BioPortfolio Limited Disposable Syringes Markets

	Disposable Syringes Markets
	1. Introduction 11 1.1 Statement of Report 11 1.2 About this Report 11 1.3 Scope of the Report 11 1.4 Objectives 12 1.5 Methodology 13 1.6 Executive Summary 14 2. Disposable Syringe Markets 16 2.1 Overview 16 2.2 Infection Control and Safety 17 2.2.1 Needlestick Injuries 17 2.2.2 Availability of Safety Syringes in the U.S. Healthcare Facilities 19 2.3 Cost of Safety Syringe 19 2.4 Market Expansion 20 2.5 Unsafe Injection Practices 20 2.6 Hospital Consolidations Pressure Companies to Reduce Prices 20 2.7 Strategic Alliance of Needleless Injector Manufacturers 21 2.8 Technological Advancements in Disposable Syringes 21 2.8.1 Reconstitution inside Sterile Syringes 21 2.8.2 Plungerless Prefilled Syringes 22 2.8.3 The Disposable UniJect™ 22 2.9 Award Winning Syringes 22 2.9.1 Episure AutoDetect Epidural Syringe 23 2.9.2 ConfiDose Disposable Autoinjector 23 2.9.3 Humatrope Reconstitution Device 24 2.9.4 Vasceze Plungerless Syringe 24 3. Disposable Syringe Market Segments 25 3.1 Overview 25 3.1.1 World Market for Disposable Syringes 25 3.1.2 U.S. Market for Disposable Syringes 27 3.1.3 Disposable Syringe Market in India 29 4. Insulin Syringes 32 4.1 Insulin Strengths: U-40 and U-100 32 4.2 Market for Insulin Pen 33 4.3 Shelf Life of Insulin Pen Cartridges 34 4.4 An Update on Insulin Injection Devices 35 4.4.1 Insulin Injection Devices Currently Available in the U.S. 35 4.4.2 Disposable Pens 36 4.4.3 Refillable Pens 36 4.4.4 Pen Needles 36 4.4.5 Benefits and Patient Preferences 37 4.4.6 Disadvantages of Pen Syringes 37 4.4.7 Insulin Pens and the Hospital Bills 38 4.5 Insulin Pens for Indian Market from IDC 38 4.6 Expansion of Facilities for Insulin Pens by Eli Lilly and Rexam 39 4.7 Major Players in Insulin Pens and Syringes 39 4.7.1 Sanofi-Aventis 39 4.7.1.1 Sanofi-Aventis' Business in Diabetes Care Segment 39 4.7.2 Novo Nordisk 41 4.7.2.1 Novo Nordisk's Diabetes Care Business in North America 41 4.7.2.2 Novo Nordisk's International Operations 42 4.7.2.3 Novo Nordisk's Business in Diabetes Care in Europe 42 4.7.3 Eli Lilly & Co. 43 4.7.3.1 Byetta 43 4.7.3.2 Humulin 44 4.7.3.3 Humalog 45 5. Safety Syringes 46 5.1 Available Safety Syringe Technologies 46 5.1.1 Retrofitted Syringes 46 5.1.2 Automatically Retractable Syringes 46 5.1.3 Manually Retractable Syringes 46 5.2 Safety Syringe Market 47 5.3 Drivers of Safety Syringes 47 6. Prefilled Syringes 48 6.1 Types of Prefilled Syringes (PFS) 48 6.2 Market for Prefilled Syringes 48 6.3 The Rise of Prefilled Syringes 49 6.4 Needle Safety for Prefilled Syringes 50 6.4.1 V-OVS NS® 51 6.4.2 Preventis™ 51 6.4.3 UltraSafe Passive® Delivery System/ERYPROSafe™ and NUFILSafe™ 51 6.5 Sterility Maintenance of Prefilled Syringes 52 6.6 Compatibility of Drugs with the Components of Prefilled Syringes 52 6.7 Some of the Drugs Available in Prefilled Syringes 53 6.7.1 Ovidrel® PreFilled Syringe 53 6.7.2 Enbrel Prefilled Syringes 53 6.7.3 Biocon's Prefilled Safety Syringes 53 6.7.4 Relistor® Prefilled Syringes 54 6.7.5 PEGASYS® 54 6.7.6 Afluria® 54 6.7.7 Enzira® 55 6.7.8 FluZone® Prefilled Syringe for Children 55 6.7.9 Novolin® N FlexPen Prefilled Insulin Syringe 55 6.7.10 