Advertisement

Topics

MatBA - Mature B-cell neoplasm array - Biotech, Pharma and Life Science Channel

00:51 EST 18th January 2017 | BioPortfolio

Mature B-cell neoplasms arise in B-cells that have entered germinal centers within lymph nodes as part of the immune response. They display great heterogeneity at the clinical, pathologic, and genetic levels and represent 6-7% and 5-6% of all new estimated cancer cases and deaths respectively in the US in 2009. They are the fifth most common neoplasm in both males and females, and of the 103,960 estimated new cases in 2009, 20,860 comprise diffuse large B-cell lymphoma (DLBCL), 20,580 multiple myeloma (MM), 15,490 chronic lymphocytic leukemia /small lymphocytic lymphoma (CLL/SLL), 14,900 follicular lymphoma (FL), 8,510 Hodgkin’s lymphoma (HL), 6,000 marginal zone lymphomas (MZL) (including the three subtypes: extranodal marginal zone of mucosa-associated lymphoid tissue [MALT], nodal marginal zone, and splenic marginal zone), and 3,730 mantle cell lymphomas (MCL), as the major subtypes. With the exclusion of HL, 32,520 deaths are expected in 2009 in the US as a result of these neoplasms.

Diagnosis of these neoplasms relies mostly on the pathologic examination of biopsy material, be it either of an incisional or excisional biopsy of a suspect lymph node, a fine needle aspirate of a suspect lymph node (as yet to be considered adequate for initial diagnosis, unless it is the only safe option), or a bone marrow aspirate. Unlike other cancers, rarely are other biopsy/surgical procedures performed prior to the initiation of treatment, thus limiting the amount of tissue available for diagnostic and prognostic purposes. CGI has optimized the utility of array CGH so that it can be routinely applied to the study of a range of specimen types including formalin-fixed paraffin-embedded (FFPE) specimens, often the only specimen available for analysis.

Source: http://cancergenetics.com/cgi-research/cgh-microarray/ UMatBA is a Registered Trademark of CGI

PubMed Articles [19185 Associated PubMed Articles listed on BioPortfolio]

Nonradioactive quantification of autophagic protein degradation with L-azidohomoalanine labeling.

At present, several assays that use radioisotope labeling to quantify the degradation of long-lived proteins have been developed to measure autophagic flux. Here, we describe a nonradioactive pulse-ch...

Fullerene C60 Penetration into Leukemic Cells and Its Photoinduced Cytotoxic Effects.

Fullerene C60 as a representative of carbon nanocompounds is suggested to be promising agent for application in photodynamic therapy due to its unique physicochemical properties. The goal of this stud...

Demonstration of Logic Operations in High-Performance RRAM Crossbar Array Fabricated by Atomic Layer Deposition Technique.

In this paper, resistive random access memory (RRAM)-based crossbar arrays with the cell structure of Pt/[AlO y /HfO x ] m /TiN were fabricated by using atomic layer deposition (ALD) technique. The RR...

Advance of autophagy in chronic kidney diseases.

Autophagy, a highly conserved mechanism for cell survival, emerges as an important pathway in many biological processes and diseases conditions. Studies of cultured renal cells, human kidney tissues a...

Spermatological characteristics of the enigmatic monogenean Dictyocotyle coeliaca Nybelin, 1941 (Monopisthocotylea: Monocotylidae) reveal possible adaptation to endoparasitism.

Spermatological characters of Dictyocotyle coeliaca Nybelin, a unique endoparasitic monogenean from the body cavity of the ray Amblyraja radiata (Elasmobranchii: Rajidae), was investigated by means of...

Anti-Anisakis sp. antibodies in serum of healthy subjects. Relationship with αβ and γδ T cells.

Anisakiosis is nowadays one of the nematodoses more prevalent in Spain, with rates that oscillate between 0.43% in Galicia (N.W. Spain), and 15.7% and 22.1% in inland and southern regions, respectivel...

Exploring possibilities for an alternative approach in experimental schistosomiasis mansoni: the peritoneal cavity of mice.

The schistosome oviposition and granuloma constitution in the peritoneal cavity of AKR/J mice were evaluated. Groups of mice intraperitoneally infected with cercariae of Schistosoma mansoni were weekl...

Microbubble moving in blood flow in microchannels: effect on the cell-free layer and cell local concentration.

