Adenosine Deaminase - Biotech, Pharma and Life Science Channel

20:03 EST 26th January 2015 | BioPortfolio

PubMed Articles [515 Associated PubMed Articles listed on BioPortfolio]

Measuring the dynamics of cyclic adenosine monophosphate level in living cells induced by low-level laser irradiation using bioluminescence resonance energy transfer.

Human Mitochondrial Hsp70 (Mortalin): Shedding Light on ATPase Activity, Interaction with Adenosine Nucleotides, Solution Structure and Domain Organization.

The human mitochondrial Hsp70, also called mortalin, is of considerable importance for mitochondria biogenesis and the correct functioning of the cell machinery. In the mitochondrial matrix, mortalin ...

Adenosine 2A receptors modulate reward behaviours for methamphetamine.

Addiction to methamphetamine (METH) is a global health problem for which there are no approved pharmacotherapies. The adenosine 2A (A2 A ) receptor presents a potential therapeutic target for METH abu...

Immunomodulatory Effects of Lippia sidoides Extract: Induction of IL-10 Through cAMP and p38 MAPK-Dependent Mechanisms.

Lippia sidoides is an aromatic shrub that grows wild in the northeastern region of Brazil. In local traditional medicine, the aerial portions of this species are used as anti-infectives, antiseptics, ...

Gene sequence analysis and screening of feature genes in spinal cord injury.

The aim of the present study was to screen for feature genes associated with spinal cord injury (SCI), in order to identify the underlying pathogenic mechanisms. Differentially expressed genes were sc...

Synthesis of locked cyclohexene and cyclohexane nucleic acids (LCeNA and LCNA) with modified adenosine units.

We describe here the preparation of conformationally locked cyclohexane nucleic acids designed as hybrids between locked nucleic acids (LNAs) and cyclohexene nucleic acids (CeNAs), both of which excel...

The relationship between on-clopidogrel platelet reactivity, genotype, and post-percutaneous coronary intervention outcomes in Chinese patients.

Background. High on-clopidogrel platelet reactivity reflects a poor response to clopidogrel and is associated with ischemic events, which has been attributed to several factors such as demographic, cl...

Measuring the effectiveness of a revised clinical practice guideline for the pre-hospital management of supraventricular tachycardia.

To evaluate the effect of changes to the pre-hospital management of patients with supraventricular tachycardia (SVT) following intervention with a revised Clinical Practice Guideline (CPG). The major ...

Hormonal regulation of colour change in eyes of a cryptic fish.

Colour change of the skin in lower vertebrates such as fish has been a subject of great scientific and public interest. However, colour change also takes place in eyes of fish and while an increasing ...

Cordycepin induces cell cycle arrest and apoptosis by inducing DNA damage and up-regulation of p53 in Leukemia cells.

Abstract Cordycepin, an adenosine analog derived from Cordyceps militaris has been shown to exert anti-tumor activity in many ways. However, the mechanisms by which cordycepin contributes to the anti-...

News Articles [59 Associated News Articles listed on BioPortfolio]

Support cells in the brain offer a new strategy to boost memory

A study by scientists from the Gladstone Institutes shows that decreasing the number of A2A adenosine receptors in a particular type of brain cells called astrocytes improved memory in healthy mice. W...

Celgene's Otezla approved in Europe for psoriasis

The European Commission (EC) has licensed Celgene's Otezla (apremilast) for the treatment of moderate-to-severe chronic plaque psoriasis and alone or in combination with Disease Modifying Antirheumati...

Intravascular ATP and Blood Flow Regulation, O2 Delivery

The authors investigate the role of intravascular adenosine triphosphate (ATP) in blood flow and oxygen supply. Exercise and Sport Sciences Reviews

Life Extension® launches AMPK Activator

FORT LAUDERDALE, Fla., Jan. 9, 2015 /PRNewswire/ -- Life Extension® scientists have compiled years of research to create AMPK (adenosine monophosphate-activated protein kinase) Activator, a ...

BEAT BioTherapeutics dATP Technology Improves Cardiac Function in End Stage Human Heart Failure Cardiac Muscle

BEAT BioTherapeutics Corporation (BEATBio) announced today the publication of an important new paper, “2-Deoxy adenosine triphosphate improves contraction in human end-stage hea...

Human enzyme (CD 39) targets Achilles heel of sepsis

Scientists use mice to show that a human membrane-bound enzyme called CD39, which can clear the dangerous buildup of adenosine triphosphate from the bloodstream, significantly improves survival of mic...

A human enzyme (CD 39) targets the Achilles heel of sepsis

There may never be a way to completely prevent infection, but sepsis may have an Achilles heel that would allow for more effective treatment of the condition. In a new report published in the January ...

