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Vantictumab - Biotech, Pharma and Life Science Channel

11:49 EDT 28th March 2017 | BioPortfolio

Anti-Fzd7 (vantictumab, OMP-18R5)

Vantictumab is OncoMed’s lead program in the Wnt pathway. Screened against the Frizzled 7 receptor, the antibody binds a conserved epitope on five of the Frizzled receptors. It has been shown in preclinical studies to induce tumor cell differentiation. Vantictumab entered Phase 1 clinical testing in 2011.

Vantictumab is a monoclonal antibody optimized to block a key signaling pathway in cancer. Specifically, vantictumab selectively targets Frizzled receptors, activators of Wnt signaling. Vantictumab exhibits broad anti-tumor activity in nonclinical models. Vantictumab is currently in Phase 1 and will be evaluated in chemotherapy combinations in Phase 1b trials. Vantictumab is part of OncoMed’s collaboration with Bayer Pharma AG.

PubMed Articles [6292 Associated PubMed Articles listed on BioPortfolio]

Anti-inflammatory coumarins from Paramignya trimera.

Paramignya trimera (Oliv.) Burkill (Rutaceae) has been used to treat liver diseases and cancer. However, the anti-inflammatory effects of this medicinal plant and its components have not been elucidat...

Anti-inflammatory and anticancer effects of flavonol glycosides from Diplotaxis harra through GSK3β regulation in intestinal cells.

Diplotaxis harra (Forssk.) Boiss. (Brassicaceae) is traditionally used as an antidiabetic, anti-inflammatory or anticancer agent. In these pathologies, the glycogen synthase kinase 3 β (GSK3β) is ov...

Antibacterial, antioxidant and anti-proliferative properties and zinc content of five south Portugal herbs.

Crataegus monogyna L. (Rosaceae) (CM), Equisetum telmateia L. (Equisataceae) (ET), Geranium purpureum Vil. (Geraniaceae) (GP), Mentha suaveolens Ehrh. (Lamiaceae) (MS), and Lavandula stoechas L. spp. ...

Priming increases the anti-tumor effect and therapeutic window of (177)Lu-octreotate in nude mice bearing human small intestine neuroendocrine tumor GOT1.

(177)Lu-[DOTA(0), Tyr(3)]-octreotate ((177)Lu-octreotate) is used for treatment of patients with somatostatin receptor (SSTR) expressing neuroendocrine tumors. However, complete tumor remission is rar...

Mechanism of anti-Vibrio activity of marine probiotic strain Bacillus pumilus H2, and characterization of the active substance.

Vibriosis is a major epizootic disease that impacts free-living and farmed fish species worldwide. Use of probiotics is a promising approach for prevention of Vibrio infections in aquaculture. A probi...

Topical application of the anti-microbial chemical triclosan induces immunomodulatory responses through the S100A8/A9-TLR4 pathway.

The anti-microbial compound triclosan is incorporated into numerous consumer products and is detectable in the urine of 75% of the general United States population. Recent epidemiological studies repo...

Anti-inflammatory activity of Ternstroemia gymnanthera stem bark extracts in bacterial lipopolysaccharide-stimulated RAW264.7 murine macrophage cells.

Ternstroemia gymnanthera Sprague (Theaceae) possesses various known pharmacological properties. However, its anti-inflammatory activity has not been reported.

Flavonoid-enriched extract from Hippophae rhamnoides seed reduces high fat diet induced obesity, hypertriglyceridemia, and hepatic triglyceride accumulation in C57BL/6 mice.

Flavonoid-enriched extract from Hippophae rhamnoides L. (Elaeagnaceae) seed (FSH) has shown beneficial effects in anti-hypertension and lowering cholesterol level. However, evidence for its efficacy i...

Targeting delivery of simvastatin using ICAM-1 antibody-conjugated nanostructured lipid carriers for acute lung injury therapy.

Acute lung injury (ALI) is a critical illness without effective therapeutic modalities currently. Recent studies indicated potential efficacy of statins for ALI, while high-dose statins was suggested ...

