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TNF-Kinoid - Biotech, Pharma and Life Science Channel

06:45 EST 19th February 2017 | BioPortfolio

Therapies targeting TNF have already demonstrated efficacy across a wide range of inflammatory diseases, including rheumatoid arthritis, juvenile idiopathic arthritis, ankylosing spondulitis, psoriasis and Crohn’s disease. The target market for Kinoids currently in development is estimated at over $24 billion, with potential to reach still broader markets (Source: LaMerie 2012).

Although powerful, current anti-TNFα therapies also have significant drawbacks, making new treatment approaches sorely needed. The most problematic aspect of monoclonal antibody (mAb) therapies is the frequent development of treatment resistance as they are used long-term to treat chronic diseases. For instance in Crohn’s disease, there is loss of response to monoclonal anti-TNF treatment in nearly 60% of patients (infliximab, adalimumab, certolizumab) during the first year of treament. Anti-TNFα treatments also have a cumbersome dosing regimen of frequent IV infusions or SC injections.

The TNF-Kinoid is a promising approach to address the shortcomings of the monoclonal antibodies.

Source: http://www.neovacs.fr/en/products/TNF-Kinoide

News Articles [15 Associated News Articles listed on BioPortfolio]

Neovacs Issued New Broad Patent in China for IFNα Kinoid

PARIS, Feb. 09, 2017 (GLOBE NEWSWIRE) -- Neovacs (Alternext Paris:ALNEV), a leader in active immunotherapy for the treatment of autoimmune diseases, today announces that it has been granted a n...

Stellar Biotechnologies Congratulates Partner's Decision to Extend Drug Development for Diabetes

LOS ANGELES, Feb. 6, 2017 /PRNewswire/ -- Stellar Biotechnologies, Inc. (Nasdaq: SBOT), a leading manufacturer of a key protein utilized in multiple immunotherapy development pipelines targeting ...

Neovacs Announces Independent Data and Safety Monitoring Board Supports Continuation of Phase IIb Clinical Trial for IFNα Kinoid in Lupus

PARIS, Feb. 03, 2017 (GLOBE NEWSWIRE) -- Neovacs (Alternext Paris:ALNEV), a leader in active immunotherapy for the treatment of autoimmune diseases, today announced that it received a positive da...

NEOVACS : REPORTS FIRST POSITIVE IMMUNOGENICITY RESULTS FOR IFN-alpha KINOID IN MODEL OF TYPE 1 DIABETES

  PRESS RELEASE · PRESS RELEASE · PRESS RELEASE NEOVACS REPORTS FIRST POSITIVE IMMUNOGENICITY RESULTS FOR IFN-alpha KINOID IN MODEL OF TYPE 1 DIABETES THE SCIENTIFIC ADVISORY B...

Neovacs Reports First Positive Immunogenicity Results for IFNα Kinoid in Model of Type 1 Diabetes

PARIS and BOSTON, Jan. 25, 2017 (GLOBE NEWSWIRE) -- Neovacs (Alternext Paris: ALNEV), a leader in active immunotherapies for the treatment of autoimmune diseases, today announced the recommendati...

Neovacs to participate in two upcoming investor events in the United States and France

PRESS RELEASE· PRESS RELEASE· PRESS RELEASE Neovacs to participate in two upcoming investor events in the United States and France Company to conduct investor meetings at LifeSci Adv...

NEOVACS to collaborate with the SUNNYBROOK RESEARCH INSTITUTE for preclinical development of VEGF Kinoid to treat colorectal cancer and ovarian cancer

PRESS RELEASE· PRESS RELEASE· PRESS RELEASE NEOVACS to collaborate with the SUNNYBROOK RESEARCH INSTITUTE for preclinical development of  VEGF Kinoid to treat  

Neovacs to collaborate with the Sunnybrook Research Institute for preclinical development of VEGF Kinoid to treat colorectal cancer and ovarian cancer

PARIS and BOSTON, Jan. 05, 2017 (GLOBE NEWSWIRE) -- Neovacs (Alternext Paris:ALNEV) a leader in active immunotherapies for the treatment of autoimmune diseases, today announced its collaboration ...

NEOVACS obtains FDA "Fast Track" designation for IFNalpha Kinoid in Lupus (SLE)

PRESS RELEASE· PRESS RELEASE· PRESS RELEASE Neovacs obtains FDA "Fast Track" designation for IFNalpha Kinoid in Lupus (SLE) Paris and Boston, December 7, 2016 - Neova...

Neovacs obtains FDA “Fast Track” designation for IFNα Kinoid in Lupus (SLE)

PARIS and BOSTON, Dec. 07, 2016 (GLOBE NEWSWIRE) -- Neovacs (Alternext Paris:ALNEV), a leader in active immunotherapies for the treatment of autoimmune diseases, today announced that the U.S. Foo...

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Clinical Trials [5 Associated Clinical Trials listed on BioPortfolio]

Study of IFN-K in Dermatomyositis

This study is a Proof of Concept study aiming to evaluate the production of anti-IFNα antibodies (immune response) in adult subjects with dermatomyositis

Study of IFN-K in Systemic Lupus Erythematosus

The safety and immunogenicity of the IFN-Kinoid (IFN-K) have been evaluated in a phase I clinical study conducted in subjects with SLE. Preliminary results were promising. The principal a...

Immunogenicity and Safety of TNFa Kinoid in Rheumatoid Arthritis With Secondary Resistance to TNFa Antagonists and ADA

The objective of this trial is to demonstrate that active immunization with anti-TNFα kinoid (TNF-K) is able to induce polyclonal anti-TNFα antibodies in RA patients who were previously ...

Safety of IFNa Kinoid in Systemic Lupus Erythematosus

Interferon alpha (IFNa) is involved in the pathogenesis of systemic lupus erythematosus (SLE)and IFNa levels are associated with the severity of the disease. Blocking IFNa could be an attr...

Safety and Immunogenicity of a TNFa Kinoid in Patients With Crohn's Disease

Evaluation of the safety and the immune response induced by active immunization through a TNFa kinoid in patients with Crohn's disease.

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