BRCA MASTR Dx - Biotech, Pharma and Life Science Channel
The BRCA MASTR Dx is a molecular diagnostic assay for the identification of mutations in the coding regions of the BRCA 1&2 genes in individuals with increased risk for breast, ovarian and/or related cancers compatible with Roche’s 454 sequencers.
Multiplicom’s MASTR (Multiplex Amplification of Specific Targets for Resequencing) assays are ready to use and offer robust performance with minimum hands-on time. All reagents necessary to enable multiplex amplification of 93 amplicons (289-430 bp) are included, for complete exon coverage of all coding sequences. The assays are compatible with all current Massive Parallel Sequencing (MPS) platforms, giving the flexibility to choose a preferred technology.
BRCA MASTR Dx is a registered trademark of Multiplicom.
PubMed Articles
Hypermethylation and prognostic implication of Syk gene in human colorectal cancer.
The study was aimed to investigate the relationship between hypermethylation of Syk gene and clinicopathological characteristics and long-term outcomes in colorectal cancer. The effect of Syk on cell...
Self-assembled multivalent RGD-peptide arrays - morphological control and integrin binding.
We report the synthesis of four different RGD peptide derivatives which spontaneously self-assemble into nanoscale architectures. Depending on the information programmed into the molecular-scale build...
Dragon's blood Croton palanostigma induces genotoxic effects in mice.
Dragon's blood is a dark-red sap produced by species from the genus Croton (Euphorbiaceae), which has been used as a famous traditional medicine since ancient times in many countries, with scarce data...
An easy assay: A synthetic substrate enables a colorimetric screen for terpene synthase cyclization activity, thereby facilitating the engineering of these enzymes. By using directed evolution, the th...
Little is known about genetic service utilization and ovarian cancer. We identified the frequency and outcome of genetic counseling referral, predictors of referral, and referral uptake for ovarian ca...
BACKGROUND: To analyze the effects of supplemental epidermal growth factor (EGF) and the roles of inflammatory cytokines (interleukin [IL]-6) in an ex vivo dry-eye model under hyperosmotic stress usin...
Highly rapid amplification-free and quantitative DNA imaging assay.
There is an urgent need for rapid and highly sensitive detection of pathogen-derived DNA in a point-of-care (POC) device for diagnostics in hospitals and clinics. This device needs to work in a 'sampl...
Recent clinical observations and experimental studies of our group indicate that macrophage migration inhibitory factor (MIF) may contribute to tumor progression in head and neck squamous cell carcino...
A protein kinase assay based on FRET between quantum dots and fluorescently-labeled peptides.
A novel protein kinase assay was developed, based on FRET between QDs and fluorescently-labeled substrate peptides. The negatively charged QDs recognize the change in net charge of the peptide upon ph...
We report the emerging role of microRNA (miRNA) deregulation associated with activation of an oncogene SOX4 (a member of the SRY-related HMG-box) in esophageal carcinoma. Paired esophageal cancer and...
News Articles
Scientists in U.S., Canada Challenged to Submit Groundbreaking Research Proposals for Chance at Collaborative Partnership Focused on Drug Discovery GlaxoSmithKline plc...
Background: Plant expansins and fungal swollenin that can disrupt crystalline cellulose have great potential for applications in conversion of biomass. Recent studies have been mainly focused on Trich...
SEATTLE, May 20, 2013 /PRNewswire/ -- Pacific Biomarkers and Clinigene International are set to unveil their collaborative laboratory solutions for developers of biosimilars at the 2013 AAPS/ Nat...
First Man Has Prostatectomy Because of BRCA Gene Mutation
A medical first: A man who found out in a clinical trial that he was carrying the BRCA2 gene mutation asked for and underwent prostatectomy. Medscape Medical News
Oncotype DX prostate cancer assay: Additional data
Lethal and rescuer genes are defined as genes that when inactivated result in cell death or enhanced cell growth, respectively. The ability to identify these genes in large-scale automated screening c...
In the largest clinical trial to date to examine the efficacy of PARP inhibitor therapy in BRCA 1/2 carriers with diseases other than breast and ovarian cancer, the oral drug olaparib was found to be...
How Will Angelina Jolie Affect Your Practice?
By Celebrity Diagnosis Have the phone calls already started? With the announcement on Tuesday that Angelina Jolie had undergone a prophylactic double mastectomy because she carries the BRCA1 gene, th...
Porvair Sciences Announces Summer Show Program
Porvair Sciences has announced that its latest applications focused microplates and microplate equipment will be exhibited at Forum LABO, European Lab Automation ASMS and HPLC 2013 Visitors to P...
Genomind Demonstrates Broader Commitment to the Mental Health Community
CHALFONT, PA--(Marketwired - May 17, 2013) - Genomind, a personalized medicine company, is pleased to announce that we will attend and present at the American Psychiatric Association (APA) Annual Me...
