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Adrenergic modifiers - Biotech, Pharma and Life Science Channel

01:33 EDT 26th September 2016 | BioPortfolio

PubMed Articles [300 Associated PubMed Articles listed on BioPortfolio]

Simultaneous determination of iron and nickel in fluoropolymers by solid sampling high-resolution continuum source graphite furnace atomic absorption spectrometry.

This paper reports the development of a method of simultaneous determination of iron and nickel in fluoropolymers by high-resolution continuum source graphite furnace atomic absorption spectrometry (H...

Selective determination of four arsenic species in rice and water samples by modified graphite electrode-based electrolytic hydride generation coupled with atomic fluorescence spectrometry.

This work describes a novel non-chromatographic approach for the accurate and selective determining As species by modified graphite electrode-based electrolytic hydride generation (EHG) for sample int...

Chronic stress accelerates the development of endometriosis in mouse through adrenergic receptor β2.

Does chronic stress in mice accelerate the development of endometriosis, and, if so, through what mechanism?

β1-adrenoceptor Arg389Gly polymorphism confers differential β-arrestin-binding tropism in cardiac myocytes.

The β1-adrenergic receptor (AR) Arg389Gly polymorphism affects efficacy of its procontractile signaling in cardiomyocytes and carriers' responses to β-blockers. To identify molecular mechanisms unde...

Anti-inflammatory activities of fenoterol through β-arrestin-2 and inhibition of AMPK and NF-κB activation in AICAR-induced THP-1 cells.

The AMP-activated protein kinase (AMPK) pathway has been shown to be able to regulate inflammation in several cell lines. We reported that fenoterol, a β2-adrenergic receptor (β2-AR) agonist, inhibi...

Cis-Acting Single Nucleotide Polymorphisms Alter MicroRNA-Mediated Regulation of Human Brain-Expressed Transcripts.

Substantial variability exists in the presentation of complex neurological disorders, and the study of single nucleotide polymorphisms (SNPs) has shed light on disease mechanisms and pathophysiologica...

Gut hormone GPCRs: structure, function, drug discovery.

Crystallization and determination of the high resolution three-dimensional structure of the β2-adrenergic receptor in 2007 was followed by structure elucidation of a number of other receptors, includ...

Chemical-space-based de novo design method to generate drug-like molecules.

To discover drug compounds in chemical space containing an enormous number of compounds, a structure generator is required to produce virtual drug-like chemical structures. The de novo design algorith...

Cognitive, behaviour, and academic functioning in adolescent and young adult survivors of childhood acute lymphoblastic leukaemia: a report from the Childhood Cancer Survivor Study.

Survivors of childhood acute lymphoblastic leukaemia (ALL) are at risk for neurocognitive deficits that affect development in adolescence and young adulthood, and influence educational attainment and ...

Role of protein phosphatase inhibitor-1 in cardiac beta adrenergic pathway.

Phosphoproteomic studies have shown that about one third of all cardiac proteins are reversibly phosphorylated, affecting virtually every cellular signaling pathway. The reversibility of this process ...

News Articles [50 Associated News Articles listed on BioPortfolio]

FSH Society Commits Over $1.36 Million in Funding for New FSH Muscular Dystrophy Research

Boston-based Non-Profit Awards Record Amount in Search for a Cure Boston, MA (PRWEB) September 20, 2016 The FSH Society, the Massachusetts-based non-profit and global leader in the quest to cure Faci...

Beta-adrenergic signaling promotes tumor angiogenesis and prostate cancer progression through HDAC2-mediated suppression of thrombospondin-1

Polyisobutylene Market Analysis By Product, By Application And Segment Forecasts To 2024

LONDON, Sept. 15, 2016 /PRNewswire/ -- The global polyisobutylene (PIB) market is expected to reach USD 7.71 billion by 2024, according to a new report by Grand View Research, Inc. Rising ...

Virtual Bootcamp on ICD-10, CPT Coding Updates 2017—The Coding Institute to Host Year’s Biggest Virtual Coding Event

The Coding Institute will host the year’s biggest Virtual Boot Camp on Specialty Specific ICD-10 and CPT Coding Updates for Urology, Pathology, Orthopedics, Ob-Gyn, Pediatrics, Pain Management, and ...

Flutiform misses in COPD study

Vectura Group plc (LSE:VEC) said Flutiform fluticasone/formoterol missed the primary endpoint in a Phase III study to treat chronic obstructive pulmonary disease (COPD), and said partner Mundiph

What journalists and consumers should know about the tug-of-war between biologics and generic ‘biosimilars’

When the body attacks itself–known as an autoimmune disease–one of the most powerful drug options patients have is what’s known commonly as a “biologic drug.” In the last...

USMLE Step 1 stumper: Can you answer it correctly?

The United States Medical Licensing Examination® (USMLE®) Step 1 exam is notorious for pushing the limits of medical students’ knowledge, so you might like to know which test prep questions are ...

