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G-protein-coupled receptors (GPCRs) - Biotech, Pharma and Life Science Channel

12:15 EDT 25th May 2017 | BioPortfolio

GPCRs are a large family of cell surface receptors that respond to a variety of external signals. Binding of a signaling molecule to a GPCR results in G protein activation, which in turn triggers the production of any number of second messengers. Through this sequence of events, GPCRs help regulate an incredible range of bodily functions, from sensation to growth to hormone responses.

Source: http://www.nature.com/scitable/topicpage/gpcr-14047471

PubMed Articles [110 Associated PubMed Articles listed on BioPortfolio]

Role of spatial inhomogenity in GPCR dimerisation predicted by receptor association-diffusion models.

G protein-coupled receptor (GPCR) association is an emerging paradigm with far reaching implications in the regulation of signalling pathways and therapeutic interventions. Recent super resolution mic...

Urotensin-II peptidomimetic incorporating a non-reducible 1,5-triazole disulfide bond reveals a pseudo-irreversible covalent binding mechanism to the urotensin G-protein coupled receptor.

The urotensin-II receptor (UTR) is a class A GPCR that predominantly binds to the pleiotropic cyclic peptide urotensin-II (U-II). U-II is constrained by a disulfide bridge that induces a β-turn struc...

Modelling and mathematical analysis of the M$_{2}$ receptor-dependent joint signalling and secondary messenger network in CHO cells.

The muscarinic M$_{2}$ receptor is a prominent member of the GPCR family and strongly involved in heart diseases. Recently published experimental work explored the cellular response to iperoxo-induced...

Water permeation through the internal water pathway in activated GPCR rhodopsin.

Rhodopsin is a light-driven G-protein-coupled receptor that mediates signal transduction in eyes. Internal water molecules mediate activation of the receptor in a rhodopsin cascade reaction and contri...

Selectivity determinants of GPCR-G-protein binding.

The selective coupling of G-protein-coupled receptors (GPCRs) to specific G proteins is critical to trigger the appropriate physiological response. However, the determinants of selective binding have ...

Between Descriptors and Properties: Understanding the Ligand Efficiency Trends for GPCR and Kinase Structure Activity Data Sets.

The chemical meaning of the ligand efficiency (LE) metrics is explained in this paper using a large G protein-coupled receptor (GPCR) and kinase structure activity (IC50, Ki) data. Although there is a...

Antibodies targeting G protein-coupled receptors: Recent advances and therapeutic challenges.

Le STUDIUM conference was held November 24-25, 2016 in Tours, France as a satellite workshop of the 5(th) meeting of the French GDR 3545 on "G Protein-Coupled Receptors (GPCRs) - From Physiology to Dr...

Quantitative image cytometry for analyzing intracellular trafficking of G protein-coupled receptors on a chemical-trapping single cell array.

G protein-coupled receptors (GPCRs) are important targets in medical and pharmaceutical research fields, because they play key roles in a variety of biological processes. Recently, intracellular traff...

Two serines in the distal C-terminus of the human ß1-adrenoceptor determine ß-arrestin2 recruitment.

G protein-coupled receptors (GPCRs) undergo phosphorylation at several intracellular residues by G protein-coupled receptor kinases. The resulting phosphorylation pattern triggers arrestin recruitment...

N-Glycosylation of the β2 adrenergic receptor regulates receptor function by modulating dimerization.

N-glycosylation is a common post-translational modification of G protein-coupled receptors (GPCRs). However, it remains unknown how N-glycosylation affects GPCR signaling. β2 adrenergic receptor (β2...

News Articles [55 Associated News Articles listed on BioPortfolio]

Heptares' Co-Founder and Chief Scientific Officer, Fiona Marshall, Receives 2017 John Daly Lecture Award in Recognition of Her Outstanding Contribution to GPCR Drug Discovery

LONDON and TOKYO, May 18, 2017 /PRNewswire/ -- Heptares Therapeutics ("Heptares"), the leading GPCR medicine design and development company and wholly-owned subsidiary of Sosei Group Corporation (...

Heptares??? Co-Founder And Chief Scientific Officer, Receives 2017 Lecture Award In Recognition Of Her Outstanding Contribution To GPCR Drug Discovery

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Shanghai Institute of Materia Medica Release: A First Full-Length Class B GPCR Crystal Structure Reveals Novel Receptor Activation Mechanisms

  Life Sciences Jobs   ...

Key Diabetes Receptor Structure Determined by International Collaboration

Shanghai Led Consortium Produces High Resolution 3D map of GLP-1R SHANGHAI, May 17, 2017 /PRNewswire/ -- An international team led by the iHuman Institute, ShanghaiTech University determined the m...

