| Table
of Contents |
| Section |
Summary |
| 1 |
Introduction
and Overview of the Vaccine Market: Drivers and Challenges
- Establishes the framework for understanding and analyzing the market
for vaccine technologies and applications
- Examines the emerging trends in the vaccine segment - both
technological and market drivers are discussed
- Reviews the FDA process and international issues regarding the
development of new vaccines and related delivery systems
|
| 2 |
Review
of the Basis of Immunity, Infectious Agents, and the Pathophysiology of
Cancer
Section 2 reviews the basics to establish the foundation of understanding
how vaccines work in the body. The pathways that can be used to alter the
body's reaction to invading organisms are examined. How various processes
can be converted from healthy responses to pathology are how these
processes might be disrupted to benefit patient well-being are discussed,
including:
- Basics of how the immune system functions
- Overview of how infectious agents invade the body and result in
disease
- Presents a review of the pathophysiology of cancer
|
| 3 |
Vaccine
Technologies and Routes of Administration
The current technological approaches to approved vaccines are reviewed in
this section. Certain technologies are key to the development of new
vaccines, including the use of genomics to identify new antigen targets,
adjuvants, and a wide variety of drug delivery systems. The technologies
impacting the development of improved existing vaccines and new vaccines
are also examined including:
- Current Vaccines - live, killed, and subunit
- DNA Vaccines - multi-component, naked DNA, anti-idiotypic,
modification of virulence genes, and conjugate vaccines
- Vaccine Adjuvants - subunit antigens, aluminum salts, calcium
phosphate, surface-active agents, bacterial products, cytokines and
hormones, unique antigen constructs, polyanions, and polyacrylics
- Drug Delivery Systems - nanoparticles, various vectors, gene-gun,
cochleates, microencapsulation, and biodegradable polymers
Also discussed are the key functions of delivery systems and how they
can enhance overall treatment by improving the efficacy of vaccines.
Current and developing delivery technologies are presented. Lastly, an
examination of how changes in system composition and morphology alter
delivery functions and the factors governing the delivery
system-physiology interactions is provided.
|
| 4 |
Market
Overview and Forecasts by Infectious Agent and Type of Cancer
Vaccines have a wide-ranging application both for the prevention of
infectious diseases and as therapeutics, particularly to deter the
re-occurrence of cancer. This section reviews the key market segments for
the applications of vaccines, including the size of each opportunity and
how it will be affected by key current strategies. Also presented are
sales forecasts of the market segments, including the underlying reasons
for growth, arranged by therapeutic category. Some of the market segments
reviewed include:
- Infectious Agents - Hepatitis A, B, and C, HIV, RSV, Influenza, CMV,
Rhinovirus, HPV, Rotavirus, Dengue, H. pylori, Salmonella, E.coli, and
much more
- Cancers - colon, lung, breast, melanoma, prostate, ovarian, and many
more
In addition, this section identifies the key patents due to expire and
the overall trends that are currently influencing the pharmaceutical
industry and affecting the development and use of vaccines.
|
| 5 |
Vaccine
Company Profiles
As the importance of vaccine use emerges, product differentiation and
positioning in the marketplace will continue to take on enhanced stature.
In this section, the role and position of some of the key vaccine and drug
delivery systems companies are reviewed. The review includes:
- Analysis of vaccine company positioning and emerging trends
- Company profiles, which is a comprehensive review of some of the
leading companies with vaccine technologies
In-depth
Company Profiles
Allergenics
American Home Products
Antigenics
Aphton Corporation
Argonex
Avax Technologies
Antex Biologics
Aventis Pharma AG
Avigen
Aviron
AVI Biopharm
Baxter
BioChem Vaccines
BioDelivery Sciences
Bioenvision
BioPort
Biomira
Cangene
CSL Limited
Cantab Pharmaceuticals plc
Cell Genesys
Celltech
Chiron Corporation
Coulter
Cortecs International
Crucell
Dynagen
Endorex
Entremed
Epimmune
EVAX Technologies
Galenica
Genentech
Genzyme
GlaxoSmithKline
Imclone Systems
Immune Response Corporation
Immunex
Innogenetics NV
Inex Pharmaceuticals
Jenner Technologies
Large Scale Biology
MedImmune
Merck
Microscience
Novavax
OraVax.
PowderJect Technologies
Progenics Pharmaceuticals
Southern Research Institute
StressGen
Therion Biologics
VaxGen
Vical
Viragen |
