Corporate PPAR Agonist Product Portfolio and R&D Pipelines
  

Chapter 3: Dipeptidyl Peptidase IV (DPP-IV) Inhibitors

• DPP-IV Inhibitors
  

Chapter 4: Glucagon-Like Peptide-1 (GLP-1) Receptor Analogs & Agonists

• GLP-1 Analogs with Daily Injection
• Long-Acting Injectable GLP-1 Analogs
• Oral GLP-1 Analogs
• Other Non-Injectable GLP-1 Analogs
• GLP-1 Analogs for Other Indications
  

Chapter 5: Sodium-Dependent Glucose (Co)Transporter (SGLT) Inhibitors

• SGLT-2 Inhibitors
• SGLT-1 and SGLT-1/2 Inhibitors

• CB1 Antagonists for Metabolic Diseases
• CB1 Antagonists for CNS Diseases
  

Chapter 7: Emerging Diabetes Drugs & Targets

Emerging diabetes treatment modalities were assigned to four different clusters:

• Metabolic Approaches
• Pancreatic Islet Cell Approaches
• Cell Therapy
• Anti-Inflammatory Approaches

Metabolic Approaches:

• Protein Tyrosine Phosphatase 1B (PTP-1B) Inhibitors - I
• Glucokinase Activators
• 11-beta Hydroxysteroid Dehydrogenase type-1 (HSD-1) Inhibitors - I
• Adenosine 5' monophosphate (AMP)-activated Protein Kinase (AMPK) Activators - I
• Glucagon Receptor Agonists & Antagonists
• Glucocorticoid Receptor Agonists & Antagonists
• Glucose-Dependent Insulinotropic Receptor (GDIR) Activators - I
• Ghrelin Receptor Antagonists
• FGF-21 Approaches
• Inhibitors of Gluconeogenese
• Various Gluco-Metabolic Approaches -I
• Various Lipo-Metabolic Approaches
• Repositioning Approaches

Pancreatic Islet Cell Approaches:

• SIRT
• Gastrin-based Approaches for beta Cell Regeneration
• Preservation of beta Cell Capacity to Produce Insulin
• Vaccines to Prevent Destruction of beta Cells
• Antibodies to Prevent Destruction of beta Cells

Cell Therapy Approach:

• Pancreatic Islet Cell Therapies

Anti-Inflammatory Approaches:

• Interleukin-1 (IL-1/R) Antagonists
• Other Anti-Inflammatory Approaches

Part 2: Corporate Diabetes R&D Pipelines:

• 7TM Pharma
• Acadia Pharmaceuticals
• Access Pharmaceuticals
• Addex Pharmaceuticals
• AdiStem
• Aeterna Zentaris
• Ajinomoto
• Akesis Pharmaceuticals
• Alba Therapeutics
• Alize Pharma
• Altea Therapeutics
• Amgen
• Amylin Pharmaceuticals
• Andromeda
• Apitope
• Apollo Life Sciences
• Aradigm
• Arena Pharmaceuticals
• Arisaph Pharmaceuticals
• Arisgen
• Array BioPharma
• Ascendis Pharma (ex Complex Biosystems)
• Astellas Pharma
• AstraZeneca
• Atherogenics
• Aurigene Discovery Technologies
• Azevan Pharmaceuticals
• Banyu Pharmaceutical Co.
• Bayhill Therapeutics
• Bellus Health
• Betagenon
• Bio Sidus
• Bio-ker
• Biocompatibles International
• Biocon
• Biodel
• BioSante Pharmaceuticals
• Biotek & Tonghua Dongbao Pharmaceutical Co.
• Bioton
• Biovitrum
• Boehringer Ingelheim
• Bristol-Myers Squibb
• CeNeRx BioPharma
• Ceptyr
• Cerenis Therapeutics
• Chemocentryx
• Chong Kun Dang
• CombinatoRx
• ConjuChem
• Coremed
• CPEX Pharmaceuticals (ex Bentley Pharmaceuticals)
• Crystal Genomics
• Daiichi Sankyo
• Dainippon Sumitomo Pharma
• Dara Bioscience
• Develogen
• Diakine Therapeutics
• Diamed Pharmaceuticals
• Diamedica
• Diamyd Medical
• DiObex
• Dong-A Pharmaceutical Co.
• Dr. Reddy’s
• Eli Lilly
• Elixir Pharmaceuticals
• Emisphere Technologies
• Ensemble Discovery
• Esteve
• Faust Pharmaceuticals
• Flamel Technologies
• Forest Pharmaceuticals
• Gan & Lee Pharmaceutical Co.
• Genaera
• Generex Biotechnology
• Genfit
• Geron
• GlaxoSmithKline
• Glenmark Pharmaceuticals
• GW Pharmaceuticals
• Halozyme Therapeutics
• HanAll Pharmaceutical
• Hanmi Pharmaceutical Co.
• Hillcrest Therapeutics
• Incyte
• Intekrin Therapeutics
• Ipsen
• Isis Pharmaceuticals
• Japan Tobacco
• Jenrin Discovery
• Johnson & Johnson
• Kalypsys
• Karo Bio
• Kissei Pharmaceutical Co.
• Kyorin Pharmaceutical Co.
• Laboratorios Cryopharma
• Lexicon Pharmaceuticals
• LG Life Sciences
• Lipoxen
• Living Cell Technologies
• Macrogenics
• MannKind
• MaxoCore Pharmaceuticals
• MDRNA (ex Nastech Pharmaceuticals)
• Merck & Co.
• Mercury Therapeutics
• Metabasis Therapeutics
• Metabolex
• MicroIslet
• Mitsubishi Tanabe Pharma
• Modigene
• Nektar Therapeutics
• Neurocrine Biosciences
• Nicholas Piramal
• Novartis
• Novo Nordisk
• Novocell
• OctoPlus
• ONO Pharmaceutical Co.
• Oramed Pharmaceuticals
• OSI Pharmaceuticals
• Osiris Therapeutics
• Otsuka Pharmaceutical Co.
• Pfizer
• Pharmstandard
• Phenomix
• Phosphagenics
• Pierre Fabre
• Plexxikon
• PR Pharmaceuticals
• Proxima Concepts (Diabetology Ltd.)
• Qdose = JV of MicroDose Technologies & Vectura (ex Innovata)
• Ranbaxy
• Roche
• Sanofi-Aventis
• Sanwa Kagaky Kenkyusho
• Schering-Plough (Diosynth Biotechnology)
• SciGen
• SemBioSys
• Servier
• Shanghai Dongbao Biopharmaceutical Co.
• Sehmyakin-Ovchinnikov Institute of Bioorganic Chemistry
• Shenzhen Chipscreen Biosciences
• Shenzhen Kexing Biotech
• Shreya Life Sciences
• Sigma-Tau
• Taisho Toyama Pharmaceutical Co.
• Takeda Pharmaceutical Co.
• Teva Pharmaceutical Industries (& CoGenesys)
• Therapeutic Proteins Ltd. (TPL)
• Tonghua Dongbao Pharmaceutical Co.
• Transgene Biotek
• Transition Therapeutics
• Transpharma Medical
• TransTech Pharma
• Unigene
• USV (India)
• Vernalis
• Wanbang Biopharma (Wanbang Biochemical Pharmaceutical Co.)
• Wockhardt
• Wyeth
• XOMA
• Yuhan
• Zydus Cadila