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Paroxysmal supraventricular tachycardia (PSVT) - Biotech, Pharma and Life Science Channel

06:25 EST 20th February 2017 | BioPortfolio

Paroxysmal supraventricular tachycardia (PSVT) is episodes of rapid heart rate that start in a part of the heart above the ventricles. "Paroxysmal" means from time to time.

The heart will suddenly start racing, then stop or slow down abruptly.  Episodes can last for seconds, minutes, hours or (in rare cases) days. They may occur regularly, several times a day, or very infrequently, once or twice a year.  The heart rate may be as high as 250 beats per minute, but is usually between 140 and 180 (a normal heartbeat should be 60-100 beats per minute at rest).

SVT is caused by abnormal electrical impulses that start suddenly in the upper chambers of your heart (the atria). These impulses override your heart's natural rhythm.  It is often a short circuit in the electrical system of your heart that causes these spontaneous impulses. The short circuit causes an electrical signal to travel continuously around in a circle. Each time the signal completes the circuit, the impulse spreads out to the rest of your heart, forcing it to beat rapidly.  SVT attacks often happen for no obvious reason. However, they may be triggered by a change in posture, exertion, emotional upset, coffee or alcohol.

Source: http://www.nhs.uk/conditions/Supraventricular-tachycardia/Pages/Introduction.aspx

View research papers on diagnosiscauses and treatment.

PubMed Articles [279 Associated PubMed Articles listed on BioPortfolio]

Associations among left ventricular systolic function, tachycardia, and cardiac preload in septic patients.

In sepsis, tachycardia may indicate low preload, adrenergic stimulation, or both. Adrenergic overstimulation is associated with septic cardiomyopathy. We sought to determine whether tachycardia was as...

Prognostic significance of masked tachycardia in hypertension: evidence from a prospective international registry.

Postural tachycardia syndrome and suicide: what we don't know.

A Case Report of Onyx Pulmonary Arterial Embolism Contributing to Hypoxemia During Awake Craniotomy for Arteriovenous Malformation Resection.

A healthy 26-year-old man with cerebral arteriovenous malformation underwent staged endovascular embolization with Onyx followed by awake craniotomy for resection. The perioperative course was complic...

Occurrence of Focal Atrial Tachycardia during the Ablation Procedure is Associated with Arrhythmia Recurrence after Termination of Persistent Atrial Fibrillation.

Catheter ablation can terminate persistent atrial fibrillation (AF). However, atrial tachycardia (AT) often arises after termination of AF.

Wide QRS tachycardia with left bundle branch block morphology: What is the mechanism?

A 55-year-old woman was referred for radiofrequency catheter ablation of narrow QRS tachycardia that was terminated with intravenous adenosine. Twelve-lead ECG was normal during sinus rhythm. The elec...

Cardiovascular testing in patients with postural tachycardia syndrome and Ehlers-Danlos type III: authors' response.

Surface ECG f Wave Analysis at Initial Onset of Paroxysmal and Persistent Atrial Fibrillation.

Dominant frequency (DF) analysis of electrocardiograms (ECGs) from patients with paroxysmal (PAF) and persistent (PeAF) atrial fibrillation has identified higher DFs in PeAF. We therefore hypothesized...

Idiopathic epicardial ventricular tachycardia from the coronary venous system: From electrocardiographic recognition to appropriate therapy.

Idiopathic epicardial ventricular tachycardias (VTs) account for 9% of idiopathic VTs. The recognition of this entity is important, as a minimally invasive ablation procedure performed exclusively thr...

Paroxysmal Hemicrania-Like Headache Secondary to Phosphodiesterase Inhibitors Administration: A Case Report.

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[Comment] The relevance of atrial fibrillation in stroke prevention

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Texas Cardiac Arrhythmia Institute at St. David's Medical Center First in Nation to Use EnSite Precision Cardiac Mapping System To Treat Ventricular Tachycardia, Supraventricular Tachycardia and Premature Ventricular Contraction

AUSTIN, Texas, Feb. 2, 2017 /PRNewswire/ --  On December 20, 2016, the Texas Cardiac Arrhythmia Institute (TCAI) at St. David's Medical Center became the first facility in the nation to use the E...

