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Adrenergic modifiers - Biotech, Pharma and Life Science Channel

15:53 EDT 31st May 2016 | BioPortfolio

PubMed Articles [347 Associated PubMed Articles listed on BioPortfolio]

Pharmacologic Therapy in Men's Health: Hypogonadism, Erectile Dysfunction, and Benign Prostatic Hyperplasia.

This article reviews current pharmacologic treatment options for 3 common men's health concerns: hypogonadism, erectile dysfunction (ED), and benign prostatic hyperplasia (BPH). Specific topics addres...

Uncoupling the structure-activity relationships of β2 adrenergic receptor ligands from membrane binding.

Ligand binding to membrane proteins may be significantly influenced by the interaction of ligands with the membrane. In particular, the microscopic ligand concentration within the membrane surface sol...

Loss of bone marrow adrenergic beta 1 and 2 receptors modifies transcriptional networks, reduces circulating inflammatory factors, and regulates blood pressure.

Hypertension (HTN) is a prevalent condition with complex etiology and pathophysiology. Evidence exists of significant communication between the nervous system and the immune system (IS), and there app...

The spectrum and clinical impact of epigenetic modifier mutations in myeloma.

Epigenetic dysregulation is known to be an important contributor to myeloma pathogenesis but, unlike in other B cell malignancies, the full spectrum of somatic mutations in epigenetic modifiers has no...

Effective Rat Lung Tumor Model for Stereotactic Body Radiation Therapy.

Stereotactic body radiation therapy (SBRT) has found an important role in the treatment of patients with non-small cell lung cancer, demonstrating improvements in dose distribution and even tumor cure...

AVN-101: A Multi-Target Drug Candidate for the Treatment of CNS Disorders.

Lack of efficacy of many new highly selective and specific drug candidates in treating diseases with poorly understood or complex etiology, as are many of central nervous system (CNS) diseases, encour...

Targeting the Sympatho-Adrenergic Link in Chronic Rheumatic Mitral Regurgitation: Assessing the Role of Oral Beta-blockers.

Chronic mitral regurgitation (MR) is characterized by adverse ventricular remodeling and progressive LV dysfunction leading to heart failure (HF). Beta-blockers (BB) improve LV remodeling and prognosi...

OBE3 and WUS Interaction in Shoot Meristem Stem Cell Regulation.

The stem cells in the shoot apical meristem (SAM) are the origin of all above ground tissues in plants. In Arabidopsis thaliana, shoot meristem stem cells are maintained by the homeobox transcription ...

SCN1A gene sequencing in 46 Turkish epilepsy patients disclosed 12 novel mutations.

The SCN1A gene is one of the most commonly mutated human epilepsy genes associated with a spectrum of phenotypes with variable degrees of severity. Despite over 1200 distinct mutations reported, it is...

Mixed Phenotype Acute Leukemia (MPAL) Exhibits Frequent Mutations in DNMT3A and Activated Signaling Genes.

Mixed phenotype acute leukemia (MPAL) is a heterogeneous group of poor-prognosis leukemias with immunophenotypic features of at least two cell lineages. The full spectrum of genetic mutations in this ...

News Articles [53 Associated News Articles listed on BioPortfolio]

Galderma announces Mirvaso gel pump dispenser for treating rosacea

Galderma Laboratories recently announced that a new pump dispenser design for Mirvaso topical gel, 0.33% is available to treat persistent erythema associated with rosacea in adults.Mirvaso (brimonidin...

Asthma Therapeutics Market Size in the Asia-Pacific Region Is Expected to Reach $5.6 Billion by 2021: Radiant Insights, Inc

SAN FRANCISCO, CA -- (Marketwired) -- 05/19/16 -- Asthma is a common chronic inflammatory disease of the airways, characterized by recurrent attacks of breathlessness and wheezing, which vary in freq...

Effect of mitochondrial stress on epigenetic modifiers

Effect of mitochondrial stress on epigenetic modifiers Larry H. Bernstein, MD, FCAP, Curator LPBI   Early Mitochondrial Stress Alters Epigenetics, Secures Lifelong Health Benefits GEN 5/3/2016  ...

Early Mitochondrial Stress Alters Epigenetics, Secures Lifelong Health Benefits

A little adversity builds character, or so the saying goes. True or not, the saying does seem an apt description of a developmental phenomenon that shapes gene expression. While it knows nothing of ...

Value of Adrenergic Blockade in Acute Severe TBI Questioned

Adrenergic blockade with propranolol and clonidine did not increase ventilator-free days after severe traumatic brain injury, a new study shows. Medscape Medical News

FDA approves AZ's Bevespi Aerosphere for COPD

AstraZeneca plc (LSE:AZN; NYSE:AZN) said FDA approved Bevespi Aerosphere (PT003) for long-term maintenance treatment of airflow obstruction in patients with chronic obstructive pulmonary disease. Beve...

