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G-protein-coupled receptors (GPCRs) - Biotech, Pharma and Life Science Channel

03:13 EDT 29th March 2017 | BioPortfolio

GPCRs are a large family of cell surface receptors that respond to a variety of external signals. Binding of a signaling molecule to a GPCR results in G protein activation, which in turn triggers the production of any number of second messengers. Through this sequence of events, GPCRs help regulate an incredible range of bodily functions, from sensation to growth to hormone responses.

Source: http://www.nature.com/scitable/topicpage/gpcr-14047471

PubMed Articles [103 Associated PubMed Articles listed on BioPortfolio]

Epidermal loss of Gαq confers a migratory and differentiation defect in keratinocytes.

G-protein coupled receptors (GPCRs), which activate heterotrimeric G proteins, are an essential class of transmembrane receptors that are responsible for a myriad of signaling events in normal and pat...

In silico design of novel probes for the atypical opioid receptor MRGPRX2.

The primate-exclusive MRGPRX2 G protein-coupled receptor (GPCR) has been suggested to modulate pain and itch. Despite putative peptide and small-molecule MRGPRX2 agonists, selective nanomolar-potency ...

Gpr124 is essential for blood-brain barrier integrity in central nervous system disease.

Although blood-brain barrier (BBB) compromise is central to the etiology of diverse central nervous system (CNS) disorders, endothelial receptor proteins that control BBB function are poorly defined. ...

The role of GPCRs in neurodegenerative diseases: avenues for therapeutic intervention.

Neurodegenerative diseases represent a large group of neurological disorders with heterogeneous clinical and pathological profiles. The majority of current therapeutic strategies provide temporary sym...

An overview of Ca(2+) mobilization assays in GPCR drug discovery.

Calcium ions (Ca(2+)) serve as a second messenger or universal signal transducer implicated in the regulation of a wide range of physiological processes. A change in the concentration of intracellular...

Method for rapid optimization of recombinant GPCR protein expression and stability using virus-like particles.

Recent innovative approaches to stabilize and crystallize GPCRs have resulted in an unprecedented breakthrough in GPCR crystal structures as well as application of the purified receptor protein in bio...

Pancreas lineage allocation and specification are regulated by sphingosine-1-phosphate signalling.

During development, progenitor expansion, lineage allocation, and implementation of differentiation programs need to be tightly coordinated so that different cell types are generated in the correct nu...

Comparison of Calcium Dynamics and Specific Features for G Protein-Coupled Receptor-Targeting Drugs Using Live Cell Imaging and Automated Analysis.

G protein-coupled receptors (GPCRs) are targets for designing a large fraction of the drugs in the pharmaceutical industry. For GPCR-targeting drug screening using cell-based assays, measurement of cy...

Lumpy skin disease outbreaks in Greece during 2015-16, implementation of emergency immunization and genetic differentiation between field isolates and vaccine virus strains.

The objective of this study is to present epizootiological data from the lumpy skin disease (LSD) outbreaks in Greece during 2015-16, following the implementation of emergency vaccination and total st...

Bioinformatic prediction of G protein-coupled receptor encoding sequences from the transcriptome of the foreleg, including the Haller's organ, of the cattle tick, Rhipicephalus australis.

The cattle tick of Australia, Rhipicephalus australis, is a vector for microbial parasites that cause serious bovine diseases. The Haller's organ, located in the tick's forelegs, is crucial for host d...

News Articles [60 Associated News Articles listed on BioPortfolio]

Omeros Announces OMS721 Presentation at Annual Meeting of the European Society for Blood and Marrow Transplantation

-- Additional Positive “Challenge-Rechallenge” Data Reported in Patient with Stem Cell Transplant-Associated TMA -- Omeros Corporation (NASDAQ: OMER) today announced prese...

Icagen Announces Collaboration With Bayer To Develop Novel XRpro® Assays

DURHAM, N.C., March 28, 2017 /PRNewswire/ -- Today the Target-to-Lead company Icagen announces a collaboration with Bayer to develop new X-ray fluorescence assays using the proprietary XRpro® pl...

Trevena Inc TRVN Pharmaceuticals Healthcare Deals and Alliances Profile [Updated: 24022017] Prices from USD $250

SummaryTrevena Inc Trevena is a biopharmaceutical company that discovers and develops Gprotein coupled receptor targeted medicines. The company's products include RV027, TRV130, TRV734 and TRV250. Its...

Daiichi, Heptares join forces to discover GPCR pain compounds

Daiichi Sankyo Co. Ltd. will collaborate with Sosei Group Corp.'s Heptares Therapeutics Ltd. on a single Heptares-discovered G protein-coupled receptor (GPCR) Daiichi selects and from which the Top Ja...

