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G-protein-coupled receptors (GPCRs) - Biotech, Pharma and Life Science Channel

21:10 EST 18th January 2017 | BioPortfolio

GPCRs are a large family of cell surface receptors that respond to a variety of external signals. Binding of a signaling molecule to a GPCR results in G protein activation, which in turn triggers the production of any number of second messengers. Through this sequence of events, GPCRs help regulate an incredible range of bodily functions, from sensation to growth to hormone responses.

Source: http://www.nature.com/scitable/topicpage/gpcr-14047471

PubMed Articles [100 Associated PubMed Articles listed on BioPortfolio]

An Update on the Physiological and Therapeutic Relevance of GPCR Oligomers.

The traditional view on GPCRs held that they function as single monomeric units composed of identical subunits. This notion was overturned by the discovery that GPCRs can form homo- and hetero-oligome...

Toward the next step in G protein-coupled receptor research: a knowledge-driven analysis for the next potential targets in drug discovery.

More than 800 G protein-coupled receptor (GPCR) genes have been discovered in the human genome. Towards the next step in GPCR research, we performed a knowledge-driven analysis of orphan class-A GPCRs...

Methods used to study the oligomeric structure of G protein-coupled receptors.

G-protein coupled receptors (GPCRs), which constitute the largest family of cell surface receptors, were originally thought to function as monomers, but are now recognized as being able to act in a wi...

Ligand discovery for a peptide-binding GPCR by structure-based screening of fragment- and lead-like chemical libraries.

Peptide-recognizing G protein-coupled receptors (GPCRs) are promising therapeutic targets, but often resist drug discovery efforts. Determination of crystal structures for peptide-binding GPCRs has pr...

Identification of Molecular Targets for 4,5-Dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT) in Teleosts: New Insight into Mechanism of Toxicity.

Environmental pollutants are capable of concomitantly inducing diverse toxic effects. However, it is largely unknown which effects are directly induced and which effects are secondary, thus calling fo...

Mycobacteria Manipulate G-Protein-Coupled Receptors to Increase Mucosal Rac1 Expression in the Lungs.

Mycobacterium bovis bacille Calmette-Guérin (BCG) is currently the only approved vaccine against tuberculosis (TB). BCG mimics M. tuberculosis (Mtb) in its persistence in the body and is used as a be...

Functional selectivity and dualsteric/bitopic GPCR targeting.

Functional selectivity provides a new avenue to selectively engage particular pathways of the pleiotropic signaling repertoire of a G protein-coupled receptor. First examples for signaling biased comp...

Structural insight to mutation effects uncover a common allosteric site in class C GPCRs.

Class C G protein-coupled receptors (GPCRs) regulate important physiological functions and allosteric modulators binding to the transmembrane domain constitute an attractive and, due to a lack of stru...

Hypoxia sensing through β-adrenergic receptors.

Life-sustaining responses to low oxygen, or hypoxia, depend on signal transduction by HIFs, but the underlying mechanisms by which cells sense hypoxia are not completely understood. Based on prior stu...

High affinity binding of the peptide agonist TIP-39 to the parathyroid hormone 2 (PTH2) receptor requires the hydroxyl group of Tyr-318 on transmembrane helix 5.

TIP39 ("tuberoinfundibular peptide of 39 residues") acts via the parathyroid hormone 2 receptor, PTH2, a Family B G protein-coupled receptor (GPCR). Despite the importance of GPCRs in human physiology...

News Articles [49 Associated News Articles listed on BioPortfolio]

Dermata Therapeutics, LLC Announces Initiation of Treatment in a Phase 2 Acne Rosacea Clinical Study

SAN DIEGO, Jan. 18, 2017 /PRNewswire/ -- Dermata Therapeutics, LLC, a biotechnology company developing new and innovative products to treat a variety of dermatological diseases, announces dosing ...

Domain Therapeutics SA Pharmaceuticals Healthcare Deals and Alliances Profile Prices from USD $250

SummaryDomain Therapeutics SA Domain Therapeutics is a biopharmaceutical company that discovers and develops innovative therapeutics for the treatment of Central Nervous System CNS diseases and cancer...

Curadev Pharma Pvt Ltd Pharmaceuticals Healthcare Deals and Alliances Profile Prices from USD $250

SummaryCuradev Pharma Pvt Ltd Curadev is a small molecule drug discovery company that concentrates on accelerating the discovery and delivery of novel formulations for better solubility and drug deliv...

