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TABLE OF CONTENTS
CHAPTER ONE: EXECUTIVE SUMMARY
- Background
- Scope and Methodology
- Size and Growth of the Market
- Key Issues and Trends Affecting Market
- Leading Competitors
CHAPTER TWO: INTRODUCTION
- Overview
- Structural Organization of the Neurological System
- Central Nervous System
- The Brain
- Aging and Alzheimer’s Disease
- Stages of Alzheimer’s Disease
- Risk Factors
- Life Expectancy and the Growing Incidence of Alzheimer’s Disease
- World Demographics
- Prevalence, Incidence and Mortality
- Insurance for the Elderly in the United States
- Generic Competition
- Teva/Mutual Pharmaceutical/United Research Laboratories and Eisai
- Dr. Reddy’s and Novartis
- Ranbaxy and Ortho-McNeil Neurologics
CHAPTER THREE: ALZHEIMER’S DISEASE PRODUCT ANALYSIS
- Overview of Products
- Aricept
- Namenda/Exiba/Axura
- Exelon
- Razadyne
- Other Products
CHAPTER FOUR: RESEARCH AND DEVELOPMENT
- Overview
- Phase III
- AAB-001
- Aricept SR
- Exelon Transdermal Patch (ONO 2540)
- Flurizan
- LY450139
- Memryte
- Namenda Once-Daily
- Rosiglitazone XR
- Xaliproden
Phase II
- Dimebon
- AC-1202
- Ispronicline
- MEM-3454
- MEM-1003
- AN-1792
- ABT-089
- ACC-001 and QS-21
- AL-108
- CX717
- ELND-005
- Huperzine A
- Immune globulin, intravenous
- LY2062430
- Lecozotan SR
- MK-0249
- MK-0952
- Neramenxane
- NIC5-15
- PRX-03140
- Rasagiline mesylate
- SAM-531
- SGS742
- T 817 MA
- TTP 488
Phase I
- 933776
- Aricept Transdermal Patch
- AV 965
- AVE 8112
- Bapineuzumab
- CAD-106
- CERE-110
- CTS-21166
- EVP 6124
- GSI 953
- Lecozotan SR
- MEM-1414
- NGX267
- Oxigon
- Paz-417
- PF-4360365
- PF-30804014
- R1450
- R4996/MEM 63908
- SSR 180711
- V 950
Preclinical Development
- TTP 4000
- AAB-002
- Alzhemed
- BACE Inhibitors (TTP 854)
- CX1739
- E2012
- Gamma-secretase inhibitor
- GSI-136
- MEM-1917
- MPI-442690
- PBT2/PBT3/PBT4
- SAR 110894
CHAPTER FIVE: MARKET AND COMPETITOR ANALYSIS
- Market Overview
- Market Analysis by Product Type
- Market Analysis by Country
- Competitive Analysis
- Leading Products
CHAPTER SIX: LEADING MANUFACTURERS
- Overview
- Eisai Co., Ltd.
- Forest Laboratories
- H. Lundbeck A/S
- Johnson & Johnson
- Merz Pharma GmbH
- Novartis AG
- Pfizer, Inc.
APPENDIX: LIST OF MAJOR COMPANIES
LIST OF EXHIBITS
CHAPTER ONE: EXECUTIVE SUMMARY
- Figure 1-1: Alzheimer’s Disease Market Analysis: 2005-2012
CHAPTER TWO: INTRODUCTION
- Table 2-1: Alzheimer’s Disease Stages 1-7 and Descriptions
- Table 2-2: Average Life Expectancy in Years by Country 1980, 2004 and 2006
- Figure 2-1: Average Life Expectancy in Years by Country 1980, 2004 and 2006
- Table 2-3: World Population by Selected Geographical Region, 2007 - 2050
- Figure 2-2: World Population by Selected Geographical Region, 2007-2050
- Table 2-4: Estimated World Population by Age and Geographical Region, 2007
- Figure 2-3: Estimated World Population by Age and Geographical Region, 2007
- Table 2-5: Percent Population Over 65 by Year and Region
- Figure 2-4: Estimated World Population by Age, 2007 and 2050
- Table 2-6: Estimated Prevalence, Incidence and Mortality for Alzheimer’s
Disease* by Region/Country, 2007
- Figure 2-5: Estimated World Prevalence and Incidence of
Alzheimer’s Diseases by Region, 2007
- Figure 2-6: World Prevalence of Alzheimer’s Disease Compared to
Rest of Population Over Age 65, 2007
- Table 2-7: Health Insurance Trends in the United States,
Estimated 2007 (millions)
CHAPTER THREE: ALZHEIMER’S DISEASE PRODUCT ANALYSIS
- Table 3-1: Comparison of Marketed Alzheimer’s Disease Treatments
- Figure 3-1: Alzheimer Product Sales Analysis, 2005-2007
- Figure 3-2: Aricept Sales Analysis, 2005-2007
- Figure 3-3: Namenda/Exiba/Axura Sales Analysis, 2005-2007
- Figure 3-4: Exelon Sales Analysis, 2005-2007
- Figure 3-5: Razadyne Sales Analysis, 2005-2007
CHAPTER FOUR: RESEARCH AND DEVELOPMENT
- Figure 4-1: Alzheimer’s Disease Treatments in Development, 2005,
2006, and 2007
- Table 4-1: Alzheimer’s Disease Therapies in Development
CHAPTER FIVE: MARKET AND COMPETITOR ANALYSIS
- Table 5-1: Alzheimer’s Disease Market Analysis, 2005-2007
- Table 5-2: Forecasted Alzheimer’s Disease Market Analysis: 2008-2012
- Figure 5-1: Alzheimer’s Disease Market Analysis: 2005-2012
- Table 5-3: Alzheimer’s Disease Market Analysis by Drug Type, (Cholinesterase inhibitors, NMDA antagonists), 2005-2007
- Figure 5-2: Alzheimer’s Disease Market Analysis by Drug Type, (Cholinesterase inhibitors, NMDA antagonists), 2005-2007
- Figure 5-3: Alzheimer’s Disease Market Share by Drug Type, (Cholinesterase inhibitors, NMDA antagonists), 2005
Figure 5-4: Alzheimer’s Disease Market Share by Drug Type, (Cholinesterase inhibitors, NMDA antagonists), 2007
- Table 5-4: Alzheimer’s Disease Market Analysis by Region/Country, 2007
- Figure 5-5: Alzheimer’s Disease Market Analysis by Region/Country, 2007
- Table 5-5: Alzheimer’s Disease Market Estimated Revenues and
Market Share of Leading Suppliers 2007
- Figure 5-6: Alzheimer’s Disease Market Estimated Market
Share by Leading Suppliers 2007
- Table 5-6: Alzheimer’s Disease Market Estimated Sales of Top Products 2007
- Figure 5-7 : Alzheimer’s Disease Market Estimated Market Share of Top Products, 2007
CHAPTER SIX: LEADING MANUFACTURERS
- Figure 6-1: Eisai’s Net Revenues and R&D Expenses for 2006 and 2007
- Figure 6-2: Forest’s Net Revenues and R&D Expenses for 2006 and 2007
- Figure 6-3: Lundbeck’s Net Revenues and R&D Expenses for 2006 and 2007
- Figure 6-4: Johnson & Johnson’s Net Revenues and
R&D Expenses for 2006 and 2007
- Figure 6-5: Merz Pharma’s Net Revenues and R&D Expenses for 2006 and 2007
- Figure 6-6: Novartis’ Net Revenues and R&D Expenses for 2006 and 2007
- Figure 6-7: Pfizer’s Net Revenues and R&D Expenses for 2006 and 2007
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