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Adrenergic modifiers - Biotech, Pharma and Life Science Channel

20:41 EDT 19th April 2014 | BioPortfolio

PubMed Articles [259 Associated PubMed Articles listed on BioPortfolio]

Changes in nerve- and endothelium-mediated contractile tone of the corpus cavernosum in a mouse model of pre-mature ageing.

Erectile dysfunction (ED) is very prevalent in the older population, although the ageing-related mechanisms involved in the development of ED are poorly understood. We propose that age-induced differe...

α2A-Adrenergic Receptor Polymorphism Potentiates Platelet Reactivity in Patients With Stable Coronary Artery Disease Carrying the Cytochrome P450 2C19*2 Genetic Variant.

Platelet α2A-adrenergic receptors (ARs) mediate platelet aggregation in response to sympathetic stimulation. The 6.3-kb variant of α2A-AR gene is associated with increased epinephrine-induced platel...

Phenotypic variability in Waardenburg syndrome resulting from a 22q12.3-q13.1 microdeletion involving SOX10.

Waardenburg syndrome (WS) is a neurocristopathy characterized by pigmentation abnormalities of the skin, hair, and iris, as well as sensorineural hearing loss. Contiguous gene deletions encompassing S...

The Membrane-Anchored Serine Protease Prostasin (CAP1/PRSS8) Supports Epidermal Development and Postnatal Homeostasis Independent of its Enzymatic Activity.

The membrane-anchored serine protease prostasin (CAP1/PRSS8) is part of a cell surface proteolytic cascade that is essential for epithelial barrier formation and homeostasis. Here we report the surpri...

Beta-2 adrenergic receptors mediate stress-evoked reinstatement of cocaine-induced conditioned place preference and increases in CRF mRNA in the bed nucleus of the stria terminalis in mice.

Understanding the mechanisms responsible for stress-induced relapse is important for guiding treatment strategies aimed at minimizing the contribution of stress to addiction. Evidence suggests that th...

Alzheimer's disease and type 2 diabetes: multiple mechanisms contribute to interactions.

Obesity, metabolic syndrome, and type 2 diabetes (T2D) are related disorders with widespread deleterious effects throughout the body. One important target of damage is the brain. Persons with metaboli...

Levosimendan in Critical Illness: A Literature Review.

Levosimendan, the active enantiomer of simendan, is a calcium sensitizer developed for treatment of decompensated heart failure, exerts its effects independently of the beta adrenergic receptor and se...

Experience with rituximab in the treatment of antineutrophil cytoplasmic antibody associated vasculitis.

Prior to the 1970s, severe cases of antineutrophil cytoplasmic antibody associated vasculitis (AAV) were thought to be invariably fatal. However, the use of cyclophosphamide-based treatment regimens f...

Thyroid hormone regulation of metabolism.

Thyroid hormone (TH) is required for normal development as well as regulating metabolism in the adult. The thyroid hormone receptor (TR) isoforms, α and β, are differentially expressed in tissues an...

Sympathetic neural activity to the cardiovascular system: integrator of systemic physiology and interindividual characteristics.

The sympathetic nervous system is a ubiquitous, integrating controller of myriad physiological functions. In the present article, we review the physiology of sympathetic neural control of cardiovascul...

News Articles [62 Associated News Articles listed on BioPortfolio]

Brimonidine gel launched for reduction of erythema associated with rosacea

Patients with rosacea can now be treated for the facial redness caused by the condition. Brimonidine gel received a licence from the European Medicines Agency in February 2014 after it was shown t...

ARCA biopharma Announces Screening of First Patient in Phase 2B/3 Clinical Trial Evaluating Gencaro in Atrial Fibrillation

Gencaro Potentially First Genetically Targeted Treatment for Atrial Fibrillation Atrial Fibrillation Estimated Global Prevalence of 33.5 Million Patients in 2010...

Acute Wounding Alters the Beta2-Adrenergic Signaling and Catecholamine Synthetic Pathways in Keratinocytes

Phenylephrine Hydrochloride Ophthalmic Solution, USP 2.5 percent and 10 percent Readily Available

PORTLAND, Ore., April 9, 2014 /PRNewswire/ -- Paragon BioTeck, Inc., a privately held biopharmaceutical company specializing in the development of ophthalmic pharmaceuticals and therapies, receiv...

Senomyx Enters Into Research Agreement With PepsiCo To Identify New Salt Flavor Modifiers

SAN DIEGO, April 9, 2014 /PRNewswire/ -- Senomyx, Inc. (NASDAQ: SNMX), a leading company in using proprietary taste science technologies to discover, develop and commercialize novel flavor i...

Energizing sick mitochondria with vitamin B3: Effective treatment for mitochondrial disease

Vitamin B3 form nicotinamide riboside can slow down the progression of mitochondrial disease, suggesting its potential as a novel therapy approach to adult-onset mitochondrial muscle diseases, new res...

Observation Service Is Back In Spot Light!

DURHAM, N.C., April 7, 2014 /PRNewswire-iReach/ -- The use of observation is often misunderstood, especially the difference between observation services and inpatient admission. The Key Indicator Repo...