BEVESPI AEROSPHERE(TM) Approved by the US FDA for Patients With COPD

WILMINGTON, DE--(Marketwired - April 25, 2016) -  AstraZeneca today announced that the US Food and Drug Administration has approved BEVESPI AEROSPHERE (glycopyrrolate and formoterol fumarate) inhalat...

Comprehensive genomic profiling of orbital and ocular adnexal lymphomas identifies frequent alterations in MYD88 and chromatin modifiers: new routes to targeted therapies

Inhibition of β2-adrenergic receptor reduces triple-negative breast cancer brain metastases

Blocking adrenaline receptors on breast cancers stymies their spread to the brain

Genetic variation in the alpha1B-adrenergic receptor and vascular response

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Companies [3 Associated Companies listed on BioPortfolio]

Partikula LLC

Partikula is a preclinical stage biotechnology company focused on developing novel therapies for cancer and other diseases based on platform chemistry technologies, including its ...

Innate Immunotherapeutics Limited

Innate Immunotherapeutics Limited is a public unlisted biopharmaceutical company based in Auckland, New Zealand. The company is focused on the development of a new generation of i...

Innate Therapeutics Limited

Innate Therapeutics Limited is a public unlisted biopharmaceutical company based in Auckland. The company is focused on the development of a new generation of immune response modi...

Clinical Trials [119 Associated Clinical Trials listed on BioPortfolio]

The Effects of Dexmedetomidine on Intestine and Other Organ Damages After Cardiac Surgeries

Cardiac surgery with cardiopulmonary bypass (CPB) provokes a systemic inflammatory response that can often lead to dysfunction of major organs. Activation of the contact system, endotoxemi...

Use of Preanesthetic Dexmedetomidine in Elderly, Treated-hypertensive Patients

Background: Dexmedetomidine is an alpha 2 adrenergic agonist with sedative, anxiolytic, and analgesic properties. This study was designed to evaluate the inhibitory effects of preoperative...

Rasch-analysis of Clinical Severity in FSHD

The purpose of this study is to make a standardized and scalable Rasch-built clinical severity scale to help in finding genetic and environmental modifiers of disease in Facioscapulohumera...

Cardiac Output Changes in Cesarean Section

Since 2011, phenylephrine was recommended as the preferred drug to maintain blood pressure in obstetric anesthesia.Phenylephrine, an α adrenoceptor agonist, can induce peripheral vasocons...

Norepinephrine Exerts an Inotropic Effect at the Early Phase of Human Septic Shock

Norepinephrine (NE) is a potent vasopressor used in septic shock to reverse hypotension. Early infusion of NE was associated with a favorable clinical outcome in a large cohort of patients...

Pilot - Peri-operative Beta Blockade

Perioperative cardiac adverse events [heart injuries caused by general anesthesia and surgical procedures] are a significant public health issue, with more than 60,000 deaths per annum in ...

Unravelling Effectiveness of a Nurse-led Behavior Change Intervention to Enhance Physical Activity in Patients

A two-armed, cluster randomized controlled trial will be conducted comparing the Activate intervention with care as usual in 26 general practices in the Netherlands, in which approximately...

Correlation Between the Polymorphism ofβ2 AR and the Labor Progress After Labor Analgesia

Labor and delivery is a unique physiological experience of women. Inappropriate length of labor progress during vaginal delivery may produce great risks for mother and fetus. Especially th...

Bilirubin Binding Capacity to Assess Bilirubin Load in Preterm Infants

Most preterm newborns are managed by phototherapy to reverse hyperbilirubinemia with the intent to prevent bilirubin neurotoxicity. A threshold-based relationship between a specific total ...

POTS Adrenergic Ab (CIHR Aims #1&2)

Objective: In this pilot study, we will test the hypothesis that patients with POTS (age 18-60 years) will have a higher percentage of functional antibodies to adrenergic receptors compare...

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Medical and Biotech [MESH] Definitions

Drugs that act on adrenergic receptors or affect the life cycle of adrenergic transmitters. Included here are adrenergic agonists and antagonists and agents that affect the synthesis, storage, uptake, metabolism, or release of adrenergic transmitters.

Drugs that bind to but do not activate ADRENERGIC RECEPTORS. Adrenergic antagonists block the actions of the endogenous adrenergic transmitters EPINEPHRINE and NOREPINEPHRINE.

A subclass of beta-adrenergic receptors (RECEPTORS, ADRENERGIC, BETA). beta-3 Adrenergic receptors are the predominant beta-adrenergic receptor type expressed in white and brown ADIPOCYTES and are involved in modulating ENERGY METABOLISM and THERMOGENESIS.

Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.

Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.

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