Adenosine Deaminase - Biotech, Pharma and Life Science Channel

17:01 EDT 21st April 2015 | BioPortfolio

PubMed Articles [475 Associated PubMed Articles listed on BioPortfolio]

An enzyme-free and label-free fluorescent biosensor for small molecules by G-quadruplex based hybridization chain reaction.

An enzyme-free and label-free fluorescent biosensor is developed by G-quadruplex-based hybridization chain reaction (HCR) for small molecules, using adenosine triphosphate (ATP) as the model. Aptamer ...

Measuring the dynamics of cyclic adenosine monophosphate level in living cells induced by low-level laser irradiation using bioluminescence resonance energy transfer.

Transcriptome-wide identification of adenosine-to-inosine editing using the ICE-seq method.

Inosine (I), a modified base found in the double-stranded regions of RNA in metazoans, has various roles in biological processes by modulating gene expression. Inosine is generated from adenosine (A) ...

An Optimized Firefly Luciferase Bioluminescent Assay for the Analysis of Free Fatty Acids.

A firefly luciferase (LUC)-based bioluminescent assay for total free fatty acids (FFA) is presented. It is based on LUC's capability of converting FFA into fatty acyl-adenylates with consumption of ad...

Adenosine Deaminase Deficient Severe Combined Immunodeficiency Presenting as Atypical Haemolytic Uraemic Syndrome.

Adenosine deaminase (ADA) deficiency is a systemic disorder of purine metabolism. Deficiency of the purine salvage enzyme ADA leads to the build-up of the toxic metabolites, deoxyadenosine triphosphat...

Outcomes in Two Japanese Adenosine Deaminase-Deficiency Patients Treated by Stem Cell Gene Therapy with No Cytoreductive Conditioning.

We here describe treatment outcomes in two adenosine deaminase (ADA)-deficiency patients (pt) who received stem cell gene therapy (SCGT) with no cytoreductive conditioning. As this protocol has featur...

Nitrogen and phosphorus co-doped graphene quantum dots: synthesis from adenosine triphosphate, optical properties, and cellular imaging.

Graphene quantum dots (GQDs) are emerging zero-dimensional materials promising a wide spectrum of applications, particularly, as superior fluorescent reporters for bio-imaging and optical sensing. Het...

Lighting up G protein-coupled purinergic receptors with engineered fluorescent ligands.

The use of G protein-coupled receptors fluorescent ligands is undergoing continuous expansion. In line with this, fluorescent agonists and antagonists of high affinity for G protein-coupled adenosine ...

Perfluorooctyl Iodide Stimulates Steroidogenesis in H295R cells via a Cyclic Adenosine Monophosphate Signaling Pathway.

Perfluorinated iodine alkanes (PFIs) are used widely in the organic fluorine industry. Increased production of PFIs has caused environmental health concerns. To evaluate the potential endocrine-disrup...

Impairment of adenylyl cyclase-mediated glutamatergic synaptic plasticity in the periaqueductal gray in a rat model of neuropathic pain.

Neuropathic pain has been attributed to nerve injury-induced elevation of peripheral neuronal discharges and spinal excitatory synaptic plasticity while little is known about the contribution of neuro...

News Articles [74 Associated News Articles listed on BioPortfolio]

Cipher is Canadian partner for Can-Fite's CF101

Cipher Pharmaceuticals Inc. licensed Canadian marketing rights to Can-Fite Biopharma Ltd.'s lead A3 adenosine receptor agonist CF101, in Phase II/III for moderate-to-severe plaque psoriasis and in Pha...

Adenosine receptor can activate 'off signals' for pain

Pain is the most common reason that people seek medical attention, but the available treatments are not always successful at relieving pain in patients with chronic pain. Now researchers found that dr...

Researchers show that A3 adenosine receptor can activate 'off signals' for pain

In a study published in the April issue of the Journal of Neuroscience, Saint Louis University scientists led by professor of pharmacological and physiological sciences Daniela Salvemini, Ph.D., disco...

Ticagrelor (Brilique) for preventing thombotic events in patients with acute ischaemic stroke or high risk transient ischaemic attack

Ticagrelor is an oral, reversibly bound antagonist of the P2Y₁₂ adenosine diphosphate receptor, which inhibits platelet aggregation. Ticagrelor belongs to a class of drugs called cyclopentyltriazo...

SLU researchers show that A3 adenosine receptor can activate 'off signals' for pain

(Saint Louis University) Pain is the most common reason that people seek medical attention, but the available treatments are not always successful at relieving pain in patients with chronic pain. Sain...

Epithelial-specific A2B adenosine receptor signaling protects the colonic epithelial barrier during acute colitis

Domain Therapeutics Launches Specific Purpose Vehicle Kaldi Pharma to Harness the Potential of its Adenosine Programs

Kaldi Pharma granted its first license to CleveXel Pharma, who will develop a preclinical candidate for Parkinson’s disease Domain Therapeutics, a biopharmaceutical company specializing in the r...