NovoLog® Insulin Prefilled Syringe 55 6.7.11 GlaxoSmithKline's Vaccines in Prefilled Syringes 56 6.8 U.S. Production of Unilife's Prefilled Syringes 56 6.9 Some of the Major Providers of Syringe-Prefilling Services and Products 57 6.9.1 Althea Technologies, Inc. 57 6.9.1.1 Althea's Clinical Manufacturing 57 6.9.1.2 Althea's Fill/Finish Services 58 6.9.1.3 Althea's Contract Manufacturing 58 6.9.2 Baxter International, Inc. 59 6.9.2.1 Baxter's Contract Manufacturing 60 6.9.2.2 Baxter's Fill and Finish Capabilities 60 6.9.2.3 Baxter's Prefilled Syringes Capability 60 6.9.2.4 Baxter's Vials 61 6.9.2.5 Baxter's Cartridges 61 6.9.3 Becton, Dickinson and Company 61 6.9.3.1 BD's Prefilled Syringe Services 62 6.9.3.2 BD Hypak SCF™ Glass Prefillable Syringes 62 6.9.3.3 BD Sterifill SCF™ Plastic Prefillable Syringe Systems 63 6.9.3.4 BD Physioject™ Disposable AutoInjector 63 6.9.3.5 BD™ MicroInfusor™ Automatic Injection System 64 6.9.3.6 BD™ Liquid Dry Injector Disposable Pen Injector 64 6.9.3.7 BD™ Pens Customized Self-Injection Systems 65 6.9.3.8 BD Soluvia™ Prefillable Microinjection System 65 6.9.3.9 BD Preventis™ Shielding System for Prefilled Syringes 66 6.9.4 Catalent Pharma Solutions, Inc. 68 6.9.4.1 The Protector Safety Shield System™ 69 6.9.4.2 The ASI™ Autoinjector and Ultra-Compact ASI Mini™ Autoinjector 69 6.9.5 Hyaluron Contract Manufacturing (HCM) 69 6.9.5.1 Hyaluron's Syringe Filling 69 6.9.6 Vetter Pharma Fertigung GmbH 70 6.10 Features of Prefilled Syringes 71 6.10.1 Dual Chamber Prefilled Syringes 71 7. Pen Syringes 72 7.1 Pen Devices for Insulin Delivery 73 7.2 Technical Advances in Insulin Pens 73 7.3 Pen Types and Styles 74 7.4 Prefilled Pens 74 7.5 Reusable Pens 74 7.6 Prefilled Autoinjecting Disposable Syringes 74 7.7 Uniject™ Injection Device 75 8. Microneedle 76 8.1 Electronic Mosquito 76 9. Needle-free Injectors 77 9.1 Needle-free Delivery of Liquids 77 9.2 Needle-free Delivery of Solid Formulations 78 9.3 Needleless Injector from Injex 79 9.4 Jet Syringe from Injex 79 9.5 Syrijet 79 9.6 PenJet 80 9.7 Needle-free Injector for Human Growth Hormone 80 10. Needle and Syringe Market Trends 81 10.1 Market Segments 81 10.2 Customer Needs 82 10.3 Competitor Analysis 82 10.3.1 Automatic Safety Syringes 82 10.3.2 Manually Locking Safety Syringes 83 10.4 Third Party Reimbursement 84 10.5 Regulation 84 10.6 Drug Discovery Trends 85 10.7 Demographic Shifts 85 10.8 Growth in Home Healthcare 85 11. Technological Developments 87 11.1 Auto-Disable Syringes 87 11.1.1 AD Syringes with Needle Retraction/Disposal Feature 88 11.1.2 AD Syringe with No Needle Retraction Feature 88 11.1.3 Needlestick Prevention Syringes 88 11.1.4 Automatic Needlestick Prevention Feature 89 11.1.4.1 UltraSafe®Passive™ Delivery System 89 11.1.4.2 Sterimatic Sleeve® 89 11.1.4.3 K3 Safety Cap 89 11.2 Manual Needlestick Prevention Feature 90 11.2.1 Safety Lok™ Syringe 90 11.2.2 Monoject®Magellan™ 90 12. Business Trends 91 12.1 Market Drivers 91 12.2 Market Prospects 92 12.3 Marketing and Distribution 93 12.4 Competitive Landscape 93 12.5 Future Technologies 94 12.5.1 Glide Solid Dose Injector (SDI™) 94 12.5.2 BD Physioject™ 94 13. Regulatory Measures 95 13.1 Safety Syringes in Europe 95 14. Company Profiles 96 14.1 