Adenosine Deaminase - Biotech, Pharma and Life Science Channel

16:16 EDT 22nd September 2014 | BioPortfolio

PubMed Articles [534 Associated PubMed Articles listed on BioPortfolio]

Profile of Nucleosides and Nucleotides in Donkey's Milk.

Nucleotides play a crucial role to cellular functions; they can be obtained from the diet or through the nucleotide salvage pathway, however, in particular situations (occurring mainly in newborns) th...

Cyclic adenosine 5'-diphosphate ribose analogs without a "southern" ribose inhibit ADP-ribosyl cyclase-hydrolase CD38.

Cyclic adenosine 5'-diphosphate ribose (cADPR) analogs based on the cyclic inosine 5'-diphosphate ribose (cIDPR) template were synthesized by recently developed stereo- and regioselective N1-ribosylat...

Unravelling the Carbon and Sulphur Metabolism in Coastal Soil Ecosystems Using Comparative Cultivation-Independent Genome-Level Characterisation of Microbial Communities.

Bacterial autotrophy contributes significantly to the overall carbon balance, which stabilises atmospheric CO2 concentration and decelerates global warming. Little attention has been paid to different...

Dietary Modulation of Thymic Enzymes.

Malnutrition is a complex syndrome caused by an inadequate intake of energy, protein, minerals and vitamins which affects the immune system. Nutritional imbalances, present in children with energy-pro...

Cardiac Fibroblasts Contribute to Myocardial Dysfunction in Mice with Sepsis: The Role of NLRP3 Inflammasome Activation.

Myocardial contractile dysfunction in sepsis is associated with the increased morbidity and mortality. Although the underlying mechanisms of the cardiac depression have not been fully elucidated, an e...

Anchored protein kinase A signalling in cardiac cellular electrophysiology.

The cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA) is an elementary molecule involved in both acute and chronic modulation of cardiac function. Substantial research in recent yea...

Efficacy of digoxin in comparison with propranolol for treatment of infant supraventricular tachycardia: analysis of a large, national database.

Introduction: Digoxin or propranolol are used as first-line enteral agents for treatment of infant supraventricular tachycardia. We used a large national database to determine whether enteral digoxin ...

Ischaemic conditioning strategies reduce ischaemia/reperfusion-induced organ injury.

Summary Reperfusion of tissues subjected to prolonged ischaemia results in ischaemic/reperfusion injury. Fortunately, there are strategies that can be applied to attenuate this injury. These include i...

The Structural Basis of ATP as an Allosteric Modulator.

Adenosine-5'-triphosphate (ATP) is generally regarded as a substrate for energy currency and protein modification. Recent findings uncovered the allosteric function of ATP in cellular signal transduct...

Effects of Noradrenaline and Adenosine Triphosphate on the Degree on Contrast Enhancement in a Rabbit Model of Atherosclerosis during Contrast-Enhanced Ultrasonography.

The aim of the study is to assess the effects of vasoactive agents on the degree of contrast enhancement in experimental atherosclerotic plaque during contrast-enhanced ultrasonography (CEUS). Abdomin...

News Articles [61 Associated News Articles listed on BioPortfolio]

AbbVie to Present Clinical Study Data on Potential New Oncology Medicines at the 2014 European Society of Medical Oncology Annual Meeting

NORTH CHICAGO, Ill., Sept. 22, 2014 /PRNewswire/ -- AbbVie (NYSE: ABBV) announced that data from several clinical studies evaluating potential new medicines in the company's oncology pipeline wil...

Adenosine kinase, glutamine synthetase and EAAT2 as gene therapy targets for temporal lobe epilepsy

Introducing The First 2 in 1 Laser in the Dental Market....EVER!

MISSISSAUGA, ONTARIO -- (Marketwired) -- 09/18/14 -- Editors Note: There are three photos associated with this press release. ZOLAR TECHNOLOGY & MFG CO. INC a leading manufacturer and distributo...

Addition of ATP to Midazolam Offers Enhanced Dental Sedation, Fewer Adverse Effects

The anesthetic drug midazolam, used widely for brief dental and medical procedures, can result in cardiorespiratory depression when it is given in higher doses or repeatedly to achieve deeper levels ...

Biotie: Formal transfer of global rights for tozadenant to Biotie concluded

BIOTIE THERAPIES CORP.           STOCK EXCHANGE RELEASE             28 August 2014 at 9.00 a.m. Biotie: Formal transfer of global rights for tozadenant to Biotie c...

Spreading depolarization-induced adenosine accumulation reflects metabolic status in vitro and in vivo

Inotek Pharmaceuticals Names David P. Southwell as President and Chief Executive Officer

Inotek Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company focused on ophthalmology, today announced that David. P. Southwell has been named President and Chief Exec...