Adenoviral-mediated imaging of gene transfer using a somatostatin receptor-cytosine deaminase fusion protein

Sigma-Tau Pharmaceuticals, Inc. Receives Orphan Drug Designation for EZN-2279 for Treatment of Adenosine deaminase--Deficient Severe Combined Immunodeficiency Disease

GAITHERSBURG, Md., March 30, 2015 (GLOBE NEWSWIRE) -- Sigma-Tau Pharmaceuticals Inc. announced today that the U.S. Food and Drug Administration (FDA) has granted an orphan drug designation for the Co...

Can-Fite inks distribution deal with Cipher for CF101 in Canada

Israel-based Can-Fite BioPharma has signed a distribution agreement with Canada-based Cipher Pharmaceuticals for the distribution of CF101, an A3 adenosine receptor agonist, designed to treat moderate...

Events [0 Results]

None

Companies [1 Associated Companies listed on BioPortfolio]

ArQule, Inc.

ArQule is a biotechnology company engaged in the research and development of next-generation, small-molecule cancer therapeutics. The Company’s targeted, broad-spectrum produ...

Clinical Trials [93 Associated Clinical Trials listed on BioPortfolio]

Study to Examine the Effects of ATP Supplementation on Muscle Excitability and Reaction Time During and Following a Repeated Sprint Bout

We hypothesize that adenosine-5'-triphosphate (ATP) supplementation will be able to enhance motor unit recruitment while simultaneously blunting the decline in power and reaction time that...

Treatment of SCID Due to ADA Deficiency With Autologous Transplantation of Cord Blood or Hematopoietic CD 34+ Cells After Addition of a Normal Human ADA cDNA by the EFS-ADA Lentiviral Vector

This is a clinical gene transfer study that aims to verify the safety and efficacy of the use of the EFS-ADA lentiviral vector to introduce the human adenosine deaminase (ADA) gene into th...

Evaluation of [123I]MNI-420 and SPECT as a Marker of the Adenosine A2a Receptor in PD, HD and Healthy Subjects.

The underlying goal of this study is to assess [123I]MNI-420 SPECT imaging as a tool to detect A2aR density in the brain of PD and HD research participants to be compared with similarly ag...

Trial of PBF-509 in Patients With Advanced NSCLC

The purpose of this study is to determine the safety, tolerability and feasibility of an adenosine A2a receptor antagonist (PBF-509) during a phase I dose escalation trial in advanced or m...

A Study to Compare the Safety of Rivaroxaban Versus Acetylsalicylic Acid in Addition to Either Clopidogrel or Ticagrelor Therapy in Participants With Acute Coronary Syndrome

The purpose of this study is to estimate the risk of bleeding with rivaroxaban, compared with acetylsalicylic acid (ASA), in addition to a single antiplatelet/ platelet adenosine diphospha...

Ticagrelor vs Clopidogrel Effect on MFR in CAD Population

Ticagrelor is one of 3 anti-platelet medications used in patients with acute coronary syndrome (ACS) to prevent further clot formation and further ischemic damage to myocardial tissue. Ove...

RTA 408 Capsules in Patients With Mitochondrial Myopathy - MOTOR

Mitochondrial myopathies are a multisystemic group of disorders that are characterized by a wide range of biochemical and genetic mitochondrial defects and variable modes of inheritance. ...

Evaluation of Biomarkers Associated With Response to Subsequent Therapies in Subjects With HER2-Positive Metastatic Breast Cancer

This is a multicenter, open-label, Phase II study in subjects with Human epidermal growth factor receptor (HER2)-positive metastatic breast cancer who received at least 2 prior lines of an...

AMP as a Better Delivery System of Adenosine

Adenosine and AMP are substances normally present in the body. Adenosine is also given for the treatment of some heart rhythm problems and may be used to reduce heart damage during heart ...

PV Reconnection After PVAI at Different Power Settings and Adenosine Provocation

In this prospective randomized study, we aim to compare the rate of PV reconnection following PVAI performed at different energy settings (30 Watts vs 40 Watts) where dormant PV conduction...

Medical and Biotech [MESH] Definitions

Drugs that inhibit ADENOSINE DEAMINASE activity.

An enzyme that catalyzes the hydrolysis of adenosine to inosine with the elimination of ammonia. Since there are wide tissue and species variations in the enzyme, it has been used as a tool in the study of human and animal genetics and in medical diagnosis. EC 3.5.4.4.

A nucleoside that is composed of adenine and d-ribose. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.

A ribonucleoside antibiotic synergist and adenosine deaminase inhibitor isolated from Nocardia interforma and Streptomyces kaniharaensis. It is proposed as an antineoplastic synergist and immunosuppressant.

A potent inhibitor of ADENOSINE DEAMINASE. The drug induces APOPTOSIS of LYMPHOCYTES, and is used in the treatment of many lymphoproliferative malignancies, particularly HAIRY CELL LEUKEMIA. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.

Search BioPortfolio:
Loading
Advertisement
Advertisement
review and buy Adenosine Deaminase market research data and corporate reports here

Channels Quicklinks