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G-protein-coupled receptors (GPCRs) - Biotech, Pharma and Life Science Channel

10:58 EDT 21st July 2017 | BioPortfolio

GPCRs are a large family of cell surface receptors that respond to a variety of external signals. Binding of a signaling molecule to a GPCR results in G protein activation, which in turn triggers the production of any number of second messengers. Through this sequence of events, GPCRs help regulate an incredible range of bodily functions, from sensation to growth to hormone responses.

Source: http://www.nature.com/scitable/topicpage/gpcr-14047471

PubMed Articles [125 Associated PubMed Articles listed on BioPortfolio]

RNA sequencing to determine the contribution of kinase receptor transactivation to G protein coupled receptor signalling in vascular smooth muscle cells.

G protein coupled receptor (GPCR) signalling covers three major mechanisms. GPCR agonist engagement allows for the G proteins to bind to the receptor leading to a classical downstream signalling casca...

AMP010014A09 in Sus Scrofa Encodes an Analog of G Protein-Coupled Receptor 109A, Which Mediates the Anti-Inflammatory Effects of Beta-Hydroxybutyric Acid.

Hydroxy-carboxylic acid receptor 2 (HCA2, also called GPR109A) belongs to the G protein-coupled receptor (GPCR) family and is found in humans, rats, mice, hamsters and guinea pigs, but there are almos...

Conformational Transitions of the Pituitary Adenylate Cyclase-Activating Polypeptide Receptor, a Human Class B GPCR.

The G protein-coupled pituitary adenylate cyclase-activating polypeptide receptor (PAC1R) is a potential therapeutic target for endocrine, metabolic and stress-related disorders. However, many questio...

Endocrinology and the brain: corticotropin-releasing hormone signaling.

Corticotropin-releasing hormone (CRH) is a key player of basal and stress activated responses in the hypothalamic-pituitary-adrenal axis (HPA) and in extrahypothalamic circuits, where it functions as ...

G protein-coupled receptor kinases: Past, present and future.

This review is provided in recognition of the extensive contributions of Dr. Robert J. Lefkowitz to the G protein-coupled receptor (GPCR) field and to celebrate his 75th birthday. Since one of the aut...

Impact of paroxetine on proximal β-adrenergic receptor signaling.

β-adrenergic receptors (βAR) regulate numerous functions throughout the body, however G protein-coupled receptor kinase (GRK)-dependent desensitization of βAR has long been recognized as a maladapt...

The Energetics of Chromophore Binding in the Visual Photoreceptor Rhodopsin.

The visual photoreceptor rhodopsin is a prototypical G-protein-coupled receptor (GPCR) that stabilizes its inverse agonist ligand, 11-cis-retinal (11CR), by a covalent, protonated Schiff base linkage....

Domain-specific control of germ cell polarity and migration by multifunction Tre1 GPCR.

The migration of primordial germ cells (PGCs) from their place of origin to the embryonic gonad is an essential reproductive feature in many animal species. In Drosophila melanogaster, a single G prot...

Regulator of G protein signaling Gβ5-R7 is a crucial activator of muscarinic M3 receptor-stimulated insulin secretion.

In pancreatic β cells, muscarinic cholinergic receptor M3 (M3R) stimulates glucose-induced secretion of insulin. Regulator of G protein signaling (RGS) proteins are critical modulators of GPCR activi...

GPR37L1 modulates seizure susceptibility: Evidence from mouse studies and analyses of a human GPR37L1 variant.

Progressive myoclonus epilepsies (PMEs) are disorders characterized by myoclonic and generalized seizures with progressive neurological deterioration. While several genetic causes for PMEs have been i...

News Articles [69 Associated News Articles listed on BioPortfolio]

Pinning Down Elusive Targets: Interviewing the Co-Founder & CSO of Heptares

Heptares is expanding into a range of indications with its GPCR platform. I caught up with CSO & co-founder Fiona Marshall to hear more about the strategy. Fiona Marshall has always worked on G-pr...

Opportunities for therapeutic antibodies directed at G-protein-coupled receptors

G protein-coupled receptors (GPCRs) are key drug targets. In this article, Marshall and colleagues discuss the progress made towards generating GPCR-targeting antibodies, including which antigen forma...

Heptares Hosts Scientific Symposium in Celebration Of 10-year Anniversary

LONDON, July 13, 2017 /PRNewswire/ -- Heptares Therapeutics ("Heptares"), the wholly-owned subsidiary of Sosei Group Corporation (TSE Mothers Index: 4565), hosts a scientific symposium today to ce...

