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Adenosine Deaminase - Biotech, Pharma and Life Science Channel

17:16 EST 10th December 2016 | BioPortfolio

PubMed Articles [431 Associated PubMed Articles listed on BioPortfolio]

Characterizing PKA-Mediated Phosphorylation of Plexin Using Purified Proteins.

Protein phosphorylation is one of the widely used posttranslational modifications that alter protein function in vivo. We recently showed phosphorylation of Drosophila Plexin A by cyclic adenosine mon...

Transcriptome and Metabolome Analyses in Exogenous FABP4- and FABP5-Treated Adipose-Derived Stem Cells.

Adipose-derived stem cells (ADSC), which exist near adipocytes in adipose tissue, have been used as a potential tool of regenerative medicine. Lipid chaperones, fatty acid-binding protein 4 (FABP4) an...

Crystal Structure of Schistosoma mansoni Adenosine Phosphorylase/5'-Methylthioadenosine Phosphorylase and Its Importance on Adenosine Salvage Pathway.

Schistosoma mansoni do not have de novo purine pathways and rely on purine salvage for their purine supply. It has been demonstrated that, unlike humans, the S. mansoni is able to produce adenine dire...

Interactions of Calcium Fluctuations during Cardiomyocyte Contraction with Real-Time cAMP Dynamics Detected by FRET.

Calcium (Ca2+) and 3',5'-cyclic adenosine monophosphate (cAMP) play a critical role for cardiac excitation-contraction-coupling. Both second messengers are known to interact with each other, for examp...

Purification and characterization of a platelet aggregation inhibitor and anticoagulant Cc 5_NTase, CD 73-like, from Cerastes cerastes venom.

The present study is the first attempt to report the characterization of a nucleotidase from Cerastes cerastes venom. A 70 kDa 5'-nucleotidase (Cc-5'NTase) was purified to homogeneity. The amino acid...

A human carboxypeptidase E/NF-α1 gene mutation in an Alzheimer's disease patient leads to dementia and depression in mice.

Patients with Alzheimer's disease (AD), a common dementia among the aging population, often also suffer from depression. This comorbidity is poorly understood. Although most forms of AD are not geneti...

Direct screening for chromatin status on DNA barcodes in yeast delineates the regulome of H3K79 methylation by Dot1.

Given the frequent misregulation of chromatin in cancer, it is important to understand the cellular mechanisms that regulate chromatin structure. However, systematic screening for epigenetic regulator...

Effects of five candidate laxatives derived from Liriope platyphylla on the 5-HT receptor signaling pathway in three cell types present in the transverse colon.

The laxative effects of aqueous extract of Liriope platyphylla (AEtLP) on loperamide (Lop)‑induced constipation have been reported; however, the key compounds and the mechanism underlying these effe...

A covalent antagonist for the human adenosine A2A receptor.

The structure of the human A2A adenosine receptor has been elucidated by X-ray crystallography with a high affinity non-xanthine antagonist, ZM241385, bound to it. This template molecule served as a s...

Modification of orthogonal tRNAs: unexpected consequences for sense codon reassignment.

Breaking the degeneracy of the genetic code via sense codon reassignment has emerged as a way to incorporate multiple copies of multiple non-canonical amino acids into a protein of interest. Here, we ...

News Articles [72 Associated News Articles listed on BioPortfolio]

RNA Modification Helps Drosophila Straighten Up and Fly Right

Absent a certain RNA modification, the flies folded their wings askew, lost their sense of direction, and wafted about more listlessly than is ordinary. The RNA modification that the flies lacked is c...

Competitor Analysis: Tumor Microenvironment Modulation via IDO, TGF?/R, CXCR4, CSF1R, CD47SIRP?, Adenosine, STING Others Prices from USD $770

Competitor Analysis: Tumor Microenvironment Modulation via IDO, TGF?/R, CXCR4, CSF1R, CD47SIRP?, Adenosine, STING amp; OthersThis Competitive Intelligence report aboutnbsp;Tumor Microenvironment Mo...

Competitor Analysis: Inhibitory and Stimulatory Immunomodulators in ImmunoOncology Prices from USD $1386

Competitor Analysis: Inhibitory and Stimulatory Immunomodulators in ImmunoOncology This product consists of four reports in pdf format describing the competitive field of new molecular entities dir...

ADARB1 catalyzes circadian A-to-I editing and regulates RNA rhythm

Yoshitaka Fukada, Hikari Yoshitane and colleagues report that rhythmic expression of ADARB1, an RNA-editing enzyme that catalyzes adenosine-to-inosine conversion, controls mRNA oscillations in the mou...

Orchard Therapeutics Announces Strategic Alliance with Oxford BioMedica

London UK & Oxford, UK  November 29, 2016 / B3C newswire / -- Orchard Therapeutics (“Orchard”), a biotechnology company dedicated to bringing transformative ex-vivo gene therapies to pat...

Neogen AccuPoint Advanced ATP Sanitation Verification System

Neogen has received approval from the AOAC Research Institute for its rapid AccuPoint Advanced ATP Sanitation Verification System. The approval follows a recent study by NSF International that showed...

