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Adenosine Deaminase - Biotech, Pharma and Life Science Channel

03:55 EDT 17th August 2017 | BioPortfolio

PubMed Articles [492 Associated PubMed Articles listed on BioPortfolio]

Unusual retinopathy in a child with severe combined immune deficiency.

We describe a case of an infant diagnosed with severe combined immune deficiency (Adenosine Deaminase (ADA), SCID) with severe retinopathy and associated low vision in both eyes at first examination. ...

Structure-Affinity Relationships and Structure-Kinetics Relationships of Pyrido2,1-fpurine-2,4-dione Derivatives as Human Adenosine A3 Receptor Antagonists.

We expanded on a series of pyrido[2,1-f]purine-2,4-dione derivatives as human adenosine A3 receptor (hA3R) antagonists to determine their kinetic profiles and affinities. Many compounds showed high af...

Adenosine and dopamine oppositely modulate a hyperpolarization activated current Ih in chemosensory neurons of the rat carotid body in co-culture.

Adenosine and dopamine (DA) act as neurotransmitters or neuromodulators at the carotid body (CB) chemosensory synapse, however, their mechanisms of action are not fully understood. Using a functional ...

Development and Evaluation of Heartbeat: A Machine Perfusion Heart Preservation System.

Static cold storage is accompanied with a partial safe ischemic interval for donor hearts. In this current study, a machine perfusion system was built to provide a better preservation for the donor he...

Changes in the process performance, sludge production and microbial activity in an activated sludge reactor with addition of a metabolic uncoupler under different operating conditions.

Sludge production in wastewater treatment plants is nowadays a big concern due to the high produced amounts and their characteristics. Consequently, the study of techniques that reduce the sludge gene...

Heterozygosity for P2Y12 receptor gene mutation associated with postoperative hemorrhage in a Greater Swiss Mountain dog.

A 3-year-old, female Greater Swiss Mountain dog developed a hemoperitoneum following an exploratory laparotomy and ovariohysterectomy. Platelet count, PT, APTT, and plasma von Willebrand factor antige...

Polypharmacology of N6-(3-iodobenzyl)adenosine-5'-N-methyluronamide (IB-MECA) and Related A3 Adenosine Receptor Ligands: Peroxisome Proliferator Activated Receptor (PPAR) γ Partial Agonist and PPAR δ Antagonist Activity Suggests Their Anti-diabetic Potential.

A3 adenosine receptor (AR) ligands including A3 AR agonist, N6-(3-iodobenzyl)adenosine-5'-N-methyluronamide 1a (IB-MECA) were examined for adiponectin production in human bone marrow mesenchymal stem ...

The Effects of Adenosinergic Modulation on Cytokine Levels in a Pentylenetetrazole-Induced Generalized Tonic-Clonic Seizure Model.

It has been suggested that the adenosinergic system and cytokines play a role in the pathogenesis of epilepsy. Although the role of the adenosinergic system in the modulation of seizure activity is we...

Potential Development of Tumor-Targeted Oral Anti-Cancer Prodrugs: Amino Acid and Dipeptide Monoester Prodrugs of Gemcitabine.

One of the main obstacles for cancer therapies is to deliver medicines effectively to target sites. Since stroma cells are developed around tumors, chemotherapeutic agents have to go through stroma ce...

Effect of Nitrogen Atom Substitution in A3 Adenosine Receptor binding: N-(4,6-diarylpyridin-2-yl)acetamides As Potent and Selective Antagonists.

We report the first family of 2-acetamidopyridines as potent and selective A3 adenosine receptor (AR) antagonists. The computer-assisted design was focused on the bioisosteric replacement of the N1 at...

News Articles [74 Associated News Articles listed on BioPortfolio]

CanFite BioPharma Ltd CANF Pharmaceuticals Healthcare Deals and Alliances Profile [Report Updated: 25072017] Prices from USD $250

SummaryCanFite BioPharma Ltd CanFite is a biopharmaceutical company that offers pharmaceutical discovery and clinical development services. The company's pipeline product portfolio includes CF101, CF1...

Concordia International Rx UK Ltd Pharmaceuticals Healthcare Deals and Alliances Profile [Report Updated: 26072017] Prices from USD $250

SummaryConcordia International Rx UK Ltd Concordia International, formerly Amdipharm Mercury Company Ltd, a subsidiary of Concordia International Corp, is a manufacturer of pharmaceutical products and...

Inotek Pharmaceuticals Corp ITEK Financial and Strategic SWOT Analysis Review [Report Updated: 07082017] Prices from USD $300

SummaryInotek Pharmaceuticals Corp IPC is a pharmaceutical company that discovers, develops and commercializes therapeutics for the treatment of glaucoma and serious diseases of the eye. The company's...

Safety Issues Not Dampening AbbVie Optimism For Humira Successors

AbbVie is optimistic that its JAK1 inhibitor upadacitinib and anti-IL23 candidate risankizumab can increase its autoimmune market share, doubting a...   

Fast-To-Market Play For AstraZeneca's Acalabrutinib With MCL Filing

Never mind MYSTIC, AstraZeneca is pushing the spotlight onto its other oncology assets, and its second-generation BTK inhibitor has just...   

Corvus Aims To Master Adenosine Mechanisms For PD-1/L1 Failures

Emerging Company Profile: CEO Richard Miller, who co-founded Idec and Pharmacyclics, explains Corvus's approach of building a pipeline around an...    

