Adrenergic modifiers - Biotech, Pharma and Life Science Channel

23:21 EDT 31st October 2014 | BioPortfolio

PubMed Articles [367 Associated PubMed Articles listed on BioPortfolio]

Direct detection of free fatty acids in edible oils using supercritical fluid chromatography coupled with mass spectrometry.

Determination of free fatty acids (FFAs) in food products is of enormous interest mainly because they are related to the quality and authenticity of the oils. In this study, supercritical fluid chroma...

Begin Preparing for 2015 Coding Changes: Use 4 New Modifiers Instead of Modifier 59.

The function of chromatin modifiers in lineage commitment and cell fate specification.

Proteins that modify the structure of chromatin are known to be important for various aspects of metazoan biology including development, disease, and possibly ageing. Yet functional details of why the...

Chemistry, Physiology, and Pharmacology of β-Adrenergic Mechanisms in the Heart. Why are β-Blocker Antiarrhythmics Superior?

Stimulation of β-adrenergic receptors in the heart is the most effective endogenous way to increase the mechanical performance of cardiac tissues to meet the requirements of a fight-or-flight situati...

Characterization of a Prawn OA/TA Receptor in Xenopus Oocytes Suggests Functional Selectivity between Octopamine and Tyramine.

Here we report the characterization of an octopamine/tyramine (OA/TA or TyrR1) receptor (OA/TAMac) cloned from the freshwater prawn, Macrobrachium rosenbergii, an animal used in the study of agonistic...

β2-Adrenergic Receptor-Dependent Attenuation of Hypoxic Pulmonary Vasoconstriction Prevents Progression of Pulmonary Arterial Hypertension in Intermittent Hypoxic Rats.

In sleep apnea syndrome (SAS), intermittent hypoxia (IH) induces repeated episodes of hypoxic pulmonary vasoconstriction (HPV) during sleep, which presumably contribute to pulmonary arterial hypertens...

Ivabradine Improves Left Ventricular Function During Chronic Hypertension in Conscious Pigs.

During chronic hypertension, increases in heart rate (HR) or adrenergic stimulation are associated with maladaptive left ventricular responses as isovolumic contraction and relaxation durations failed...

Insights into the Role of Asp79(2.50) in β2 Adrenergic Receptor Activation from Molecular Dynamics Simulations.

Achieving a molecular level understanding of G-protein coupled receptor (GPCR) activation has been a long-standing goal in biology and could be important for the development of novel drugs. Recent bre...

Does hypercholesterolemia affect the relaxation of the detrusor smooth muscle in rats? In vitro and in vivo studies.

To evaluate the effects of hypercholesterolemia on the relaxation function of the urinary bladder, we examined the physiological mechanisms involved in the isoproterenol-induced relaxation in isolated...

Genetic characterization of Spinocerebellar ataxia 1 in a South Indian cohort.

BackgroundSpinocerebellar ataxia type 1 (SCA1) is a late onset autosomal dominant cerebellar ataxia, caused by CAG triplet repeat expansion in the ATXN1 gene. The frequency of SCA1 occurrence is more ...

News Articles [70 Associated News Articles listed on BioPortfolio]

Onxeo S.A.: Positive Phase II preliminary results of Validive® For the prevention of Severe Oral Mucositis in Head and Neck cancer patients

Significant reduction of incidence of severe mucositis Improved oral mucositis related symptoms and decreased adverse events related to radiotherapy ...

New Biotage® SNAP ULTRA C18 Cartridges – High Performance Reversed Phase Flash Purification

  Uppsala, Sweden, October 30, 2014 / B3C newswire / - Biotage (STO: BIOT), a leading global supplier of solutions and technology for analytical, medicinal and peptide chemistry, announces the l...

The contribution of de novo coding mutations to autism spectrum disorder

Family-based exome sequencing in a large autism study has identified 27 high-confidence gene targets and accurately estimates the contribution of both de novo gene-disrupting and missense mutations to...

Sunovion Pharmaceuticals Inc. to Present Data for COPD Portfolio and Pipeline at CHEST 2014

Data Presented by Sunovion Further Demonstrates Commitment to Providing Treatment Options for Patients with COPD Sunovion Pharmaceuticals Inc. (Sunovion) announced today that ...

The Nuts and Bolts of Global Surgical Package Requirements

Expert speaker Dr. Duane Abbey is reviewing the Global Surgical Package Concept in healthcare payment system on Tue, Oct 21 on behalf of AudioEducator.com. Durham, NC (PRWEB) October 20, 2014 In a ma...

Neothetics, PolyPid file for IPOs

Neothetics Inc. (San Diego, Calif.) and PolyPid Ltd. (Petach Tikva, Israel) filed for IPOs on NASDAQ. Neothetics filed to raise up to $63.3 million with Piper Jaffray; Guggenheim Securities; and Need...

