Paroxysmal supraventricular tachycardia (PSVT) - Biotech, Pharma and Life Science Channel

03:19 EDT 29th March 2017 | BioPortfolio

Paroxysmal supraventricular tachycardia (PSVT) is episodes of rapid heart rate that start in a part of the heart above the ventricles. "Paroxysmal" means from time to time.

The heart will suddenly start racing, then stop or slow down abruptly.  Episodes can last for seconds, minutes, hours or (in rare cases) days. They may occur regularly, several times a day, or very infrequently, once or twice a year.  The heart rate may be as high as 250 beats per minute, but is usually between 140 and 180 (a normal heartbeat should be 60-100 beats per minute at rest).

SVT is caused by abnormal electrical impulses that start suddenly in the upper chambers of your heart (the atria). These impulses override your heart's natural rhythm.  It is often a short circuit in the electrical system of your heart that causes these spontaneous impulses. The short circuit causes an electrical signal to travel continuously around in a circle. Each time the signal completes the circuit, the impulse spreads out to the rest of your heart, forcing it to beat rapidly.  SVT attacks often happen for no obvious reason. However, they may be triggered by a change in posture, exertion, emotional upset, coffee or alcohol.


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PubMed Articles [303 Associated PubMed Articles listed on BioPortfolio]

Associations among left ventricular systolic function, tachycardia, and cardiac preload in septic patients.

In sepsis, tachycardia may indicate low preload, adrenergic stimulation, or both. Adrenergic overstimulation is associated with septic cardiomyopathy. We sought to determine whether tachycardia was as...

Paroxysmal nocturnal haemoglobinuria in a patient with primary Budd-Chiari syndrome: a contraceptive challenge.

In this report, we describe the unique case of a 21 year-old woman, gravida 1, para 1, with paroxysmal nocturnal haemoglobinuria (PNH) and Budd-Chiari syndrome, as well as severe vaginismus and cervic...

Usefulness of laboratory and radiological investigations in the management of supraventricular tachycardia.

Although ED patients presenting with supraventricular tachycardia (SVT) are commonly investigated, the value of these investigations has been questioned. We aimed to determine the frequency and utilit...

Catheter ablation of supraventricular tachycardias: where we have been, where we are, and where we are going.

Long-term symptom improvement and patient satisfaction following catheter ablation of supraventricular tachycardia: insights from the German ablation registry.

To analyse outcomes of supraventricular tachycardia (SVT) ablations performed within a prospective German Ablation Quality Registry.

Embolization of Watchman Device Following a Hybrid Radiofrequency Ablation of Atrial Fibrillation and Watchman Implantation Procedure.

A 24-year-old man with a history of type 1 diabetes mellitus, an ischemic left middle cerebral artery stroke and atrial flutter with a prior ablation was found to have paroxysmal atrial fibrillation (...

Atrioventricular nodal echoes over a wide echo window as a therapeutic end point for the catheter-guided radiofrequency ablation of atrioventricular nodal reentrant tachycardia: a prospective study.

In previous retrospective studies, it was shown that the presence of residual single atrioventricular node (AVN) echoes with an echo zone longer than 30 ms may increase the rate of recurrence after ...

Pharmacological blockade of small conductance Ca(2+)-activated K(+) channels by ICA reduces arrhythmic load in rats with acute myocardial infarction.

Acute myocardial infarction (AMI) with development of ventricular fibrillation (VF) is a common cause of sudden cardiac death (SCD). At present, no pharmacological treatment has successfully been able...

Long-term outcome after second-generation cryoballoon ablation for paroxysmal atrial fibrillation - a 3-years follow-up.

The second-generation cryoballoon (cryoballoon Advance; CB-A) offers excellent outcomes on the mid-term follow-up. To the best of our knowledge, little is known regarding the long-term outcome after C...

The use of a novel signal analysis to identify the origin of idiopathic right ventricular outflow tract ventricular tachycardia during sinus rhythm: Simultaneous amplitude frequency electrogram transformation mapping.

The signal characteristics of intracardiac bipolar electrograms at the origin of idiopathic RVOT-VT during sinus rhythm remain unclear.