Sosei Subsidiary Heptares, Daiichi Sankyo partner to treat pain

Sosei Group subsidiary Heptares Therapeutics has entered into a drug discovery and licensing agreement with Daiichi Sankyo focused on a single G protein-coupled receptor (GPCR) nominated by Daiichi Sa...

Sosei Subsidiary Heptares and Daiichi Sankyo to Discover and Develop Novel, Small-Molecules for the Treatment of Pain

Monday, March 13th 2017 at 7:05am UTC TOKYO–(BUSINESS WIRE)– Sosei Group Corporation (“Sosei”; TSE Mothers Index:4565) reported that its subsidiaries, Heptares Therapeutics (“Heptare...

Heptares Enters Agreement With Daiichi Sankyo to Develop Novel, Small Molecule Pain Treatments

NewsDaiichi Sankyo will receive exclusive global rights to develop, manufacture and commercialize novel, small molecules discovered by Heptares focused on the nominated GPCR.

Heptares and Daiichi Sankyo Ink $4M Upfront Pain Relief GPCR Drug Deal

Daiichi Sankyo and Heptares Therapeutics have established a drug discovery and licensing agreement to discover and develop small molecule drug candidates that target a specific G protein-coupled recep...

Sosei Subsidiary Heptares and Daiichi Sankyo to Discover and Develop Novel, Small-Molecules for the Treatment of Pain

Sosei Group Corporation (“Sosei”; TSE Mothers Index:4565) reported that its subsidiaries, Heptares Therapeutics (“Heptares”) has announced that it have entered into a drug...

Heptares Therapeutics Enters Agreement With Daiichi Sankyo to Discover and Develop Novel, Small-molecules for the Treatment of Pain

LONDON, March 13, 2017 /PRNewswire/ -- Heptares Therapeutics ("Heptares"), a wholly owned subsidiary of Sosei Group Corporation ("Sosei"; TSE Mothers Index: 4565) announces that it has entered int...

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Companies [12 Associated Companies listed on BioPortfolio]

Carmot Therapeutics, Inc.

Carmot Therapeutics, Inc. is pioneering a transformative lead-identification technology, Chemotype Evolution, to identify superior therapeutics for human diseases. The technology ...

Lanthio Pharma

Lanthio Pharma is a privately held drug discovery company that applies its proprietary lanthionine-peptide technology to the discovery of novel peptide therapeutics with longer ha...

Anchor Therapeutics, Inc.

Anchor Therapeutics, Inc. is a leader in the development of pepducin technology. The Company is engaged in the licensing of pepducin technology as research tools for drug developm...

Receptos, Inc.

Receptos is a biopharmaceutical company developing best- and first-in-class G protein-coupled receptor (GPCR) therapeutic candidates through information-driven drug discovery, inc...

Anchor Therapeutics

Anchor Therapeutics is developing first-in-class pepducin drug candidates, novel molecules that can selectively target G protein coupled receptors (GPCRs) to allosterically modula...

Tranzyme Pharma

Tranzyme Pharma is a clinical-stage drug development company that discovers and develops novel small molecule macrocyclic drugs for both acute care (hospital-based) and chronic in...

BioFocus

BioFocus is a collaborative drug discovery company providing an integrated platform of expertise and technologies in medicinal chemistry and biological screening to the global biopharmaceutical indust...

Dimerix Bioscience Pty Ltd

Dimerix is a Perth-based drug discovery company focused on developing pharmaceutical products targeting heteromers or complexes of GPCRs. Approximately 40% of all currently market...

DiscoveRx® Corporation

Founded in 2000, DiscoveRx is a privately held, venture-backed company headquartered in Fremont, California, with an additional office in Birmingham, England. The Company pioneere...

Tocris Bioscience

The Tocris Bioscience range contains over 3,000 products, from the very latest exclusive research tools to established biochemical standards. Neurochemicals Signal Transduction Agents P...

Clinical Trials [2 Associated Clinical Trials listed on BioPortfolio]

A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Efficacy of BC 007 in Healthy Subjects

Berlin Cures develops BC 007 to treat patients suffering from diseases (chronic heart failure, pulmonary hypertension, chronic fatigue syndrome etc.) which are associated with functional a...

Ghrelin Resistance in Adolescents With Idiopathic Scoliosis

Adolescent idiopathic Scoliosis (AIS) is the most common spine pathology. It is opposed to secondary scoliosis due to chronic diseases. Many hypotheses have been made to elucidate the orig...

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