Coding GPCR-G protein specificity

BioMed Realty and Omeros Sign New 64,500 Square Foot Lease in Seattle

SAN DIEGO, Feb. 1, 2012 /PRNewswire/ -- BioMed Realty Trust, Inc. (NYSE: BMR) announced today the signing of a new 15-year lease with Omeros Corporation (NASDAQ: OMER) for BioMed's Waterfront Res...

PeptiDream, Heptares sign deal on GPCR-targeting drug studies

Heptares Therapeutics agreed to collaborate with PeptiDream to identify, develop and market drugs that target G protein-coupl -More- 

Heptares Grants Shire an Exclusive Worldwide Licence to Develop and Commercialise Novel Drug Candidate for CNS Disorders

WELWYN GARDEN CITY, England and BOSTON, Massachusetts, March 20, 2012 /PRNewswire/ -- Heptares Therapeutics, the leading GPCR drug discovery company, announces that an operating company of Shire PLC ...

Otsuka Ties Up With Mylan To Advance MDR-TB Drug In India?

Otsuka, which has been under fire over delayed access to delamanid in India, appears to have allied with Mylan, which...   

Immuno-Oncology Outlook: Pfizer's Inlyta Fits Well In Combos For Kidney Cancer

As the RCC field braces for another paradigm change, early studies combining tyrosine kinase inhibitors with PD-1/L1 inhibitors suggest the...   

Hack Attack: Biopharma Cyber Chiefs Fight Back

News that Merck & Co was affected by the recent global ransomware attack hits home the increasing importance of cybersecurity...   

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Companies [12 Associated Companies listed on BioPortfolio]

Carmot Therapeutics, Inc.

Carmot Therapeutics, Inc. is pioneering a transformative lead-identification technology, Chemotype Evolution, to identify superior therapeutics for human diseases. The technology ...

Lanthio Pharma

Lanthio Pharma is a privately held drug discovery company that applies its proprietary lanthionine-peptide technology to the discovery of novel peptide therapeutics with longer ha...

Anchor Therapeutics, Inc.

Anchor Therapeutics, Inc. is a leader in the development of pepducin technology. The Company is engaged in the licensing of pepducin technology as research tools for drug developm...

Receptos, Inc.

Receptos is a biopharmaceutical company developing best- and first-in-class G protein-coupled receptor (GPCR) therapeutic candidates through information-driven drug discovery, inc...

Anchor Therapeutics

Anchor Therapeutics is developing first-in-class pepducin drug candidates, novel molecules that can selectively target G protein coupled receptors (GPCRs) to allosterically modula...

Tranzyme Pharma

Tranzyme Pharma is a clinical-stage drug development company that discovers and develops novel small molecule macrocyclic drugs for both acute care (hospital-based) and chronic in...

BioFocus

BioFocus is a collaborative drug discovery company providing an integrated platform of expertise and technologies in medicinal chemistry and biological screening to the global biopharmaceutical indust...

Dimerix Bioscience Pty Ltd

Dimerix is a Perth-based drug discovery company focused on developing pharmaceutical products targeting heteromers or complexes of GPCRs. Approximately 40% of all currently market...

DiscoveRx® Corporation

Founded in 2000, DiscoveRx is a privately held, venture-backed company headquartered in Fremont, California, with an additional office in Birmingham, England. The Company pioneere...

Tocris Bioscience

The Tocris Bioscience range contains over 3,000 products, from the very latest exclusive research tools to established biochemical standards. Neurochemicals Signal Transduction Agents P...

Clinical Trials [2 Associated Clinical Trials listed on BioPortfolio]

A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Efficacy of BC 007 in Healthy Subjects

Berlin Cures develops BC 007 to treat patients suffering from diseases (chronic heart failure, pulmonary hypertension, chronic fatigue syndrome etc.) which are associated with functional a...

Ghrelin Resistance in Adolescents With Idiopathic Scoliosis

Adolescent idiopathic Scoliosis (AIS) is the most common spine pathology. It is opposed to secondary scoliosis due to chronic diseases. Many hypotheses have been made to elucidate the orig...

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Medical and Biotech [MESH] Definitions

Non-visual system arrestins that negatively regulate G-PROTEIN-COUPLED RECEPTORS (GPCRs) and may also function independently of GPCR signaling. They bind and recruit many different signaling factors, including MITOGEN-ACTIVATED PROTEIN KINASES; SRC-FAMILY-KINASES; and FILAMIN to GPCRs and may recognize different phosphorylation states of the receptors to determine the specificity of the cellular response to signaling.

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