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Cryo vs. RF Ablation - Electrophysiologists Take a Tempered Approach

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Cryo vs. RF Ablation: Electrophysiologists Take a Tempered Approach

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Another Good Reason to Consider Early Ablation for Ventricular Tachycardia

In a retrospective cohort of patients with structural heart disease and ventricular tachycardia, amiodarone often could be safely reduced or discontinued after ablation.

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Alexion Pharmaceuticals Inc.

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Topera, Inc.

Topera Medical (Topera, Inc.) is developing the proprietary FIRMap® System to assist electrophysiologists in the identification of the electrical source of cardiac arrhythmias....

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Clinical Trials [310 Associated Clinical Trials listed on BioPortfolio]

Termination Therapy for Ventricular Tachyarrhythmias

This observation study evaluates the safety and effectiveness of UPT therapy in subjects during either an indicated ventricular tachycardia ablation procedure or an ICD implant procedure.

Liner Ablation Using Contact-force in Atrial Fibrillation

Linear ablation is frequently used in the procedure for persistent atrial fibrillation. However, it has a limitation because of technical difficulty. Incomplete block is common and an impo...

Cardiac Resynchronization Therapy: Relevance of the Surgical Approach in the Implantation of the Left Ventricular Probe

Heart failure is very common and reaches more than 56 million people worldwide. 17 to 45 percent die in the first year of hospitalization. The most affected populations live in Western cou...

Phase 2 Safety and Efficacy Study of RA101495 to Treat PNH Patients

The purpose of the study is to evaluate the safety and efficacy of RA101495 in patients with Paroxysmal Nocturnal Hemoglobinuria (PNH). There will be two groups of patients in the study: t...

Atrial Fibrillation Ablation Registry

This is a single centre prospective data registry. In this study atrial conduction characteristics of extended surface Electrocardiograms (esECG), biomarkers and genetic analysis will be p...

Hemodynamic Response of Neuropathic And Non-Neuropathic POTS Patients To Adrenoreceptor Agonist And Antagonist

The purpose of this study is to test the hypothesis that patients with non-neuropathic POTS will have different responsiveness than patients with neuropathic POTS to direct alpha-1 adrenor...

Evaluation of Ablation Index and VISITAG™ (ABI-173)

The purpose of this study is to assess the safety, acute and long term effectiveness, during standard RF ablation procedures while using Ablation Index and VISITAG™ software in combinati...

ALXN1210 Versus Eculizumab in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) Currently Treated With Eculizumab

The purpose of this study is to assess ALXN1210 compared to eculizumab in adult patients with PNH who are clinically stable on eculizumab for at least 6 months

CardioFocus vs. Contact Force Guided Pulmonary Vein Isolation in Paroxysmal Atrial Fibrillation

The aim of the study is to compare the acute procedure and safety outcomes as well as long term clinical outcomes of 2 groups of patients treated with the HeartLight® Endoscopically Guide...

A Treatment Study of ACH-0144471 in Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH)

The purpose of this study is to determine the safety and effectiveness of ACH-0144471 in currently untreated patients with PNH.


None available.

Medical and Biotech [MESH] Definitions

A generic expression for any tachycardia that originates above the BUNDLE OF HIS.

A rare form of supraventricular tachycardia caused by automatic, not reentrant, conduction initiated from sites at the atrioventricular junction, but not the ATRIOVENTRICULAR NODE. It usually occurs during myocardial infarction, after heart surgery, or in digitalis intoxication with a HEART RATE ranging from 140 to 250 beats per minute.

Abnormally rapid heartbeats with sudden onset and cessation.

An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the BUNDLE OF HIS, either as autonomic impulse formation or reentrant impulse conduction. Depending on the etiology, onset of ventricular tachycardia can be paroxysmal (sudden) or nonparoxysmal, its wide QRS complexes can be uniform or polymorphic, and the ventricular beating may be independent of the atrial beating (AV dissociation).

A condition characterized by the recurrence of HEMOGLOBINURIA caused by intravascular HEMOLYSIS. In cases occurring upon cold exposure (paroxysmal cold hemoglobinuria), usually after infections, there is a circulating antibody which is also a cold hemolysin. In cases occurring during or after sleep (paroxysmal nocturnal hemoglobinuria), the clonal hematopoietic stem cells exhibit a global deficiency of cell membrane proteins.

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