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Vantictumab - Biotech, Pharma and Life Science Channel

13:39 EDT 21st August 2017 | BioPortfolio

Anti-Fzd7 (vantictumab, OMP-18R5)

Vantictumab is OncoMed’s lead program in the Wnt pathway. Screened against the Frizzled 7 receptor, the antibody binds a conserved epitope on five of the Frizzled receptors. It has been shown in preclinical studies to induce tumor cell differentiation. Vantictumab entered Phase 1 clinical testing in 2011.

Vantictumab is a monoclonal antibody optimized to block a key signaling pathway in cancer. Specifically, vantictumab selectively targets Frizzled receptors, activators of Wnt signaling. Vantictumab exhibits broad anti-tumor activity in nonclinical models. Vantictumab is currently in Phase 1 and will be evaluated in chemotherapy combinations in Phase 1b trials. Vantictumab is part of OncoMed’s collaboration with Bayer Pharma AG.

PubMed Articles [6467 Associated PubMed Articles listed on BioPortfolio]

Hemoadsorption corrects hyperresistinemia and restores anti-bacterial neutrophil function.

Mounting evidence suggests that sepsis-induced morbidity and mortality are due to both immune activation and immunosuppression. Resistin is an inflammatory cytokine and uremic toxin. Septic hyperresis...

Priming increases the anti-tumor effect and therapeutic window of (177)Lu-octreotate in nude mice bearing human small intestine neuroendocrine tumor GOT1.

(177)Lu-[DOTA(0), Tyr(3)]-octreotate ((177)Lu-octreotate) is used for treatment of patients with somatostatin receptor (SSTR) expressing neuroendocrine tumors. However, complete tumor remission is rar...

Mechanism of anti-Vibrio activity of marine probiotic strain Bacillus pumilus H2, and characterization of the active substance.

Vibriosis is a major epizootic disease that impacts free-living and farmed fish species worldwide. Use of probiotics is a promising approach for prevention of Vibrio infections in aquaculture. A probi...

Topical application of the anti-microbial chemical triclosan induces immunomodulatory responses through the S100A8/A9-TLR4 pathway.

The anti-microbial compound triclosan is incorporated into numerous consumer products and is detectable in the urine of 75% of the general United States population. Recent epidemiological studies repo...

Anti-inflammatory activity of Ternstroemia gymnanthera stem bark extracts in bacterial lipopolysaccharide-stimulated RAW264.7 murine macrophage cells.

Ternstroemia gymnanthera Sprague (Theaceae) possesses various known pharmacological properties. However, its anti-inflammatory activity has not been reported.

Anti-inflammatory coumarins from Paramignya trimera.

Paramignya trimera (Oliv.) Burkill (Rutaceae) has been used to treat liver diseases and cancer. However, the anti-inflammatory effects of this medicinal plant and its components have not been elucidat...

Flavonoid-enriched extract from Hippophae rhamnoides seed reduces high fat diet induced obesity, hypertriglyceridemia, and hepatic triglyceride accumulation in C57BL/6 mice.

Flavonoid-enriched extract from Hippophae rhamnoides L. (Elaeagnaceae) seed (FSH) has shown beneficial effects in anti-hypertension and lowering cholesterol level. However, evidence for its efficacy i...

Anti-fungal activity, mechanism studies on α-Phellandrene and Nonanal against Penicillium cyclopium.

Essential oils from plants have been reported to have wide spread antimicrobial activity against various bacterial and fungal pathogens, and these include α-Phellandrene, Nonanal and other volatile s...

Cytotoxicity and anti-Leishmania amazonensis activity of Citrus sinensis leaf extracts.

Leishmania amazonensis is the main agent of diffuse cutaneous leishmaniasis, a disease characterized by lesional polymorphism and the commitment of skin surface. Previous reports demonstrated that the...

Biomarker for early renal microvascular and diabetic kidney diseases.

Recognition of early stage of diabetic kidney disease, under common practice using biomarkers, namely microalbuminuria, serum creatinine level above 1 mg/dL and accepted definition of diabetic kidne...