CIRM grants Orchard, UCLA $20M for ADA-SCID trial

Gene therapy company Orchard Therapeutics Ltd. (London, U.K.) said the California Institute for Regenerative Medicine (CIRM) awarded the company and University of California Los Angeles researchers $2...

Orchard Therapeutics and UCLA receive $20 mn in latest round of funding

Biospectrum The grant will fund a new clinical trial for Severe Combined Immunodeficiency caused by adenosine deaminase...

Orchard Therapeutics and UCLA Receive USD20 Million in Latest Round of Funding from California’s Stem Cell Agency

London, UK, November 23, 2016 / B3C newswire / -- Orchard Therapeutics Limited, a clinical-stage biotechnology company, dedicated to bringing transformative gene therapies to patients with serio...

Orchard Therapeutics and UCLA Receive $20 Million in Latest Round of Funding from California’s Stem Cell Agency

London, UK, November 23, 2016 / B3C newswire / -- Orchard Therapeutics Limited, a clinical-stage biotechnology company, dedicated to bringing transformative gene therapies to patients with serio...

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Companies [2 Associated Companies listed on BioPortfolio]

Inotek Pharmaceuticals Corp.

Inotek Pharmaceuticals is a clinical-stage biopharmaceutical company focused on the discovery, development and commercialization of therapies for glaucoma and other eye diseases. ...

ArQule, Inc.

ArQule is a biotechnology company engaged in the research and development of next-generation, small-molecule cancer therapeutics. The Company’s targeted, broad-spectrum produ...

Clinical Trials [127 Associated Clinical Trials listed on BioPortfolio]

Immunoregulatory Mechanisms of Treg Cells Induced by Tocilizumab

We can speculate that the best responders to tocilizumab should have multiple related elements (Treg CD39, adenosine, IL-35) successfully induced and expressed in order to play its benefic...

Interactions of Environmental and Human Microbial Communities in a Pediatric Oncology Hospital

Microorganisms that colonize hospital environments play an important role in the transmission of hospital acquired infections (HAI) and multi-drug resistant organisms. Previous studies exa...

Glasgow MRI and Rotablation Study

Percutaneous coronary intervention (PCI) with adjunctive high speed rotational atherectomy (HSRA) is commonly used to treat complex and calcified coronary artery stenoses. Theoretically, H...

Blood Biomarkers in Suicidal Behaviour

Suicidal behavior (SB) is a major public health problem in France, with more than 10,000 suicides and 220,000 suicide attempts per year. According to the commonly accepted model for under...

Long-term Remote Ischemic Preconditioning Improve Long-term Prognosis of Acute Myocardial Infarction Patients Without Emergency Reperfusion Therapy

Patients with acute myocardial infarction (AMI) are in critical condition especially without emergency reperfusion therapy. For example, heart failure, heart rupture, malignant arrhythmia ...

Peripheral Vasodilation in Obese Humans

The growing population of obese adults is predicted to create a large public health burden in the next few decades. This study examines function of small blood vessels providing blood flow...

Ghrelin Resistance in Adolescents With Idiopathic Scoliosis

Adolescent idiopathic Scoliosis (AIS) is the most common spine pathology. It is opposed to secondary scoliosis due to chronic diseases. Many hypotheses have been made to elucidate the orig...

Contact Force Guided Ablation Versus Conventional Pulmonary Vein Isolation for Paroxysmal Atrial Fibrillation

The investigators prospectively investigate the differences between contact-force guided pulmonary vein isolation (PVI) and conventional pulmonary vein isolation in patients with paroxysma...

Effects of Ticagrelor on No-reflow in Patients With Acute ST-segment Elevation Myocardial Infarction

The 'no-reflow' phenomenon after a percutaneous coronary intervention (PCI) in patients with acute ST-segment elevation myocardial infarction (STEMI) is a strong predictor of both short- a...

A Time-to-effect Based Dosing Strategy in Cryoballoon Ablation of Patients With Paroxysmal Atrial Fibrillation

This study aims to validate a new dosage of cryotherapy based on time to effect in pulmonary vein ablation procedures in patients with paroxysmal atrial fibrillation.

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Medical and Biotech [MESH] Definitions

Drugs that inhibit ADENOSINE DEAMINASE activity.

An enzyme that catalyzes the hydrolysis of adenosine to inosine with the elimination of ammonia. Since there are wide tissue and species variations in the enzyme, it has been used as a tool in the study of human and animal genetics and in medical diagnosis. EC 3.5.4.4.

A nucleoside that is composed of adenine and d-ribose. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.

A ribonucleoside antibiotic synergist and adenosine deaminase inhibitor isolated from Nocardia interforma and Streptomyces kaniharaensis. It is proposed as an antineoplastic synergist and immunosuppressant.

A potent inhibitor of ADENOSINE DEAMINASE. The drug induces APOPTOSIS of LYMPHOCYTES, and is used in the treatment of many lymphoproliferative malignancies, particularly HAIRY CELL LEUKEMIA. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.

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