Anti-Infectives World Markets 2nd Edition Vol. I-III Complete Series
CHAPTER ONE: Executive Summary
Introduction
Scope and Methodology
Size and Growth of the Market
Issues and Trends Affecting Market
Leading Competitors
CHAPTER TWO: Introduction
Overview
Introduction to Pathogens
Antimicrobial Spectrum
Bacterial Resistance
Principles of Anti-infective Therapy
Infecting Organism
Antibiotic Sensitivity Testing
Site of Infection
Host Defenses and Organ Function
Antibiotic Pharmcokinetics
Monitoring Therapy
Combination Therapy and Prophylactic Use
Fungal Infections
Types of Fungal Infections
Superficial
Systemic
Histoplasmosis
Coccidioidomycosis
Blastomycosis
Demographics and Statistics
CHAPTER THREE: Systemic Antifungal Drugs
Overview
Description of Products
Allylamines
Terbinafine (Lamisil - Novartis)
Azoles
Fluconazole (Diflucan - Pfizer)
Ketoconazole (Nizoral, Johnson & Johnson)
Miconazole (Monistat, Johnson & Johnson)
Itraconazole (Sporanox, Johnson & Johnson)
Posaconazole (Noxafil, Schering-Plough)
Virconazole (Vfend, Pfizer)
Polyene Macrolides
Amphotericin B (Ambisome, Astellas; Abelcet, Enzon; Fungizone, Apothecon).
Griseofluvin (Fulvicin, Schering)
Nystatin (Mycostatin, Westwood Squibb)
Miscellaneous Antifungals
Flucytosine (Ancoban, Valeant)
Echinocandins
Generic Drug Impact and Availability
Research and Development
Market Size and Growth
Competitive Analysis
CHAPTER FOUR: Topical Antifungal Drugs
Overview
Description of Products
Allylamines
Naftifine (Naftin, Allergan)
Terbinafine (Lamisil - Novartis)
Butenafine (Mentax, Bertek)
Azoles
Miconazole (Monistat -Derm, OrthoDermatological)
Clotrimazole (Mycelex, Bayer; Lotrimin, Schering)
Ketoconazole (Nizoral, J&J; Xolegel, Barrier Therapeutics)
Oxiconazole (Oxistat, GlaxoSmithKline/Elan)
Econazole (Spectazole, Ortho Dermatological)
Sulconazole (Exelderm, Westwood-Squibb)
Terconazole (Terazol, Ortho Dermatological)
Polyene Macrolides
Nystatin (Mycostatin, Westwood Squibb)
Miscellaneous Antifungals
Ciclopirox (Penlac, Sanofi-Aventis/Dermik)
Selenium sulfide (Selsun, Chattem Inc)
Amorolfine (Loceryl, Roche)
Alcortin (Iodoquinol, hydrocortisone, Primus Pharmaceuticals)
Generic Drug Impact and Availability
Research and Development
Market Size and Growth
Competitive Analysis
CHAPTER FIVE: Issues and Trends Affecting the Antifungal Market
Introduction
Fungal Infections and Immunocompromised Patients
Reimbursement
Infection Imaging
Expanded Use of Azoles
Drug Resistance and Interactions
Standardized Susceptibility Testing
Generic Impact and Availability
Importance of Drug Delivery
Rx-to-OTC Switches
The Antifungal Market and Enchiocandins
chapter six: Antifungal Drugs: Total Market Size and Forecast
Overview
Total market Size and Forecast
CHAPTER SEVEN: Corporate Profiles
Introduction
Astellas Pharma Inc
Barrier Therapeutics, Inc
Johnson & Johnson Group
Merck & Company, Inc
Novartis Pharmaceuticals Corporation
Pfizer, Inc
Schering-Plough Corporation
CHAPTER EIGHT: Company Directory
Vol II: Antibacterials
Executive Summary
Introduction
Scope and Methodology
Size and Growth of the Market
Issues and Trends Affecting Market
Leading Competitors
Introduction The World Market for Anti-Infectives Volume 2:
Antibacterial Drugs
Introduction to pathogens
Classification of Antibacterial Organisms
Antimicrobial Spectrum
Bacterial Resistance
Principles of Anti-infective Therapy
Infecting Organism
Antibiotic Sensitivity Testing
Site of Infection
Host Defenses and Organ Function
