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Adenosine Deaminase - Biotech, Pharma and Life Science Channel

17:39 EDT 31st July 2014 | BioPortfolio

PubMed Articles [545 Associated PubMed Articles listed on BioPortfolio]

The Use of Rapid Indicators for the Detection of Organic Residues on Clinically Used Gastrointestinal Endoscopes with and without Visually Apparent Debris.

Background. Outbreaks of multidrug-resistant organisms have been linked to endoscope reprocessing lapses. Meticulous manual cleaning before high-level disinfection (HLD) is essential in reducing res...

The impact of aging on adipose structure, function, and vasculature in the B6D2F1 mouse: Evidence of significant multisystem dysfunction.

The critical influence of the white adipose tissue (WAT) on metabolism is well-appreciated in obesity, but adipose tissue dysfunction as a mechanism underlying age-associated metabolic dysfunction req...

Adenosine modulates light responses of rat retinal ganglion cell photoreceptors through cyclic AMP-mediated pathway.

Adenosine is an established neuromodulator in the mammalian retina, with A1 adenosine receptors being especially prevalent in the innermost ganglion cell layer. Activation of A1 receptors causes inhib...

Activated STING in a Vascular and Pulmonary Syndrome.

Background The study of autoinflammatory diseases has uncovered mechanisms underlying cytokine dysregulation and inflammation. Methods We analyzed the DNA of an index patient with early-onset systemic...

Human APOBEC3F Incorporation into Human Immunodeficiency Virus Type 1 Particles.

APOBEC3 proteins are a family of cytidine deaminases that exhibit broad antiretroviral activity. Among APOBEC3 proteins, APOBEC3G (hA3G) and APOBEC3F (hA3F) exhibit the most potent anti-HIV-1 activiti...

Comparison of the endothelial toxicity induced by short-term amiodarone and diazepam exposure in a human umbilical vein endothelial cell line (EVC304).

Abstract Context: Venous irritation is the most common side effect of intravenous therapy. Although many in vitro models have been developed to evaluate intravenous drug irritation, these models are n...

Real time expression of ACC oxidase and PR-protein genes mediated by Methylobacterium spp. in tomato plants challenged with Xanthomonas campestris pv. vesicatoria.

Biotic stress like pathogenic infection increases ethylene biosynthesis in plants and ethylene inhibitors are known to alleviate the severity of plant disease incidence. This study aimed to reduce the...

Alterations of platelet functions in children and adolescents with iron-deficiency anemia and response to therapy.

Abstract Several changes in platelets have been reported in patients with iron-deficiency anemia (IDA), so a relationship between iron metabolism and thrombopoiesis should be considered. We aimed to s...

Processive DNA Demethylation via DNA Deaminase-Induced Lesion Resolution.

Base modifications of cytosine are an important aspect of chromatin biology, as they can directly regulate gene expression, while DNA repair ensures that those modifications retain genome integrity. H...

UTP is not a biased agonist at human P2Y11 receptors.

Biased agonism describes a multistate model of G protein-coupled receptor activation in which each ligand induces a unique structural conformation of the receptor, such that the receptor couples diffe...

News Articles [68 Associated News Articles listed on BioPortfolio]

Biotie updates outlook on tozadenant and SYN120

BIOTIE THERAPIES CORP.              STOCK EXCHANGE RELEASE     30 July 2014      at 8.50 a.m. Biotie updates outlook on tozadenant and SYN120 Tozadenant to advanc...

ArQule to Report Second Quarter 2014 Financial Results on August 5, 2014

ArQule, Inc. (NASDAQ: ARQL) today announced that it will report its financial results for the second quarter of 2014 on Tuesday, August 5, 2014 at 7:00 a.m. Eastern Time. The Comp...

The role of adenosine receptors A2A and A2B signaling in renal fibrosis

Can-Fite CEO to Deliver Scientific Presentation and Serve on Expert Panel at Purines 2014 in Bonn, Germany on July 23-27, 2014

PETACH TIKVA, Israel, July 21, 2014 /PRNewswire/ -- Can-Fite BioPharma Ltd. (NYSE MKT: CANF) (TASE: CFBI), a biotechnology company with a pipeline of proprietary small molecule drugs that address...

Association of Adenosine Receptor Gene Polymorphisms and In Vivo Adenosine A1 Receptor Binding in The Human Brain

A Toxic-Free Alternative: Rigorous Assay of Chloride and Sulfate in Adenosine

Thermo Fisher Scientific has developed a fast and robust ion chromatography (IC)-based method for the determination of chloride and sulfate in adenosine. Application Note 1075: Ion Chro...