PLOS ONE publishes results of cardiac-directed catalytically inactive AC6 in mice after sustained β-adrenergic stimulation

SAN DIEGO, Aug. 2, 2017 /PRNewswire-USNewswire/ -- Renova™ Therapeutics, a biotechnology company developing gene and peptide-based treatments for cardiovascular and metabolic diseases, today an...

Sagent Pharmaceuticals Inc Medical Equipment Deals and Alliances Profile. [Report Updated: 20072017] Prices from USD $250

SummarySagent Pharmaceuticals Inc Sagent, formerly Sagent Holding Co., is a specialty pharmaceutical company which develops and manufactures pharmaceutical products with specific concentration on inje...

Okayama University researchers identify clodronate for chronic pain treatment

Researchers at Japan’s Okayama University have demonstrated the effect of clodronate on the regulation of adenosine triphosphate (ATP) release and its potential as a drug for the treatment of chroni...

Potential drug for treating chronic pain with few side effects

Researchers at Okayama University describe in the Proceedings of the National Academy of Sciences the effect of clodronate on the regulation of adenosine triphosphate release and its potential as a dr...

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Companies [2 Associated Companies listed on BioPortfolio]

Inotek Pharmaceuticals Corp.

Inotek Pharmaceuticals is a clinical-stage biopharmaceutical company focused on the discovery, development and commercialization of therapies for glaucoma and other eye diseases. ...

ArQule, Inc.

ArQule is a biotechnology company engaged in the research and development of next-generation, small-molecule cancer therapeutics. The Company’s targeted, broad-spectrum produ...

Clinical Trials [151 Associated Clinical Trials listed on BioPortfolio]

Performance of a New REsting Pressure Index During Invasive Angiography Compared To Adenosine Hyperemic FFR

To test the feasibility and diagnostic accuracy of a new automated pressure derived resting index (Pd/Pamin), using FFR as gold standard, in de novo coronary lesions in which invasive phys...

A Dose Titration Study to Assess the Effects of SAR407899 in Patients With Microvascular Angina and/or Persistent Stable Angina Despite Angiographically Successful Elective PCI

The Primary Objective of this study: -To assess the effects of SAR407899 on coronary vasomotor function using the coronary flow reserve (CFR) in patients with microvascular angina and/or ...

Hyperemic Efficacy of IV Adenosine in HFrEF

Little is known about the hyperemic efficacy of IV adenosine as well as safety in patients with heart failure with reduced ejection fraction (HFrEF) because they were excluded from the maj...

Evaluating the Effectiveness of STRIMVELIS Risk Minimization Measures (RMMs)

STRIMVELIS is a medicinal product developed by GSK that restores adenosine deaminase (ADA) function in hematopoietic cell lineages, thereby preventing impaired immune function. STRIMVELIS ...

Coronary Artery Vasculopathy in Pediatric Heart Transplant Patients

Heart transplantation is a life-sustaining therapy that allows patients with either congenital or acquired heart disease and severe cardiac dysfunction to survive. Over time, however, the ...

Varlitinib Plus Capecitabine in Chinese Patients With Advanced or Metastatic Biliary Tract Cancer

This protocol for Varlitinib is developed for the treatment of Biliary Tract Cancer. Varlitinib (also known as ASLAN001) is a small-molecule, adenosine triphosphate competitive inhibitor o...

Effect of Light-Emitting Diode on the Strenght and Resistence Capacities of Cycling Athletes

Phototherapy is a therapeutic resource of increasing use in the last decade. The photobiomodulatory effects are commonly produced by means of low intensity lasers or LED emitting diodes, a...

A2 AR as a Novel Biomarkers for Physician Decision-making Improvement Evaluation's Patients With Suspected Acute Coronary Syndrome But Negative Troponin.

One proposed strategy is the stratification of troponin-negative patients with biomarker testing at presentation to facilitate the clinically-appropriate rapid discharge from the emergency...

Use of Adenosine to Determine the Electrophysiological Mechanism of Premature Ventricular Contractions

Unblinded, controlled, non-randomized, mechanistic study to determine whether physiological mechanisms underlying PVC are sensitive to adenosine. Twenty subjects undergoing clinically-indi...

Myocardial Perfusion and Fibrosis in Cancer Survivors

This is a cross-sectional pilot study. The investigators seek to obtain early information pertaining to the relationship between measurements of myocardial perfusion reserve and myocardial...

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Medical and Biotech [MESH] Definitions

Drugs that inhibit ADENOSINE DEAMINASE activity.

An enzyme that catalyzes the hydrolysis of adenosine to inosine with the elimination of ammonia. Since there are wide tissue and species variations in the enzyme, it has been used as a tool in the study of human and animal genetics and in medical diagnosis. EC 3.5.4.4.

A nucleoside that is composed of adenine and d-ribose. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.

A ribonucleoside antibiotic synergist and adenosine deaminase inhibitor isolated from Nocardia interforma and Streptomyces kaniharaensis. It is proposed as an antineoplastic synergist and immunosuppressant.

A potent inhibitor of ADENOSINE DEAMINASE. The drug induces APOPTOSIS of LYMPHOCYTES, and is used in the treatment of many lymphoproliferative malignancies, particularly HAIRY CELL LEUKEMIA. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.

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