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Vantictumab - Biotech, Pharma and Life Science Channel

20:16 EDT 23rd May 2017 | BioPortfolio

Anti-Fzd7 (vantictumab, OMP-18R5)

Vantictumab is OncoMed’s lead program in the Wnt pathway. Screened against the Frizzled 7 receptor, the antibody binds a conserved epitope on five of the Frizzled receptors. It has been shown in preclinical studies to induce tumor cell differentiation. Vantictumab entered Phase 1 clinical testing in 2011.

Vantictumab is a monoclonal antibody optimized to block a key signaling pathway in cancer. Specifically, vantictumab selectively targets Frizzled receptors, activators of Wnt signaling. Vantictumab exhibits broad anti-tumor activity in nonclinical models. Vantictumab is currently in Phase 1 and will be evaluated in chemotherapy combinations in Phase 1b trials. Vantictumab is part of OncoMed’s collaboration with Bayer Pharma AG.

PubMed Articles [6427 Associated PubMed Articles listed on BioPortfolio]

Anti-inflammatory and anticancer effects of flavonol glycosides from Diplotaxis harra through GSK3β regulation in intestinal cells.

Diplotaxis harra (Forssk.) Boiss. (Brassicaceae) is traditionally used as an antidiabetic, anti-inflammatory or anticancer agent. In these pathologies, the glycogen synthase kinase 3 β (GSK3β) is ov...

Antibacterial, antioxidant and anti-proliferative properties and zinc content of five south Portugal herbs.

Crataegus monogyna L. (Rosaceae) (CM), Equisetum telmateia L. (Equisataceae) (ET), Geranium purpureum Vil. (Geraniaceae) (GP), Mentha suaveolens Ehrh. (Lamiaceae) (MS), and Lavandula stoechas L. spp. ...

Priming increases the anti-tumor effect and therapeutic window of (177)Lu-octreotate in nude mice bearing human small intestine neuroendocrine tumor GOT1.

(177)Lu-[DOTA(0), Tyr(3)]-octreotate ((177)Lu-octreotate) is used for treatment of patients with somatostatin receptor (SSTR) expressing neuroendocrine tumors. However, complete tumor remission is rar...

Mechanism of anti-Vibrio activity of marine probiotic strain Bacillus pumilus H2, and characterization of the active substance.

Vibriosis is a major epizootic disease that impacts free-living and farmed fish species worldwide. Use of probiotics is a promising approach for prevention of Vibrio infections in aquaculture. A probi...

Topical application of the anti-microbial chemical triclosan induces immunomodulatory responses through the S100A8/A9-TLR4 pathway.

The anti-microbial compound triclosan is incorporated into numerous consumer products and is detectable in the urine of 75% of the general United States population. Recent epidemiological studies repo...

Anti-inflammatory activity of Ternstroemia gymnanthera stem bark extracts in bacterial lipopolysaccharide-stimulated RAW264.7 murine macrophage cells.

Ternstroemia gymnanthera Sprague (Theaceae) possesses various known pharmacological properties. However, its anti-inflammatory activity has not been reported.

Anti-inflammatory coumarins from Paramignya trimera.

Paramignya trimera (Oliv.) Burkill (Rutaceae) has been used to treat liver diseases and cancer. However, the anti-inflammatory effects of this medicinal plant and its components have not been elucidat...

Flavonoid-enriched extract from Hippophae rhamnoides seed reduces high fat diet induced obesity, hypertriglyceridemia, and hepatic triglyceride accumulation in C57BL/6 mice.

Flavonoid-enriched extract from Hippophae rhamnoides L. (Elaeagnaceae) seed (FSH) has shown beneficial effects in anti-hypertension and lowering cholesterol level. However, evidence for its efficacy i...

Anti-fungal activity, mechanism studies on α-Phellandrene and Nonanal against Penicillium cyclopium.

Essential oils from plants have been reported to have wide spread antimicrobial activity against various bacterial and fungal pathogens, and these include α-Phellandrene, Nonanal and other volatile s...

Cytotoxicity and anti-Leishmania amazonensis activity of Citrus sinensis leaf extracts.

Leishmania amazonensis is the main agent of diffuse cutaneous leishmaniasis, a disease characterized by lesional polymorphism and the commitment of skin surface. Previous reports demonstrated that the...

News Articles [2316 Associated News Articles listed on BioPortfolio]

[Articles] Irinotecan–temozolomide with temsirolimus or dinutuximab in children with refractory or relapsed neuroblastoma (COG ANBL1221): an open-label, randomised, phase 2 trial

Irinotecan–temozolomide–dinutuximab met protocol-defined criteria for selection as the combination meriting further study whereas irinotecan–temozolomide–temsirolimus did not. Irinotecan–tem...

[Comment] Chemoimmunotherapy for high-risk neuroblastoma

A multicentre phase 2 study by Rajen Mody and colleagues1 published in The Lancet Oncology shows that irinotecan–temozolomide in combination with the anti-GD2 antibody dinutuximab and granulocyte-ma...

FDA Grants Accelerated Approval to Merck’s Keytruda for Solid Tumors with Specific Biomarkers

KENILWORTH, N.J.–(BUSINESS WIRE)–Merck (NYSE:MRK), known as MSD outside the United States and Canada, today announced that the U.S. Food and Drug Administration (FDA) has approved a new i...

Serum Institute of India Ltd Pharmaceuticals Healthcare Deals and Alliances Profile [Updated: 16052017] Prices from USD $250

SummarySerum Institute of India Ltd SIIL is a drug development and manufacturing company that manufactures and markets vaccines and biologicals. The company offers polio vaccine, diphtheria, tetanus, ...

