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Adenosine Deaminase - Biotech, Pharma and Life Science Channel

01:55 EDT 28th May 2016 | BioPortfolio

PubMed Articles [424 Associated PubMed Articles listed on BioPortfolio]

Mitochondrial transplantation for therapeutic use.

Mitochondria play a key role in the homeostasis of the vast majority of the body's cells. In the myocardium where mitochondria constitute 30 % of the total myocardial cell volume, temporary attenuati...

Validation of a sensitive LC/MSMS method for chloronucleoside analysis in biological matrixes and its applications.

Myeloperoxidase promotes several kinds of damage and is involved in the development of various diseases (as atherosclerosis and cancers). An example of these damage is the chlorination of nucleic acid...

Adenosine diphosphate restricts the protein remodeling activity of Hsp104 chaperone to Hsp70 assisted disaggregation.

Hsp104 disaggregase provides thermotolerance in yeast by recovering proteins from aggregates in cooperation with the Hsp70 chaperone. Protein disaggregation involves polypeptide extraction from aggreg...

Calculations of the Energetics of Oxidation of Aqueous Nucleosides and the Effects of Prototropic Equilibria.

Recently the calculated standard reduction potentials of the radical-cations of N-methyl substituted DNA bases have been reported that agree fairly well with the experimental results. However there ar...

Synthesis of Firefly Luciferin Analogues and Evaluation of the Luminescent Properties.

Five new firefly luciferin (1) analogues were synthesized and their light emission properties were examined. Modifications of the thiazoline moiety in 1 were employed to produce analogues containing a...

The Antiallodynic Effects of Nefopam Are Mediated by the Adenosine Triphosphate-Sensitive Potassium Channel in a Neuropathic Pain Model.

Nefopam hydrochloride is a centrally acting compound that induces antinociceptive and antihyperalgesic properties in neuropathic pain models. Previous reports have shown that activation of adenosine t...

A 1,3-Capped Calix4 Conjugate Possessing an Amine Moiety as an Anion Receptor: Reversible Anion Sensing Detected by Spectroscopy and Characterization of the Supramolecular Features by Microscopy.

A phenylenediamine-capped conjugate of calix[4]arene (Lamino ) was synthesized by reducing its precursor, Limino , with sodium borohydride in methanol. The Lamino sample binds to anions due to the mor...

High Level Expression and Purification of Recombinant Proteins from Escherichia coli with AK-TAG.

Adenylate kinase (AK) from Escherichia coli was used as both solubility and affinity tag for recombinant protein production. When fused to the N-terminus of a target protein, an AK fusion protein coul...

Vinegar as a functional ingredient to improve postprandial glycaemic control - the human intervention findings and the molecular mechanisms.

Type 2 diabetes prevalence worldwide is increasing and the burden is particularly high in Asian countries. Identification of functional food ingredients to curb the rise of diabetes among various Asia...

Apoptosis in pancreatic β-islet cells in Type 2 diabetes.

Apoptosis plays important roles in the pathophysiology of Type 2 diabetes mellitus (T2DM). The etiology of T2DM is multifactorial, including obesity-associated insulin resistance, defective insulin se...

News Articles [83 Associated News Articles listed on BioPortfolio]

Structural basis of N6-adenosine methylation by the METTL3–METTL14 complex

Chemical modifications of RNA have essential roles in a vast range of cellular processes. N6-methyladenosine (m6A) is an abundant internal modification in messenger RNA and long non-coding RNA that ca...

Hypothalamic AMPK: a canonical regulator of whole-body energy balance

Activation of AMP-activated protein kinase (AMPK) is dependent on adenosine nucleotides levels in the cell, which vary according to the energy status; AMPK is therefore described as an energy sensor. ...

Ribosome-dependent activation of stringent control

In order to survive, bacteria continually sense, and respond to, environmental fluctuations. Stringent control represents a key bacterial stress response to nutrient starvation that leads to rapid and...

Activation of the A2A adenosine G-protein-coupled receptor by conformational selection

The adenosine A2A receptor, a class A G-protein-coupled receptor, exists as an ensemble of two inactive and two active states in equilibrium and is activated by conformational selection rather than in...

Gene therapy play Orchard raises L21M

Orchard Therapeutics (London, U.K.) raised L21 million ($30.7 million) in a series A round to develop ex vivo autologous hematopoietic stem cell gene therapies for primary immune deficiencies, metabol...

Orchard Therapeutics Launches and Announces Academic Partnerships for Development of Transformative Gene Therapies

London, UK, May 3, 2016 / B3C newswire/ – ORCHARD THERAPEUTICS, a clinical-stage biotechnology company with operations in London and the United States, has officially launched today with a £21-mil...

Performing Cyclic AMP HTRF Screening Assays

G-protein coupled receptors (GPCRs) are a major class of targets for drug discovery. Cyclic AMP (cyclic adenosine 3′,5′-monophosphate) is a second messenger and one of the most important...

