Advertisement

Topics

Adenosine Deaminase - Biotech, Pharma and Life Science Channel

00:39 EST 20th January 2017 | BioPortfolio

PubMed Articles [446 Associated PubMed Articles listed on BioPortfolio]

Hepatitis B virus X protein is capable of down-regulating protein level of host antiviral protein APOBEC3G.

The apolipoprotein B mRNA editing catalytic polypeptide-like (APOBEC) family proteins bind RNA and single-stranded DNA, and create C-to-U base modifications through cytidine deaminase activity. APOBEC...

c-di-AMP modulates Listeria monocytogenes central metabolism to regulate growth, antibiotic resistance, and osmoregulation.

Cyclic di-adenosine monophosphate (c-di-AMP) is a conserved nucleotide second messenger critical for bacterial growth and resistance to cell wall-active antibiotics. In Listeria monocytogenes, the sol...

Corrigendum: Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex.

The spectral properties of DNA and RNA macromolecules at low temperatures: fundamental and applied aspects.

This paper summarizes the results of studies of the spectral properties-optical absorption, fluorescence and phosphorescence-of DNA and RNA macromolecules and synthetic poly-, oligo- and mono-nucleoti...

The role of glutamine synthetase in energy production and glutamine metabolism during oxidative stress.

Oxidative stress is known to severely impede aerobic adenosine triphosphate (ATP) synthesis. However, the metabolically-versatile Pseudomonas fluorescens survives this challenge by invoking alternativ...

Chemical proteomics reveals ADP-ribosylation of small GTPases during oxidative stress.

ADP-ribosylation is a post-translational modification that is known to be involved in cellular homeostasis and stress but has been challenging to analyze biochemically. To facilitate the detection of ...

Inhibition of TRPML1 by lysosomal adenosine involved in severe combined immunodeficiency diseases.

Impaired adenosine homeostasis has been associated with numerous human diseases. Lysosomes are referred to as the cellular recycling centers which generate adenosine by breaking down nucleic acids or ...

A Bioorganometallic Approach to the Study Histidine Kinase Auto-Phosphorylation.

Auto-phosphorylation of bacterial histidine kinases PhoR, PhoQ and EnvZ have been investigated using Adenosine-5'-[γ-ferrocene] triphosphate (Fc-ATP) as a co-substrate for the first time. The study h...

Structure of a Pancreatic ATP-Sensitive Potassium Channel.

ATP-sensitive potassium channels (KATP) couple intracellular ATP levels with membrane excitability. These channels play crucial roles in many essential physiological processes and have been implicated...

Structures of the Human HCN1 Hyperpolarization-Activated Channel.

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels underlie the control of rhythmic activity in cardiac and neuronal pacemaker cells. In HCN, the polarity of voltage dependence is uniq...

News Articles [64 Associated News Articles listed on BioPortfolio]

Corrigendum: Structural basis of N6-adenosine methylation by the METTL3–METTL14 complex

Rubraca (rucaparib) for the Treatment of Advanced Ovarian Cancer

Poly adenosine diphosphate (ADP) ribose polymerase (PARP) inhibitor Rubraca™ (rucaparib) is indicated for the treatment of BRCA mutation-linked advanced ovarian cancer.

SanofiAventis Deutschland GmbH Pharmaceuticals Healthcare Deals and Alliances Profile Prices from USD $250

SummarySanofiAventis Deutschland GmbH SanofiAventis, a subsidiary of Sanofi is a healthcare service provider that conducts research, development, manufacture and marketing of prescription and over the...

Orchard Therapeutics Ltd. Announces a Manufacturing Alliance with PharmaCell B.V.

London, UK & Maastricht, the Netherlands,  January 09, 2017 / B3C newswire / -- Orchard Therapeutics (“Orchard”), a clinical-stage biotechnology company dedicated to bringing transformat...

Can-Fite Receives IRB Approval to Commence Patient Enrollment in Phase II NAFLD/NASH Trial in Q1 2017

PETACH TIKVA, Israel, Jan. 9, 2017 /PRNewswire/ -- Can-Fite BioPharma Ltd. (NYSE MKT: CANF) (TASE:CFBI), a biotechnology company with a pipeline of proprietary small molecule drugs being develope...

Sagent Pharmaceuticals Inc SGNT Pharmaceuticals Healthcare Deals and Alliances Profile Prices from USD $250

SummarySagent Pharmaceuticals Inc Sagent, formerly Sagent Holding Co., is a specialty pharmaceutical company which develops and manufactures pharmaceutical products with specific concentration on inje...

Inotek Pharmaceuticals Corp ITEK Pharmaceuticals Healthcare Deals and Alliances Profile Prices from USD $250

SummaryInotek Pharmaceuticals Corp IPC is a pharmaceutical company that discovers, develops and commercializes therapeutics for the treatment of glaucoma and serious diseases of the eye. The company's...