FDA Approves Pembrolizumab for Pancreatic Cancers with Mismatch Repair Deficiency

BETHPAGE, N.Y., May 23, 2017 /PRNewswire-USNewswire/ -- In an unprecedented, fast-tracked review, the Food and Drug Administration (FDA) approved the use of pembrolizumab (anti-PDI) immunotherapy for ...

Chondroitin sulfate as good as widely used anti-inflammatory for knee osteoarthritis

High quality (pharmaceutical grade) chondroitin sulfate is as good as a widely prescribed non-steroidal anti-inflammatory drug (celecoxib) for the treatment of painful knee osteoarthritis, concludes r...

Sanofi/Regeneron's Kevzara Priced To Break Into A Crowded Market

The partners are looking to create a compelling value proposition for the interleukin-6 inhibitor, approved by FDA to treat moderate...   

Merck & Co Accused Of Anti-Competitive Biosimilar Pricing

The UK's anti-competition authority has accused Merck & Co of anti-competitive behavior in its UK pricing strategy for its biosimilar...   

NeuroVive To Take Traumatic Brain Injury Drug Into Mid-Stage Studies

Protecting the function of mitochondria may be key to developing medicines to reduce the nerve damage caused by traumatic brain...   

Anti-VEGF Injections Bring on Eye Anxiety

(MedPage Today) -- Many patients report stress from intravitreal treatments

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endpoint

Endpoint provides clients with high-quality, authoritative advice on the clinical development of medicines. Endpoint's clients include multinational pharmaceutical companies, emerging biomedical ventu...

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Tiziana Life Sciences plc

Tiziana Life Sciences plc is a UK biotechnology company that focuses on the discovery and development of novel molecules that treat human disease in oncology and immunology. The C...

Appili Therapeutics Inc.

Appili is dedicated to identifying, acquiring and advancing novel therapeutics for infectious disease. The company has two anti-infective programs, ATI-1501 and ATI-1503, in its p...

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Visualant, Inc.

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Affigen

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Clinical Trials [2179 Associated Clinical Trials listed on BioPortfolio]

Safety and Efficacy of MEDI0457 and Durvalumab in Patients With HPV Associated Recurrent/Metastatic Head and Neck Cancer

This is a Phase 1b/2a, open-label, multi-center study to evaluate the safety and tolerability, anti-tumor activity, and immunogenicity of MEDI0457 (also known as INO 3112) a HPV DNA vaccin...

Study to Investigate the Safety, Tolerability, and Pharmacokinetics of DSTA4637S in Participants With Staphylococcus Aureus Bacteremia Receiving Standard-of-Care (SOC) Antibiotics

This is a Phase Ib, randomized double-blind, placebo-controlled multiple-ascending dose study to investigate the safety, tolerability, and pharmacokinetics of multiple doses of DSTA4637S w...

A Study Evaluating the Efficacy and Safety of Guselkumab Administered Subcutaneously in Participants With Active Psoriatic Arthritis Including Those Previously Treated With Biologic Anti -Tumor Necrosis Factor (TNF) Alpha Agent(s)

The primary purpose of this study is to evaluate the efficacy of guselkumab treatment in participants with active Psoriatic Arthritis (PsA) by assessing the reduction in signs and symptoms...

Anti-Müllerian Hormone is Not Predictive of Pregnancy in Donor Insemination Cycles in Non-infertile Women

To evaluate if ovarian reserve (measured by means of anti-mullerian hormone -AMH- and antral follicle count -AFC-) can predict pregnancy in donor insemination cycles (dIUI) performed in no...

An Open-Label Phase II Study to Evaluate the Efficacy and Safety of IdeS in Anti-GBM Disease (GOOD-IDES)

This study will evaluate the safety and tolerability of IdeS in patients with severe anti-GBM (Glomerular Basement Membrane) disease receiving standard care consisting of pulse-methylpredn...

Assessment of a New Fluorescence Imaging Technique Using Biopsies From Prostate Resection

In this study, we aim to evaluate the feasibility of anti-PSMA labelling to detect post-operative prostatic tissues by two ex vivo fluorescence techniques. We will evaluate the feasibility...

The Immunomodulatory Effects of Oral Nanocurcumin in Multiple Sclerosis Patients

Multiple sclerosis is the most common autoimmune disease of the central nervous system, most ranging in age from 40-20 years of age is associated with neurons inflammation and demyelinatio...

Stereotactic Body Radiation Therapy Combined With Anti-PD-1 Antibody in Metastatic Triple Negative Breast Cancer

The objective of this study is to evaluate the safety and tolerance of Stereotactic Body Radiation Therapy Combined With Anti-PD-1 Antibody in Patients in Metastatic Triple Negative Breast...

A Study of Ixekizumab (LY2439821) Versus Adalimumab in Participants With Psoriatic Arthritis

The main purpose of this study is to evaluate the effectiveness and safety of ixekizumab versus adalimumab in participants with psoriatic arthritis (PsA) who are biologic disease-modifying...

Prevalence of Thyroid Function Abnormalities in HIV-infected Patients: State of Play in 2012

Since the appearance of high-efficiency anti-retrovirals (HAARTs) in the treatment of Human Immunodeficiency Virus (HIV), several studies have shown an increase in the prevalence of hypoth...

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Medical and Biotech [MESH] Definitions

A non-steroidal anti-fertility agent with anti-hormonal properties.

One of the ADRENERGIC BETA-ANTAGONISTS used as an antihypertensive, anti-anginal, and anti-arrhythmic agent.

An IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It inhibits prostaglandin synthesis and has been proposed as an anti-arthritic.

An anti-inflammatory, anti-allergic glucocorticoid that can be administered orally, by inhalation, locally, and parenterally. It may cause water and salt retention.

An anti-inflammatory, synthetic glucocorticoid. It is used topically as an anti-inflammatory agent and in aerosol form for the treatment of ASTHMA.

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