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Adenosine Deaminase - Biotech, Pharma and Life Science Channel

15:45 EDT 29th July 2016 | BioPortfolio

PubMed Articles [430 Associated PubMed Articles listed on BioPortfolio]

Mitochondrial transplantation for therapeutic use.

Mitochondria play a key role in the homeostasis of the vast majority of the body's cells. In the myocardium where mitochondria constitute 30 % of the total myocardial cell volume, temporary attenuati...

10. Low-Intensity Pulsed Ultrasound (LIPUS) Stimulation Helps to Maintain the Differentiation Potency of Mesenchymal Stem Cells by Induction in Nanog Protein Transcript Levels and Phosphorylation.

Mesenchymal Stem Cells (MSCs) are pluripotent cells that can be differentiated as osteoblasts, adipocytes, myocytes or chondrocytes depending on the culture condition. However, MSCs are known to lose ...

Von Willebrand Factor Multimers during Transcatheter Aortic-Valve Replacement.

Background Postprocedural aortic regurgitation occurs in 10 to 20% of patients undergoing transcatheter aortic-valve replacement (TAVR) for aortic stenosis. We hypothesized that assessment of defects ...

The Landscape of A-to-I RNA Editome Is Shaped by Both Positive and Purifying Selection.

The hydrolytic deamination of adenosine to inosine (A-to-I editing) in precursor mRNA induces variable gene products at the post-transcription level. How and to what extent A-to-I RNA editing diversif...

A Molecular Model for Lithium's Bioactive Form.

Lithium carbonate, a drug for the treatment of bipolar disorder, provides mood stability to mitigate recurrent episodes of mania and/or depression. Despite its long-term and widespread use, the mechan...

Structure-based screening of unchartered chemical space for atypical adenosine receptor agonists.

Small molecule screening libraries cover only a small fraction of astronomical number of possible drug-like compounds, limiting the success of ligand discovery efforts. Computational screening of virt...

Comparing Inverse Probability of Treatment Weighting and Instrumental Variable Methods for the Evaluation of Adenosine Diphosphate Receptor Inhibitors After Percutaneous Coronary Intervention.

There is increasing interest in performing comparative effectiveness analyses in large observational databases, yet these analyses must adjust for treatment selection issues.

Treatments for the prevention of Sudden Unexpected Death in Epilepsy (SUDEP).

Sudden Unexpected Death in Epilepsy (SUDEP) is defined as sudden, unexpected, witnessed or unwitnessed, non-traumatic or non-drowning death of people with epilepsy, with or without evidence of a seizu...

Spare Adenosine A2a Receptors Are Associated With Positive Exercise Stress Test In Coronary Artery Disease.

During exercise, cardiac oxygen-consumption increases and the resulting low oxygen level in myocardium triggers coronary vasodilation. This response to hypoxia is controlled notably by the vasodilator...

LBBB Tachycardia: What is the Mechanism?

A 55-year-old gentleman presented with recurrent episodes of palpitation and documented wide QRS tachycardia not reverted with intravenous adenosine and required electrical cardioversion. There was mi...

News Articles [78 Associated News Articles listed on BioPortfolio]

Introducing the LightStim LED Bed

IRVINE, Calif., July 28, 2016 /PRNewswire/ -- New Release  The state-of-the-art LightStim LED Bed is composed of 18,240 LEDs designed to rejuvenate, repair and energize every cell in the b...

Structure of the adenosine A2A receptor bound to an engineered G protein

G-protein-coupled receptors (GPCRs) are essential components of the signalling network throughout the body. To understand the molecular mechanism of G-protein-mediated signalling, solved structures of...

FutureCeuticals' Sports Nutrition Ingredient elevATP® Shown to Increase Strength, Power, and Performance in Functional Study

MOMENCE, Ill., July 27, 2016 /PRNewswire/ -- FutureCeuticals today announced the publication of a new study supporting the functional efficacy of their Sports Nutrition and Healthy Energy in...

HLAC to Expand Accreditation Standards with ATP Testing, Textile Bioburdens

The board of directors of the Healthcare Laundry Accreditation Council (HLAC) has approved funding for application development and field testing of two process monitoring tools -- adenosine triphospha...

Can-Fite Completes Phase II Study Design for CF102 in the Treatment of NASH/NAFLD

PETACH TIKVA, Israel, July 25, 2016 /PRNewswire/ -- Can-Fite BioPharma Ltd. (NYSE MKT: CANF) (TASE: CFBI), a biotechnology company with a pipeline of proprietary small molecule drugs being develo...

Juno buys RedoxTherapies for $10mm plus earn-outs

Juno Therapeutics Inc. paid $10mm up front to acquire private biotech RedoxTherapies Inc., developer of adenosine receptor antagonists. Juno could also hand over earn-outs based on clinical, regulator...

