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G-protein-coupled receptors (GPCRs) - Biotech, Pharma and Life Science Channel

07:28 EDT 22nd September 2017 | BioPortfolio

GPCRs are a large family of cell surface receptors that respond to a variety of external signals. Binding of a signaling molecule to a GPCR results in G protein activation, which in turn triggers the production of any number of second messengers. Through this sequence of events, GPCRs help regulate an incredible range of bodily functions, from sensation to growth to hormone responses.

Source: http://www.nature.com/scitable/topicpage/gpcr-14047471

PubMed Articles [127 Associated PubMed Articles listed on BioPortfolio]

Receptor Quaternary Organization Explains G Protein-Coupled Receptor Family Structure.

The organization of Rhodopsin-family G protein-coupled receptors (GPCRs) at the cell surface is controversial. Support both for and against the existence of dimers has been obtained in studies of most...

Formyl Peptide Receptors in Mice and Men: Similarities and Differences in Recognition of Conventional Ligands and Modulating Lipopeptides.

The pattern recognition formyl peptide receptors (FPRs) belong to the class of G protein-coupled receptors (GPCRs), the largest group of cell-surface receptors involved in a range of physiological pro...

Mapping the STK4/Hippo signaling network in prostate cancer cell.

Dysregulation of MST1/STK4, a key kinase component of the Hippo-YAP pathway, is linked to the etiology of many cancers with poor prognosis. However, how STK4 restricts the emergence of aggressive canc...

Membrane cholesterol effect on the 5-HT2A receptor: Insights into the lipid-induced modulation of an antipsychotic drug target.

The serotonin 5-hydroxytryptamine 2A (5-HT2A ) receptor is a G-protein-coupled-receptor (GPCR) relevant for the treatment of CNS disorders. In this regard, neuronal membrane composition in the brain p...

Spirohexene-Tetrazine Ligation Enables Bioorthogonal Labeling of Class B G Protein-Coupled Receptors in Live Cells.

A new bioorthogonal reactant pair, spiro[2.3]hex-1-ene (Sph) and 3,6-di-(2-pyridyl)-s-tetrazine (DpTz), for the strain-promoted inverse electron-demand Diels-Alder cycloaddition, i.e., tetrazine ligat...

GPCR signaling from within the cell.

Traditionally, signal transduction from G protein-coupled receptors (GPCRs) is thought to emanate from the cell surface where receptor interactions with external stimuli can be transformed into a broa...

Two independent but synchronized Gβγ subunit-controlled pathways are essential for trailing-edge retraction during macrophage migration.

Chemokine-induced directional cell migration is a universal cellular mechanism and plays crucial roles in numerous biological processes, including embryonic development, immune system function, and ti...

Distinct Signaling Patterns of Allosteric Antagonism at the P2Y1 Receptor.

Traditionally, GPCR antagonists are classified as competitive or non-competitive and surmountable or insurmountable based on functional antagonism. P2Y1 receptor (P2Y1R) structures showed two antagoni...

Incidence of elephant endotheliotropic herpesvirus in Asian elephants in India.

Elephant endotheliotropic herpesviruses (EEHVs) are the cause of acute hemorrhagic disease in endangered Asian and African elephants. In the present study, we report the incidence of EEHV infection an...

RGS4 Overexpression in Lung Attenuates Airway Hyper-responsiveness in Mice.

A cardinal feature of asthma is airway hyper-responsiveness (AHR) to spasmogens, many of which activate G protein-coupled receptors (GPCRs) on airway smooth muscle (ASM) cells. Asthma subtypes associa...

News Articles [65 Associated News Articles listed on BioPortfolio]

Trevena Inc TRVN Pharmaceuticals Healthcare Deals and Alliances Profile [Report Updated: 23082017] Prices from USD $250

SummaryTrevena Inc Trevena is a biopharmaceutical company that discovers and develops Gprotein coupled receptor targeted medicines. The company's products include RV027, TRV130, TRV734 and TRV250. Its...

Fidelta Announces An Extension Of Its Drug Discovery Service Agreement With Heptares

Zagreb, Croatia, 5th September 2017 Fidelta, a Galapagos company, is pleased to announce the continuation of an agreement with Heptares, whereby Fidelta will provide medicinal chemistry, DMPK and pha...

Allergan Takes to the Clinic the First Alzheimer’s Drug from a €3Bn Deal

Allergan’s partner Heptares Therapeutics has dosed the first patient with a GPCR drug to treat major symptoms of Alzheimer’s disease. A year ago, Allergan signed a massive deal of up to ...