Antibiotic Pharmacokinetics
Monitoring Therapy
Combination Therapy and Prophylactic Use
Demographics and Statistics
Issues and Trends Affecting the Antibacterial Drug Market
Introduction
Drug Resistance and Interactions
Antibiotic Abuse
Antibiotic Cycling
addressing market trends
Antibiotic use in Agriculture
Antibiotic Education
Children and Bacterial resistance
The Elderly and Bacterial Resistance
Compromised Individuals and Bacterial Resistance
Screening Hospitalized patients
Side Effects of Antibiotics
Partnerships and Alliances
Environment and Drug Resistance
Methicillin-resistant Staphylococcus Aureus (MRSA)
Cephalosporin Antibiotics
Overview
Description of Products
First Generation Cephalosporins
Cephalexin (Keflex, Advancis Pharmaceuticals)
Cefazolin (Ancef, GlaxoSmithKline; Cefamezin, Astellas)
Cefadroxil (Duricef, Bristol-Myers Squibb/Warner Chilcot)
Second Generation Cephalosporins
Cefuroxime (Ceftin, GlaxoSmithKline)
Cefoxitin (Mefoxin, Merck)
Third Generation Cephalosporins
Cefotaximen (Claforan offered by Sanofi-Aventis)
Cefoperazone (Cefobid, Pfizer)
Ceftibutin (Cedax, Shionogi)
Ceftizoxime (Cefizox, Astellas)
Ceftriaxone (Rocephin, Roche)
Ceftazidime (Fortaz, GlaxoSmithKline)
Cefixime (Suprax, Wyeth/Lupin Pharmaceuticals)
Cefpodoxime (Vantin, Pfizer)
Fourth Generation Cephalosporins
Cefepime (Maxipime, Bristol-Myers Squibb)
Generic Drug Impact and Availability
Research and Development
Market Size and Growth
Competitive Analysis
Macrolide Antibiotics
Overview
Description of Products
Azithromycin (Zithromax, Pfizer; Zmax, Pfizer)
Clarithromycin (Biaxin, Abbott Laboratories)
Erythromycin (Erythrocin, Abbott Laboratories; EryPed, Abbott Laboratories)
Telithromycin (Ketek, Sanofi-Aventis)
Generic Drug Impact and Availability
Research and Development
Market Size and Growth
Competitive Analysis
Penicillin Antibiotics
Overview
Natural Penicillins
Penicillinase-Resistant Penicillins
Broad -Spectrum Penicillins
Extended-Spectrum Penicillins
Description of Products
Natural Penicillins
Penicillin G (Bicillin, King Pharmaceuticals; Pfizerpen, Pfizer)
Penicillinase-resistant Penicillins
Cloxacillin (Cloxapen, GlaxoSmithKline)
Oxacillin (Bactocill, GlaxoSmithKline)
Broad-spectrum Penicillins
Amoxicillin (Augmentin, GlaxoSmithKline; Amoxil,GlaxoSmithKline)
Ampicillin (Unasyn, Pfizer)
Extended-spectrum Penicillins
Carbenicillin (Geocillin, Pfizer)
Piperacillin (Pipracil, Wyeth; Zosyn, Wyeth)
Ticarcillin (Timentin, GlaxoSmithKline)
Generic Drug Impact and Availability
Research and Development
Market Size and Growth
Competitive Analysis
Quinolone Antibiotics
Overview
Description of Products
Ciprofloxacin (Cipro, Bayer; Proquin XR, Depomed)
Gemifloxacin (Factive, LG Chem Ltd. and Oscient Pharmaceuticals)
Lomefloxacin (Maxaquin, Unimed)
Nalidixic (NegGram, Sanofi-Aventis)
Norfloxacin (Noroxin, Merck)
Ofloxacin (Floxin, Ortho-McNeil)
Moxifloxicin (Avelox, Bayer; Vigamox, Alcon)
Levofloxacin (Levaquin, Ortho-McNeil; Tavanic, Sanofi-Aventis; Cravit, Daiichi
Sankyo; Quixin, Santen)
Gatifloxacin (Zymar, Allergan/Kyorin)
Trovafloxacin (Trovan, Pfizer)
Generic Drug Impact and Availability
Research and Development
Market Size and Growth
Competitive Analysis
Sulfonamide Antibiotics
Overview
Description of Products
Sulfisoxazole (Gantrisin Pediatric, Roche)
Oxytetracycline/Sulfamethizole/Phenazopyridine (Urobiotic, Pfizer)
Erythromycin ethylsuccinate and Sulfisoxazole acetyl (Pediazole, Ross)
Dapsone (Aczone Gel, QLT USA-Tolmar Inc.)
