Adrenergic modifiers - Biotech, Pharma and Life Science Channel

05:55 EST 30th January 2015 | BioPortfolio

PubMed Articles [374 Associated PubMed Articles listed on BioPortfolio]

Direct detection of free fatty acids in edible oils using supercritical fluid chromatography coupled with mass spectrometry.

Determination of free fatty acids (FFAs) in food products is of enormous interest mainly because they are related to the quality and authenticity of the oils. In this study, supercritical fluid chroma...

Noradrenergic and cholinergic effects on speed and sensitivity measures of phasic alerting.

An intense but task-irrelevant auditory accessory stimulus that is presented almost simultaneously with a visual imperative stimulus can reduce reaction times (RTs) to that stimulus. The information-p...

Silk Fibroin Scaffolds Promote Formation of the Ex Vivo Niche for Salivary Gland Epithelial Cell Growth, Matrix Formation, and Retention of Differentiated Function.

Abstract Salivary gland hypofunction often results from a number of causes including the use of various medications, radiation for head and neck tumors, autoimmune diseases, diabetes, and aging. Since...

Model selection emphasises the importance of non-chromosomal information in genetic studies.

Ever since the case of the missing heritability was highlighted some years ago, scientists have been investigating various possible explanations for the issue. However, none of these explanations incl...

The long intergenic noncoding RNA landscape of human lymphocytes highlights the regulation of T cell differentiation by linc-MAF-4.

Long noncoding RNAs are emerging as important regulators of cellular functions, but little is known of their role in the human immune system. Here we investigated long intergenic noncoding RNAs (lincR...

Nedd4 Haploinsufficient Mice Display Moderate Insulin Resistance, Enhanced Lipolysis, and Protection against High-fat Diet Induced Obesity.

Nedd4 is the prototypical protein in the Nedd4 ubiquitin ligase (E3) family, which governs ubiquitin-dependent endocytosis and/or degradation of plasma membrane proteins. Loss of Nedd4 results in embr...

Sim1 Inhibits Bone Formation by Enhancing the Sympathetic Tone in Male Mice.

Sim1 is a bHLH-PAS transcription factor that is important for neuronal development in the hypothalamus. Loss-of-function mutation of Sim1 causes early onset obesity. However, it is unknown whether and...

PRP4K is a HER2-regulated modifier of taxane sensitivity.

ABSTRACT The taxanes are used alone or in combination with anthracyclines or platinum drugs to treat breast and ovarian cancer, respectively. Taxanes target microtubules in cancer cells and modifiers ...

Variable Expression of PIK3R3 and PTEN in Ewing Sarcoma Impacts Oncogenic Phenotypes.

Ewing Sarcoma is an aggressive malignancy of bone and soft tissue affecting children and young adults. Ewing Sarcoma is driven by EWS/Ets fusion oncoproteins, which cause widespread alterations in gen...

Norepinephrine enhances angiotensin II responses via p38 MAPK activation after hypoxia/re-oxygenation in renal interlobar arteries.

Hypoxia and sympathetic activation are main factors in the pathogenesis of acute kidney injury (AKI). We tested the hypothesis that norepinephrine (NE) in combination with hypoxia aggravates the vasor...

News Articles [59 Associated News Articles listed on BioPortfolio]

New book on retinal disorders from Cold Spring Harbor Laboratory Press

(Cold Spring Harbor Laboratory) 'Retinal Disorders' from Cold Spring Harbor Laboratory Press reviews recent work on retinal diseases, describing their genetic and molecular basis, their clinical chara...

Vicus Therapeutics Announces Safety and Survival Benefit of VT-122 in Combination with Anti-Cancer Therapies for Advanced Liver and Pancreatic Cancers

MORRISTOWN, N.J., Jan. 16, 2015 /PRNewswire/ -- Vicus Therapeutics, an immuno-oncology company focused on bringing breakthrough immunotherapies to patients with solid-tumor cancers, today announc...

Odd Structures, Subjected to Powerful Computations

Here's a paper in Nature Chemistry on computational simulation of GPCR activation, using the beta-2 receptor as a model. I'm writing as someone who's worked on GPCRs, who is interested in such mechani...

Anesthesia Business Consultants Advises Anesthesiologists of Medicare Elimination of Patient Cost-Sharing for Anesthesia for Screening Colonoscopies

Anesthesia Business Consultants (ABC) advises in its weekly Alert,

Cocaine Increases Dopaminergic Neuron and Motor Activity via Midbrain α1 Adrenergic Signaling

PharmaPoint: Asthma - Global Drug Forecast and Market Analysis to 2023

Recently added to the BioPortfolio report store, PharmaPoint: Asthma - Global Drug Forecast and Market Analysis to 2023 is a new report from GlobalData published on 2014-08-30. This 383-page report i...

