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Adrenergic modifiers - Biotech, Pharma and Life Science Channel

01:07 EST 22nd February 2017 | BioPortfolio

PubMed Articles [300 Associated PubMed Articles listed on BioPortfolio]

Associations among left ventricular systolic function, tachycardia, and cardiac preload in septic patients.

In sepsis, tachycardia may indicate low preload, adrenergic stimulation, or both. Adrenergic overstimulation is associated with septic cardiomyopathy. We sought to determine whether tachycardia was as...

Increased Atrial β-Adrenergic Receptors and GRK-2 Gene Expression Can Play a Fundamental Role in Heart Failure After Repair of Congenital Heart Disease with Cardiopulmonary Bypass.

Surgeries to correct congenital heart diseases are increasing in Brazil and worldwide. However, even with the advances in surgical techniques and perfusion, some cases, especially the more complex one...

The pineal gland: A model for adrenergic modulation of ubiquitin ligases.

A recent study of the pineal gland of the rat found that the expression of more than 3000 genes showed significant day/night variations (The Hartley dataset). The investigators of this report made ava...

Expression level is a key determinant of E2F1-mediated cell fate.

The Rb/E2F network has a critical role in regulating cell cycle progression and cell fate decisions. It is dysfunctional in virtually all human cancers, because of genetic lesions that cause overexpre...

Alpha adrenergic receptor blockade increases capillarisation and fractional O2 extraction and lowers blood flow in contracting human skeletal muscle.

To investigate the effect of elevated basal shear stress on angiogenesis in humans, and the role of enhanced skeletal muscle capillarisation on blood flow and O2 extraction.

Predictors of Distal Adding-on in Thoracic Major Curves With AR Lumbar Modifiers.

Retrospective review of prospectively collected data.

A Role for Adrenergic Receptors in the Uterotonic Effects of Ergometrine in Isolated Human Term Nonlaboring Myometrium.

Ergometrine is a uterotonic agent that is recommended in the prevention and management of postpartum hemorrhage. Despite its long-standing use, the mechanism by which it acts in humans has never been ...

Quantitative FLIM-FRET Microscopy to Monitor Nanoscale Chromatin Compaction In Vivo Reveals Structural Roles of Condensin Complexes.

How metazoan genomes are structured at the nanoscale in living cells and tissues remains unknown. Here, we adapted a quantitative FRET (Förster resonance energy transfer)-based fluorescence lifetime ...

Rapid integumental color changes due to novel iridophores in the chameleon sand tilefish Hoplolatilus chlupatyi.

The chameleon sand tilefish Hoplolatilus chlupatyi displays rapid color changes in integument from blue to red. Our microscopic observations revealed that the rapid color changes were generated by mot...

The influence of adrenergic stimulation on sex differences in left ventricular twist mechanics.

Sex differences in LV mechanics exist at rest and during acute physiological stress. Differences in cardiac autonomic and adrenergic control may contribute to sex differences in LV mechanics and LV he...

News Articles [52 Associated News Articles listed on BioPortfolio]

β2-adrenergic receptor control of endosomal PTH receptor signaling via Gβγ

Cells express several G-protein-coupled receptors (GPCRs) at their surfaces, transmitting simultaneous extracellular hormonal and chemical signals into cells. A comprehensive understanding of mechanis...

G-Protein-coupled receptors: Decoding mixed signals

A new mechanism of functional crosstalk between two distinct G-protein-coupled receptors (GPCRs)—the parathyroid hormone receptor (PTHR) and β2-adrenergic receptor (β2 Ar)—that occurs at the lev...

Acadia Pharmaceuticals Inc ACAD Pharmaceuticals Healthcare Deals and Alliances Profile Prices from USD $250

SummaryAcadia Pharmaceuticals Inc Acadia is a biopharmaceutical company, which focuses on the discovery, development and commercialization of small molecule drugs for the treatment of central nervous ...

Noradrenaline enhances vision through ?-adrenergic receptors

Noradrenaline is a neuromodulator secreted in the brain depending on behavioral context and physiological states of animal, influencing a wide range of physiological functions by modulating brain acti...

Noradrenaline enhances vision through beta-adrenergic receptors

Noradrenaline is a neuromodulator secreted in the brain depending on behavioral context and physiological states of animal, influencing a wide range of physiological functions by modulating brain acti...

Noradrenaline enhances vision through β-adrenergic receptors

(Osaka University) Osaka University researchers show that the positive effects on vision by noradrenaline act through β-adrenergic receptors.