Research and Development
Market Size and Growth
Competitive Analysis
Tetracycline Antibiotics
Overview
Description of Products
Generic Drug Impact and Availability
Research and Development
Market Size and Growth
Competitive Analysis
Other Miscellaneous Antibiotics
Overview
Description of Products
Aminoglycosides
Amikacin Sulfate (Amikin, Bristol-Myers Squibb)
Kanamycin Sulfate (Kantrex, Bristol-Myers Squibb)
Neomycin Sulfate (Neo-fradin, X Gen Pharms)
Streptomycin Sulfate (Streptomycin, Pfizer)
Lincomycin
Clindamycin (Cleocin, Pfizer; Clindesse, KV Pharmaceutical Company; Evoclin,
Connetics Corp.; Ziana Gel, Medicis/Dow)
Chloramphenicol
Chloramphenicol (Chloromycetin,Pfizer)
Glycopeptide
Vancomycin (Vancocin, Viropharma)
Monobactams
Aztreonam (Azactam, Bristol-Myers Squibb)
Carbapenems
Imipenem/cilastatin (Primaxin, Merck)
Meropenem (Merrem, AstraZeneca)
Metronidazole
Metronidazole (Flagyl, Pfizer; Pylera, Axcan; Metrogel-Vaginal, 3M
Pharmaceuticals; MetroGel, Galderma)
Antituberculars
Rifampicin (Rifater, Sanofi-Aventis)
Capreomycin (Capastat sulfate, Eli Lilly & Co.)
Ethionamide (Trecator SC, Wyeth)
Aminosalicylic acid granules (Paser Granules, Jacobus Pharmaceutical)
Cycloserine (Seromycin, Eli Lilly & Co.)
Antileprotics
Dapsone (Dapsone, Jacobus)
Oxazolidinones
Linezolid (Zyvox, Pfizer)
Ketolides
Telithromycin (Ketek, Sanofi-Aventis)
Lipopeptides
Daptomycin (Cubicin, Cubist Pharmaceutical)
Glycyclines
Tigecycline (Tygacil, Wyeth)
Generic Drug Impact and Availability
Research and Development
Market Size and Growth
Competitive Analysis
Corporate Profiles
Introduction
Abbott Laboratories
AstraZeneca plc
Bayer Schering Pharma AG
Cubist Pharmaceuticals, Inc
Daiichi Sankyo Co., Ltd.
GlaxoSmithKline
Johnson & Johnson Group
King Pharmaceuticals, Inc.
Merck & Company, Inc.
Pfizer, Inc.
Roche
Sanofi-Aventis
Wyeth
Company Names and Addresses
Volume III: Antivirals
Chapter One: Executive Summary
Introduction
Scope and Methodology
Size and Growth of the Market
Issues and Trends Affecting Market
Leading Competitors
Chapter Two: Introduction
Introduction to Viruses
Examples of Pathogenic Viruses
Virus Function and Life History
Replication in DNA Viruses
Replication of RNA Viruses
Replication in Retroviruses
Host Defenses Against Viruses
Viral Ploys to Invade Host Cells and Circumvent Host Responses
Invasion of Host Cells
Subversion of the Immune Response
Avoidance of Immune Detection and Attack by Killer Cells
HIV and AIDS
Demographics and Epidemiology
Cytomegalovirus
Hepatitis B Virus
Hepatitis C Virus (HCV)
Herpes
Human Immunodeficiency Virus (HIV)
Human Papillomavirus (HPV)
Influenza
Respiratory Syncytial Virus (RSV)
Population Demographics
Chapter Three: Nucleoside Analogs, Transcriptase Inhibitors, and DNA Polymerase
Inhibitors
Overview
Description of Products
Nucleoside Reverse Transcriptase Inhibitors
Zidovudine (Retrovir, GlaxoSmithKline)
Didanosine (Videx, Bristol-Myers Squibb)
Zalcitabine (Hivid, Roche)
Lamividine(Epivir, GlaxoSmithKline; Zeffix, GlaxoSmithKline)
Stavudine (Zerit, Bristol-Myers Squibb)
