Adenosine Deaminase - Biotech, Pharma and Life Science Channel

13:31 EDT 5th July 2015 | BioPortfolio

PubMed Articles [478 Associated PubMed Articles listed on BioPortfolio]

Polyethyleneimine-grafted boronate affinity materials for selective enrichment of cis-diol-containing compounds.

Polyethyleneimine (PEI)-grafted and 3-acrylamidophenylboronic acid (AAPBA)-functionalized SiO2 boronate affinity materials were synthesized for the selective enrichment of cis-diol-containing compound...

Coenzyme Q10 and Fish Oil Synergistically Alleviate Aluminum Chloride-induced Suppression of Testicular Steroidogenesis and Antioxidant Defense.

Aluminum (Al) is an environmental xenobiotic that stimulates free radical generation and hence reproductive toxicity. Coenzyme Q10 (CoQ10) shows effectiveness in counteracting free radicals-induced ti...

Small polyanion recognition of a triazolium cyclodextrin click cluster in water.

In order to detect small polyanions (sPAs), which play important roles in many biological systems, a triazolium cyclodextrin click cluster (, hexakis{6-(3-methyl-4-hydroxymethyl-1H-1,2,3-triazolium-1-...

Splenic leukocytes mediate the hyperglycemic exacerbation of myocardial infarct size in mice.

Acute hyperglycemia during acute myocardial infarction is associated with worse myocardial injury and increased mortality. Using a mouse model of myocardial ischemia/reperfusion injury, we tested the ...

Effects of Caffeine Supplementation on Plasma and Blood Mononuclear Cell IL-10 Levels After Exercise.

The aim of this study was to compare the response of IL-10, and also of IL-6 and IL-12 p40, to exercise and caffeine supplementation between plasma and blood mononuclear cells (BMNCs). Participants in...

Bedaquiline for the treatment of multidrug-resistant tuberculosis: great promise or disappointment?

Acquired drug resistance by Mycobacterium tuberculosis (MTB) may result in treatment failure and death. Bedaquiline was recently approved for the treatment of multidrug-resistant tuberculosis (MDR-TB)...

Treatment of Myocardial Ischemia/Reperfusion Injury by Ischemic and Pharmacological Postconditioning.

Timely reperfusion is the only way to salvage ischemic myocardium from impending infarction. However, reperfusion also adds a further component to myocardial injury such that the ultimate infarct size...

Tightly regulated 'all in one' lentiviral vectors for protection of human hematopoietic cells from anticancer chemotherapy.

Successful application of gene therapy strategies may require stringently regulated transgene expression. Along this line, we describe a Doxycycline (Dox)-inducible "all-in-one" lentiviral vector desi...

Helper-dependent adenovirus achieve more efficient and persistent liver transgene expression in non-human primates under immunosuppression.

Helper-dependent adenoviral (HDA) vectors constitute excellent gene-therapy tools for metabolic liver diseases. We have previously shown that an HDA vector encoding human porphobilinogen deaminase (PB...

Structural Characterization of Dihydrofolate Reductase Complexes by Top-down Ultraviolet Photodissociation Mass Spectrometry.

The step-wise reduction of dihydrofolate to tetrahydrofolate entails significant conformational changes of dihydrofolate reductase (DHFR). Binary and ternary complexes of DHFR containing co-factor NAD...

News Articles [60 Associated News Articles listed on BioPortfolio]

Enzyme provides built-in protection against atherosclerosis

ANN ARBOR, Mich., July 1, 2015 /PRNewswire-USNewswire/ -- Staying active, never smoking and controlling diabetes and cholesterol can prevent hardening of the arteries, but effective treatment of ather...

The Eye Machine Acquires Acuity Medical and Two U.S. Patents

Purchase May Shorten FDA Approval Timeframe Indian Wells, CA (PRWEB) June 17, 2015 The Eye Machine, LLC (TEM) announced today that it has acquired the assets of Acuity Medical International Inc. Dr....

Adenosine in Ambrosia pollen increases allergic response

Ragweed (Ambrosia artemisiifolia) - an otherwise unremarkable plant - produces pollen that can trigger strong allergic reactions such as asthma even in very small quantities. Scientists from Technisch...

Biotie raises $92.9M in listing, note deal

Biotie Therapies Corp. (HSE:BTH1V; NASDAQ:BITI) gained $5.73 (39%) to $20.61 in its first day of trading on NASDAQ after raising $92.9 million via a listing of ADSs and a concurrent note deal. The com...

Neogen launches AccuPoint® Advanced

LANSING, Mich., June 9, 2015 /PRNewswire/ -- Neogen has released an enhanced version of its popular AccuPoint® ATP Hygiene Monitoring System that makes the product the most sensitive an...

Researchers find possible molecular explanation for caffeine reducing mood disorders

(Medical Xpress)—An international team of researchers has found a possible molecular explanation for the stress reducing capabilities of caffeine. In their paper published in Proceedings of the Nati...

Suzhou NeuPharma Starts Phase I Trial of Cancer Treatment

Suzhou NeuPharma has begun a Phase I clinical trial of RX108 in Australia in patients with various solid tumor cancers. RX108 is a novel small-molecule inhibitor of sodium-potassium adenosine triphosp...

