Adenosine Deaminase - Biotech, Pharma and Life Science Channel

07:18 EDT 24th May 2015 | BioPortfolio

PubMed Articles [471 Associated PubMed Articles listed on BioPortfolio]

Enzymatic cleavage and mass amplification strategy for small molecule detection using aptamer-based fluorescence polarization biosensor.

Fluorescence polarization (FP) assays incorporated with fluorophore-labeled aptamers have attracted great interest in recent years. However, detecting small molecules through the use of FP assays stil...

An enzyme-free and label-free fluorescent biosensor for small molecules by G-quadruplex based hybridization chain reaction.

An enzyme-free and label-free fluorescent biosensor is developed by G-quadruplex-based hybridization chain reaction (HCR) for small molecules, using adenosine triphosphate (ATP) as the model. Aptamer ...

The Effects of Phellinus linteus Polysaccharide Extracts on Cholesterol Efflux in Oxidized Low-Density Lipoprotein-Loaded THP-1 Macrophages.

The removal of excess cellular cholesterol is critical for maintaining cellular cholesterol homeostasis. Phellinus linteus polysaccharide extracts (PLPEs) is an immunomudulatory agent with a molecular...

Parp3 Negatively Regulates Immunoglobulin Class Switch Recombination.

To generate highly specific and adapted immune responses, B cells diversify their antibody repertoire through mechanisms involving the generation of programmed DNA damage. Somatic hypermutation (SHM) ...

Binding of the Antagonist Caffeine to the Human Adenosine Receptor hA2AR in Nearly Physiological Conditions.

Lipid composition may significantly affect membrane proteins function, yet its impact on the protein structural determinants is not well understood. Here we present a comparative molecular dynamics (M...

Quality testing of autoclaved rodent drinking water during short-term and long-term storage.

All animals need clean water to drink. At the authors' animal facility, drinking water for immunocompromised rodents is filtered by reverse osmosis, acidified during bottling and sterilized in an auto...

Intrathecal delivery of IL-6 reactivates the intrinsic growth capacity of pyramidal cells in the sensorimotor cortex after spinal cord injury.

We have previously demonstrated the growth-promoting effect of intrathecal delivery of recombinant rat IL-6 immediately after corticospinal tract (CST) injury. Our present study aims to further clarif...

Cilostazol attenuates ovariectomy-induced bone loss by inhibiting osteoclastogenesis.

Cilostazol has been reported to alleviate the metabolic syndrome induced by increased intracellular adenosine 3',5'-cyclic monophosphate (cAMP) levels, which is also associated with osteoclast (OC) di...

Extracellular ATP metabolism on vascular endothelial cells: A pathway with pro-thrombotic and anti-thrombotic molecules.

Vascular endothelial contributes to the metabolism and interconversion of extracellular adenine nucleotides via ecto-ATPase/ADPase (CD39) and ecto-5'nucleotidase (CD73) activities. These enzymes colle...

The role of purinergic and dopaminergic systems on MK-801-induced antidepressant effects in zebrafish.

Depression is a serious disease characterized by low mood, anhedonia, loss of interest in daily activities, appetite and sleep disturbances, reduced concentration, and psychomotor agitation. There is ...

News Articles [71 Associated News Articles listed on BioPortfolio]

New Data Presented at EuroPCR 2015 Adds to the Growing Body of Clinical Evidence Supporting St. Jude Medical Fractional Flow Reserve Technology

Data from the DEFER study demonstrates sustained benefits of FFR after 15 years, while the CONTRAST study shows contrast FFR offers superior diagnostic accuracy over iFR ...

Pollen-derived adenosine key in ragweed-induced allergy

(HealthDay)—Pollen-derived adenosine is an important element in ragweed pollen-induced allergic airway inflammation, according to a study published online May 2 in Allergy.

EU approval of gene therapy for rare immune disorder sought by GSK, partners

An application to market the investigational gene therapy GSK2696273 to treat adenosine deaminase severe combined immunodefic -More- 

GSK files for European approval of gene therapy

GlaxoSmithKline has filed for approval to market a gene therapy in Europe. GSK2696273, developed with Italian scientists from Fondazione Telethon (Telethon) and Ospedale San Raffaele (OSR), is for the...

GSK submits MAA for ADA-SCID gene therapy

GlaxoSmithKline plc (LSE:GSK; NYSE:GSK) submitted an MAA to EMA for autologous gene therapy GSK2696273 to treat severe combined immunodeficiency (SCID) due to adenosine deaminase deficiency (ADA-SCID)...

Tocagen plans to advance GBM gene therapy

Tocagen Inc. (San Diego, Calif.) said it plans to start a Phase II/III trial in 4Q15 of Toca 511 vocimagene amiretrorepvec and Toca FC to treat patients undergoing resection for first or second recurr...

GSK gene therapy close to EU submission, CRISPR closes new cash, Takeda settles Actos (Morning Read)

Takeda has reached a settle over the cancer lawsuits connected to Actos diabetes treatment. Three big players came in on CRISPR Therapeutics' round. And it looks like GlaxoSmithKline will be the first...

