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Adrenergic modifiers - Biotech, Pharma and Life Science Channel

18:35 EDT 26th May 2017 | BioPortfolio

PubMed Articles [325 Associated PubMed Articles listed on BioPortfolio]

Associations among left ventricular systolic function, tachycardia, and cardiac preload in septic patients.

In sepsis, tachycardia may indicate low preload, adrenergic stimulation, or both. Adrenergic overstimulation is associated with septic cardiomyopathy. We sought to determine whether tachycardia was as...

Epigenetics of reproductive infertility.

Infertility is a complex pathophysiological condition. It may caused by specific or multiple physical and physiological factors, including abnormalities in homeostasis, hormonal imbalances and genetic...

Hypertension management in a population of older adults in rural South Africa.

Assess awareness, treatment, and control of hypertension, as an indication of its management, in rural South Africa, especially regarding modifiers of these variables.

Racial and Ethnic Differences in Mortality Associated with Serum Potassium in a Large Hemodialysis Cohort.

Hyperkalemia is observed in chronic kidney disease patients and may be a risk factor for life-threatening arrhythmias and death. Race/ethnicity may be important modifiers of the potassium-mortality re...

Cardiac hyporesponsiveness in severe sepsis is associated with nitric oxide-dependent activation of G-protein receptor kinase.

G protein-coupled receptor kinase isoform 2 (GRK2) has a critical role in physiological and pharmacological responses to endogenous and exogenous substances. Sepsis causes an important cardiovascular ...

A Novel Combination of Withaferin A and Sulforaphane Inhibits Epigenetic Machinery, Cellular Viability and Induces Apoptosis of Breast Cancer Cells.

With cancer often classified as a disease that has an important epigenetic component, natural compounds that have the ability to regulate the epigenome become ideal candidates for study. Humans have a...

Beta Blockers and Improved Progression Free Survival in Patients with Advanced HER2 Negative Breast Cancer: a Retrospective Analysis of the ROSE/TRIO-012 Study.

Recent retrospective studies suggest that beta-adrenergic blocking drugs (BB) are associated with improved outcomes in people with a range of cancers. Although limited and discordant data suggest that...

Intracoronary Hypothermia Before Reperfusion to Reduce Reperfusion Injury in Acute Myocardial Infarction: A Novel Hypothesis and Technique.

Because current reperfusion strategies in acute myocardial infarction (AMI) seem to be exhausted in terms of additional mortality benefit, there remains a need for new methods to attenuate reperfusion...

Angiopoietin-like 8 (Angptl8) controls adipocyte lipolysis and phospholipid composition.

Angiopoietin-like 8 (Angptl8) inhibits lipolysis in the circulation together with Angplt3 and controls post-prandial fat storage in white adipose tissue (WAT). It is strongly induced by insulin in viv...

SUMO-4: A novel functional candidate in the human placental protein SUMOylation machinery.

Small ubiquitin-like modifiers (SUMOs) conjugate to proteins post-translationally, thereby affecting target localization, activity and stability. Functional SUMO family members identified in the human...

News Articles [46 Associated News Articles listed on BioPortfolio]

Driveline Additives Market: Global Industry Analysis and Opportunity Assessment 20152025 [Updated: 12022016] Prices from USD $5000

Report SynopsisFMI study offers a 10year forecast for the global driveline additives market between 2015 and 2025. The market is expected to register a CAGR of 6.9% during the projected period. The st...

Asthma Pipeline Review, H1 2017 [Updated: 16052017] Prices from USD $2500

Asthma Pipeline Review, H1 2017SummaryGlobal Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Asthma Pipeline Review, H1 2017, provides an overview of the Asthma Respirat...

Treatment of Neurodegenerative Diseases and Premature Aging by Modulating the Expression of P53 Isoform

Cellular senescence is an evolutionarily conserved mechanism that serves to limit the replicative lifespan of a cell, and is critical in limiting uncontrolled proliferation of cells such as what occur...

Arbutus Biopharma Corp ABUS Pharmaceuticals Healthcare Deals and Alliances Profile [Updated: 24042017] Prices from USD $250

SummaryArbutus Biopharma Corp Arbutus Biopharma formerly Tekmira Pharmaceuticals Corporation, is a biopharmaceutical company which focuses on the development and commercialization of proprietary drugs...

Global Modified Bitumen Market 20172021 [Updated: 03052017] Prices from USD $3500

ABSTRACTAbout Modified BitumenModified bitumen is a derivative of bitumen with modifiers that impart plastic or rubberlike properties. Atactic polypropylene APP and styrene butadiene styrene SBS are a...

Lab error leads to skin cancer discovery

A laboratory error, by US researchers, has led to the discovery of beta blocker carvedilol’s cancer-fighting properties. A new study by the researchers at the Western University of Health Sciences ...

Addivant™ Receives Formal Approval from the FDA for Use of Its Nonylphenol-Free Antioxidant WESTON® 705 in Infant Food and Breast Milk Plastic Packaging

Addivant™, the world leading supplier of liquid phosphite antioxidants for plastics, announced today that its nonylphenol-free stabilizer, WESTON® 705, has received formal appr...