Anoro's COPD Drug Shows Improved Lung Function

Respiratory Medicine has published positive results from a third lung function study comparing the efficacy and safety of Anoro Ellipta (umeclidinium /vilanterol, ‘UMEC/VI’), the combination long-...

Xolair (Asthma) - Forecast and Market Analysis to 2023

Recently added to the BioPortfolio report store, Xolair (Asthma) - Forecast and Market Analysis to 2023 is a new report from GlobalData published on 2014-08-30. This 52-page report is available in PD...

Singulair (Asthma) - Forecast and Market Analysis to 2023

Recently added to the BioPortfolio report store, Singulair (Asthma) - Forecast and Market Analysis to 2023 is a new report from GlobalData published on 2014-08-30. This 54-page report is available in...

Spiriva (Asthma) - Forecast and Market Analysis to 2023

Recently added to the BioPortfolio report store, Spiriva (Asthma) - Forecast and Market Analysis to 2023 is a new report from GlobalData published on 2014-08-30. This 55-page report is available in P...

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Companies [2 Associated Companies listed on BioPortfolio]

Innate Immunotherapeutics Limited

Innate Immunotherapeutics Limited is a public unlisted biopharmaceutical company based in Auckland, New Zealand. The company is focused on the development of a new generation of i...

Innate Therapeutics Limited

Innate Therapeutics Limited is a public unlisted biopharmaceutical company based in Auckland. The company is focused on the development of a new generation of immune response modi...

Clinical Trials [80 Associated Clinical Trials listed on BioPortfolio]

Combination of Dronabinol and Clonidine for Cannabis Dependence in Patients With Schizophrenia

Cannabis use disorders are an important public health problem in the United States, but no effective pharmacotherapies are available to treat these disorders. People with schizophrenia ar...

Terlipressin + Albumin Versus Midodrine + Octreotide in the Treatment of Hepatorenal Syndrome

From 1999, several studies have showed that the use of vasoconstrictors in association with albumin are effective in the treatment of hepatorenal syndrome (HRS). The rationale of the use o...

Stress During Deep Sedation With Propofol With and Without Alfentanil

This is a randomized clinical trial of deep procedural sedation with propofol with and without supplemental alfentanil. Patients will be assessed for total and fractionated serum catechol...

Study to Evaluate Esmolol (Brevibloc) to Manage Cardiac Function in Patients With Subarachnoid Hemorrhage

The purpose of this study is to evaluate the clinical effect of esmolol treatment on cardiac function and electrophysiology; to assess the effects of esmolol treatment on serum adrenergic ...

Atrial Fibrillation Follow-Up Investigation of Rhythm Management (AFFIRM)

To compare two standard treatment strategies for atrial fibrillation: ventricular rate control and anticoagulation vs. rhythm control and anticoagulation.

Study of Alpha-2 Adrenergic Receptor Dysfunction in Regional Lipoatrophy

OBJECTIVES: I. Determine the response in plasma norepinephrine concentration and plasma glycerol to the agonist (clonidine) and the antagonist (yohimbine) of the alpha-2 adrenergic recept...

Occluded Artery Trial (OAT)

The purpose of this study is to determine whether opening an occluded infarcted artery 3-28 days after an acute myocardial infarction in high-risk asymptomatic patients reduces the composi...

Active Immunotherapy Of Metastatic Renal Cell Carcinoma Using Autologous Dendritic Cells Transfected With Autologous Total Tumor RNA

The feasibility and dose-limiting toxicity of administering escalating doses of dendritic cells transfected with autologous renal cell carcinoma RNA DC(DCRCC-RNA) will be defined. As a sec...

Brain Receptors in Sympathetic Nervous System Regulation

The purpose of this study is to investigate the role of brain receptors called alpha2-adrenoreceptors in regulating the sympathetic nervous system, which maintains the supply of blood and ...

Gene Modifiers of Cystic Fibrosis Lung Disease

Ths purpose of this study is to examine genetic modifiers of the severity of cystic fibrosis lung disease.

Medical and Biotech [MESH] Definitions

Drugs that act on adrenergic receptors or affect the life cycle of adrenergic transmitters. Included here are adrenergic agonists and antagonists and agents that affect the synthesis, storage, uptake, metabolism, or release of adrenergic transmitters.

Drugs that bind to but do not activate ADRENERGIC RECEPTORS. Adrenergic antagonists block the actions of the endogenous adrenergic transmitters EPINEPHRINE and NOREPINEPHRINE.

A subclass of beta-adrenergic receptors (RECEPTORS, ADRENERGIC, BETA). beta-3 Adrenergic receptors are the predominant beta-adrenergic receptor type expressed in white and brown ADIPOCYTES and are involved in modulating ENERGY METABOLISM and THERMOGENESIS.

Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.

Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.

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