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G-protein-coupled receptors (GPCRs) - Biotech, Pharma and Life Science Channel

06:27 EST 20th February 2017 | BioPortfolio

GPCRs are a large family of cell surface receptors that respond to a variety of external signals. Binding of a signaling molecule to a GPCR results in G protein activation, which in turn triggers the production of any number of second messengers. Through this sequence of events, GPCRs help regulate an incredible range of bodily functions, from sensation to growth to hormone responses.

Source: http://www.nature.com/scitable/topicpage/gpcr-14047471

PubMed Articles [105 Associated PubMed Articles listed on BioPortfolio]

Conformational profiling of the AT1 angiotensin II receptor reflects biased agonism, G protein coupling and cellular context.

Here, we report the design and use of GPCR-based biosensors to monitor ligand-mediated conformational changes in receptors in intact cells. These biosensors use Bioluminescence Resonance Energy Transf...

G protein-coupled receptor kinase-2 (GRK-2) regulates serotonin metabolism through the monoamine oxidase AMX-2 in Caenorhabditis elegans.

G protein-coupled receptors (GPCRs) regulate many animal behaviors. GPCR signaling is mediated by agonist-promoted interactions of GPCRs with heterotrimeric G proteins, GPCR kinases (GRKs) and arresti...

G protein coupled receptor-mediated transactivation of extracellular proteases.

G protein-coupled receptors (GPCRs) comprise the largest family of receptors in humans. Traditional activation of GPCRs involves binding of a ligand to the receptor, activation of heterotrimeric G pro...

Propagation of the allosteric modulation induced by sodium in the δ opioid receptor.

Allosteric sodium in the helix bundle of a G protein-coupled receptor (GPCR) can modulate the receptor activation on the intracellular side. This phenomenon has confounded the GPCR community for decad...

Potential of GPCRs to modulate MAPK and mTOR pathways in Alzheimer's disease.

Despite efforts to understand the mechanism of neuronal cell death, finding effective therapies for neurodegenerative diseases is still a challenge. Cognitive deficits are often associated with neurod...

The G protein-coupled receptor N-terminus and receptor signalling: N-tering a new era.

G protein-coupled receptors (GPCRs) are a vast family of membrane-traversing proteins, essential to the ability of eukaryotic life to detect, and mount an intracellular response to, a diverse range of...

Bitopic Ligands and Metastable Binding Sites: Opportunities for G Protein-Coupled Receptor (GPCR) Medicinal Chemistry.

G protein-coupled receptors (GPCRs) belong to a large superfamily of membrane receptors mediating a variety of physiological functions. As such they are attractive targets for drug therapy. However, i...

Recent advances in drug discovery of GPCR allosteric modulators for neurodegenerative disorders.

The activation or the inhibition of G-protein coupled receptors (GPCRs) implicated in the pathophysiology of neurodegenerative disorders is considered as a relevant approach for the treatment of these...

Allosteric "beta-blocker" isolated from a DNA-encoded small molecule library.

The β2-adrenergic receptor (β2AR) has been a model system for understanding regulatory mechanisms of G-protein-coupled receptor (GPCR) actions and plays a significant role in cardiovascular and pulm...

New Insights into Mechanisms of Nuclear Translocation of G-protein Coupled Receptors.

The G-protein coupled receptor (GPCR) signaling was long believed to involve activation of receptor exclusively at the cell surface, followed by its binding to heterotrimeric G-proteins and arrestins ...

News Articles [52 Associated News Articles listed on BioPortfolio]

Confo Therapeutics is awarded EUR 2.6M in non-dilutive funding for the discovery of new fibrosis treatments and for expanding the use of its unique Confo® technology

Ghent, Belgium - February 1, 2017   Confo Therapeutics, an emerging drug discovery company, today announced that it has received a €1.6 million grant from Flanders Innovation & E...

Heptares, University of Cambridge Launch Research Collaboration

Heptares Therapeutics said today it will partner with the laboratory of Anthony Davenport, Ph.D., of the University of Cambridge to fight cardiovascular diseases by discovering novel molecules that ta...

Heptares Enters a New Research Collaboration Under Its 'Orbit' Initiative With the University of Cambridge

LONDON and CAMBRIDGE, England, January 31, 2017 /PRNewswire/ -- New Programme Focused on Apelin Receptor in Cardiovascular Diseases   Heptares Therapeutics ("Heptares"), the wholly-owned...

Abilita Bio Signs a New Research Collaboration with a Global Pharmaceutical Company and 2016 Milestone Review

Abilita Bio Inc. today announced a second research collaboration agreement with a major pharmaceutical partner, which will leverage Abilita Bio’s proprietary EMP™ membrane pro...