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Companies
Rockland Immunochemicals has supported the biopharma and diagnostic industries for over 40 years with antibodies and antibody based toolsâ¢Â for basic research, assay develo...
Altogen Labs (www.altogenlabs.com) is a life sciences company dedicated to providing pre-clinical research services to pharmaceutical and biotechnology organizations worldwide....
Accelr8 Technology Corporation (www.accelr8.com) is a developer of innovative materials and instrumentation for advanced applications in medical instrumentation, basic research, d...
BioLegend develops and manufactures world-class, cutting-edge antibodies and reagents at an outstanding value to customers for biomedical research. The broad product portfolio inc...
Cambridge Biomedical is a contract research organization (CRO) and diagnostic laboratory providing bioanalytical support to the pharmaceutical, biotechnology, and medical d...
HemoGenix® is a privately-held Contract Research Service and Assay Development Laboratory based in Colorado Springs, Colorado. Specializing in predictive in vitro stem cell tox...
AIBioTech is a comprehensive Contract Research Organization which provides research services, drug development, assay development, and clinical testing services to organizations i...
AI BioTech is a comprehensive Contract Research Organization which provides research services, drug development, assay development, and clinical testing services to organizations...
AIBioTech is a comprehensive Life Sciences Company which provides Genetic and DNA Identity services, contract research services, drug development services, assay development, and...
Absorption Systems, founded in 1996, assists pharmaceutical, biotechnology and medical device companies in identifying and overcoming ADMET (Absorption, Distribution, Metabolism,...
Clinical Trials
Background: - BRCA1 and BRCA2 gene mutations have been linked to a higher risk of developing breast cancer and other cancers, and may be associated with types of breast cancer that are mo...
Gene Expression in Cumulus Cells to Predict Pregnancy
The purpose of this study is to determine the performance of a genetic assay, GemART, in cumulus cells predictive of embryo viability, and pregnancy success in women undergoing in vitro fe...
Valganciclovir (VGCV) has recently been approved by the Food and Drug Administration (FDA) for the treatment and prevention of cytomegalovirus (CMV) retinitis in HIV patients. It is under...
Safety of a Diagnostic Strategy With D-Dimer Testing for PE
To determine whether D-Dimer testing, using the MDA D-Dimer assay, can be used to simplify the diagnostic process for pulmonary embolism (PE). This will be assessed by performing a cohort...
IVIG Versus Placebo for the Treatment of Patients With Severe C-Diff
In this trial, eligible patients will be randomly assigned to receive a single dose of 400 mg/kg of IVIG or a normal saline infusion as placebo over 4-6 hours, in addition to their usual m...
Organ Transplant Infection Prevention and Detection Project
Fungal infections are leading causes of morbidity and mortality in transplant recipients, yet comprehensive epidemiologic studies in this area are lacking. For this reason, the Centers for...
Proliferation of Endometrial Stromal Cells in Adenomyosis
Adenomyosis refers to the presence of endometrial glands and stroma that is haphazardly deep within the myometrium. However, the etiology and pathologic mechanism responsible for adenomyos...
Environmental Enterovirus Monitoring
From last decades, because of lacking the powerful quantitative methods, such as real-time qPCR, there is no environmental monitoring data about enterovirus transmission. If the major tra...
Aspergillus is a fungus found in soil, on farms and on construction sites. In those whose immune system is impaired it causes severe infection. The people who are particularly at high-risk...
Genetic Determinants of the Bronchodilatation Effect of Albuterol ex-Vivo
The role played by ß2AR polymorphisms in determining the bronchial response to ß2AR agonist drugs, has been confirmed by several studies. The purpose of the present study is to examine...
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Medical and Biotech [MESH] Definitions
Dna, Catenated
CIRCULAR DNA that is interlaced together as links in a chain. It is used as an assay for the activity of DNA TOPOISOMERASES. Catenated DNA is attached loop to loop in contrast to CONCATENATED DNA which is attached end to end.
Enzyme Assays
Methods used to measure the relative activity of a specific enzyme or its concentration in solution. Typically an enzyme substrate is added to a buffer solution containing enzyme and the rate of conversion of substrate to product is measured under controlled conditions. Many classical enzymatic assay methods involve the use of synthetic colorimetric substrates and measuring the reaction rates using a spectrophotometer.
High-throughput Screening Assays
Rapid methods of measuring the effects of an agent in a biological or chemical assay. The assay usually involves some form of automation or a way to conduct multiple assays at the same time using sample arrays.
Serum Bactericidal Antibody Assay
Procedures for identification and measurement of IMMUNOGLOBULINS in the blood that initiate lysis of bacteria.
Enzyme-linked Immunospot Assay
A method of detection of the number of cells in a sample secreting a specific molecule. Wtih this method a population of cells are plated over top of the immunosorbent substrate that captures the secreted molecules.