News Articles [2153 Associated News Articles listed on BioPortfolio]

Medivir begins phase I/II study of birinapant in combo with Keytruda in patients with treatment─refractory solid tumours

Medivir AB has announces that the first patient has been enrolled in the company's phase I/II study of birinapant in combination with the anti─PD─1 therapy Keytruda (pembrolizumab), which is marke...

Viewpoint: Netflix promotes anti-GMO films, suppresses legitimate science

Blade Therapeutics Announces Appointment of Dr. Maria E. Fuentes as Executive Vice President, Research

Blade Therapeutics, a private biopharmaceutical company advancing novel anti-fibrotic therapies to meet important patient needs, today announced the appointment of Maria E. Fuente...

Ligand to receive $2m from WuXi for licensing clinical-stage anti-PD-1 antibody

Ligand Pharmaceuticals will get a payment of $2m from WuXi Biologics subsequent to their licensing of exclusive rights to the anti-PD-1 antibody GLS-010 to Arcus Biosciences in North America, Europe, ...

Anti-ageing Cosmeceuticals Market 2017-2027

LONDON, August 21, 2017 /PRNewswire/ -- Antiwrinkle, Antistretch Mark, UV Absorbers, Hair, Topical, Invasive, Acne Therapy, Liposuction, Breast Augmentation, Hair Growth, Eyelid Surgery, Botox, An...

Why the anti-vaxxer label makes this medical student uncomfortable

I’ve had some of the most wonderful experiences of my entire medical training working with kids and their families. And this, to me, is not surprising. After all, I envisioned myself as a pediat...

Predicting brain surgery outcomes

For patients with a common type of epilepsy known as temporal lobe epilepsy (TLE), the only treatment choices are anti-seizure drugs or surgery to remove the focus of the seizures in part of the brain...

Sugars in some breast milk could help protect babies from group B strep

Group B strep (GBS) bacteria remain the leading cause of severe infections in newborns worldwide. Now researchers have found that although the pathogen can be transmitted to infants through breastfeed...

Medivir enrols first patient in combination trial for refractory solid tumours

Swedish pharmaceutical company Medivir has started patient enrolment in a Phase I/II clinical trial of its product candidate birinapant in combination with Merck’s anti-PD-1 therapy Keytruda (pembro...

Syneron's elure Advanced Skin Lightening Products Become the NEW Solution for Hyperpigmentation

LAGUNA NIGUEL, Calif., March 6, 2012 /PRNewswire/ -- Board Certified Dermatologist, Dr. Lorrie Klein, nationally recognized for her expertise in anti-aging treatments and technology, is pleased t...

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Companies [138 Associated Companies listed on BioPortfolio]

Turnstone Biologics

Turnstone Biologics is a clinical-stage, immuno-oncology company focused on the development of next-generation oncolytic viral immunotherapies for patients with a broad range of s...

Helix BioMedix, Inc

Helix BioMedix, Inc. was founded in 1988 with the mission of developing and commercializing small proteins known as bioactive-peptides. We are headquartered in Bothell, Washington and shares of our co...

Applied DNA Sciences, Inc.

Applied DNA Sciences makes life real and safe by providing innovative, molecular-based technology solutions and services that can help protect products, brands, entire supply chai...

TeamViewer GmbH

TeamViewer is a leading global software provider for digital networking and collaboration. Founded in 2005 in Göppingen, Germany, the company employs around 700 people from mor...

Blade Therapeutics

Blade Therapeutics is a private biopharmaceutical company advancing novel anti-fibrotic therapies to meet important patient needs. Blade has assembled a critical mass of fibrosis ...

Genexine, Inc.

Genexine, Inc., listed on KOSDAQ (095700) since 2009, is a leading biotherapeutics company focused on immuno-oncology and orphan disease. Genexine has robust pipelines in clinical...

Checkmate Pharmaceuticals, Inc.

