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Vantictumab - Biotech, Pharma and Life Science Channel

09:15 EST 21st February 2017 | BioPortfolio

Anti-Fzd7 (vantictumab, OMP-18R5)

Vantictumab is OncoMed’s lead program in the Wnt pathway. Screened against the Frizzled 7 receptor, the antibody binds a conserved epitope on five of the Frizzled receptors. It has been shown in preclinical studies to induce tumor cell differentiation. Vantictumab entered Phase 1 clinical testing in 2011.

Vantictumab is a monoclonal antibody optimized to block a key signaling pathway in cancer. Specifically, vantictumab selectively targets Frizzled receptors, activators of Wnt signaling. Vantictumab exhibits broad anti-tumor activity in nonclinical models. Vantictumab is currently in Phase 1 and will be evaluated in chemotherapy combinations in Phase 1b trials. Vantictumab is part of OncoMed’s collaboration with Bayer Pharma AG.

PubMed Articles [6275 Associated PubMed Articles listed on BioPortfolio]

Anti-inflammatory and anticancer effects of flavonol glycosides from Diplotaxis harra through GSK3β regulation in intestinal cells.

Diplotaxis harra (Forssk.) Boiss. (Brassicaceae) is traditionally used as an antidiabetic, anti-inflammatory or anticancer agent. In these pathologies, the glycogen synthase kinase 3 β (GSK3β) is ov...

Antibacterial, antioxidant and anti-proliferative properties and zinc content of five south Portugal herbs.

Crataegus monogyna L. (Rosaceae) (CM), Equisetum telmateia L. (Equisataceae) (ET), Geranium purpureum Vil. (Geraniaceae) (GP), Mentha suaveolens Ehrh. (Lamiaceae) (MS), and Lavandula stoechas L. spp. ...

Priming increases the anti-tumor effect and therapeutic window of (177)Lu-octreotate in nude mice bearing human small intestine neuroendocrine tumor GOT1.

(177)Lu-[DOTA(0), Tyr(3)]-octreotate ((177)Lu-octreotate) is used for treatment of patients with somatostatin receptor (SSTR) expressing neuroendocrine tumors. However, complete tumor remission is rar...

Mechanism of anti-Vibrio activity of marine probiotic strain Bacillus pumilus H2, and characterization of the active substance.

Vibriosis is a major epizootic disease that impacts free-living and farmed fish species worldwide. Use of probiotics is a promising approach for prevention of Vibrio infections in aquaculture. A probi...

Topical application of the anti-microbial chemical triclosan induces immunomodulatory responses through the S100A8/A9-TLR4 pathway.

The anti-microbial compound triclosan is incorporated into numerous consumer products and is detectable in the urine of 75% of the general United States population. Recent epidemiological studies repo...

Anti-inflammatory activity of Ternstroemia gymnanthera stem bark extracts in bacterial lipopolysaccharide-stimulated RAW264.7 murine macrophage cells.

Ternstroemia gymnanthera Sprague (Theaceae) possesses various known pharmacological properties. However, its anti-inflammatory activity has not been reported.

Targeting delivery of simvastatin using ICAM-1 antibody-conjugated nanostructured lipid carriers for acute lung injury therapy.

Acute lung injury (ALI) is a critical illness without effective therapeutic modalities currently. Recent studies indicated potential efficacy of statins for ALI, while high-dose statins was suggested ...

Improved oral absorption and anti-lung cancer activity of paclitaxel-loaded mixed micelles.

The aim of this study was to establish a paclitaxel (PTX)-loaded mixed micelle delivery system (PTX-TP-M) with vitamin E-TPGS (TPGS) and Plasdone®S-630 Copovidone (PVPS630) as carriers to improve the...

Improving anti-tumor activity of sorafenib tosylate by lipid- and polymer-coated nanomatrix.

In the present study, we select the Sylysia 350 (Sylysia) as mesoporous material, distearoylphosphatidylethanolamine-poly(ethylene glycol)2000 (DSPE-PEG) as absorption enhancer and hydroxy propyl meth...