Adrenergic receptor α 2 (ADRA2)

Mouse studies suggest inhibiting

Molecular modifiers reveal a mechanism of pathological crystal growth inhibition

Crystalline materials are crucial to the function of living organisms, in the shells of molluscs, the matrix of bone, the teeth of sea urchins, and the exoskeletons of coccoliths. However, pathologica...

Rising Healthcare Expenditure and Worldwide Diseases Prevalence to Boost Hospital Pharmaceutical Drugs Market to USD 235 Billion by 2020 - iHealthcareAnalyst, Inc.

Maryland Heights, MO, August 07, 2016 --(PR.com)-- According to a new market research report published by iHealthcareAnalyst, Inc., Hospital Pharmaceutical Drugs Market – Global Hospital-Associ...

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Companies [3 Associated Companies listed on BioPortfolio]

Partikula LLC

Partikula is a preclinical stage biotechnology company focused on developing novel therapies for cancer and other diseases based on platform chemistry technologies, including its ...

Innate Immunotherapeutics Limited

Innate Immunotherapeutics Limited is a public unlisted biopharmaceutical company based in Auckland, New Zealand. The company is focused on the development of a new generation of i...

Innate Therapeutics Limited

Innate Therapeutics Limited is a public unlisted biopharmaceutical company based in Auckland. The company is focused on the development of a new generation of immune response modi...

Clinical Trials [125 Associated Clinical Trials listed on BioPortfolio]

Study of a Propranolol (HEMANGIOL®) and Oral Metronomic Vinorelbine (NAVELBINE®) Combination for Children and Teenagers With Refractory/Relapsing Solid Tumors

Cancer remains the first cause of death due to disease in children and adolescents despite important progress and 70% of the survivors present sequelae. It is therefore mandatory to genera...

Renal Nerve Stimulation and Renal Denervation in Patients With Sympathetic Ventricular Arrhythmias

Rationale: Sympathetic activity plays an important role in the pathogenesis of ventricular tachyarrhythmia. Previous studies have shown evidence of significant heritable influences on ...

Effects of Dexmedetomidine as Adjunct to Pudendal Block for Pediatric Penile Surgery

Caudal block is often performed to relieve postoperative pain in pediatric urological surgery. Recently, pudendal block is also used in penile surgery and it has advantage because of less ...

Pharmacological Activation of Brown Adipose Tissue Metabolism

Lean tissue intracellular triglycerides (ICTG) accretion is an important marker of lean tissue lipotoxicity that significantly contributes to the development of type 2 diabetes (T2D). The ...

Using Reconsolidation Blockade to Treat Trauma Related Disorders After Paris Attacks: an Effectiveness Study

The purpose of this study is: (1) to examine the effectiveness of reconsolidation blockade as a treatment for trauma-related disorders, (2) to evaluate the feasibility of implementing this...

A Pilot Study of the Effects of Mirabegron on Symptoms in Patients With Interstitial Cystitis

Bladder pain syndrome/interstitial cystitis (BPS/IC) is a difficult disease to both diagnose and treat. It is defined as an unpleasant sensation (pain, pressure, or discomfort) perceived t...

The Effects of Dexmedetomidine on Intestine and Other Organ Damages After Cardiac Surgeries

Cardiac surgery with cardiopulmonary bypass (CPB) provokes a systemic inflammatory response that can often lead to dysfunction of major organs. Activation of the contact system, endotoxemi...

Use of Preanesthetic Dexmedetomidine in Elderly, Treated-hypertensive Patients

Background: Dexmedetomidine is an alpha 2 adrenergic agonist with sedative, anxiolytic, and analgesic properties. This study was designed to evaluate the inhibitory effects of preoperative...

Rasch-analysis of Clinical Severity in FSHD

The purpose of this study is to make a standardized and scalable Rasch-built clinical severity scale to help in finding genetic and environmental modifiers of disease in Facioscapulohumera...

Cardiac Output Changes in Cesarean Section

Since 2011, phenylephrine was recommended as the preferred drug to maintain blood pressure in obstetric anesthesia.Phenylephrine, an α adrenoceptor agonist, can induce peripheral vasocons...

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Medical and Biotech [MESH] Definitions

Drugs that act on adrenergic receptors or affect the life cycle of adrenergic transmitters. Included here are adrenergic agonists and antagonists and agents that affect the synthesis, storage, uptake, metabolism, or release of adrenergic transmitters.

Drugs that bind to but do not activate ADRENERGIC RECEPTORS. Adrenergic antagonists block the actions of the endogenous adrenergic transmitters EPINEPHRINE and NOREPINEPHRINE.

A subclass of beta-adrenergic receptors (RECEPTORS, ADRENERGIC, BETA). beta-3 Adrenergic receptors are the predominant beta-adrenergic receptor type expressed in white and brown ADIPOCYTES and are involved in modulating ENERGY METABOLISM and THERMOGENESIS.

Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.

Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.

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