Primary Immune Deficiency (PID) - Pipeline Review, H2 2014

Recently added to the BioPortfolio report store, Primary Immune Deficiency (PID) - Pipeline Review, H2 2014 is a new report from Global Markets Direct published on 2014-12-30. This 68-page report is ...

TDP-1, the Caenorhabditis elegans ortholog of TDP-43, limits the accumulation of double-stranded RNA

Caenorhabditis elegans mutants deleted for TDP-1, an ortholog of the neurodegeneration-associated RNA-binding protein TDP-43, display only mild phenotypes. Nevertheless, transcriptome sequencing revea...

Second Part of the Glaucoma Phase II study has been Approved in a European Country

PETACH TIKVA, Israel, Dec. 15, 2014 /PRNewswire/ -- Can-Fite BioPharma Ltd. (TASE: CFBI), (NYSE MKT: CANF), a biotechnology company developing a pipeline of small molecule...

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Companies [1 Associated Companies listed on BioPortfolio]

ArQule, Inc.

ArQule is a biotechnology company engaged in the research and development of next-generation, small-molecule cancer therapeutics. The Company’s targeted, broad-spectrum produ...

Clinical Trials [88 Associated Clinical Trials listed on BioPortfolio]

PV Reconnection After PVAI at Different Power Settings and Adenosine Provocation

In this prospective randomized study, we aim to compare the rate of PV reconnection following PVAI performed at different energy settings (30 Watts vs 40 Watts) where dormant PV conduction...

Adenosine Effect on Persistent Pulmonary Vein Isolation Line Evaluation (APPLE Trial)

The investigators studied the effects of adenosine on the reconnection rate after successful pulmonary veins isolation by radiofrequency catheter ablation in patients with drug-resistant...

Caffeine for Apnea of Prematurity (CAP)

At least 5 of every 1000 live-born babies are very premature and weigh only 500 to 1250 grams at birth. Approximately 30-40% of these high-risk infants either die or survive with lasting ...

Treatment of SCID Due to ADA Deficiency With Autologous Transplantation of Cord Blood or Hematopoietic CD 34+ Cells After Addition of a Normal Human ADA cDNA by the EFS-ADA Lentiviral Vector

This is a clinical gene transfer study that aims to verify the safety and efficacy of the use of the EFS-ADA lentiviral vector to introduce the human adenosine deaminase (ADA) gene into th...

RTA 408 Capsules in Patients With Mitochondrial Myopathy - MOTOR

Mitochondrial myopathies are a multisystemic group of disorders that are characterized by a wide range of biochemical and genetic mitochondrial defects and variable modes of inheritance. ...

Adenosine-induced Myocardial Blood Flow in Peripheral Artery Disease Patients

The purpose of the study is to assess the effect of blood flow to the heart when subjects are treated with ticagrelor (Brilinta) or clopidogrel (antiplatelet drugs that stop the blood from...

Treatment of the Recessive Nonbullous Congenital Ichthyosis by the Epigallocatechine Cutaneous

Lamellar ichthyosis (IL) is a rare autosomal recessive genodermatosis with a defect of keratinization of the skin which results in a severe generalized cutaneous xerosis with dark brown bi...

Molecular and Clinical Studies of Primary Immunodeficiency Diseases

This study will try to identify mutations in the genes responsible for primary immunodeficiency disorders (inherited diseases of the immune system) and evaluate the course of these disease...

KW-6002 to Treat Parkinson's Disease

This study will evaluate the effects of an experimental drug called KW-6002 on Parkinson's disease symptoms and on dyskinesias (involuntary movements) that develop as a result of long-term...

Gene Transfer Therapy for Severe Combined Immunodeficieny Disease (SCID) Due to Adenosine Deaminase (ADA) Deficiency

This study will evaluate a new method for delivering gene transfer therapy to patients with severe combined immunodeficiency disease (SCID) due to a defective adenosine deaminase (ADA) gen...

Medical and Biotech [MESH] Definitions

Drugs that inhibit ADENOSINE DEAMINASE activity.

An enzyme that catalyzes the hydrolysis of adenosine to inosine with the elimination of ammonia. Since there are wide tissue and species variations in the enzyme, it has been used as a tool in the study of human and animal genetics and in medical diagnosis. EC 3.5.4.4.

A nucleoside that is composed of adenine and d-ribose. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.

A ribonucleoside antibiotic synergist and adenosine deaminase inhibitor isolated from Nocardia interforma and Streptomyces kaniharaensis. It is proposed as an antineoplastic synergist and immunosuppressant.

A potent inhibitor of ADENOSINE DEAMINASE. The drug induces APOPTOSIS of LYMPHOCYTES, and is used in the treatment of many lymphoproliferative malignancies, particularly HAIRY CELL LEUKEMIA. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.

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