Cause of Stroke Immunodeficiency Uncovered

As if the devastating effects on the brain after having a stroke weren’t enough, new research from investigators at the Roslin, located on the University of Edinburgh's Easter Bush Campus, point...

Teva simultaneously launches AirDuo RespiClick and its authorized generic

Brian BerkDrugs are used for the treatment of asthma in patients aged 12 years and older who are uncontrolled on an inhaled corticosteroid or whose disease severity clearly warrants the use of an ICS/...

Mono-unsaturated fatty acids link H3K4me3 modifiers to C. elegans lifespan

A deficiency in H3K4me3 methyltransferase causes accumulation of mono-unsaturated fatty acids, which is important for lifespan extension in C. elegans and could be relevant in mammals.

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Companies [4 Associated Companies listed on BioPortfolio]

Addivant

Addivant™ is an innovator in the field of polymer additives, developing customized solutions that provide customers enhanced application performance, safe handling, and reduc...

Partikula LLC

Partikula is a preclinical stage biotechnology company focused on developing novel therapies for cancer and other diseases based on platform chemistry technologies, including its ...

Innate Immunotherapeutics Limited

Innate Immunotherapeutics Limited is a public unlisted biopharmaceutical company based in Auckland, New Zealand. The company is focused on the development of a new generation of i...

Innate Therapeutics Limited

Innate Therapeutics Limited is a public unlisted biopharmaceutical company based in Auckland. The company is focused on the development of a new generation of immune response modi...

Clinical Trials [145 Associated Clinical Trials listed on BioPortfolio]

Prevelance of Fragmented QRS Complex and Prolonged QT Interval in Cirrhotic Patients

.Cardiac affection in liver cirrhosis is a clinical condition characterized by impaired diastolic relaxation and contractility with electrophysiological abnormalities. .Cirrhotic patients...

Comparative Low and High Dose of Dexmedethomidine in Pituitary Tumor Removal by Transphenoid Approach

Transnasal transsphenoidal (TNTS) resection of pituitary tumors involves wide fluctuation in hemodynamic parameter and causes hypertension and tachycardia due to intense noxious stimuli du...

B2 Adrenergic Receptor Gene Polymorphism in Bronchial Asthma

The b2-adrenoceptor (b2AR) mediates the physiological responses in the airway, which include bronchodilation, bronchoprotection. The b2-adrenoceptor (b2AR) mediates the physiological respo...

Efficacy of Ketamine Infusion Compared With Traditional Anti-epileptic Agents in Refractory Status Epilepticus

The study will investigate the efficacy of the NMDA receptor antagonist ketamine as a first line agent in refractory status epilepticus versus traditional general anesthetic agents used fo...

Adrenergic System in Islet Transplantation

To determine the effect of sympathetic neural and hormonal (epinephrine) input on islet cell hormonal responses to insulin-induced hypoglycemia in type 1 diabetic recipients of intrahepati...

Dexmedetomidine Versus Magnesium Sulphate for Caesarean Delivery

Regional anesthesia has become more popular in cesarean deliveries because most of the parturients prefer being awake during the birth process. In addition, regional anesthesia may be a sa...

Physiological Responses and Adaptation of Brown Adipose Tissue to Chronic Treatment With Beta 3-Adrenergic Receptor Agonists

Background: Brown adipose tissue (BAT) is a type of fat in the body. It may prevent weight gain, improve insulin sensitivity, and reduce fatty liver. Researchers want to see if BAT helps ...

Ephedrine and Phenylephrine for Spinal Hypotension

Spinal anesthesia is widely used as the procedure of choice for cesarean delivery. In comparison to epidural anesthesia it is faster, easier to perform, patients are more comfortable, comp...

Trelegy ELLIPTA ® Inhaler: Qualitative Analysis and Subject Preference Survey

Three main classes of inhaled treatment exist for chronic obstructive pulmonary disease (COPD): Beta2-adrenergic agonists (which may be short (SABA) or long (LABA) acting), long-acting mus...

Cutaneous Autonomic Pilomotor Testing to Unveil the Role of Neuropathy Progression in Early Parkinson's Disease

In Parkinson's disease (PD), alpha-synuclein accumulation in cutaneous autonomic pilomotor and sudomotor nerve fibers has been linked to autonomic nervous system disturbances even in the e...

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Medical and Biotech [MESH] Definitions

Drugs that act on adrenergic receptors or affect the life cycle of adrenergic transmitters. Included here are adrenergic agonists and antagonists and agents that affect the synthesis, storage, uptake, metabolism, or release of adrenergic transmitters.

Drugs that bind to but do not activate ADRENERGIC RECEPTORS. Adrenergic antagonists block the actions of the endogenous adrenergic transmitters EPINEPHRINE and NOREPINEPHRINE.

A subclass of beta-adrenergic receptors (RECEPTORS, ADRENERGIC, BETA). beta-3 Adrenergic receptors are the predominant beta-adrenergic receptor type expressed in white and brown ADIPOCYTES and are involved in modulating ENERGY METABOLISM and THERMOGENESIS.

Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.

Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.

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