Two-component spin-coated Ag/CNT composite films based on a silver heterogeneous nucleation mechanism adhesion-enhanced by mechanical interlocking and chemical grafting.

In this paper, a new method for the synthesis of silver carbon nanotube (Ag/CNT) composite films as conductive connection units for flexible electronic devices is presented. This method is about a two...

News Articles [2217 Associated News Articles listed on BioPortfolio]

Affigen Announces $17 Million Series A Led by Black Beret Life Sciences

Funding for Development of Cancer Immunotherapies Targeting Cell Lineage-Specific Tumor Proteins Affigen, a biotechnology company that develops therapeutics targeting c...

Macrophage migration inhibitory factor downregulation: a novel mechanism of resistance to anti-angiogenic therapy

Anti-aging study reveals role of mitochondria pointing towards new medicine

A joint study between researchers from Russia and Sweden has revealed the extent to which mitochondria play a role in the aging process. The study was conducted on mice that had been genetically-modif...

Leading Integrative Medicine Institute Reveals the Single Unifying Cause of All Disease

CHICAGO, Feb. 21, 2017 /PRNewswire/ -- In physics the search goes on to find the one unified theory of how all forces in the universe originate from a single field, a single unifying force. Einstein s...

TheraBreath Launches Kids Rinse Just in Time for Children’s Oral Health Month

Dr. Harold KATZ, a respected pioneer in the fight against bad breath, announces new children’s oral rinse line. The rinse, made from organic grapes, is free of artificial dyes and colors. (PRWEB) Fe...

Anti-reflective Coatings (AR Coatings) Market Worth $7.5 Billion by 2025: Grand View Research, Inc.

SAN FRANCISCO, February 21, 2017 /PRNewswire/ -- The global anti-reflective coatings market is expected to reach USD 7.50 billion by 2025, according to a new report by Grand View Research, In...

Sirukumab effective for antiTNF intolerant RA

Sirukumab was effective for patients with rheumatoid arthritis who were intolerant to other anti-tumor necrosis factor inhibitors, according to recently published data.“The phase 3 SIRROUND-T study ...

‘Chemical free’ organic industry’s unacknowledged ‘pesticide problem’

The organic label is often touted as meaning "pesticide free" and has become a rallying cry for anti-GMO activists. But imported organics, particularly from China, are not not well policed, and pesti...

Dual anti-ischemic effects of rosmarinic acid n-butyl ester via alleviation of DAPK-p53-mediated neuronal damage and microglial inflammation

Krebs Biochemicals Industries Ltd KREBSBIO Financial and Strategic SWOT Analysis Review [Updated: 13012017] Prices from USD $300

SummaryKrebs Biochemicals Industries Ltd KBIL is a contract manufacturing company that manufactures and markets painkillers, antiasthmatic and antiHIV drugs. The company's products include simvastati...

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Companies [124 Associated Companies listed on BioPortfolio]

Affigen

Affigen (www.affigen.com) develops tumor-identifying therapeutics that target cell lineage-specific tumor proteins in certain incurable cancers. The Company's growing team ...

Promethera Biosciences

Promethera Biosciences is a global innovator in liver cell-based medicines whose mission is to help patients overcome acute and chronic liver diseases. Our lead clinical program, ...

Medpace Holdings, Inc.

Medpace is a scientifically-driven, global, full-service clinical contract research organization (CRO) providing Phase I-IV clinical development services to the biotechnology, pha...

Shinkowa Pharmaceutical Co., Ltd.

Based in Tokyo, Japan, Shinkowa Pharmaceutical Co., Ltd. (http://shinkowapharma.com/) is a pharmaceutical company that has developed and sells dietary supplements and cosmetics in...

Gadeta

Founded in 2015, Gadeta has developed a technology platform based on combinatorial T Cell receptor exchange (CTE) to create optimized gamma delta (γδ) T-cell receptors (TCRs...

Tizona Therapeutics, Inc.

Tizona Therapeutics, Inc., is a privately held immunology company harnessing the power of the immune system to develop treatments for cancer and autoimmune disorders. A healthy im...

Santalis Pharmaceuticals, Inc.