Adenosine A2A Receptors in the Amygdala Control Synaptic Plasticity and Contextual Fear Memory

Juno pays $10M-plus to acquire RedoxTherapies

RedoxTherapies was purchased by Juno Therapeutics in a deal that gives Juno access to vipadenant, a small molecule adenosine  -More- 

Juno Buys RedoxTherapies for $10M+

Juno Therapeutics has acquired RedoxTherapies for $10 million upfront-plus, giving the cancer immunotherapy developer a small molecule adenosine A2a receptor antagonist that it plans to study in com...

Juno Acquires RedoxTherapies for $10M+

Juno Therapeutics has acquired RedoxTherapies for $10 million upfront-plus, giving the cancer immunotherapy developer a small molecule adenosine A2a receptor antagonist that it plans to study in com...

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Companies [2 Associated Companies listed on BioPortfolio]

Inotek Pharmaceuticals Corp.

Inotek Pharmaceuticals is a clinical-stage biopharmaceutical company focused on the discovery, development and commercialization of therapies for glaucoma and other eye diseases. ...

ArQule, Inc.

ArQule is a biotechnology company engaged in the research and development of next-generation, small-molecule cancer therapeutics. The Company’s targeted, broad-spectrum produ...

Clinical Trials [123 Associated Clinical Trials listed on BioPortfolio]

Long-term Remote Ischemic Preconditioning Improve Long-term Prognosis of Acute Myocardial Infarction Patients Without Emergency Reperfusion Therapy

Patients with acute myocardial infarction (AMI) are in critical condition especially without emergency reperfusion therapy. For example, heart failure, heart rupture, malignant arrhythmia ...

Peripheral Vasodilation in Obese Humans

The growing population of obese adults is predicted to create a large public health burden in the next few decades. This study examines function of small blood vessels providing blood flow...

Ghrelin Resistance in Adolescents With Idiopathic Scoliosis

Adolescent idiopathic Scoliosis (AIS) is the most common spine pathology. It is opposed to secondary scoliosis due to chronic diseases. Many hypotheses have been made to elucidate the orig...

Contact Force Guided Ablation Versus Conventional Pulmonary Vein Isolation for Paroxysmal Atrial Fibrillation

The investigators prospectively investigate the differences between contact-force guided pulmonary vein isolation (PVI) and conventional pulmonary vein isolation in patients with paroxysma...

Effects of Ticagrelor on No-reflow in Patients With Acute ST-segment Elevation Myocardial Infarction

The 'no-reflow' phenomenon after a percutaneous coronary intervention (PCI) in patients with acute ST-segment elevation myocardial infarction (STEMI) is a strong predictor of both short- a...

A Time-to-effect Based Dosing Strategy in Cryoballoon Ablation of Patients With Paroxysmal Atrial Fibrillation

This study aims to validate a new dosage of cryotherapy based on time to effect in pulmonary vein ablation procedures in patients with paroxysmal atrial fibrillation.

High On-treatment Platelet Reactivity Identified by Multiple Platelet Function Assay

High on-treatment platelet reactivity to adenosine diphosphate was a important reason to cause ischemic events in antiplatelet therapy. Using single testing to definite HPR may miss the "t...

Adenosine as an Adjunct to Blood Cardioplegia

Myocardial protection is a major issue in cardiac surgery, since inadequate protection increases the risk of postoperative cardiac dysfunction. The main principle of myocardial protection ...

A Study of Cediranib and Olaparib at Disease Worsening in Ovarian Cancer

This is a proof of concept study (a study to initially assess the benefit a new drug indication) of the combination of two investigational drugs cediranib and olaparib in patients with ova...

Oral THU-Decitabine + Nivolumab for Advanced Non-Small Cell Lung Cancer

This study looks at the effect of three drugs on lung cancer tumors. This study includes two groups of patients randomized to either Nivolumab, which is the standard of care for this lung ...

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Medical and Biotech [MESH] Definitions

Drugs that inhibit ADENOSINE DEAMINASE activity.

An enzyme that catalyzes the hydrolysis of adenosine to inosine with the elimination of ammonia. Since there are wide tissue and species variations in the enzyme, it has been used as a tool in the study of human and animal genetics and in medical diagnosis. EC 3.5.4.4.

A nucleoside that is composed of adenine and d-ribose. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.

A ribonucleoside antibiotic synergist and adenosine deaminase inhibitor isolated from Nocardia interforma and Streptomyces kaniharaensis. It is proposed as an antineoplastic synergist and immunosuppressant.

A potent inhibitor of ADENOSINE DEAMINASE. The drug induces APOPTOSIS of LYMPHOCYTES, and is used in the treatment of many lymphoproliferative malignancies, particularly HAIRY CELL LEUKEMIA. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.

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