Anchor Therapeutics Inc Pharmaceuticals Healthcare Deals and Alliances Profile Prices from USD $250

SummaryAnchor Therapeutics Inc Anchor, formerly Ascent Therapeutics, Inc. is a biopharmaceutical company that develops peptide modulators of G proteincoupled receptors. The company offers products suc...

Domain Therapeutics Grants Alkermes a Non-Exclusive License for its G Protein-Coupled Receptor BioSens-All™ Technology

Technology provides access to a new set of sensitive biosensors that will facilitate drug discovery  Domain Therapeutics, a France- and Quebec-based biopharmaceutical company that specializes in ...

Trevena Inc TRVN Pharmaceuticals Healthcare Deals and Alliances Profile Prices from USD $250

SummaryTrevena Inc Trevena is a biopharmaceutical company that discovers and develops Gprotein coupled receptor targeted medicines. The company's products include RV027, TRV130, TRV734 and TRV250. Its...

Dermata Therapeutics, LLC Announces Initiation of Treatment in a Phase 2 Acne Rosacea Clinical Study

SAN DIEGO, Jan. 18, 2017 /PRNewswire/ -- Dermata Therapeutics, LLC, a biotechnology company developing new and innovative products to treat a variety of dermatological diseases, announces dosing ...

Domain Therapeutics SA Pharmaceuticals Healthcare Deals and Alliances Profile Prices from USD $250

SummaryDomain Therapeutics SA Domain Therapeutics is a biopharmaceutical company that discovers and develops innovative therapeutics for the treatment of Central Nervous System CNS diseases and cancer...

Curadev Pharma Pvt Ltd Pharmaceuticals Healthcare Deals and Alliances Profile Prices from USD $250

SummaryCuradev Pharma Pvt Ltd Curadev is a small molecule drug discovery company that concentrates on accelerating the discovery and delivery of novel formulations for better solubility and drug deliv...

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Companies [12 Associated Companies listed on BioPortfolio]

Carmot Therapeutics, Inc.

Carmot Therapeutics, Inc. is pioneering a transformative lead-identification technology, Chemotype Evolution, to identify superior therapeutics for human diseases. The technology ...

Lanthio Pharma

Lanthio Pharma is a privately held drug discovery company that applies its proprietary lanthionine-peptide technology to the discovery of novel peptide therapeutics with longer ha...

Anchor Therapeutics, Inc.

Anchor Therapeutics, Inc. is a leader in the development of pepducin technology. The Company is engaged in the licensing of pepducin technology as research tools for drug developm...

Receptos, Inc.

Receptos is a biopharmaceutical company developing best- and first-in-class G protein-coupled receptor (GPCR) therapeutic candidates through information-driven drug discovery, inc...

Anchor Therapeutics

Anchor Therapeutics is developing first-in-class pepducin drug candidates, novel molecules that can selectively target G protein coupled receptors (GPCRs) to allosterically modula...

Tranzyme Pharma

Tranzyme Pharma is a clinical-stage drug development company that discovers and develops novel small molecule macrocyclic drugs for both acute care (hospital-based) and chronic in...

BioFocus

BioFocus is a collaborative drug discovery company providing an integrated platform of expertise and technologies in medicinal chemistry and biological screening to the global biopharmaceutical indust...

Dimerix Bioscience Pty Ltd

Dimerix is a Perth-based drug discovery company focused on developing pharmaceutical products targeting heteromers or complexes of GPCRs. Approximately 40% of all currently market...

DiscoveRx® Corporation

Founded in 2000, DiscoveRx is a privately held, venture-backed company headquartered in Fremont, California, with an additional office in Birmingham, England. The Company pioneere...

Tocris Bioscience

The Tocris Bioscience range contains over 3,000 products, from the very latest exclusive research tools to established biochemical standards. Neurochemicals Signal Transduction Agents P...

Clinical Trials [2 Associated Clinical Trials listed on BioPortfolio]

A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Efficacy of BC 007 in Healthy Subjects

Berlin Cures develops BC 007 to treat patients suffering from diseases (chronic heart failure, pulmonary hypertension, chronic fatigue syndrome etc.) which are associated with functional a...

Ghrelin Resistance in Adolescents With Idiopathic Scoliosis

Adolescent idiopathic Scoliosis (AIS) is the most common spine pathology. It is opposed to secondary scoliosis due to chronic diseases. Many hypotheses have been made to elucidate the orig...

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