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Vantictumab - Biotech, Pharma and Life Science Channel

00:56 EST 18th January 2017 | BioPortfolio

Anti-Fzd7 (vantictumab, OMP-18R5)

Vantictumab is OncoMed’s lead program in the Wnt pathway. Screened against the Frizzled 7 receptor, the antibody binds a conserved epitope on five of the Frizzled receptors. It has been shown in preclinical studies to induce tumor cell differentiation. Vantictumab entered Phase 1 clinical testing in 2011.

Vantictumab is a monoclonal antibody optimized to block a key signaling pathway in cancer. Specifically, vantictumab selectively targets Frizzled receptors, activators of Wnt signaling. Vantictumab exhibits broad anti-tumor activity in nonclinical models. Vantictumab is currently in Phase 1 and will be evaluated in chemotherapy combinations in Phase 1b trials. Vantictumab is part of OncoMed’s collaboration with Bayer Pharma AG.

PubMed Articles [6199 Associated PubMed Articles listed on BioPortfolio]

Anti-inflammatory and anticancer effects of flavonol glycosides from Diplotaxis harra through GSK3β regulation in intestinal cells.

Diplotaxis harra (Forssk.) Boiss. (Brassicaceae) is traditionally used as an antidiabetic, anti-inflammatory or anticancer agent. In these pathologies, the glycogen synthase kinase 3 β (GSK3β) is ov...

Antibacterial, antioxidant and anti-proliferative properties and zinc content of five south Portugal herbs.

Crataegus monogyna L. (Rosaceae) (CM), Equisetum telmateia L. (Equisataceae) (ET), Geranium purpureum Vil. (Geraniaceae) (GP), Mentha suaveolens Ehrh. (Lamiaceae) (MS), and Lavandula stoechas L. spp. ...

Serosurvey of anti-Toxoplasma gondii antibodies in sport horses from Paraiba state, Northeastern Brazil.

Although the infection by Toxoplasma gondii in horses is usually asymptomatic, it may be characterized by the presence of tissue cysts and maintenance of detectable antibody titers. The aim of this st...

Anti-Anisakis sp. antibodies in serum of healthy subjects. Relationship with αβ and γδ T cells.

Anisakiosis is nowadays one of the nematodoses more prevalent in Spain, with rates that oscillate between 0.43% in Galicia (N.W. Spain), and 15.7% and 22.1% in inland and southern regions, respectivel...

Comparative study of colloidal gold and quantum dots as labels for multiplex screening tests for multi-mycotoxin detection.

Quantum dots (QDs) and colloidal gold nanoparticles (CG) were evaluated as labels for multiplex lateral flow immunoassay (LFIA) for determination of mycotoxins deoxynivalenol (DON), zearalenone (ZEN) ...

Comparison of phytochemical profiles, antioxidant and cellular antioxidant activities of different varieties of blueberry (Vaccinium spp.).

Numerous reports have demonstrated that the consumption of fruits and vegetables is beneficial for the human health. Blueberries, in particular, are rich in phytochemicals including free and bound for...

Spices in the management of diabetes mellitus.

Diabetes mellitus (DM) remains a major health care problem worldwide both in developing and developed countries. Many factors, including age, obesity, sex, and diet, are involved in the etiology of DM...

High resolution magic angle spinning NMR spectroscopy reveals that pectoralis muscle dystrophy in chicken is associated with reduced muscle content of anserine and carnosine.

Increased incidences of pectoralis muscle dystrophy are observed in commercial chicken products, but the muscle physiological causes for the condition remain to be identified. In the present study a h...

Dietary intake mediates the relationship of body fat to pain.

Prior studies have documented an association of obesity with chronic pain, but the mechanism explaining the association remains unknown. This study evaluated the degree to which dietary intake of food...

Anti-Diabetic Agent Sodium Tungstate Induces the Secretion of Pro- and Anti-Inflammatory Cytokines by Human Kidney Cells.

Diabetic kidney disease (DKD) is the major cause of end stage renal disease. Sodium tungstate (NaW) exerts anti-diabetic and immunomodulatory activities in diabetic animal models. Here, we used primar...