SENOMYX TO WEBCAST CORPORATE PRESENTATION AT THE 13TH ANNUAL NEEDHAM HEALTHCARE CONFERENCE

SAN DIEGO, April 3, 2014 /PRNewswire/ -- Senomyx, Inc. (NASDAQ: SNMX), a leading company using proprietary taste science technologies to discover, develop, and commercialize novel flavor ingredients f...

Global Market for Nanocellulose to 2020: Worldwide Industry Share, Investment Trends, Growth, Size, Strategy and Forecast Research Report 2020

Markets Research Reports.biz added deep and professional market research reports on "Global Market For Nanocellulose To 2020" Market Analysis and Overview. Albany, NY (PRWEB) April 02, 2014...

Which Social Networks Are Best For Drug And Medical Information?

April Flowers for redOrbit.com - Your Universe Online The Internet abounds with a wealth of information — true and otherwise — about healthcare. So where should you turn to find the latest inform...

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Companies [2 Associated Companies listed on BioPortfolio]

Innate Immunotherapeutics Limited

Innate Immunotherapeutics Limited is a public unlisted biopharmaceutical company based in Auckland, New Zealand. The company is focused on the development of a new generation of i...

Innate Therapeutics Limited

Innate Therapeutics Limited is a public unlisted biopharmaceutical company based in Auckland. The company is focused on the development of a new generation of immune response modi...

Clinical Trials [79 Associated Clinical Trials listed on BioPortfolio]

Behavior and Exercise Versus Drug Treatment in Men With Nocturia (BEDTiMe)

Nocturia, waking at night from sleep to void, is a prevalent and troublesome symptom. Treatment with an alpha-adrenergic antagonist medication (α-blockers) is a standard therapy for LUTS...

Study to Evaluate Esmolol (Brevibloc) to Manage Cardiac Function in Patients With Subarachnoid Hemorrhage

The purpose of this study is to evaluate the clinical effect of esmolol treatment on cardiac function and electrophysiology; to assess the effects of esmolol treatment on serum adrenergic...

Spanish Cohort for the Study of the Effect of CPAP in Hypertension (CEPECTA)

AIMS:To know the effects of the treatment with nasal positive continuous airway pressure (CPAP) on systemic blood pressure and the expression of biological mediators, in systemic hypertens...

The Effect of Antecedent Hypoglycaemia on β2-Adrenergic Sensitivity

Hypoglycaemia unawareness is a common complication in patients with type 1 diabetes and with insulin-treated type 2 diabetes of long duration. The loss of autonomic symptoms to hypoglycemi...

Levosimendan in High Risk Heart Valve Surgery

Prospective, randomized, double blind study investigating the efficacy of levosimendan in heart failure after cardiac surgery. Study hypothesis: Levosimendan diminishes the need for adren...

The Effect of Alfa-Adrenergic Receptor Blockade on Insulin-Stimulated Forearm Glucose Uptake and Metabolism in Chronic Heart Failure

The activity of the sympathetic nervous system seems to influence the uptake (and handling) of glucose by the skeletal muscle of the forearm. Conditions in which sympathetic activity is in...

The Role of Norepinephrine in Emotional Processing

This study will examine the role of a brain chemical called norepinephrine in thinking, decision-making, and emotional processing. After norepinephrine is released from a brain cell, it bi...

Trial to Compare Alfuzosin Versus Placebo in the Treatment of Chronic Prostatitis/Chronic Pelvic Pain Syndrome

The purpose of this randomized clinical trial is to evaluate the efficacy and safety of the alpha adrenergic blocker Alfuzosin (Uroxatral) in men with relatively new onset of chronic prost...

Brain Receptors in Sympathetic Nervous System Regulation

The purpose of this study is to investigate the role of brain receptors called alpha2-adrenoreceptors in regulating the sympathetic nervous system, which maintains the supply of blood and...

Study of Alpha-2 Adrenergic Receptor Dysfunction in Regional Lipoatrophy

OBJECTIVES: I. Determine the response in plasma norepinephrine concentration and plasma glycerol to the agonist (clonidine) and the antagonist (yohimbine) of the alpha-2 adrenergic recept...

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How to Pronounce Lead

Learn how to say Lead correctly with EmmaSaying's "how do you pronounce" free tutorials. Definition of lead (oxford dictionary): verb (past and past particip...

Medical and Biotech [MESH] Definitions

Drugs that act on adrenergic receptors or affect the life cycle of adrenergic transmitters. Included here are adrenergic agonists and antagonists and agents that affect the synthesis, storage, uptake, metabolism, or release of adrenergic transmitters.

Drugs that bind to but do not activate ADRENERGIC RECEPTORS. Adrenergic antagonists block the actions of the endogenous adrenergic transmitters EPINEPHRINE and NOREPINEPHRINE.

A subclass of beta-adrenergic receptors (RECEPTORS, ADRENERGIC, BETA). beta-3 Adrenergic receptors are the predominant beta-adrenergic receptor type expressed in white and brown ADIPOCYTES and are involved in modulating ENERGY METABOLISM and THERMOGENESIS.

Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.

Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.

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