Study: Stress can disrupt process of fat tissue development

Using experimental models, researchers at Boston University School of Medicine (BUSM) showed that adenosine, a metabolite released when the body is under stress or during an inflammatory response, sto...

Obesity may be impacted by stress, study shows

A new study shows that stress may play a role in the development of obesity. Using experimental models, researchers showed that adenosine, a metabolite released when the body is under stress or during...

Obesity may be impacted by stress, study says

Using experimental models, researchers at Boston University School of Medicine (BUSM) showed that adenosine, a metabolite released when the body is under stress or during an inflammatory response, sto...

BUSM study: Obesity may be impacted by stress

(Boston University Medical Center) A new study shows that stress may play a role in the development of obesity. Using experimental models, researchers at Boston University School of Medicine showed th...

Events [0 Results]

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Companies [1 Associated Companies listed on BioPortfolio]

ArQule, Inc.

ArQule is a biotechnology company engaged in the research and development of next-generation, small-molecule cancer therapeutics. The Company’s targeted, broad-spectrum produ...

Clinical Trials [83 Associated Clinical Trials listed on BioPortfolio]

Effects of Allergen Inhalation on Adenosine Receptor Expression in Sputum and Peripheral Blood

The purpose of this study is to determine whether asthmatics have different adenosine receptor expression profiles than healthy controls. We hypothesize that asthmatics will have increased...

AMP as a Better Delivery System of Adenosine

Adenosine and AMP are substances normally present in the body. Adenosine is also given for the treatment of some heart rhythm problems and may be used to reduce heart damage during heart...

The Effect of Caffeine on Ischemic Preconditioning

Ischaemic preconditioning (IP) describes the phenomenon that brief periods of ischaemia render the (myocardial) muscle more resistant to a subsequent more prolonged period of ischaemia and...

Adenosine Receptors Influence Ischemia-Reperfusion Injury

Ischemic preconditioning is defined as the development of tolerance to ischemia-reperfusion injury by a previous short bout of ischemia resulting in a marked reduction in infarct size. Thi...

Ischemic Injury and Ischemic Preconditioning in Diabetes

In this proof-of-concept study, forearm vulnerability to ischemic exercise is studied in patients with type 1 diabetes mellitus with and without prior ischemic preconditioning (short perio...

Does Caffeine Affect the Sensitivity of Adenosine Perfusion Scans?

We are studying the affect of caffeine on the sensitivity of detecting coronary artery disease (blockages in the blood flow to the heart) with adenosine tracer scans. Adenosine is a drug u...

Enhancement of Postocclusive Reactive Hyperaemia by Dipyridamole

The purpose of this study is to determine whether dipyridamole enhances postocclusive reactive hyperaemia by increasing extracellular adenosine concentrations during ischemia and reperfusi...

Comparison the Level of CTGF Protein and Related Cytokine in Pleural Effusion

Connective tissue growth factor (CTGF) is known to be a fibrogenic cytokine, it could be expressed in various fibrosis diseases. But, recent research showed that CTGF also be considered to...

Lantus Effect on Myocardial Glucose Metabolism in T2

The primary objective of the present study is to assess changes of myocardial glucose uptake (MGU) during clamp studies using positron emission tomography (PET) scanning in patients with t...

PROTECT-2: A Study of the Selective A1 Adenosine Receptor Antagonist KW-3902 for Patients Hospitalized With Acute HF and Volume Overload to Assess Treatment Effect on Congestion and Renal Function

The study is being conducted to examine whether KW-3902IV will result in greater improvement in signs and symptoms of heart failure, with less treatment failure than standard therapy, when...

Medical and Biotech [MESH] Definitions

Drugs that inhibit ADENOSINE DEAMINASE activity.

An enzyme that catalyzes the hydrolysis of adenosine to inosine with the elimination of ammonia. Since there are wide tissue and species variations in the enzyme, it has been used as a tool in the study of human and animal genetics and in medical diagnosis. EC 3.5.4.4.

A nucleoside that is composed of adenine and d-ribose. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.

A ribonucleoside antibiotic synergist and adenosine deaminase inhibitor isolated from Nocardia interforma and Streptomyces kaniharaensis. It is proposed as an antineoplastic synergist and immunosuppressant.

A potent inhibitor of ADENOSINE DEAMINASE. The drug induces APOPTOSIS of LYMPHOCYTES, and is used in the treatment of many lymphoproliferative malignancies, particularly HAIRY CELL LEUKEMIA. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.

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