News Articles [2227 Associated News Articles listed on BioPortfolio]

Conference to tackle drug-resistant infections

Registrations are now open for the Solutions for Drug-Resistant Infections conference (SDRI 2017), taking place at the Brisbane Convention and Exhibition Centre from 3–5 April 2017. With the inaugur...

Natural Compound Blocks Creation of Toxins Linked to Parkinson's

NewsSqualamine, a natural product studied for its anticancer and anti-infective properties, could also lead to future treatments for Parkinson's disease.

OncoMed Pharmaceuticals Inc OMED Pharmaceuticals Healthcare Deals and Alliances Profile Prices from USD $250

SummaryOncoMed Pharmaceuticals Inc OncoMed which focuses on the discovery and development of monoclonal antibody therapeutics that targets cancer stem cells. The company's clinical stage pipeline prod...

Researchers Find That Certain Anti-Influenza Compounds Also Inhibit Zika Virus Infection

Globalization, environmental changes, population growth and urbanization make emerging virus diseases a major threat to public health. An example of such epidemics is the Zika outbreak which is ongoin...

Balance Board Re-Invented: Patented New “Pono Board” Uniquely Designed to Engage the Body & Free the Mind

Pono Ola's patented Pono Board is the world’s only fitness and exercise balance board built to reduce vertical movement by isolating motion on the horizontal plain. This exclusive design natural...

MonoSol Rx files patent infringement case against BioDelivery Sciences International

MonoSol Rx has filed a patent infringement case against BioDelivery Sciences International (BDSI) for infringement of U.S. Patent No. 8,765,167 (the ‘167 patent), which is entitled “Uniform films ...

OBÉSITÉ : Un médicament à restriction périphérique pour bloquer la suralimentation - Physiology & Behavior

Les chercheurs de l'Université de Californie Riverside désignent ici la signalisation endocannabinoïde périphérique comme cible pharmaceutique possible pour réd...

EXERCICE: Une seule séance agit comme un anti-inflammatoire - Brain, Behavior and Immunity

20 minutes seulement ont déjà un effet anti-inflammatoire, suggère cette étude de l'Université de Californie - San Diego : une seule séance d'exercice mo...

BioLineRx Announces Initiation of Immuno-Oncology Phase 2 Study to Investigate Combination of BL-8040 and KEYTRUDA® for Pancreatic Cancer

TEL AVIV, Israel, January 17, 2017 /PRNewswire/ -- BioLineRx Ltd. (NASDAQ: BLRX; TASE: BLRX), a clinical-stage biopharmaceutical company dedicated to identifying, in-licensing and developing promi...

SocksLane Launches New Anti-Allergic Compression Socks on Amazon.com

Portland, OR, January 17, 2017 --(PR.com)-- SocksLane, the leading developer of anti-allergic compression garments, announces the release of a new revolutionary high quality combed cotton support soc...

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Companies [121 Associated Companies listed on BioPortfolio]

Shinkowa Pharmaceutical Co., Ltd.

Based in Tokyo, Japan, Shinkowa Pharmaceutical Co., Ltd. (http://shinkowapharma.com/) is a pharmaceutical company that has developed and sells dietary supplements and cosmetics in...

Gadeta

Founded in 2015, Gadeta has developed a technology platform based on combinatorial T Cell receptor exchange (CTE) to create optimized gamma delta (γδ) T-cell receptors (TCRs...

Tizona Therapeutics, Inc.

Tizona Therapeutics, Inc., is a privately held immunology company harnessing the power of the immune system to develop treatments for cancer and autoimmune disorders. A healthy im...

Santalis Pharmaceuticals, Inc.

Santalis Pharmaceuticals, Inc. is a wholly-owned subsidiary of TFS Corporation, Ltd. (ASX: TFC). Santalis, and its sister company, ViroXis, were acquired by TFS in July 2015 and a...

Biothera Pharmaceuticals Inc.

Biothera Pharmaceuticals is a privately held biotechnology company developing Imprime PGG, a first-in-class, mid-clinical stage cancer immunotherapy that orchestrates an integrate...

Tarveda Therapeutics, Inc.

Tarveda Therapeutics, Inc., is a biopharmaceutical company discovering and developing Pentarins™ as a new class of targeted anti-cancer medicines to advance the treatment of ...

PsiOxus Therapeutics Ltd.

