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Adrenergic modifiers - Biotech, Pharma and Life Science Channel

07:30 EDT 31st July 2014 | BioPortfolio

PubMed Articles [376 Associated PubMed Articles listed on BioPortfolio]

Synthesis of a New Cyclosporine-based Stationary Phase and Separation Behaviors toward Aromatic Positional Isomers by High-Performance Liquid Chromatography.

A new cyclosporine-bonded stationary phase has been synthesized through the Staudinger reaction between azido cyclosporine A (CsA) and aminopropyl silica gel and applied in separations of six disubsti...

The "Bear" Essentials: Actualistic Research on Ursus arctos arctos in the Spanish Pyrenees and Its Implications for Paleontology and Archaeology.

Neotaphonomic studies of large carnivores are used to create models in order to explain the formation of terrestrial vertebrate fossil faunas. The research reported here adds to the growing body of kn...

Melanocyte biology and function with reference to oral melanin hyperpigmentation in HIV-seropositive subjects.

The colour of normal skin and of oral mucosa is not determined by the number of melanocytes in the epithelium but rather by their melanogenic activity. Pigmented biopolymers or melanins, are synthesiz...

Surface-coated PLA nanoparticles loaded with temozolomide for improved brain deposition and potential treatment of gliomas: development, characterization and in vivo studies.

Abstract Hydrophobicity of PLA nanoparticles makes them a good substrate for macrophageal and reticulo-endothelial system uptake. Long-circulating properties can be imparted to these particles by coat...

beta-Adrenoreceptor antagonists reduce cancer cell proliferation, invasion, and migration.

Abstract Context: Propranolol, atenolol, and ICI118,551 are non-selective β-adrenergic receptor (AR), β1-AR, and β2-AR antagonists, respectively. Objective: We investigated the efficacy of proprano...

Differences in Allosteric Communication Pipelines in the Inactive and Active States of a GPCR.

G-protein-coupled receptors (GPCRs) are membrane proteins that allosterically transduce the signal of ligand binding in the extracellular (EC) domain to couple to proteins in the intracellular (IC) do...

Chemokine (C-X-C motif) receptor 4 and atypical chemokine receptor 3 regulate vascular α1-adrenergic receptor function.

Chemokine (C-X-C motif) receptor (CXCR) 4 and atypical chemokine receptor (ACKR) 3 ligands have been reported to modulate cardiovascular function in various disease models. The underlying mechanisms,...

Both JNK and P38 MAPK Pathways Participate in the Protection by Dexmedetomidine Against Isoflurane-Induced Neuroapoptosis in the Hippocampus of Neonatal Rats.

Dexmedetomidine, a highly selective α2-adrenergic agonist, has been reported to attenuate isoflurane-induced cognitive impairment and neuroapoptosis. However, the underlying molecular mechanisms rema...

EFFECTS OF MILD TO MODERATE SEDATION ON SACCADIC EYE MOVEMENTS.

Sedatives alter the metrics of saccadic eye movements. If these effects are nonspecific consequences of sedation, like drowsiness and loss of attention to the task, or differ between sedatives is stil...

Differential Regulation of Endosomal GPCR/Beta-arrestin Complexes and Trafficking by MAPK.

Beta-arrestins are signaling adaptors that bind to agonist-occupied G protein-coupled receptors (GPCRs) and target them for endocytosis; however, the mechanisms regulating receptor/β-arrestin complex...

News Articles [80 Associated News Articles listed on BioPortfolio]

Global Parkinson%s Disease Market 2014-2018

LONDON, July 28, 2014 /PRNewswire/ -- Reportbuyer.com has added a new market research report:Global Parkinson%s Disease Market 2014-2018https://www.reportbuyer.com/product/1600461/Global-Parkinso...

ratiopharm GmbH - Strategic SWOT Analysis Review

Recently added to the BioPortfolio report store, ratiopharm GmbH - Strategic SWOT Analysis Review is a new report from GlobalData published on 2014-07-14. This 19-page report is available in PDF from...

Insulators recruit histone methyltransferase dMes4 to regulate chromatin of flanking genes

Chromosomal domains in Drosophila are marked by the insulator-binding proteins (IBPs) dCTCF/Beaf32 and cofactors that participate in regulating long-range interactions. Chromosomal borders are further...

GSK and Theravance Initiate Phase III Program for COPD Treatment

GlaxoSmithKline and Theravance today announced the start of a global phase III study, known as IMPACT, to evaluate the efficacy and safety of the 'closed' triple combination of FF/UMEC/VI in patients...

Impaired Adrenergic-Mediated Plasticity of Prefrontal Cortical Glutamate Synapses in Rats with Developmental Disruption of the Ventral Hippocampus

Sunovion Pharmaceuticals Inc. Announces Data Published in the CHEST Journal from a One-year, Large Simple Safety Study Evaluating BROVANA® (arformoterol tartrate) Inhalation Solution

The study objective was met demonstrating that chronic obstructive pulmonary disease (COPD) patients treated with BROVANA are not at an increased risk of respiratory...

Monday's most followed in U.S. including MannKind, Flamel, Yahoo, American Apparel, U.S. Steel, GM, Philips, TreeHouse, PPG Industries, GoPro

U.S. shares wavered between gains and losses as a jump in pending home sales balanced weaker-than-forecast manufacturing data. The S&P 500 (INDEXSP:.INX) inched up 0.1 percent at 11:32 a.m. in New...