Improved oral absorption and anti-lung cancer activity of paclitaxel-loaded mixed micelles.

The aim of this study was to establish a paclitaxel (PTX)-loaded mixed micelle delivery system (PTX-TP-M) with vitamin E-TPGS (TPGS) and Plasdone®S-630 Copovidone (PVPS630) as carriers to improve the...

News Articles [2234 Associated News Articles listed on BioPortfolio]

White House Shies Away From Planned Parenthood Defunding Talk

Press secretary Sean Spicer says the Trump administration won't commit to including the hot-button issue in the upcoming spending bill. In other women's health news, some states are still moving to pr...

Euclises Pharmaceuticals, Inc. to Present Preclinical Efficacy Results at American Association for Cancer Research

Euclises Pharmaceuticals, Inc., a biopharmaceutical company developing next-generation therapies that prevent tumor immune evasion and kill cancer by disrupting the tumor microenv...

Eagle Surgical Products to Exhibit Electro Lube® at the Association of periOperative Registered Nurses Global Surgical Conference April 1-5 in Boston, Massachusetts

President of Eagle Surgical Products, LLC, to demonstrate surgical product’s effectiveness as an anti-stick solution for electrocautery instruments. AUSTIN, Texas (PRWEB) March 28, 2017 Eagle Surgi...

Biogen to Present Data at the 13th International Conference on Alzheimer’s and Parkinson’s Diseases

Biogen (NASDAQ: BIIB) will present data from its Alzheimer’s and Parkinson’s disease programs at the 13th International Conference on Alzheimer’s and Parkinson’s Di...

North America Aesthetic Services Market to Reach US$ 28,152.1 Million by 2024; Growing Demand for Retaining Young and Beauty is Expected to Increase the Overall Market Share in the United States

ALBANY, New York, March 28, 2017 /PRNewswire/ -- According to the report, the North America aesthetic Services Market was valued at US$ 14,409.0 Mn in 2015 and is projected to expand at ...

Anti-Diabetes Compound Encumbers Coactivator, Reduces Blood Sugar

A new way to suppress the liver’s glucose production has been identified, thanks to a chemical screen that can quantify the ability of small molecules to increase the acetylation of a gene coactivat...

Cardax Astaxanthin Compound CDX-085 Stimulates Anti-Aging Gene in Mice

Almost 90% Increase in FOXO3 Gene Expression Demonstrated in University of Hawaii Research Cardax, Inc. (“Cardax”) (OTCQB:CDXI) and the University of Hawaii (“UH”) ...

Novel drug delivery beats swine flu at gene level

Scientists from Tomsk Polytechnic University together with their colleagues from St. Petersburg and London have elaborated a new approach to deliver anti-viral RNAi to target cells against H1N1 influe...

CureLab Oncology, Inc. Publishes Results of Phase I/IIa Clinical Trials of Its Anti-Cancer DNA Vaccine, Elenagen™

BOSTON, March 28, 2017 /PRNewswire/ -- Oncology journal, Oncotarget, has published a pre-print of the research conducted by the Boston based biotech start-up CureLab Oncology, Inc. The paper describes...

Scientists reveal novel drug delivery approach to fight swine flu at gene level

Scientists from Tomsk Polytechnic University together with their colleagues from St. Petersburg and London have elaborated a new approach to deliver anti-viral RNAi to target cells against H1N1 influe...

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Visualant, Inc. (OTCBB:VSUL and www.visualant.net) develops low-cost, high speed, light-based security and quality control solutions for use in homeland security, anti-counterfeit...

Affigen

Affigen (www.affigen.com) develops tumor-identifying therapeutics that target cell lineage-specific tumor proteins in certain incurable cancers. The Company's growing team ...

Promethera Biosciences

Promethera Biosciences is a global innovator in liver cell-based medicines whose mission is to help patients overcome acute and chronic liver diseases. Our lead clinical program, ...

Medpace Holdings, Inc.

Medpace is a scientifically-driven, global, full-service clinical contract research organization (CRO) providing Phase I-IV clinical development services to the biotechnology, pha...