Gas embolisms can hinder blood flow and lead to occlusion of the vessels and ischemia. Bubbles in microvessels circulate as tubular bubbles (Taylor bubbles) and can be trapped, blocking the normal flo...

Plasmon-enhanced fluorescence imaging with silicon-based silver chips for protein and nucleic acid assay.

Metal-enhanced fluorescence shows great potential for improving the sensitivity of fluoroscopy, which has been widely used in protein and nucleic acid detection for biosensor and bioassay applications...

Natural variation in folate levels among tomato (Solanum lycopersicum) accessions.

Folate content was estimated in tomato (Solanum lycopersicum) accessions using microbiological assay (MA) and by LC-MS. The MA revealed that in red-ripe fruits folate levels ranged from 4 to 60μg/100...

News Articles [6813 Associated News Articles listed on BioPortfolio]

Prostate cancer: On the down-low — low luminal cell CD38 expression is prognostic

Aurora B expression modulates paclitaxel response in non-small cell lung cancer

CAR T-cell therapy of solid tumors

Negative regulation of type I IFN signaling by phosphorylation of STAT2 on T387

The transcription factor ISGF3, comprised of IRF9 and tyrosine-phosphorylated STATs 1 and 2, transmits the signal from the type I interferon receptor to the genome. We have discovered a novel phosphor...

Unloading of homologous recombination factors is required for restoring double-stranded DNA at damage repair loci

Cells use homology-dependent DNA repair to mend chromosome breaks and restore broken replication forks, thereby ensuring genome stability and cell survival. DNA break repair via homology-based mechani...

Maintaining hair follicle stem cell identity in a dish

Identifying and mimicking the signals that regulate stem cell self-renewal, differentiation and maintenance in a petri dish is crucial to faithfully recapitulate stem cell behaviour in vitro. In ...

Hair follicle stem cell cultures reveal self-organizing plasticity of stem cells and their progeny

Understanding how complex tissues are formed, maintained, and regenerated through local growth, differentiation, and remodeling requires knowledge on how single-cell behaviors are coordinated on the p...

Endothelial basement membrane laminin 511 is essential for shear stress response

Shear detection and mechanotransduction by arterial endothelium requires junctional complexes containing PECAM-1 and VE-cadherin, as well as firm anchorage to the underlying basement membrane. While c...

Removing the waste bags: how p97 drives autophagy of lysosomes

Removal of ruptured lysosomes by autophagy is one of the mechanisms by which cells alleviate detrimental consequences of lysosome leakage and may prevent the initiation of signaling cascades that lead...

PrimeGen Biotech LLC Pharmaceuticals Healthcare Deals and Alliances Profile Prices from USD $250

SummaryPrimeGen Biotech LLC PrimeGen is a stem cell research company committed to optimize the therapeutic potential of adult stem cells. It focuses on the therapeutic potential of adipose stem cells,...

Events [0 Results]

None

Companies [434 Associated Companies listed on BioPortfolio]

Selexis SA

Selexis is a privately held Swiss biotechnology company dedicated to the development of innovative technologies and expert services that enable significant improvements in the time, effort, and costs ...

Gadeta

Founded in 2015, Gadeta has developed a technology platform based on combinatorial T Cell receptor exchange (CTE) to create optimized gamma delta (γδ) T-cell receptors (TCRs...

Antelope Valley Healthcare District

Antelope Valley Hospital, a 420-bed district hospital located in the city of Lancaster in northern Los Angeles County, has been serving the community for more than 60 years. The a...

SanBio, Inc.

SanBio is a regenerative medicine company with cell based products in various stages of research, development and clinical trials. Its proprietary cell based product, SB623, is be...

Octapharma Group

Headquartered in Lachen, Switzerland, Octapharma is one of the largest human protein manufacturers in the world, developing and producing human proteins from human plasma and huma...

GE Healthcare Camden Group

With offices across the country, GE Healthcare Camden Group is one of the nation’s leading healthcare business advisory and activation firms. The firm provides a broad array ...

The FlowMetric Family of Companies

The FlowMetric Family of Companies consist of FlowMetric, Inc. and two additional affiliate companies, FlowMetric Europe, S.p.A. and FlowMetric Diagnostics, Inc. FlowMetric, Inc. ...

Society for Healthcare Strategy and Market Development (SHSMD)

SHSMD, a personal membership group of the American Hospital Association, is the largest and most prominent voice for healthcare professionals in strategic planning, marketing, pub...

Xcell Biosciences, Inc.