PsiOxus Therapeutics is an Oxford, UK-based development stage biotechnology company with a particular focus on immune therapeutics in oncology. PsiOxus has developed a pate...

Ora, Inc.

Ocular Therapeutix, Inc. is a biopharmaceutical company focused on the development and commercialization of innovative therapies for diseases and conditions of the eye using its p...

Oncoceutics, Inc.

Oncoceutics, Inc. is a clinical-stage drug discovery and development company targeting the most potent suppressor pathways in human cancer. The first lead compound to result from ...

Minerva Biotechnologies

Minerva Biotechnologies is a pioneer in the field of stem cells and cancer stem cells. Minerva was first to discover that cancer cells hijack an otherwise normal stem cell growth ...

Clinical Trials [2030 Associated Clinical Trials listed on BioPortfolio]

Clinical Trial To Study The Anti-scarring Effect Of Cicatricell

This study tries to prove that Cicatricell cream significantly reduces scarring with better wound appearance as compared to no treatment.

Effect of Intranasal Anti-IgE Antibodies on IgE Production

In this study, participants will receive either intranasal anti-IgE-antibodies (n=5) or intranasal allergen (n=5) or intranasal placebo (n=5). Blood samples will be obtained before nasal a...

Phase 1 Study of CAR-20/19-T Cells in Patients With Relapsed Refractory B Cell Malignancies

This is a phase 1, interventional single arm, open label, treatment study designed to evaluate the safety and feasibility of infusion of autologous T cells engineered to contain an anti-CD...

A Phase IB/II Study With Azacitidine, Durvalumab, and Tremelimumab in Recurrent and/or Metastatic Head and Neck Cancer Patients

This is a non-randomized, open-label, Phase Ib/II study to assess the safety and efficacy of azacitidine, durvalumab (MEDI4736), and tremelimumab combination therapy in the treatment of pa...

Golimumab Effect in the Modulation of Gut Microbiota in Ulcerative Colitis

This study aims to characterize the changes on intestinal microbiota pattern associated with the use of golimumab in order to determine if intestinal microbiota markers may correlate with ...

Safety and Pharmacokinetics of Recombinant Anti-EGFr Antibody in Patients With Metastatic Colorectal Cancer

A single-central,open-label,safety,pharmacokinetics,phase I study. Biological:Recombinant Anti-EGFr Antibody Two dose levels: Low-dose level patients received initial dose 100 mg/m2 and 4 ...

RABIOPRED - a Validation Study of Theranostic Test to PREDict Treatment Response of Anti-TNFα BIologicals in Rheumatoid Arthritis

RABIOPRED is an in vitro non-invasive blood test, which aims to identify patients with rheumatoid arthritis (RA) who are not likely to respond to anti-TNFα and methotrexate combination th...

Safety and Efficacy of Recombinant Humanized Anti-PD-1 mAb for Patients With Locally Advanced or Metastatic Melanoma

This is a multi-center, open-label, phase 2 study evaluating the humanized anti-PD-1 antibody JS001, as a monotherapy in patients with locally advanced or metastatic melanoma who have fail...

A Single-center Clinical Trial of Bortezomib in Management of Immune Thrombocytopenia (ITP)

Primary immune thrombocytopenia (ITP) is a disorder caused by autoantibody-mediated platelet destruction and decreased platelet production. It has been reported that refractory ITP is clos...

Nivolumab in Patients With Metastatic Renal Cell Carcinoma Who Have Progresses During or After Prior Systemic Anti-angiogenic Regimen

The primary objective of this study is to evaluate the incidence of high-grade (i.e. Grade 3-4 and Grade 5 of CTCAE v4.0) adverse reactions of interest in patients with metastatic RCC who ...

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Medical and Biotech [MESH] Definitions

A non-steroidal anti-fertility agent with anti-hormonal properties.

One of the ADRENERGIC BETA-ANTAGONISTS used as an antihypertensive, anti-anginal, and anti-arrhythmic agent.

An IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It inhibits prostaglandin synthesis and has been proposed as an anti-arthritic.

An anti-inflammatory, anti-allergic glucocorticoid that can be administered orally, by inhalation, locally, and parenterally. It may cause water and salt retention.

An anti-inflammatory, synthetic glucocorticoid. It is used topically as an anti-inflammatory agent and in aerosol form for the treatment of ASTHMA.

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