Santalis Pharmaceuticals, Inc. is a wholly-owned subsidiary of TFS Corporation, Ltd. (ASX: TFC). Santalis, and its sister company, ViroXis, were acquired by TFS in July 2015 and a...

Biothera Pharmaceuticals Inc.

Biothera Pharmaceuticals is a privately held biotechnology company developing Imprime PGG, a first-in-class, mid-clinical stage cancer immunotherapy that orchestrates an integrate...

Tarveda Therapeutics, Inc.

Tarveda Therapeutics, Inc., is a biopharmaceutical company discovering and developing Pentarins™ as a new class of targeted anti-cancer medicines to advance the treatment of ...

PsiOxus Therapeutics Ltd.

PsiOxus Therapeutics is an Oxford, UK-based development stage biotechnology company with a particular focus on immune therapeutics in oncology. PsiOxus has developed a pate...

Clinical Trials [2070 Associated Clinical Trials listed on BioPortfolio]

The Impact of Depression and/or Anxiety on PCI Patients

The purpose of this study is to evaluate how major depressive disorder or generalized anxiety disorder could effect the prognosis of the patients post-ACS after PCI and whether the treatme...

Treatment of Tuberculosis Multidrug Resistance Treatment of Tuberculosis Multidrug Resistance

The principal objective is to provide curative treatment to patients with confirmed multidrug-resistant tuberculosis who do not respond to treatment with standard first line anti tuberculo...

A Phase 1/2 Safety Study of Intratumorally Dosed INT230-6

This study evaluates the intratumoral administration of escalating doses of a novel, experimental drug, INT230-6. The study is being conducted in patients with several types of refractory ...

Cytokine and Visual Outcome Variations in Eyes Receiving Ranibizumab

Objective: To determine the association between baseline aqueous cytokine levels and treatment intervals for patients under a variable dosing regimen with intravitreal ranibizumab in patie...

Cytokine and Visual Outcome Variations in Eyes Receiving Aflibercept

Objective: To determine the association between baseline aqueous cytokine levels and treatment intervals for patients under a variable dosing regimen with intravitreal aflibercept in patie...

Optimal Duration of Clopidogrel in Second-Generation Drug-Eluting Stents

Investigators try to assess the safety of 6-months or 12-months maintenance of dual antiplatelet therapy (DAPT, aspirin + clopidogrel) in patients undergoing percutaneous coronary interven...

Haloperidol Versus Ondansetron for Cannabis Hyperemesis Syndrome (HaVOC)

Cannabis Hyperemesis Syndrome (CHS) has become a well-documented syndrome since 2004 and is expected to increase in prevalence with continuing liberalization of marijuana and recognition o...

Precise Local Injection of Anti-cancer Drugs Using Presage's CIVO™ Device in Soft Tissue Sarcoma

This is a feasibility study in patients with localized or metastatic soft tissue sarcoma undergoing surgery to determine how sarcoma in situ responds to injected microdoses of anti-cancer ...

Does Short-Term Anti-Seizure Prophylaxis After Traumatic Brain Injury Decrease Seizure Rates?

The primary objective of this study is to prospectively assess in randomized fashion whether short term anti-seizure prophylaxis in traumatic brain injured patients decreases the incidence...

Durvalumab, Cetuximab and Radiotherapy in Head Neck Cancer

In over 60% of cases, squamous cell carcinoma of the head and neck (SCCHN) is discovered at a loco-regionally advanced stage that requires a combined multimodal strategy in order to pursue...

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Medical and Biotech [MESH] Definitions

A non-steroidal anti-fertility agent with anti-hormonal properties.

One of the ADRENERGIC BETA-ANTAGONISTS used as an antihypertensive, anti-anginal, and anti-arrhythmic agent.

An IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It inhibits prostaglandin synthesis and has been proposed as an anti-arthritic.

An anti-inflammatory, anti-allergic glucocorticoid that can be administered orally, by inhalation, locally, and parenterally. It may cause water and salt retention.

An anti-inflammatory, synthetic glucocorticoid. It is used topically as an anti-inflammatory agent and in aerosol form for the treatment of ASTHMA.

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