Xcell Biosciences, Inc., is developing revolutionary products and workflows for life science and translational research that reproduce physiologically relevant conditions to enabl...

Delos and Sino-Ocean Land

As the pioneer of Wellness Real Estate™, Delos is transforming our homes, offices, schools, and other indoor environments by placing health and wellness at the center of desi...

Clinical Trials [5316 Associated Clinical Trials listed on BioPortfolio]

A Study to Investigate Biomarker Effects of Pre-Surgical Treatment With DNA Damage Repair (DDR) Agents in Patients With Head and Neck Squamous Cell Carcinoma (HNSCC)

This biomarker window basket study has been designed with the intent of assessing the effects of different agents in both tumour tissue and peripheral samples to further inform optimal com...

Kinetics of B-Cell Responses to Live Attenuated Influenza Vaccine (LAIV) in Young Children Two Years of Age

This pilot study will investigate the peak of the post-immunization B-cell responses following vaccination with live, attenuated influenza vaccine in healthy children 2 years of age from b...

Immunogenicity and Safety of Quadrivalent Influenza Vaccine in Children Aged 6~35 Months

This study is a multi-center, randomized, double-blind Phase III Clinical trial. The purpose of this study is to assess the immunogenicity and safety of the quadrivalent cell culture-deriv...

To Evaluate the Efficacy and Safety of SCB01A in Subjects With r/m Squamous Cell Head and Neck Cancer

The aim of this study is to evaluate the efficacy and safety of i.v. infusion for 24-hour of SCB01A in subjects with squamous cell carcinoma of head and neck who have failed previous plati...

Pembrolizumab for T/NK-cell lymphomasNK-cell Lymphomas

Conventional chemotherapeutic regimens designed for aggressive B-cell lymphomas are generally less effective when applied to mature T-cell or NK-cell lymphomas. The treatment outcome for r...

Cord Blood-derived NK Cells With HDC/Auto SCT for MCL

The goal of this clinical research study is to learn about the safety of giving immune cells called natural killer (NK) cells with chemotherapy and a stem cell transplant to patients with ...

Phase 1 Study of CAR-20/19-T Cells in Patients With Relapsed Refractory B Cell Malignancies

This is a phase 1, interventional single arm, open label, treatment study designed to evaluate the safety and feasibility of infusion of autologous T cells engineered to contain an anti-CD...

R-ACVBP and DA-EPOCH-R in Patients With Non-GCB DLBCL

This is a randomized, open-label, multi-center, phase 3 study evaluating the efficacy of R-ACVBP and DA-EPOCH-R in patients with newly diagnosed non-germinal b-cell-like diffuse large B-ce...

Calcineurin Inhibitor-Free GVHD Prevention Regimen After Related Haplo PBSCT

The purpose of this study is to find out if a combination of drugs (these are called: cyclophosphamide, sirolimus, and mycophenolate mofetil) will protect participants better against graft...

Post Marketing Surveillance of Nintedanib in Indian Patients With Non-small Cell Lung Cancer (NSCLC) After First-line Therapy

This active surveillance will include all NSCLC patients treated with nintedanib per the inclusion/exclusion criteria at approximately 20 selected centers until it is confirmed that 100 pa...

Videos

None available.

Medical and Biotech [MESH] Definitions

Glycoproteins expressed on all mature T-cells, thymocytes, and a subset of mature B-cells. Antibodies specific for CD5 can enhance T-cell receptor-mediated T-cell activation. The B-cell-specific molecule CD72 is a natural ligand for CD5. (From Abbas et al., Cellular and Molecular Immunology, 2d ed, p156)

Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.

A focal malformation resembling a neoplasm, composed of an overgrowth of mature cells and tissues that normally occur in the affected area.

Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.

Mapping of the full chromosome set of the nucleus of a cell. The chromosome characteristics of an individual or a cell line are usually presented as a systematized array of metaphase chromosomes from a photomicrograph of a single cell nucleus arranged in pairs in descending order of size and according to the position of the centromere. (From Stedman, 25th ed)

Quick Search
Advertisement
 

Relevant Topic

Head and neck cancers
Cancer can occur in any of the tissues or organs in the head and neck. There are over 30 different places that cancer can develop in the head and neck area. Mouth cancers (oral cancers)  - Mouth cancer can develop on the lip, the tongue, the floor...

review and buy MatBA - Mature B-cell neoplasm array market research data and corporate reports here

Channels Quicklinks