Primary Immune Deficiency (PID) - Pipeline Review, H1 2015

Recently added to the BioPortfolio report store, Primary Immune Deficiency (PID) - Pipeline Review, H1 2015 is a new report from Global Markets Direct published on 2015-04-28. This 67-page report is ...

BioLife Solutions Reports Increased Adoption of CryoStor® and HypoThermosol® Clinical Grade Biopreservation Media Products and Strong Interest in Cloud Based biologistex™ App & evo™ Smart Shipper at ISCT Conference

BOTHELL, Wash., June 3, 2015 /PRNewswire/ -- BioLife Solutions, Inc. (NASDAQ: BLFS), a leading developer, manufacturer and marketer of proprietary clinical grade cell and tissue hypothermic stora...

New Data Presented at EuroPCR 2015 Adds to the Growing Body of Clinical Evidence Supporting St. Jude Medical Fractional Flow Reserve Technology

Data from the DEFER study demonstrates sustained benefits of FFR after 15 years, while the CONTRAST study shows contrast FFR offers superior diagnostic accuracy over iFR ...

Events [0 Results]

None

Companies [1 Associated Companies listed on BioPortfolio]

ArQule, Inc.

ArQule is a biotechnology company engaged in the research and development of next-generation, small-molecule cancer therapeutics. The Company’s targeted, broad-spectrum produ...

Clinical Trials [96 Associated Clinical Trials listed on BioPortfolio]

Clinical Usefulness of Fractional Flow Reserve Measurement for Significant Stenosis in Proximal Coronary Artery

Fractional flow reserve (FFR) is a pressure-wire-based index that is used during coronary angiography to assess the potential of a coronary stenosis to induce myocardial ischemia. Recent E...

Peripheral Endothelial Function Assessment of Patients on Ticagrelor vs. Clopidogrel Who Have Undergone PCI

Usage of antiplatelet agents and cardiac procedures such as coronary angioplasty has dramatically improved the morbidity and mortality associated with coronary artery disease. In patients ...

Ticagrelor vs Clopidogrel Effect on MFR in CAD Population

Ticagrelor is one of 3 anti-platelet medications used in patients with acute coronary syndrome (ACS) to prevent further clot formation and further ischemic damage to myocardial tissue. Ove...

A Study to Compare the Safety of Rivaroxaban Versus Acetylsalicylic Acid in Addition to Either Clopidogrel or Ticagrelor Therapy in Participants With Acute Coronary Syndrome

The purpose of this study is to estimate the risk of bleeding with rivaroxaban, compared with acetylsalicylic acid (ASA), in addition to a single antiplatelet/ platelet adenosine diphospha...

CONTRAST (Can cONTrast Injection Better Approximate FFR compAred to Pure reSTing Physiology?)

The purpose of this study is to determine the diagnostic performances of iodine contrast medium and resting conditions to predict fractional flow reserve (FFR). Reference FFR will be measu...

Study to Examine the Effects of ATP Supplementation on Muscle Excitability and Reaction Time During and Following a Repeated Sprint Bout

We hypothesize that adenosine-5'-triphosphate (ATP) supplementation will be able to enhance motor unit recruitment while simultaneously blunting the decline in power and reaction time that...

Treatment of SCID Due to ADA Deficiency With Autologous Transplantation of Cord Blood or Hematopoietic CD 34+ Cells After Addition of a Normal Human ADA cDNA by the EFS-ADA Lentiviral Vector

This is a clinical gene transfer study that aims to verify the safety and efficacy of the use of the EFS-ADA lentiviral vector to introduce the human adenosine deaminase (ADA) gene into th...

Evaluation of [123I]MNI-420 and SPECT as a Marker of the Adenosine A2a Receptor in PD, HD and Healthy Subjects.

The underlying goal of this study is to assess [123I]MNI-420 SPECT imaging as a tool to detect A2aR density in the brain of PD and HD research participants to be compared with similarly ag...

Trial of PBF-509 in Patients With Advanced NSCLC

The purpose of this study is to determine the safety, tolerability and feasibility of an adenosine A2a receptor antagonist (PBF-509) during a phase I dose escalation trial in advanced or m...

RTA 408 Capsules in Patients With Mitochondrial Myopathy - MOTOR

Mitochondrial myopathies are a multisystemic group of disorders that are characterized by a wide range of biochemical and genetic mitochondrial defects and variable modes of inheritance. ...

Videos

None available.

Medical and Biotech [MESH] Definitions

Drugs that inhibit ADENOSINE DEAMINASE activity.

An enzyme that catalyzes the hydrolysis of adenosine to inosine with the elimination of ammonia. Since there are wide tissue and species variations in the enzyme, it has been used as a tool in the study of human and animal genetics and in medical diagnosis. EC 3.5.4.4.

A nucleoside that is composed of adenine and d-ribose. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.

A ribonucleoside antibiotic synergist and adenosine deaminase inhibitor isolated from Nocardia interforma and Streptomyces kaniharaensis. It is proposed as an antineoplastic synergist and immunosuppressant.

A potent inhibitor of ADENOSINE DEAMINASE. The drug induces APOPTOSIS of LYMPHOCYTES, and is used in the treatment of many lymphoproliferative malignancies, particularly HAIRY CELL LEUKEMIA. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.


Advertisement
 
Advertisement
 
review and buy Adenosine Deaminase market research data and corporate reports here

Channels Quicklinks