Neothetics loses ground after $65.1M IPO

Neothetics Inc. (NASDAQ:NEOT) fell $2 (14%) to $12 in its first day of trading on Thursday after it raised $65.1 million through the sale of 4.7 million shares at $14 in an IPO. The deal valued Neothe...

Onxeo proposes EUR 35.4M rights offering

Orphan cancer company Onxeo S.A. (Euronext:ONXEO) proposed to raise EUR 35.4 million ($44.1 million) in a rights offering underwritten by Natixis and Oddo & Cie. The company plans to issue 7.9 million...

Medicare Clarifies Billing Modifiers for Therapy Services

Hospital Pharmaceuticals Market (Cardiology, Oncology, Nephrology & Urology, Neurology, pain and Infection) - Global Industry Analysis, Size, Share, Growth, Trends and Forecast, 2014 - 2020

      LONDON, Nov. 12, 2014 /PRNewswire/ -- Pharmaceutical drug sales are sold through various channels such as retail, mail orders, clinics and hospitals. Retail channe...

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Companies [2 Associated Companies listed on BioPortfolio]

Innate Immunotherapeutics Limited

Innate Immunotherapeutics Limited is a public unlisted biopharmaceutical company based in Auckland, New Zealand. The company is focused on the development of a new generation of i...

Innate Therapeutics Limited

Innate Therapeutics Limited is a public unlisted biopharmaceutical company based in Auckland. The company is focused on the development of a new generation of immune response modi...

Clinical Trials [82 Associated Clinical Trials listed on BioPortfolio]

Molecular Immunohematology in Ethiopian Sub-Populations

Alloimmunization to blood products in transfused patients is a recognized management challenge in the clinical setting. In particular the ethnic and racial specificity of RBC antigens and ...

Combination of Dronabinol and Clonidine for Cannabis Dependence in Patients With Schizophrenia

Cannabis use disorders are an important public health problem in the United States, but no effective pharmacotherapies are available to treat these disorders. People with schizophrenia ar...

Terlipressin + Albumin Versus Midodrine + Octreotide in the Treatment of Hepatorenal Syndrome

From 1999, several studies have showed that the use of vasoconstrictors in association with albumin are effective in the treatment of hepatorenal syndrome (HRS). The rationale of the use o...

Stress During Deep Sedation With Propofol With and Without Alfentanil

This is a randomized clinical trial of deep procedural sedation with propofol with and without supplemental alfentanil. Patients will be assessed for total and fractionated serum catechol...

Study to Evaluate Esmolol (Brevibloc) to Manage Cardiac Function in Patients With Subarachnoid Hemorrhage

The purpose of this study is to evaluate the clinical effect of esmolol treatment on cardiac function and electrophysiology; to assess the effects of esmolol treatment on serum adrenergic ...

Atrial Fibrillation Follow-Up Investigation of Rhythm Management (AFFIRM)

To compare two standard treatment strategies for atrial fibrillation: ventricular rate control and anticoagulation vs. rhythm control and anticoagulation.

Study of Alpha-2 Adrenergic Receptor Dysfunction in Regional Lipoatrophy

OBJECTIVES: I. Determine the response in plasma norepinephrine concentration and plasma glycerol to the agonist (clonidine) and the antagonist (yohimbine) of the alpha-2 adrenergic recept...

Occluded Artery Trial (OAT)

The purpose of this study is to determine whether opening an occluded infarcted artery 3-28 days after an acute myocardial infarction in high-risk asymptomatic patients reduces the composi...

Active Immunotherapy Of Metastatic Renal Cell Carcinoma Using Autologous Dendritic Cells Transfected With Autologous Total Tumor RNA

The feasibility and dose-limiting toxicity of administering escalating doses of dendritic cells transfected with autologous renal cell carcinoma RNA DC(DCRCC-RNA) will be defined. As a sec...

Brain Receptors in Sympathetic Nervous System Regulation

The purpose of this study is to investigate the role of brain receptors called alpha2-adrenoreceptors in regulating the sympathetic nervous system, which maintains the supply of blood and ...

Medical and Biotech [MESH] Definitions

Drugs that act on adrenergic receptors or affect the life cycle of adrenergic transmitters. Included here are adrenergic agonists and antagonists and agents that affect the synthesis, storage, uptake, metabolism, or release of adrenergic transmitters.

Drugs that bind to but do not activate ADRENERGIC RECEPTORS. Adrenergic antagonists block the actions of the endogenous adrenergic transmitters EPINEPHRINE and NOREPINEPHRINE.

A subclass of beta-adrenergic receptors (RECEPTORS, ADRENERGIC, BETA). beta-3 Adrenergic receptors are the predominant beta-adrenergic receptor type expressed in white and brown ADIPOCYTES and are involved in modulating ENERGY METABOLISM and THERMOGENESIS.

Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.

Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.

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