Abbott Laboratories 96 14.1.1 HUMIRA® Prefilled Syringe 96 14.1.2 HUMIRA® Pen 97 14.1.3 Precision Sure-Dose® Insulin Syringes 97 14.2 Albert David Limited 98 14.3 Alshifa Medical Syringes Manufacturing Company Ltd. 99 14.4 Althea Technologies, Inc. 99 14.5 Avitro, Inc. 100 14.6 Baxter International, Inc. 100 14.6.1 Baxter's Medication Delivery 100 14.6.2 Baxter's IV Therapies 101 14.6.3 Baxter's Global Injectables 101 14.6.4 Baxter's Infusion Systems 102 14.6.5 Baxter's IV Infusion Pumps and Infusion Sets 103 14.6.6 Baxter's Pharma Partnering 103 14.7 Becton, Dickinson and Company (BD) 103 14.7.1 BD's Role in Designing Devices for Safe and Effective Injections and Infusions 103 14.7.2 BD's Products 103 14.8 Boston Scientific Corporation 113 14.9 B. Braun 113 14.9.1 The Hospital Care Division 113 14.9.2 The Aesculap Division 114 14.9.3 The Out Patient Market (OPM) Division 114 14.9.4 The B. Braun Avitum Division 115 14.9.5 B. Braun's Syringe Products 116 14.10 Bioject Medical Technologies, Inc. 122 14.10.1 Biojector® 2000 124 14.10.2 Drug Reconstitution System 125 14.10.3 Vitajet® 125 14.10.4 Cool.click™ 125 14.10.5 SeroJet™ 126 14.11 Catalent Pharma Solutions, Inc. 126 14.11.1 Catalent's Oral Technologies Segment 127 14.11.2 Catalent's Sterile Technologies Segment 128 14.11.3 Catalent's Packaging Services Segment 129 14.11.4 Catalent's Manufacturing Capabilities 130 14.11.5 Catalent's Employee Strength 130 14.11.6 Catalent's Syringes 131 14.12 C.R. Bard, Inc. 131 14.12.1 Bard's Vascular Business 131 14.12.2 Bard's Urology Business 132 14.12.3 Bard's Oncology Business 133 14.12.4 Bard's Business in Surgical Specialties 134 14.12.5 Bard's Overseas Expansion 134 14.12.6 Bard's Bulb Syringes and Trays 135 14.12.7 Bard's Piston Syringes and Trays 135 14.13 Coeur, Inc. 136 14.13.1 Angiographic Syringes from Coeur, Inc. 136 14.13.2 CT Syringes from Coeur, Inc. 137 14.14 Covidien Ltd. 137 14.14.1 Covidien's Medical Devices Segment 138 14.14.2 Covidien's R&D 139 14.14.3 Covidien's Competitors in Medical Devices 139 14.14.4 Covidien's Syringes 140 14.15 Henke-Sass, Wolf GmbH 144 14.15.1 Two-Part Disposable Syringes 1-50(60) ml 144 14.15.2 Three-Part Disposable Syringes 1-30 ml 144 14.15.3 Disposable Needles HSW FINE-JECT® 145 14.16 Hindustan Syringes & Medical Devices, Ltd. (HMD) 145 14.16.1 Insulin Syringes from HMD 145 14.16.2 HMD's Single Use Needles 146 14.16.3 HMD's Single Use Syringes 147 14.17 Hi-Tech Medical Products Ltd. 147 14.18 Hyaluron Contract Manufacturing 148 14.18.1 HCM's Major Markets 148 14.18.2 HCM's Facility 148 14.19 International Medication System Ltd. 149 14.19.1 Delivery Systems from IMS 149 14.19.2 PCA Products from IMS 151 14.19.3 Phytonadione Injection USP 151 14.19.4 Lidocaine HCl Jelly, USP 2% (Preservative-free) 152 14.20 Life-Shield Products, Inc. 152 14.21 Merit Medical Systems, Inc. 154 14.21.1 Merit's Products 154 14.21.2 Merit's Vascular Access Products 154 14.21.3 Merit's Business in the U.S. 155 14.21.4 Merit's International Business 156 14.21.5 Merit's Customers 156 14.21.6 Merit's R&D 156 14.21.7 Merit's Manufacturing Facilities 157 14.22 Milestone Scientific 157 14.22.1 Milestone Scientific's Product Platform 158 14.22.2 Milestone Scientific's