Abacavir (Ziagen, GlaxoSmithKline)
Nucleotide Analogue Reverse Transcriptase Inhibitors
Tenofovir (Viread, Gilead Sciences)
Adefovir dipivoxil (Hepsera, Gilead Sciences)
Combination Nucleoside Reverse Transcriptase Inhibitors
Lamivudine and Zidovudine (Combivir, GlaxoSmithKline)
Abacavir and Lamivudine (Kivexa, GlaxoSmithKline)
Abacavir sulfate, Lamivudine and Zidovudine (Trizivir, GlaxoSmithKline)
Non-Nucleoside Reverse Transcriptase Inhibitors
Nevirapine (Viramune, Boehringer Ingelheim)
Efavirenz (Sustiva, Bristol-Myers Squibb Oncology)
Delavirdine mesylate (Rescriptor, Agouron Pharmaceuticals)
Emtricitabine (Emtriva, Gilead Sciences)
DNA Polymerase Inhibitors
Acyclovir (Zovirax, GlaxoSmithKline)
Valacyclovir (Valtrex, GlaxoSmithKline)
Famciclovir (Famvir, Novartis)
Penciclovir (Denavir, Novartis)
Ganciclovir (Cytovene, Roche)
Ribavirin (Virazole, ICN Pharmaceuticals)
Foscarnet (Foscavir, AstraZeneca)
Valganciclovir (Valcyte, Hoffman-LaRoche)
Cidofovir (Vistide, Gilead Sciences)
Research and Development
Baraclude
Truvada
Telbivudine
Viramidine
Capravirine
Elvucitabine
Epzicom
Etravirine (TMC125)
GW5634
MIV 150
Pradefovir
Reverset
TMC278
Valopicitabine
Valtorcitabine
BILR 355
Calanolide A
DPC 961 and DPC 963
GW8248
MCC-478
MIV-310
Market Size and Growth
Competitive Analysis
Chapter Four: Protease Inhibitors
Overview
Description of Products
Single Agents
Saquinavir (Fortovase, Hoffman-LaRoche; Invirase, Hoffman-LaRoche)
Nelfinavir (Viracept, Agouron Pharmaceuticals)
Indinavir (Crixivan, Merck)
Ritonavir (Norvir, Abbott Laboratories)
Amprenavir (Agenerase, GlaxoSmithKline
Fosamprenavir (Lexiva, Vertex and GlaxoSmithKline)
Atazanavir (Reyataz, Bristol-Myers Squibb)
Combination Protease Inhibitors
Lopinavir and Ritonavir (Kaletra, Abbott Laboratories)
Research and Development
Tipranavir (PNU-140690)
GW640385 (VX-385)
TMC-114
BMS232632
RO033-4649
VX-950
Market Size and Growth
Competitive Analysis
Chapter Five: Other Antivirals
Overview
Description of Products
Aldara
CytoGam
Flumadine
Fuzeon
Infergen
Pegasys
Pegasys + Copegus
Rebetol, Rebetron
Relenza
RespiGam
Symmetrel
Synagis
Tamiflu
Vistide
Research and Development
Attachment and Fusion Inhibitors
Gene Therapies
Integrase Inhibitors
Maturation Inhibitors
Zinc Finger Inhibitors
Antisense Drugs
Cytokines
Other
Market Size and Growth
Competitive Analysis
Chapter Six: Issues and Trends
Introduction
Antiviral Drug Resistance
HIV Drug Cost Controversy
Antiretroviral Treatment Regimens
HIV and Women
Global Surveillance
Biochemical Prevention and Treatment of Viral Infections
New Treatment for Hepatitis C
Costs and Funding of HIV Treatment
Access to HIV/AIDS Treatment
Chapter Seven: Total Market Size and Forecast
Overview
Total Market Size and Forecast
chapter Eight: Corporate Profiles
Introduction
Abbott Laboratories
Boehringer Ingelheim GmbH
Bristol-Myers Squibb Company
Gilead Sciences, Inc.
GlaxoSmithKline
MedImmune, Inc.
Merck & Company, Inc.
Novartis Pharmaceuticals Corporation
Roche
Schering-Plough Corporation
APPENDIX: Company Names and Addresses