Acute Lymphocytic Leukemia ALL - Biotech, Pharma and Life Science Channel
Acute lymphocytic leukemia (ALL) is a life-threatening disease in which the cells that normally develop into lymphocytes become cancerous and rapidly replace normal cells in the bone marrow. ALL accounts for 25% of childhood cancers, but is found across all age groups.
In ALL, very immature leukemia cells accumulate in the bone marrow, destroying and replacing cells that produce normal blood cells. The leukemia cells are also carried in the bloodstream to the liver, spleen, lymph nodes, brain, and testes, where they may continue to grow and divide. They can irritate the layers of tissue covering the brain and spinal cord, causing inflammation and organ damage.
Treatment has extended the life expectancy from 4 months to a cure for 80% of patients; induction chemotherapy, allopurinol, prednisone, anthracycline and consolidation chemotherapy.
Source; Adapted from Merck Manuals
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PubMed Articles
This retrospective data analysis examined the outcome of 99 acute lymphoblastic leukemia (ALL) patients treated at Tawam Hospital between January 2000 and December 2009. Sixteen patients were treated...
Expression of CD133 in acute leukemia.
There have been conflicting results regarding a correlation between CD133 expression and disease outcome. To assess CD133 expression in patients with acute myeloid leukemia (AML) and acute lymphoblast...
Treatment for hepatitis C virus-induced portal hypertension in leukemic children.
Children with acute leukemia are at high risk of hepatitis C infection, either by immunosuppression secondary to chemotherapy or by multiple transfusions of blood products during the course of the dis...
Application of five prognostic survival scores to primary myelofibrosis in 62 Brazilian patients.
Primary myelofibrosis (PM) is a Philadelphia-negative clonal hematopoietic stem cell disorder characterized by intense reactive changes of bone marrow stroma with collagen fibrosis, osteosclerosis and...
Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults in Western countries. It is characterized by heterogeneous clinical course of the disease and new prognostic factors are still...
Nutritional therapy in acute pancreatitis.
Acute pancreatitis is a frequent clinical entity in the West. About 80% of patients with acute pancreatitis develop edematous pancreatitis, while 20% develop necrotizing pancreatitis: The latter is a...
BACKGROUND: Acute myeloid leukemia (AML) is the most common form of acute leukemia affecting adults, with incidence increasing with patient age. Previous studies have found that older AML patients, co...
BACKGROUND: The purpose of the present study was to determine the prevalence of diabetes and its effect on surgical outcomes in patients undergoing emergent, in-patient cholecystectomy for acute chole...
Oxidative stress is revealed as the main contributor in the pathophysiology of neuroinflammation. Analyzing plasma and cerebrospinal fluid (CSF) of patients with different clinical phenotypes of neuro...
The role of individual monocyte subsets in inflammation and recovery post-myocardial infarction (MI) is insufficiently understood. It was the objective of this study to evaluate the dynamics of monocy...
News Articles
Alnylam reports pre-clinical data from ALN-AS1 program for treatment of AIP
Alnylam Pharmaceuticals, Inc., a leading RNAi therapeutics company, announced today that it has presented key pre-clinical proof-of-concept data from its RNAi therapeutic program targeting aminolevuli...
CSF3R T618I is a highly prevalent and specific mutation in chronic neutrophilic leukemia
The MLL recombinome of acute leukemias in 2013
Public offering nets $18.8mm for [Cyclacel]
[Cyclacel Pharmaceuticals Inc.] (mainly cancer therapies; also has projects for kidney disease, diabetes, and HIV/AIDS) netted $18.8mm through public offering of 6.67mm common shares at $3 each. Proce...
Ysios and Axis provide [STAT-Diagnostica & Innovation] with €2mm Series A financing
[STAT-Diagnostica & Innovation SL] (near-patient testing systems that integrate molecular diagnostics and immunoassays to provide rapid results in acute care settings) raised €2mm ($3mm) in its Seri...
This Whitepaper describes how a multi-specialty chain of outpatient clinics in a large acute-care hospital system instituted a comprehensive environmental hygiene program consisting of disinfection of...
MorphoSys initiates Phase 2 clinical study of antibody treatment for non-Hodgkin's lymphoma
MorphoSys AG has initiated a Phase 2 clinical trial of its antibody drug candidate MOR208 in non-Hodgkin’s lymphoma (NHL). MOR208 is a potent Fc-optimised anti-CD19 antibody to which MorphoSys gaine...
New protein-targeting drug shows promise in early trial for patients with high-risk CLL
A new oral targeted drug, idelalisib (GS-1101), has the potential to stave off the need for additional treatments for relapsed or treatment-resistant chronic lymphocytic leukemia (CLL), according to a...
Evidence does not support racecadotril use, says DTB
On current evidence, racecadotril does not have a place in the management of acute diarrhoea, according to the Drug and Therapeutics Bulletin (2013;51:54). The DTB review covered five trials in a...
Events
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Companies
Promedior has developed a novel drug discovery platform to regulate the monocyte-derived cell populations that play key roles in fibrotic, inflammatory and autoimmune diseases. By...
Eutropics Pharmaceuticals Inc.
Eutropics is addressing the need for improving the treatment of aggressive forms of leukemia, myeloma, lymphoma, and other cancers. The company is developing a novel diagnostic te...