Evotec and ex scientia join forces to discover bispecific small molecule immuno-oncology therapeutics

Initial focus will be cancer-related adenosine targets which are increasingly recognised to play important roles in immuno-oncology

Base pair editing to correct point mutations using a nuclease-dead CRISPR-associated protein 9 (Cas9) variant conjugated to a cytidine deaminase

A CRISPR-based method of editing base pairs could correct point mutations more efficiently than traditional CRISPR-

Frontier IP investee firm in tie up to find next wave of cancer drugs

Frontier IP Group Plc (LON:FIPP) investee company ex scientia is teaming up with Germany’s Evotec discover the next wave of immuno-oncology drugs that use the body’s immune system to attack the ki...

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Companies [2 Associated Companies listed on BioPortfolio]

Inotek Pharmaceuticals Corp.

Inotek Pharmaceuticals is a clinical-stage biopharmaceutical company focused on the discovery, development and commercialization of therapies for glaucoma and other eye diseases. ...

ArQule, Inc.

ArQule is a biotechnology company engaged in the research and development of next-generation, small-molecule cancer therapeutics. The Company’s targeted, broad-spectrum produ...

Clinical Trials [117 Associated Clinical Trials listed on BioPortfolio]

High On-treatment Platelet Reactivity Identified by Multiple Platelet Function Assay

High on-treatment platelet reactivity to adenosine diphosphate was a important reason to cause ischemic events in antiplatelet therapy. Using single testing to definite HPR may miss the "t...

Adenosine as an Adjunct to Blood Cardioplegia

Myocardial protection is a major issue in cardiac surgery, since inadequate protection increases the risk of postoperative cardiac dysfunction. The main principle of myocardial protection ...

A Study of Cediranib and Olaparib at Disease Worsening in Ovarian Cancer

This is a proof of concept study (a study to initially assess the benefit a new drug indication) of the combination of two investigational drugs cediranib and olaparib in patients with ova...

Oral THU-Decitabine + Nivolumab for Advanced Non-Small Cell Lung Cancer

This study looks at the effect of three drugs on lung cancer tumors. This study includes two groups of patients randomized to either Nivolumab, which is the standard of care for this lung ...

Study to Evaluate the Safety and Tolerability of CPI-444 Alone and in Combination With Atezolizumab

This is a phase 1/1b open-label, multicenter, dose-selection study of CPI-444, an oral small molecule targeting the adenosine-A2A receptor on T-lymphocytes and other cells of the immune sy...

A Study to Assess the Efficacy of a 5-day, 10- mg PBF-680 Oral Administration on Late Asthmatic Responses (LAR) in Mild to Moderate Asthmatic Patients.

This study is the second Phase-II trial analyzing efficacy outcomes of PBF-680 in asthmatic subjects, following the supportive data from the proof-of-concept trial on the effect of PBF-680...

Neoadjuvant Run-In Study With TAK-228 (MLN0128) Followed by Letrozole/TAK-228 (MLN0128) in Women With High-Risk ER+/HER2- Breast Cancer

Millennium has developed TAK-228, which is a novel, highly selective, orally bioavailable adenosine 5' triphosphate (ATP)-competitive inhibitor of the serine/threonine kinase referred to a...

Comparing Ticagrelor Versus Clopidogrel on Microcirculation

Recently, data (PLATO) from an AstraZeneca study of platelet inhibition and patient outcomes, a Phase III pivotal efficacy and safety study with a duration of up to 12 months comparing tic...

Ticagrelor in Human Endotoxemia Response to Human Endotoxemia

Rationale: In patients suffering a myocardial infarction the P2Y12 receptor antagonists prasugrel and ticagrelor improve outcome and prognosis compared to clopidogrel. Moreover, ticagrelo...

Adjuvant Chemotherapy Based on the Adenosine Triphosphate Tumor Chemosensitivity Assay for Hepatocellular Carcinoma After Liver Transplantation

This study is a randomized, open-label, controlled study that will explore the efficacy of adjuvant chemotherapy based on the adenosine triphosphate tumor chemosensitivity assay for patien...

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Medical and Biotech [MESH] Definitions

Drugs that inhibit ADENOSINE DEAMINASE activity.

An enzyme that catalyzes the hydrolysis of adenosine to inosine with the elimination of ammonia. Since there are wide tissue and species variations in the enzyme, it has been used as a tool in the study of human and animal genetics and in medical diagnosis. EC 3.5.4.4.

A nucleoside that is composed of adenine and d-ribose. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.

A ribonucleoside antibiotic synergist and adenosine deaminase inhibitor isolated from Nocardia interforma and Streptomyces kaniharaensis. It is proposed as an antineoplastic synergist and immunosuppressant.

A potent inhibitor of ADENOSINE DEAMINASE. The drug induces APOPTOSIS of LYMPHOCYTES, and is used in the treatment of many lymphoproliferative malignancies, particularly HAIRY CELL LEUKEMIA. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.

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