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Researchers use ion technology to irradiate heart, treat atrial fibrillation

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Stroke Risk Lower for Paroxysmal vs Persistent or Permanent AF

"When you are sitting with a patient and discussing anticoagulation, the frequency of AF can now play a part in that decision," says the lead author. Heartwire from Medscape

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Companies [5 Associated Companies listed on BioPortfolio]

Alexion Pharmaceuticals Inc.

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Topera, Inc.

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Clinical Trials [303 Associated Clinical Trials listed on BioPortfolio]

ALXN1210 Versus Eculizumab in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) Currently Treated With Eculizumab

The purpose of this study is to assess ALXN1210 compared to eculizumab in adult patients with PNH who are clinically stable on eculizumab for at least 6 months

CardioFocus vs. Contact Force Guided Pulmonary Vein Isolation in Paroxysmal Atrial Fibrillation

The aim of the study is to compare the acute procedure and safety outcomes as well as long term clinical outcomes of 2 groups of patients treated with the HeartLight® Endoscopically Guide...

A Treatment Study of ACH-0144471 in Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH)

The purpose of this study is to determine the safety and effectiveness of ACH-0144471 in currently untreated patients with PNH.

Ephedrine and Phenylephrine for Spinal Hypotension

Spinal anesthesia is widely used as the procedure of choice for cesarean delivery. In comparison to epidural anesthesia it is faster, easier to perform, patients are more comfortable, comp...

Comparison of RF and crYoballoon ablatiOn Therapy of AF(CRYO-AF)

It's a multi-center, prospective, randomized, controlled clinical trial of cryoballoon versus radiofrequency ablation for paroxysmal atrial fibrillation.

Zero-fluoroscopy Approach Versus Fluoroscopic Approach for the Ablation of Paroxysmal Supraventricular Tachycardia

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Vitamin D Deficiency and Dysautonomia

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Adenosine to Assess Complete Conduction Block During Catheter Ablation of Paroxysmal Atrial Fibrillation

The purpose of this study is to determine if additional ablation during the first procedure as the result of the ability to medically induce quiet atrial arrhythmias will improve clinical ...

Propafenone Versus Amiodarone in Septic Shock

Arrhythmias accompany septic shock in increased rates than in other ICU cohorts and their presence and management are related to patient´s prognosis. 1c class antiarrhythmics are seldom a...

Phase 2 Safety and Efficacy Study of RA101495 to Treat PNH Patients Who Have an Inadequate Response to Eculizumab

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Medical and Biotech [MESH] Definitions

A generic expression for any tachycardia that originates above the BUNDLE OF HIS.

A rare form of supraventricular tachycardia caused by automatic, not reentrant, conduction initiated from sites at the atrioventricular junction, but not the ATRIOVENTRICULAR NODE. It usually occurs during myocardial infarction, after heart surgery, or in digitalis intoxication with a HEART RATE ranging from 140 to 250 beats per minute.

Abnormally rapid heartbeats with sudden onset and cessation.

An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the BUNDLE OF HIS, either as autonomic impulse formation or reentrant impulse conduction. Depending on the etiology, onset of ventricular tachycardia can be paroxysmal (sudden) or nonparoxysmal, its wide QRS complexes can be uniform or polymorphic, and the ventricular beating may be independent of the atrial beating (AV dissociation).

A condition characterized by the recurrence of HEMOGLOBINURIA caused by intravascular HEMOLYSIS. In cases occurring upon cold exposure (paroxysmal cold hemoglobinuria), usually after infections, there is a circulating antibody which is also a cold hemolysin. In cases occurring during or after sleep (paroxysmal nocturnal hemoglobinuria), the clonal hematopoietic stem cells exhibit a global deficiency of cell membrane proteins.

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