Reverse Medical Corporation is a privately-held medical device company focused on expanding the endovascular management of acute stroke and neurovascular disease. The technology p...
LifePoint Hospitals, Inc. is a leading hospital company focused on providing quality healthcare services close to home. Through its subsidiaries, LifePoint operates 48 hospital ca...
Stanley Healthcare Solutions provides over 5,000 acute care hospitals and 12,000 long-term care organizations with enterprise solutions that transform safety, security and operati...
National Health Investors, Inc.
National Health Investors, Inc. is a healthcare real estate investment trust that specializes in the financing of healthcare real estate by purchase and leaseback transactions and...
DecImmune Therapeutics was founded by Michael Carroll PhD (The Immune Disease Institute, Harvard Medical School), and Francis Moore Jr. MD (Brigham and Womenâs Hospital, Harv...
Neurowave Medical Technologies
Neurowave Medical TechnologiesTM (NMT) is a rapidly growing, privately held Chicago-based medical device company that develops and manufactures transdermal neuromodulation devices...
Comprehensive Pharmacy Services
CPS is the nationâs leading pharmacy services provider, serving acute care and specialty hospitals, medical centers and healthcare facilities. Currently, CPS works with 300+...
Baxter International Inc. and Takeda Pharmaceutical Company Limited
Baxter International Inc. (NYSE:Â BAX), through its subsidiaries, develops, manufactures and markets products that save and sustain the lives of people with hemophilia, immune d...
Clinical Trials
To evaluate the efficacy and safety of Vanquix for the management of selected, refractory, patients with epilepsy who require intermittent medical intervention provided by caregivers who a...
This randomized phase II trial is studying how well giving tacrolimus and mycophenolate mofetil (MMF) together with or without sirolimus works in preventing acute graft-versus-host disease...
Ketoprofen 10% Cream for Treatment of Pain Associated With Mild to Moderate Acute Soft Tissue Injury
Imprimis Pharmaceuticals is investigating a proprietary, topical cream formulation consisting of 10% ketoprofen (containing 100 mg of ketoprofen in 1gram of cream) for the local treatment...
The objective of this NIS is to assess in a real-life setting, usage patterns and associated outcomes in the management (healthcare resource utilisation and associated costs) of patients w...
Randomized Study of ON 01910.Na in Refractory Myelodysplastic Syndrome Patients With Excess Blasts
The primary objective of this study is to compare overall survival (OS) in patients receiving ON 01910.Na + best supportive care (BSC) to OS of patients receiving BSC in a population of pa...
Mesenchymal Stromal Cells (MSCs) for the Treatment of Graft Versus Host Disease (GVHD)
This is a bicentric, prospective, non randomized study. Pediatric and adult patients will be treated. Rationale: MSC have shown promising effects by reversal of severe therapy-resistant a...
Effects of Acute Intake of Caffeinated Beverages in Type 1 Diabetes
The aim of this pilot study is to determine the impact of caffeine-enhanced energy drinks on blood glucose excursion on heart rate, blood pressure, cardiac output and cognitive performance...
RATIONALE: Sorafenib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the cancer. PURPOSE: This randomized phase I...
RATIONALE: Drugs used in chemotherapy, such as vorinostat, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Vorinos...
The objective is to obtain initial information regarding the safety and efficacy of the use of Filgrastim in the setting of acute myocardial infarction. The secondary objectives are to ob...
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Medical and Biotech [MESH] Definitions
Rna-binding Protein Fus
A multifunctional heterogeneous-nuclear ribonucleoprotein that may play a role in homologous DNA pairing and recombination. The N-terminal portion of protein is a potent transcriptional activator, while the C terminus is required for RNA binding. The name FUS refers to the fact that genetic recombination events result in fusion oncogene proteins (ONCOGENE PROTEINS, FUSION) that contain the N-terminal region of this protein. These fusion proteins have been found in myxoid liposarcoma (LIPOSARCOMA, MYXOID) and acute myeloid leukemia.
Calgranulin A
A 10.8-kDa member of the S-100 family of calcium-binding proteins that can form homo- or heterocomplexes with CALGRANULIN B and a variety of other proteins. The calgranulin A/B heterodimer is known as LEUKOCYTE L1 ANTIGEN COMPLEX. Calgranulin A is found in many cell types including GRANULOCYTES; KERATINOCYTES; and myelomonocytes, and has been shown to act as a chemotactic substance for NEUTROPHILS. Because it is present in acute inflammation but absent in chronic inflammation, it is a useful biological marker for a number of pathological conditions.
Stress Disorders, Traumatic, Acute
A class of traumatic stress disorders that is characterized by the significant dissociative states seen immediately after overwhelming trauma. By definition it cannot last longer than 1 month, if it persists, a diagnosis of post-traumatic stress disorder (STRESS DISORDERS, POST-TRAUMATIC) is more appropriate.
Candida Tropicalis
A species of MITOSPORIC FUNGI that is a major cause of SEPTICEMIA and disseminated CANDIDIASIS, especially in patients with LYMPHOMA; LEUKEMIA; and DIABETES MELLITUS. It is also found as part of the normal human mucocutaneous flora.
Cholecystitis, Acute
Acute inflammation of the GALLBLADDER wall. It is characterized by the presence of ABDOMINAL PAIN; FEVER; and LEUKOCYTOSIS. Gallstone obstruction of the CYSTIC DUCT is present in approximately 90% of the cases.