Investment in R&D 159 14.22.3 Milestone Scientific's Business Performance 160 14.23 Novo Nordisk A/S 161 14.23.1 Novo Nordisk's Business in Diabetes Care Segment 161 14.23.2 Novo Nordisk's Modern Insulins, Human Insulins and Insulin-related Products 162 14.23.3 Novo Nordisk's Geographic Performance in Diabetes Care Products 163 14.23.4 Pipeline Progress in Nova Nordisk 163 14.23.5 Novo Nordisk's Modern Insulin Portfolio 164 14.24 Owen Mumford Ltd. 166 14.24.1 Owen Mumford's Global Locations 166 14.24.2 Owen Mumford's Products 168 14.25 Plas-Pak Industries, Inc. 170 14.25.1 Dial-A-Dose® Disposable Veterinary Syringes 170 14.25.2 Dual Syringe and Dental Syringe from Plas-Pak 170 14.25.3 Mini Dual Syringe 170 14.25.4 Manual Dual Syringes 171 14.26 Retractable Technologies, Inc. 172 14.26.1 Retractable Technologies' Principal Products 173 14.26.2 Retractable Technologies' Principal Markets 173 14.26.3 Retractable Technologies' R&D 174 14.26.4 Retractable Technologies' VanishPoint Products 175 14.27 Revolutions Medical Corporation 176 14.27.1 Rev Vac Safety Syringe 177 14.28 Safety Syringes, Inc. 177 14.28.1 Custom Engineering from Safety Syringes, Inc. 178 14.28.2 Syringe Products from Safety Syringes, Inc. 178 14.29 Smiths Medical International/Medex, Inc. 180 14.29.1 Smiths Medical's Markets 180 14.29.2 Smiths Medical's Medication Delivery Segment 181 14.29.3 Smiths Medical's Vital Care Segment 182 14.29.4 Smiths Medical's Safety Devices Segment 182 14.29.5 Smiths Medical's Business Performance 182 14.29.6 Smiths Medical's Business Performance on Geographic Basis 182 14.29.7 Smiths Medical's R&D 183 14.29.8 Syringes from Smiths Medicals 183 14.30 Specialized Health Products International, Inc. 188 14.30.1 SHPI's Products and Services 189 14.30.2 SHPI's Licensed Products 190 14.31 Star Syringe Ltd. 190 14.31.1 Star Alliances 191 14.31.2 Preoducts from Star Syringe Ltd. 192 14.32 Terumo's Medical Corporation 193 14.32.1 Terumo's General Hospital Products 193 14.32.2 Terumo's Diabetes Care Products 194 14.32.3 Terumo's Syringe Products 195 14.33 UltiMed, Inc. 203 14.33.1 UltiCare™ Insulin Syringes 204 14.33.2 UltiCare™ Pen Needles 204 14.34 Unilife Medical Solutions, Ltd. 205 14.34.1 Pharmaceutical Market for Unilife's Prefilled Syringes 205 14.34.2 Unilife Partnership with Sanofi-Aventis 205 14.34.3 Unilife's Licensing Agreement with Sanofi-Aventis 206 14.34.4 Unilife's Partnership with Gerresheimer Bünde 206 14.34.5 Unilife's Portfolio of Safety Syringes 207 14.34.6 Unilife's Prefilled Syringes 207 14.34.7 Unilife's Contract Manufacturing Activities 207 14.34.8 Unilife's Performance in Syringe Market 208 14.35 Vetter Pharma-Fertigung GmbH & Co., KG 208 14.35.1 Vetter Services and Solutions 208 14.35.2 Dual-Chamber Technology 209 14.36 Vita Needle Company, Inc. 209 14.36.1 Disposable Stainless Steel Needle Blunts from Vita Needle 209 14.36.2 Teflon® Dispensing Needles 210 14.36.3 Vita Needle's Polypropylene Needles 210 14.36.4 Vita Needle's Taper Tip Needles 211 14.37 West Pharmaceutical Services, Inc. 211 14.37.1 West's Pharmaceutical Systems Segment 211 14.37.2 West's Tech Group Segment 212 14.37.3 West's R&D Activities 213 14.37.4 West's Syringe Products 214 14.38 Wuxi Yushou Medical