Allergan Takes to the Clinic a New Alzheimer’s Drug from a €3Bn Deal

Allergan’s partner Heptares Therapeutics has dosed the first patient with a GPCR drug to treat major symptoms of Alzheimer’s disease. A year ago, Allergan signed a massive deal of up to ...

Heptares Enters a New Research and Drug Discovery Collaboration Under its 'Orbit' Initiative with Juntendo University

LONDON and TOKYO, September 1, 2017 /PRNewswire/ -- Heptares Therapeutics ("Heptares"), the wholly-owned subsidiary of Sosei Group Corporation (TSE Mothers Index: 4565), announces the launch of a ...

Functional autoantibodies targeting G protein-coupled receptors in rheumatic diseases

Autoantibodies are known to regulate the function of G protein-coupled receptors (GPCRs), but the involvement of such functional autoantibodies in autoimmune disorders is not fully understood. In this...

Commensal bacteria make GPCR ligands that mimic human signalling molecules

Commensal bacteria have N-acyl amide synthase genes that encode signalling molecules (N-acyl amides) that can interact with G-protein-coupled receptors and elicit host cellular responses similar to eu...

Integral Molecular Doubles Antibody Discovery Capacity

Integral Molecular, a Philadelphia based biotechnology company, announces the expansion of its facility, personnel, and resources dedicated to antibody discovery for membrane prot...

A kinetic view of GPCR allostery and biased agonism

Domain Therapeutics SA Pharmaceuticals Healthcare Deals and Alliances Profile [Report Updated: 27072017] Prices from USD $250

SummaryDomain Therapeutics SA Domain Therapeutics is a biopharmaceutical company that discovers and develops innovative therapeutics for the treatment of Central Nervous System CNS diseases and cancer...

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Companies [12 Associated Companies listed on BioPortfolio]

Carmot Therapeutics, Inc.

Carmot Therapeutics, Inc. is pioneering a transformative lead-identification technology, Chemotype Evolution, to identify superior therapeutics for human diseases. The technology ...

Lanthio Pharma

Lanthio Pharma is a privately held drug discovery company that applies its proprietary lanthionine-peptide technology to the discovery of novel peptide therapeutics with longer ha...

Anchor Therapeutics, Inc.

Anchor Therapeutics, Inc. is a leader in the development of pepducin technology. The Company is engaged in the licensing of pepducin technology as research tools for drug developm...

Receptos, Inc.

Receptos is a biopharmaceutical company developing best- and first-in-class G protein-coupled receptor (GPCR) therapeutic candidates through information-driven drug discovery, inc...

Anchor Therapeutics

Anchor Therapeutics is developing first-in-class pepducin drug candidates, novel molecules that can selectively target G protein coupled receptors (GPCRs) to allosterically modula...

Tranzyme Pharma

Tranzyme Pharma is a clinical-stage drug development company that discovers and develops novel small molecule macrocyclic drugs for both acute care (hospital-based) and chronic in...

BioFocus

BioFocus is a collaborative drug discovery company providing an integrated platform of expertise and technologies in medicinal chemistry and biological screening to the global biopharmaceutical indust...

Dimerix Bioscience Pty Ltd

Dimerix is a Perth-based drug discovery company focused on developing pharmaceutical products targeting heteromers or complexes of GPCRs. Approximately 40% of all currently market...

DiscoveRx® Corporation

Founded in 2000, DiscoveRx is a privately held, venture-backed company headquartered in Fremont, California, with an additional office in Birmingham, England. The Company pioneere...

Tocris Bioscience

The Tocris Bioscience range contains over 3,000 products, from the very latest exclusive research tools to established biochemical standards. Neurochemicals Signal Transduction Agents P...

Clinical Trials [2 Associated Clinical Trials listed on BioPortfolio]

A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Efficacy of BC 007 in Healthy Subjects

Berlin Cures develops BC 007 to treat patients suffering from diseases (chronic heart failure, pulmonary hypertension, chronic fatigue syndrome etc.) which are associated with functional a...

Ghrelin Resistance in Adolescents With Idiopathic Scoliosis

Adolescent idiopathic Scoliosis (AIS) is the most common spine pathology. It is opposed to secondary scoliosis due to chronic diseases. Many hypotheses have been made to elucidate the orig...

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Medical and Biotech [MESH] Definitions

Non-visual system arrestins that negatively regulate G-PROTEIN-COUPLED RECEPTORS (GPCRs) and may also function independently of GPCR signaling. They bind and recruit many different signaling factors, including MITOGEN-ACTIVATED PROTEIN KINASES; SRC-FAMILY-KINASES; and FILAMIN to GPCRs and may recognize different phosphorylation states of the receptors to determine the specificity of the cellular response to signaling.

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