A first full-length class B GPCR crystal structure reveals novel receptor activation mechanisms

- Structure of the full-length human glucagon receptor ignites new excitement in GPCR research SHANGHAI, May 17, 2017 /PRNewswire/ -- A team of scientists from Shanghai Institute of Materia M...

Shanghai Scientists Decipher the Multi-domain Full Length Structure of the Human Smoothened Receptor

Cancer Target Studied with Designed Chemical Probe SHANGHAI, May 17, 2017 /PRNewswire/ -- A team of scientists led by the iHuman Institute of ShanghaiTech University in collaboration with Fud...

Sevion Therapeutics Inc SVON Pharmaceuticals Healthcare Deals and Alliances Profile [Updated: 24022017] Prices from USD $250

SummarySevion Therapeutics Inc Sevion, formerly Senesco Technologies, Inc. is a pharmaceutical company that discovers, develops and acquires product candidates for the treatment of cancer and immunolo...

Selectivity determinants of GPCR–G-protein binding

The identification of the positions and patterns of amino acids that form the selectivity determinants for the entire human G-protein and G-protein-coupled receptor signalling system.

Domain Therapeutics SA Pharmaceuticals Healthcare Deals and Alliances Profile [Updated: 26042017] Prices from USD $250

SummaryDomain Therapeutics SA Domain Therapeutics is a biopharmaceutical company that discovers and develops innovative therapeutics for the treatment of Central Nervous System CNS diseases and cancer...

Omeros Corporation to Announce First Quarter 2017 Financial Results on May 10, 2017

Omeros Corporation (NASDAQ:OMER), today announced that the company will issue its first quarter 2017 financial results for the period ended March 31, 2017, on Wednesday, May 10, 2...

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Companies [12 Associated Companies listed on BioPortfolio]

Carmot Therapeutics, Inc.

Carmot Therapeutics, Inc. is pioneering a transformative lead-identification technology, Chemotype Evolution, to identify superior therapeutics for human diseases. The technology ...

Lanthio Pharma

Lanthio Pharma is a privately held drug discovery company that applies its proprietary lanthionine-peptide technology to the discovery of novel peptide therapeutics with longer ha...

Anchor Therapeutics, Inc.

Anchor Therapeutics, Inc. is a leader in the development of pepducin technology. The Company is engaged in the licensing of pepducin technology as research tools for drug developm...

Receptos, Inc.

Receptos is a biopharmaceutical company developing best- and first-in-class G protein-coupled receptor (GPCR) therapeutic candidates through information-driven drug discovery, inc...

Anchor Therapeutics

Anchor Therapeutics is developing first-in-class pepducin drug candidates, novel molecules that can selectively target G protein coupled receptors (GPCRs) to allosterically modula...

Tranzyme Pharma

Tranzyme Pharma is a clinical-stage drug development company that discovers and develops novel small molecule macrocyclic drugs for both acute care (hospital-based) and chronic in...

BioFocus

BioFocus is a collaborative drug discovery company providing an integrated platform of expertise and technologies in medicinal chemistry and biological screening to the global biopharmaceutical indust...

Dimerix Bioscience Pty Ltd

Dimerix is a Perth-based drug discovery company focused on developing pharmaceutical products targeting heteromers or complexes of GPCRs. Approximately 40% of all currently market...

DiscoveRx® Corporation

Founded in 2000, DiscoveRx is a privately held, venture-backed company headquartered in Fremont, California, with an additional office in Birmingham, England. The Company pioneere...

Tocris Bioscience

The Tocris Bioscience range contains over 3,000 products, from the very latest exclusive research tools to established biochemical standards. Neurochemicals Signal Transduction Agents P...

Clinical Trials [2 Associated Clinical Trials listed on BioPortfolio]

A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Efficacy of BC 007 in Healthy Subjects

Berlin Cures develops BC 007 to treat patients suffering from diseases (chronic heart failure, pulmonary hypertension, chronic fatigue syndrome etc.) which are associated with functional a...

Ghrelin Resistance in Adolescents With Idiopathic Scoliosis

Adolescent idiopathic Scoliosis (AIS) is the most common spine pathology. It is opposed to secondary scoliosis due to chronic diseases. Many hypotheses have been made to elucidate the orig...

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Medical and Biotech [MESH] Definitions

Non-visual system arrestins that negatively regulate G-PROTEIN-COUPLED RECEPTORS (GPCRs) and may also function independently of GPCR signaling. They bind and recruit many different signaling factors, including MITOGEN-ACTIVATED PROTEIN KINASES; SRC-FAMILY-KINASES; and FILAMIN to GPCRs and may recognize different phosphorylation states of the receptors to determine the specificity of the cellular response to signaling.

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