SENOMYX ANNOUNCES INCLUSION IN THE RUSSELL 2000® AND RUSSELL 3000® INDEXES

SAN DIEGO, June 30, 2014 /PRNewswire/ -- Senomyx, Inc. (NASDAQ: SNMX), a leading company using proprietary taste science technologies to discover, develop and commercialize novel flavor ingredien...

Flamel Technologies Announces FDA Approval of VAZCULEP

LYON, FRANCE -- (Marketwired) -- 06/30/14 -- Flamel Technologies (NASDAQ: FLML) today announced that the U.S. Food and Drug Administration (FDA) has approved the company's New Drug Application (NDA)...

GSK and Theravance Announce Submission to US Regulatory Authorities for Fluticasone Furoate/Vilanterol in Asthma

LONDON, UNITED KINGDOM and SOUTH SAN FRANCISCO, CA -- (Marketwired) -- 06/30/14 -- GlaxoSmithKline plc (LSE: GSK) (NYSE: GSK) and Theravance, Inc. (NASDAQ: THRX) today announced the submission of a s...

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Companies [2 Associated Companies listed on BioPortfolio]

Innate Immunotherapeutics Limited

Innate Immunotherapeutics Limited is a public unlisted biopharmaceutical company based in Auckland, New Zealand. The company is focused on the development of a new generation of i...

Innate Therapeutics Limited

Innate Therapeutics Limited is a public unlisted biopharmaceutical company based in Auckland. The company is focused on the development of a new generation of immune response modi...

Clinical Trials [79 Associated Clinical Trials listed on BioPortfolio]

Study to Evaluate Esmolol (Brevibloc) to Manage Cardiac Function in Patients With Subarachnoid Hemorrhage

The purpose of this study is to evaluate the clinical effect of esmolol treatment on cardiac function and electrophysiology; to assess the effects of esmolol treatment on serum adrenergic...

Occluded Artery Trial (OAT)

The purpose of this study is to determine whether opening an occluded infarcted artery 3-28 days after an acute myocardial infarction in high-risk asymptomatic patients reduces the composi...

Trial to Compare Alfuzosin Versus Placebo in the Treatment of Chronic Prostatitis/Chronic Pelvic Pain Syndrome

The purpose of this randomized clinical trial is to evaluate the efficacy and safety of the alpha adrenergic blocker Alfuzosin (Uroxatral) in men with relatively new onset of chronic prost...

Balloon Catheters and Stents to Prevent Heart Rhythm Irregularities in Individuals Post-Heart Attack

The purpose of this study is to determine if opening blocked arteries with heart balloons and stents prevents heart rhythm problems in individuals 3 to 28 days after a heart attack.

Naltrexone and Adrenergic Agents to Reduce Heroin Use in Heroin Addicts

Naltrexone is a medication that is currently used to treat drug and alcohol addiction. Guanfacine is a medication that is currently used to manage the withdrawal symptoms in individuals un...

The Effect of Antecedent Hypoglycaemia on β2-Adrenergic Sensitivity

Hypoglycaemia unawareness is a common complication in patients with type 1 diabetes and with insulin-treated type 2 diabetes of long duration. The loss of autonomic symptoms to hypoglycemi...

Carvedilol Versus Metoprolol for the Prevention of Atrial Fibrillation After Off-Pump Coronary Bypass Surgery

Postoperative new-onset atrial fibrillation (AF) is the most common complication stemming from coronary artery bypass graft surgery, and is associated with increased early and late morta...

Asthma Clinical Research Network (ACRN) Trial - Long-Acting Beta Agonist Response by Genotype (LARGE)

The purpose of this trial is to determine whether regularly scheduled use of an inhaled long-acting beta agonist (salmeterol) in the setting of concomitant use of inhaled corticosteroids (...

Spanish Cohort for the Study of the Effect of CPAP in Hypertension (CEPECTA)

AIMS:To know the effects of the treatment with nasal positive continuous airway pressure (CPAP) on systemic blood pressure and the expression of biological mediators, in systemic hypertens...

Beta-2 Polymorphisms and Beta Receptor Selectivity

We hypothesize that b2 adrenergic polymorphisms affect b-receptor selectivity in patients with heart failure treated with either a b1-selective or a b-nonselective agent. b-2 polymorphisms...

Medical and Biotech [MESH] Definitions

Drugs that act on adrenergic receptors or affect the life cycle of adrenergic transmitters. Included here are adrenergic agonists and antagonists and agents that affect the synthesis, storage, uptake, metabolism, or release of adrenergic transmitters.

Drugs that bind to but do not activate ADRENERGIC RECEPTORS. Adrenergic antagonists block the actions of the endogenous adrenergic transmitters EPINEPHRINE and NOREPINEPHRINE.

A subclass of beta-adrenergic receptors (RECEPTORS, ADRENERGIC, BETA). beta-3 Adrenergic receptors are the predominant beta-adrenergic receptor type expressed in white and brown ADIPOCYTES and are involved in modulating ENERGY METABOLISM and THERMOGENESIS.

Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.

Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.

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