Shinkowa Pharmaceutical Co., Ltd.

Based in Tokyo, Japan, Shinkowa Pharmaceutical Co., Ltd. (http://shinkowapharma.com/) is a pharmaceutical company that has developed and sells dietary supplements and cosmetics in...

Gadeta

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Tizona Therapeutics, Inc.

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Santalis Pharmaceuticals, Inc.

Santalis Pharmaceuticals, Inc. is a wholly-owned subsidiary of TFS Corporation, Ltd. (ASX: TFC). Santalis, and its sister company, ViroXis, were acquired by TFS in July 2015 and a...

Clinical Trials [2102 Associated Clinical Trials listed on BioPortfolio]

Savolitinib vs. Sunitinib in MET-driven PRCC

This study is designed for patients diagnosed with MET-driven, unresectable and locally advanced or metastatic Papillary Renal Cell Carcinoma. The purpose of this study is to see if an inv...

Microbiome Shift in Peri-mucositis by Anti-inflammatory Drugs

Dental implants are often used to replace missing teeth. In fact, in the US over 700,000 implants are places every year and over 2 million implants are places world wide. Peri-implant muco...

Sub-optimal Response to Anti-Tumor Necrosis Factor's in Inflammatory Bowel Disease in Emerging Markets

The purpose of this study is to establish the incidence of sub-optimal response to anti-TNF therapy in UC and CD participants.

Personalising Anti-TNF Therapy in Crohns Disease (PANTS)

To develop a cost-effective, individualised anti-TNF treatment strategy for patients with Crohn's disease which maximizes benefit and minimises harm. The primary objective of this study i...

Trial of Consolidation Pembrolizumab After Concurrent Chemotherapy and Proton Reirradiation for Thoracic Recurrences of Non-Small Cell Lung Cancer

The main purpose of this study is to assess the safety, tolerability and anti-tumor activity of the experimental study drug pembrolizumab (also known as Keytruda or MK-3475) in people with...

A Multicenter Observational Study to Evaluate Pediatric Multiple Sclerosis in Brazil

Pediatric Multiple sclerosis (MS) is a chronic inflammatory disease defined by multiple episodes of demyelination of the central nervous system (CNS) separated by time and space as specifi...

A Study to Evaluate SHR-1210 as Second-line Therapy in Patients With NSCLC

This is an open-label, single-arm, multi-center, phase 2 Study to evaluate SHR-1210(anti-PD-1 antibody) as second-line therapy in in adult Chinese patients with advanced or metastatic non-...

Anti-GPC3 CAR-T for Treating GPC3-positive Advanced Hepatocellular Carcinoma (HCC)

The goal of this clinical trial is to evaluate the safety and efficacy of anti-GPC3 scFv-41BB-CD3ζ-tEGFR chimeric antigen receptor (CAR)-modified T (CAR-T) cells in treating patients with...

Neoadjuvant Degarelix +/- Apalutamide (ARN-509) Followed by Radical Prostatectomy

RATIONALE: Neoadjuvant hormonal therapy using luteinizing hormone releasing hormone (LHRH) agonists and/or anti-androgens has already demonstrated to downstage primary prostate cancer in p...

Salivary Therapeutic Drug Monitoring of Anti-Tuberculosis Drugs

In tuberculosis patients, salivary concentrations will be compared to plasma/serum concentrations of several anti-tuberculosis drugs. If salivary concentrations correctly represent blood c...

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Medical and Biotech [MESH] Definitions

A non-steroidal anti-fertility agent with anti-hormonal properties.

One of the ADRENERGIC BETA-ANTAGONISTS used as an antihypertensive, anti-anginal, and anti-arrhythmic agent.

An IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It inhibits prostaglandin synthesis and has been proposed as an anti-arthritic.

An anti-inflammatory, anti-allergic glucocorticoid that can be administered orally, by inhalation, locally, and parenterally. It may cause water and salt retention.

An anti-inflammatory, synthetic glucocorticoid. It is used topically as an anti-inflammatory agent and in aerosol form for the treatment of ASTHMA.

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