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Lupus : A major unmet medical need
Lupus is a chronic and severe autoimmune disease in which the immune system produces antibodies to cells within the body leading to widespread inflammation and tissue damage. It may affect multiple organ systems, including the skin, the joints, the heart, the lungs and the kidneys. It can result in arthritis, kidney failure, cardio-vascular and pulmonary problems, nervous system disorders, inflammation of the circulatory system and hematologic abnormalities. Lupus is a life-threatening disease, with mortality most frequently a result of secondary effects of the disease, most commonly glomerular nephritis leading to kidney failure. Lupus disease may first occur at any age, though peak diagnosis is between the ages of 15 and 40. It is far more common in women than men: approximately 90% of cases are diagnosed in women. Prevalence estimates for the disease vary widely, and range as high as 1.5 million in North America (the Lupus Foundation of America) and 5 million worldwide.
There is currently no targeted therapy for lupus: rather the treatment strategy is to control symptoms and prevent disease flares. This strategy relies on the use of corticosteroids and immunosuppressants, which have significant tolerability and toxicity issues in a chronic use setting. Some biologics are also used off-label, but their efficacy appears modest.
SummaryNeovacs SA Neovacs is a biotechnology company that develops various therapeutic vaccines for autoimmune disorders, inflammatory diseases and cancers. The company offers TNF kinoid and IFNa kino...
SummaryNeovacs SA Neovacs is a biotechnology company which develops various therapeutic vaccines for autoimmune disorders, inflammatory diseases and cancers. It offers TNF kinoid and IFNa kinoid produ...
This study is a Proof of Concept study aiming to evaluate the production of anti-IFNα antibodies (immune response) in adult subjects with dermatomyositis
The safety and immunogenicity of the IFN-Kinoid (IFN-K) have been evaluated in a phase I clinical study conducted in subjects with SLE. Preliminary results were promising. The principal a...
This is a phase 3, randomized, multi-center study to evaluate the efficacy and safety of albumin interferon alfa 2b (alb-IFN)in combination with ribavirin compared with peginterferon alfa-...
Influenza vaccination reduces the morbidity and mortality associated with influenza infection in at risk groups including the elderly and individuals with an impaired immune response, but...
The objective of this trial is to demonstrate that active immunization with anti-TNFα kinoid (TNF-K) is able to induce polyclonal anti-TNFα antibodies in RA patients who were previously ...
Interferon alpha (IFNa) is involved in the pathogenesis of systemic lupus erythematosus (SLE)and IFNa levels are associated with the severity of the disease. Blocking IFNa could be an attr...
Evaluation of the safety and the immune response induced by active immunization through a TNFa kinoid in patients with Crohn's disease.
This study aims to investigate effects of polymorphisms in key Th-17 immune response genes on the susceptibility to HBeAg-positive (HBeAg(+)) chronic hepatitis B (CHB) and response to PEG-IFNa-2α. A ...
Numerous nurses work in operating rooms and recovery rooms or participate in the performance of anaesthesia in China. However, the scope of practice and the education for Chinese Anaesthesia Nurses is...
Tumor necrosis factor (TNF) an inflammatory cytokine expressed by human fetal liver cells (HFLCs) following infection with cell culture-derived hepatitis C virus. TNF has been reported to increase ent...
Arthritis Fibromyalgia Gout Lupus Rheumatic Rheumatology is the medical specialty concerned with the diagnosis and management of disease involving joints, tendons, muscles, ligaments and associated structures (Oxford Medical Diction...
Lupus is a complex and poorly understood condition that affects many parts of the body and causes symptoms ranging from mild to life-threatening. There are several types of lupus. The main types are: discoid lupus erythematosus drug-induced lu...
Autoimmune disorders are conditions that occurs when the immune system mistakenly attacks and destroys healthy body tissue. There are more than 80 different types of autoimmune disorders. Normally the immune system's white blood cells help protect ...