Sevion Therapeutics Inc SVON Pharmaceuticals Healthcare Deals and Alliances Profile Prices from USD $250

SummarySevion Therapeutics Inc Sevion, formerly Senesco Technologies, Inc. is a pharmaceutical company that discovers, develops and acquires product candidates for the treatment of cancer and immunolo...

Bird Rock Bio Receives Approval to Start First in Human Clinical Trial for Namacizumab, Enters Into Agreement with GE Healthcare for Process Development and Scale-up to Provide Clinical Phase 2 cGMP Material, and Enters into a Collaboration and Opti

LA JOLLA, Calif., Jan. 11, 2017 /PRNewswire/ --  Bird Rock Bio, Inc. a clinical stage biopharmaceutical company, announced today that it has received approval for the initiation of a two-part Pha...

Novus Biologicals LLC Pharmaceuticals Healthcare Deals and Alliances Profile Prices from USD $250

SummaryNovus Biologicals LLC Novus Biologicals, a subsidiary of BioTechne is a biotechnology company that offers biological research services. The company provides scientific discovery and develops pr...

ChanTest Corp Pharmaceuticals Healthcare Deals and Alliances Profile Prices from USD $250

SummaryChanTest Corp ChanTest, a subsidiary of Charles River Laboratories International Inc is a contract research organization that discovers and develops drugs in ion channel and GPCR biology fields...

MaxCyte Inc MXCT Pharmaceuticals Healthcare Deals and Alliances Profile Prices from USD $250

SummaryMaxCyte Inc MaxCyte is a biotherapeutic company that conducts research and develops cell transfection technologies. The company utilizes flow electroporation technology for discovery, developme...

High-resolution crystal structure of the human CB1 cannabinoid receptor

The human cannabinoid G-protein-coupled receptors (GPCRs) CB1 and CB2 mediate the functional responses to the endocannabinoids anandamide and 2-arachidonyl glycerol (2-AG) and to the widely consumed p...

Domain Therapeutics signs GPCR licensing agreement with Alkermes

Biopharmaceutical company Domain Therapeutics has signed a licensing agreement for its G-protein-coupled receptors (GPCR) BioSens-All technology with Ireland-based Alkermes.

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Companies [12 Associated Companies listed on BioPortfolio]

Carmot Therapeutics, Inc.

Carmot Therapeutics, Inc. is pioneering a transformative lead-identification technology, Chemotype Evolution, to identify superior therapeutics for human diseases. The technology ...

Lanthio Pharma

Lanthio Pharma is a privately held drug discovery company that applies its proprietary lanthionine-peptide technology to the discovery of novel peptide therapeutics with longer ha...

Anchor Therapeutics, Inc.

Anchor Therapeutics, Inc. is a leader in the development of pepducin technology. The Company is engaged in the licensing of pepducin technology as research tools for drug developm...

Receptos, Inc.

Receptos is a biopharmaceutical company developing best- and first-in-class G protein-coupled receptor (GPCR) therapeutic candidates through information-driven drug discovery, inc...

Anchor Therapeutics

Anchor Therapeutics is developing first-in-class pepducin drug candidates, novel molecules that can selectively target G protein coupled receptors (GPCRs) to allosterically modula...

Tranzyme Pharma

Tranzyme Pharma is a clinical-stage drug development company that discovers and develops novel small molecule macrocyclic drugs for both acute care (hospital-based) and chronic in...

BioFocus

BioFocus is a collaborative drug discovery company providing an integrated platform of expertise and technologies in medicinal chemistry and biological screening to the global biopharmaceutical indust...

Dimerix Bioscience Pty Ltd

Dimerix is a Perth-based drug discovery company focused on developing pharmaceutical products targeting heteromers or complexes of GPCRs. Approximately 40% of all currently market...

DiscoveRx® Corporation

Founded in 2000, DiscoveRx is a privately held, venture-backed company headquartered in Fremont, California, with an additional office in Birmingham, England. The Company pioneere...

Tocris Bioscience

The Tocris Bioscience range contains over 3,000 products, from the very latest exclusive research tools to established biochemical standards. Neurochemicals Signal Transduction Agents P...

Clinical Trials [2 Associated Clinical Trials listed on BioPortfolio]

A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Efficacy of BC 007 in Healthy Subjects

Berlin Cures develops BC 007 to treat patients suffering from diseases (chronic heart failure, pulmonary hypertension, chronic fatigue syndrome etc.) which are associated with functional a...

Ghrelin Resistance in Adolescents With Idiopathic Scoliosis

Adolescent idiopathic Scoliosis (AIS) is the most common spine pathology. It is opposed to secondary scoliosis due to chronic diseases. Many hypotheses have been made to elucidate the orig...

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