Checkmate Pharmaceuticals is a research and development company pursuing a novel approach to specifically activating the innate arm of the immune system to recognize and ultimatel...

endpoint

Endpoint provides clients with high-quality, authoritative advice on the clinical development of medicines. Endpoint's clients include multinational pharmaceutical companies, emerging biomedical ventu...

Rigontec

Rigontec is the leader in RIG-I targeting therapeutics. Utilizing our proprietary RIG-I agonist platform, we harness one of the most essential pathways in the innate immune system...

Tiziana Life Sciences plc

Tiziana Life Sciences plc is a UK biotechnology company that focuses on the discovery and development of novel molecules that treat human disease in oncology and immunology. The C...

Clinical Trials [2266 Associated Clinical Trials listed on BioPortfolio]

Duration of Dual Anti-Platelet Therapy (DUAL-ACS2)

Despite substantial evidence supporting the use of dual anti-platelet therapy in patients with acute coronary syndrome, there remains major uncertainty regarding the optimal duration of th...

Study on the Efficacy of Alprostadil Injection in Patients With Acute Ischemic Stroke

Ischemic stroke has a variety of treatments and currently drug therapy is one of the main treatments.A number of clinical studies have proved that alprostadil (PGE1) has pharmacological ef...

Meclizine for Hepatocellular Carcinoma

Meclizine hydrochloride is an antihistamine widely used for treatment of vertigo and motion sickness. In HCC it has been used for anti-emetic effects, but it is used here as a CAR (constit...

Predictive Value of Drug Sensitivity Testing Tumorspheres From Patients With Metastatic Colorectal Cancer

The purpose of the present study is to investigate the benefit of anti-cancer therapy administered on the basis of drug sensitivity testing. This concerns colorectal cancer patients who ha...

SHR-1210 Alone or in Combination With Decitabine in Relapsed or Refractory Hodgkin Lymphoma

The purpose of this study is to evaluate whether treatment with the study drug decitabine in combination with SHR-1210 is safe and feasible, is more effective than treatment with SHR-1210 ...

Study of TSR-033 With an Anti-PD-1

This is a multicenter, open-label, first-in-human Phase 1 study evaluating TSR-033, an anti-LAG-3 Monoclonal Antibody, alone and in combination with an anti-PD-1 in Patients with Advanced ...

Investigation of Anti-obesity Properties of Lactobacillus Sakei in Obese Human Subjects

In this study, we investigated the efficacy of Lactobacillus Sakei on reduction of fat mass assessed by DEXA compared to plaebo. We enrolled subjects whose BMI was equal to higher than 25,...

Pembrolizumab in Combination With Anti-platelet Therapy for Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck

The purpose of this study is to see if anti-platelet therapy combined with anti-PD-1 immunotherapy can cause a more favorable immunologic response thatn with immunotherapy alone in patient...

Immunotherapy of Neuroblastoma Patients Using a Combination of Anti-GD2 and NK Cells

Neuroblastoma is a neoplasm of the sympathetic nervous system which affects mostly children younger than 5 years of age. It is a heterogeneous disease, with nearly 50% of patients presenti...

Assessment of Anti-RANKL Antibody in Post-menopausal Women

This is a single-center, open-label, dose-escalating study to evaluate the safety, pharmacokinetics, immunogenicity, and preliminary efficacy of single dose subcutaneous injection of a ful...

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Medical and Biotech [MESH] Definitions

A non-steroidal anti-fertility agent with anti-hormonal properties.

One of the ADRENERGIC BETA-ANTAGONISTS used as an antihypertensive, anti-anginal, and anti-arrhythmic agent.

An IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It inhibits prostaglandin synthesis and has been proposed as an anti-arthritic.

An anti-inflammatory, anti-allergic glucocorticoid that can be administered orally, by inhalation, locally, and parenterally. It may cause water and salt retention.

An anti-inflammatory, synthetic glucocorticoid. It is used topically as an anti-inflammatory agent and in aerosol form for the treatment of ASTHMA.

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