Inotek plummets on Phase III glaucoma miss

Inotek Pharmaceuticals Corp. (NASDAQ:ITEK) sank $4.35 (71%) to $1.75 after it said trabodenoson (INO-8875) monotherapy missed the primary endpoint of the Phase III MATrX-1 trial to treat primary open-...

Reversible methylation of m6Am in the 5′ cap controls mRNA stability

Fat mass and obesity-associated protein (FTO) preferentially demethylates m6Am, a modified adenosine that, when present at the 5′ end of certain mRNAs, positively influences mRNA stability by preven...

Gut bacteria may hold key to treating autoimmune disease

Defects in the body's regulatory T cells (T reg cells) cause inflammation and autoimmune disease by altering the type of bacteria living in the gut, researchers from The University of Texas Health Sci...

Events [0 Results]

None

Companies [2 Associated Companies listed on BioPortfolio]

Inotek Pharmaceuticals Corp.

Inotek Pharmaceuticals is a clinical-stage biopharmaceutical company focused on the discovery, development and commercialization of therapies for glaucoma and other eye diseases. ...

ArQule, Inc.

ArQule is a biotechnology company engaged in the research and development of next-generation, small-molecule cancer therapeutics. The Company’s targeted, broad-spectrum produ...

Clinical Trials [130 Associated Clinical Trials listed on BioPortfolio]

Long-term Remote Ischemic Preconditioning Improve the Prognosis of Myocardial Infarction Patients With Emergency Reperfusion Therapy

Patients with acute myocardial infarction (AMI) are in critical condition. When primary percutaneous coronary intervention (PCI) was performing, no-reflow, reperfusion injury,heart failu...

Autologous Cryopreserved CD34+ Hematopoietic Cells Transduced With EFS-ADA Lentivirus for Adenosine Deaminase Deficient SCID

This is a prospective, non-randomized, single-cohort, longitudinal, single-center, clinical study designed to assess the efficacy and safety of a cryopreserved formulation of OTL-101 (auto...

Phase 2a, AMP Challenge, Dose Escalation Study to Assess the Dose Response for Topical Efficacy and Systemic Activity in Asthmatic Subjects

This is a randomized, placebo-controlled, 2-period crossover, escalating repeat dose study, aiming to investigate whether higher potency of different inhaled corticosteroid confers an impr...

Immunoregulatory Mechanisms of Treg Cells Induced by Tocilizumab

We can speculate that the best responders to tocilizumab should have multiple related elements (Treg CD39, adenosine, IL-35) successfully induced and expressed in order to play its benefic...

Interactions of Environmental and Human Microbial Communities in a Pediatric Oncology Hospital

Microorganisms that colonize hospital environments play an important role in the transmission of hospital acquired infections (HAI) and multi-drug resistant organisms. Previous studies exa...

Glasgow MRI and Rotablation Study

Percutaneous coronary intervention (PCI) with adjunctive high speed rotational atherectomy (HSRA) is commonly used to treat complex and calcified coronary artery stenoses. Theoretically, H...

Blood Biomarkers in Suicidal Behaviour

Suicidal behavior (SB) is a major public health problem in France, with more than 10,000 suicides and 220,000 suicide attempts per year. According to the commonly accepted model for under...

Long-term Remote Ischemic Preconditioning Improve Long-term Prognosis of Acute Myocardial Infarction Patients Without Emergency Reperfusion Therapy

Patients with acute myocardial infarction (AMI) are in critical condition especially without emergency reperfusion therapy. For example, heart failure, heart rupture, malignant arrhythmia ...

Peripheral Vasodilation in Obese Humans

The growing population of obese adults is predicted to create a large public health burden in the next few decades. This study examines function of small blood vessels providing blood flow...

Ghrelin Resistance in Adolescents With Idiopathic Scoliosis

Adolescent idiopathic Scoliosis (AIS) is the most common spine pathology. It is opposed to secondary scoliosis due to chronic diseases. Many hypotheses have been made to elucidate the orig...

Videos

None available.

Medical and Biotech [MESH] Definitions

Drugs that inhibit ADENOSINE DEAMINASE activity.

An enzyme that catalyzes the hydrolysis of adenosine to inosine with the elimination of ammonia. Since there are wide tissue and species variations in the enzyme, it has been used as a tool in the study of human and animal genetics and in medical diagnosis. EC 3.5.4.4.

A nucleoside that is composed of adenine and d-ribose. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.

A ribonucleoside antibiotic synergist and adenosine deaminase inhibitor isolated from Nocardia interforma and Streptomyces kaniharaensis. It is proposed as an antineoplastic synergist and immunosuppressant.

A potent inhibitor of ADENOSINE DEAMINASE. The drug induces APOPTOSIS of LYMPHOCYTES, and is used in the treatment of many lymphoproliferative malignancies, particularly HAIRY CELL LEUKEMIA. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.

Quick Search
Advertisement
 
review and buy Adenosine Deaminase market research data and corporate reports here

Channels Quicklinks