Physician Views: Will PEGASUS data make AstraZeneca's Brilinta fly?

Recently added to the BioPortfolio report store, Physician Views: Will PEGASUS data make AstraZeneca's Brilinta fly? is a new report from Firstword published on 2015-04-26. This report is available f...

GSK readies 'bubble boy' drug as big pharma bets on gene therapy

By Ben Hirschler LONDON (Reuters) - GlaxoSmithKline is close to seeking European approval for a

Cipher is Canadian partner for Can-Fite's CF101

Cipher Pharmaceuticals Inc. licensed Canadian marketing rights to Can-Fite Biopharma Ltd.'s lead A3 adenosine receptor agonist CF101, in Phase II/III for moderate-to-severe plaque psoriasis and in Pha...

Events [0 Results]

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Companies [1 Associated Companies listed on BioPortfolio]

ArQule, Inc.

ArQule is a biotechnology company engaged in the research and development of next-generation, small-molecule cancer therapeutics. The Company’s targeted, broad-spectrum produ...

Clinical Trials [93 Associated Clinical Trials listed on BioPortfolio]

Study to Examine the Effects of ATP Supplementation on Muscle Excitability and Reaction Time During and Following a Repeated Sprint Bout

We hypothesize that adenosine-5'-triphosphate (ATP) supplementation will be able to enhance motor unit recruitment while simultaneously blunting the decline in power and reaction time that...

Treatment of SCID Due to ADA Deficiency With Autologous Transplantation of Cord Blood or Hematopoietic CD 34+ Cells After Addition of a Normal Human ADA cDNA by the EFS-ADA Lentiviral Vector

This is a clinical gene transfer study that aims to verify the safety and efficacy of the use of the EFS-ADA lentiviral vector to introduce the human adenosine deaminase (ADA) gene into th...

Evaluation of [123I]MNI-420 and SPECT as a Marker of the Adenosine A2a Receptor in PD, HD and Healthy Subjects.

The underlying goal of this study is to assess [123I]MNI-420 SPECT imaging as a tool to detect A2aR density in the brain of PD and HD research participants to be compared with similarly ag...

Trial of PBF-509 in Patients With Advanced NSCLC

The purpose of this study is to determine the safety, tolerability and feasibility of an adenosine A2a receptor antagonist (PBF-509) during a phase I dose escalation trial in advanced or m...

A Study to Compare the Safety of Rivaroxaban Versus Acetylsalicylic Acid in Addition to Either Clopidogrel or Ticagrelor Therapy in Participants With Acute Coronary Syndrome

The purpose of this study is to estimate the risk of bleeding with rivaroxaban, compared with acetylsalicylic acid (ASA), in addition to a single antiplatelet/ platelet adenosine diphospha...

Ticagrelor vs Clopidogrel Effect on MFR in CAD Population

Ticagrelor is one of 3 anti-platelet medications used in patients with acute coronary syndrome (ACS) to prevent further clot formation and further ischemic damage to myocardial tissue. Ove...

RTA 408 Capsules in Patients With Mitochondrial Myopathy - MOTOR

Mitochondrial myopathies are a multisystemic group of disorders that are characterized by a wide range of biochemical and genetic mitochondrial defects and variable modes of inheritance. ...

Evaluation of Biomarkers Associated With Response to Subsequent Therapies in Subjects With HER2-Positive Metastatic Breast Cancer

This is a multicenter, open-label, Phase II study in subjects with Human epidermal growth factor receptor (HER2)-positive metastatic breast cancer who received at least 2 prior lines of an...

AMP as a Better Delivery System of Adenosine

Adenosine and AMP are substances normally present in the body. Adenosine is also given for the treatment of some heart rhythm problems and may be used to reduce heart damage during heart ...

PV Reconnection After PVAI at Different Power Settings and Adenosine Provocation

In this prospective randomized study, we aim to compare the rate of PV reconnection following PVAI performed at different energy settings (30 Watts vs 40 Watts) where dormant PV conduction...

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Medical and Biotech [MESH] Definitions

Drugs that inhibit ADENOSINE DEAMINASE activity.

An enzyme that catalyzes the hydrolysis of adenosine to inosine with the elimination of ammonia. Since there are wide tissue and species variations in the enzyme, it has been used as a tool in the study of human and animal genetics and in medical diagnosis. EC 3.5.4.4.

A nucleoside that is composed of adenine and d-ribose. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.

A ribonucleoside antibiotic synergist and adenosine deaminase inhibitor isolated from Nocardia interforma and Streptomyces kaniharaensis. It is proposed as an antineoplastic synergist and immunosuppressant.

A potent inhibitor of ADENOSINE DEAMINASE. The drug induces APOPTOSIS of LYMPHOCYTES, and is used in the treatment of many lymphoproliferative malignancies, particularly HAIRY CELL LEUKEMIA. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.

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