Appliances Co., Ltd. 217 14.39 Ypsomed Holding AG 217 14.39.1 Ypsomed's Injection Systems 218 14.39.2 Ypsomed's Insulin Delivery Systems 218 14.39.3 Additional Indication Areas for Pen Systems 218 14.39.4 Ypsomed's Innovative Injection Systems at a Glance 219 14.39.5 Ypsomed's Complete Product Range for Insulin Suppliers 219 14.39.6 Ypsomed's New Dual-Chamber Injecting Systems 220 14.39.7 Ypsomed's ServoPen 220 14.39.8 Growth of Ypsomed's Pen Needles 220 14.39.9 Ypsomed's Performance in 2008/2009 222 14.39.10 Ypsomed's R&D 223 14.40 The Medical House PLC (TMH) 224 14.40.1 TMH's Products 224 Appendix 1: U.S. Healthcare Expenditure Projections, 2008-2018 228 Appendix 2: Syringe Needle Terminology 234 Appendix 3: Medication Errors and Syringe Safety 236 Appendix 3.1: Injectable Medication Errors 236 Appendix 3.2: Frequency of Syringe Usage 236 Appendix 3.3: Labeling Injectable Medications 236 Appendix 3.4: Challenges of Labeling 236 Appendix 3.5: Benefits of a Write-On Stripe 236 Appendix 3.6: Nurses Influence on Selection of Sharp Devices 237 Appendix 3.7: Needlestick Injuries 237 Appendix 3.8: Prevention of Needlestick Injuries 237 Appendix 3.9: Protection from Needlestick Injuries 238 INDEX OF FIGURES Figure 2.1: Principal Causes of Needlestick Injuries 17 Figure 2.2: Availability of Safety Syringes in the U.S. Healthcare Facilities, 2008 19 Figure 3.1: Worldwide Unit Market for Syringes and Needles, 2004-2012 26 Figure 3.2: Global Syringe Market, 2009 26 Figure 3.3: Worldwide Market for Disposable Syringes and Needles, 2004-2012 27 Figure 3.4: U.S. Market for Disposable Syringes and Needles, 2006-2013 28 Figure 3.5: Market Segments of the U.S. Syringe Market, 2009 28 Figure 3.6: E.U. Market for Syringes, Needles and Catheters, 2007 and 2008 29 Figure 3.7: Worldwide Market Share for Hypodermic Syringes, 2009 29 Figure 3.8: Disposable Syringe Market in India, 2008-2012 30 Figure 3.9: Market Share for Disposable Syringes in India, 2008 30 Figure 3.10: Market Share for Disposable Needles in India, 2008 31 Figure 4.1: Market Growth for Insulin Pen, 2007-2014 33 Figure 4.2: Market Growth for Insulin Pens in Europe, 2007-2014 34 Figure 4.3: Global Sales Performance of Sanofi-Aventis' Lantus, 2007 and 2008 40 Figure 4.4: Global Sales Performance of Sanofi-Aventis' Amaryl, 2007 and 2008 40 Figure 4.5: Sales Performance of Sanofi-Aventis' Lantus by Geography, 2008 41 Figure 4.6: Novo Nordisk's Business Performance in Diabetes Care by Geography, 2008 41 Figure 4.7: Novo Nordisk's Performance in Diabetes Care, 2004-2008 42 Figure 4.8: Eli Lilly's Business Performance in Byetta, 2006 and 2007 43 Figure 4.9: Eli Lilly's Business Performance in Humulin, 2006-2008 44 Figure 4.10: Eli Lilly's Sales Performance in Humalog, 2006-2008 45 Figure 5.1: Growth of Safety Syringe Market, 2008-2012 47 Figure 6.1: Market Growth for Prefilled Syringes, 2009-2013 48 Figure 6.2: Growth of Prefilled Syringes Market in E.U., 2008-2012 49 Figure 10.1: Breakdown of U.S. Syringe Market, 2009 81 Figure 10.2: U.S. Home Healthcare Products Market, 2007-2012 85 Figure 14.1: Abbott's Global Business Performance by Country, 2008 96 Figure 14.2: Abbott's Global Business Performance, 2004-2008 98 Figure 14.3: Baxter's