Noncoding RNA transcription targets AID to divergently transcribed loci in B cells

The vast majority of the mammalian genome has the potential to express noncoding RNA (ncRNA). The 11-subunit RNA exosome complex is the main source of cellular 3′–5′ exoribonucleolytic activity ...

A3 Adenosine Receptor Agonists for Treating Chronic Neuropathic Pain

Chronic neuropathic pain (NP) is a widespread condition that is often associated with diabetes, cancer, injury as well as a variety of other diseases. Current therapies for NP are not always effectiv...

Biotie updates outlook on tozadenant and SYN120

BIOTIE THERAPIES CORP.              STOCK EXCHANGE RELEASE     30 July 2014      at 8.50 a.m. Biotie updates outlook on tozadenant and SYN120 Tozadenant to advanc...

Events [0 Results]

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Companies [1 Associated Companies listed on BioPortfolio]

ArQule, Inc.

ArQule is a biotechnology company engaged in the research and development of next-generation, small-molecule cancer therapeutics. The Company’s targeted, broad-spectrum produ...

Clinical Trials [83 Associated Clinical Trials listed on BioPortfolio]

Treatment of the Recessive Nonbullous Congenital Ichthyosis by the Epigallocatechine Cutaneous

Lamellar ichthyosis (IL) is a rare autosomal recessive genodermatosis with a defect of keratinization of the skin which results in a severe generalized cutaneous xerosis with dark brown bi...

Molecular and Clinical Studies of Primary Immunodeficiency Diseases

This study will try to identify mutations in the genes responsible for primary immunodeficiency disorders (inherited diseases of the immune system) and evaluate the course of these disease...

KW-6002 to Treat Parkinson's Disease

This study will evaluate the effects of an experimental drug called KW-6002 on Parkinson's disease symptoms and on dyskinesias (involuntary movements) that develop as a result of long-term...

Gene Transfer Therapy for Severe Combined Immunodeficieny Disease (SCID) Due to Adenosine Deaminase (ADA) Deficiency

This study will evaluate a new method for delivering gene transfer therapy to patients with severe combined immunodeficiency disease (SCID) due to a defective adenosine deaminase (ADA) gen...

Genetic Causes of Panic Disorder

This study will try to identify genes that increase the risk of developing panic disorder-an anxiety disorder characterized by recurrent unexpected panic attacks-and that contribute to the...

Effects of Allergen Inhalation on Adenosine Receptor Expression in Sputum and Peripheral Blood

The purpose of this study is to determine whether asthmatics have different adenosine receptor expression profiles than healthy controls. We hypothesize that asthmatics will have increased...

The Effect of Omalizumab on Airway Responsiveness to Adenosine in Patients With Poorly Controlled Asthma

The purpose of this study is to determine whether the addition of omalizumab in patients with poorly controlled asthma (because of poor adherence) will decrease allergic airway inflammatio...

ATP/AMP Challenge in Healthy Non-Smokers, Smokers, Patients With Asthma, and Patients With Chronic Obstructive Pulmonary Disease (COPD)

In this randomised, cross-over, controlled study, a total of 84 subjects will be included: 12 healthy non-smoking volunteers; 12 current smokers; 30 patients with mild steroid-naïve asthm...

AMP as a Better Delivery System of Adenosine

Adenosine and AMP are substances normally present in the body. Adenosine is also given for the treatment of some heart rhythm problems and may be used to reduce heart damage during heart ...

Caffeine for Apnea of Prematurity (CAP)

At least 5 of every 1000 live-born babies are very premature and weigh only 500 to 1250 grams at birth. Approximately 30-40% of these high-risk infants either die or survive with lasting ...

Medical and Biotech [MESH] Definitions

Drugs that inhibit ADENOSINE DEAMINASE activity.

An enzyme that catalyzes the hydrolysis of adenosine to inosine with the elimination of ammonia. Since there are wide tissue and species variations in the enzyme, it has been used as a tool in the study of human and animal genetics and in medical diagnosis. EC 3.5.4.4.

A nucleoside that is composed of adenine and d-ribose. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.

A ribonucleoside antibiotic synergist and adenosine deaminase inhibitor isolated from Nocardia interforma and Streptomyces kaniharaensis. It is proposed as an antineoplastic synergist and immunosuppressant.

A potent inhibitor of ADENOSINE DEAMINASE. The drug induces APOPTOSIS of LYMPHOCYTES, and is used in the treatment of many lymphoproliferative malignancies, particularly HAIRY CELL LEUKEMIA. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.

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