DuPont Awards Deadline Extended: There’s Still Time to Honor Your Packaging Achievements

The submission deadline for the 29th DuPont Awards for Packaging Innovation has been extended to Feb. 17, 2017 Wilmington, Del. (PRWEB) February 07, 2017 The submission deadline for the 29th DuPont A...

Modified Bitumen Market by Modifier Type SBS, APP, Crumb Rubber, Natural Rubber, Application Method Hot Asphalt, Cold Asphalt, TorchApplied, EndUse Industry Road Construction, Building Construction, and Region Global Forecast to 2021 [Updated: 24012017]

The modified bitumen market is projected to register a CAGR of 6.5% during the forecast periodThe global modified bitumen market is projected to reach USD 19.29 billion by 2021, at a CAGR of 6.5% from...

Evaluation of copy-number variants as modifiers of breast and ovarian cancer risk for BRCA1 pathogenic variant carriers

Roche Diabetes Care Chooses DuPont™ Delrin® to Develop its Renowned Accu-Chek® LinkAssist Plus Application

The development of this application would not have been possible without the close collaboration of Balda Group, Roche Diabetes Care, and DuPont GENEVA (PRWEB) February 01, 2017 Roche Diabetes Care, ...

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Companies [3 Associated Companies listed on BioPortfolio]

Partikula LLC

Partikula is a preclinical stage biotechnology company focused on developing novel therapies for cancer and other diseases based on platform chemistry technologies, including its ...

Innate Immunotherapeutics Limited

Innate Immunotherapeutics Limited is a public unlisted biopharmaceutical company based in Auckland, New Zealand. The company is focused on the development of a new generation of i...

Innate Therapeutics Limited

Innate Therapeutics Limited is a public unlisted biopharmaceutical company based in Auckland. The company is focused on the development of a new generation of immune response modi...

Clinical Trials [139 Associated Clinical Trials listed on BioPortfolio]

Physiological Responses and Adaptation of Brown Adipose Tissue to Chronic Treatment With Beta 3-Adrenergic Receptor Agonists

Background: Brown adipose tissue (BAT) is a type of fat in the body. It may prevent weight gain, improve insulin sensitivity, and reduce fatty liver. Researchers want to see if BAT helps ...

Ephedrine and Phenylephrine for Spinal Hypotension

Spinal anesthesia is widely used as the procedure of choice for cesarean delivery. In comparison to epidural anesthesia it is faster, easier to perform, patients are more comfortable, comp...

Trelegy ELLIPTA ® Inhaler: Qualitative Analysis and Subject Preference Survey

Three main classes of inhaled treatment exist for chronic obstructive pulmonary disease (COPD): Beta2-adrenergic agonists (which may be short (SABA) or long (LABA) acting), long-acting mus...

Cutaneous Autonomic Pilomotor Testing to Unveil the Role of Neuropathy Progression in Early Parkinson's Disease

In Parkinson's disease (PD), alpha-synuclein accumulation in cutaneous autonomic pilomotor and sudomotor nerve fibers has been linked to autonomic nervous system disturbances even in the e...

The Influence of Electronic and Traditional Cigarettes Smoking on Hemodynamic Parameters

It is intended to examine 50 healthy volunteers aged 18 - 60 years. 12-hour abstinence from tobacco smoke, alcohol or coffee before the experiment will be required. The exclusion criteria ...

Dexmedetomidine on Basal Ganglia Neuronal Activity in Parkinson's Disease

The implantation of a deep brain stimulator (DBS) is an established option to improve the symptoms of Parkinson's disease (PD) in patients that do not respond adequately to medical therapy...

Pulse Reduction On Beta-blocker and Ivabradine Therapy

Heart failure with reduced left ventricular ejection fraction (HFrEF) is the most common form of chronic heart failure in subjects ≤ 75 years of age. Beta-blocker therapy greatly reduces...

Effect of Topical Phenylephrine 2.5% on EVP in Normal Human Eyes

Phenylephrine hydrochloride ophthalmic solution is an alpha-1 adrenergic receptor agonist commonly used topically for dilation prior to ocular fundus examination. In the eye, phenylephrine...

Preoperative Administration of Tamsulosin for Prevention of Post Operative Urinary Retention in Males Undergoing Elective Inguinal Hernia Repair

Double blinded, randomized controlled prospective study looking at 2 preoperative doses of Tamsulosin an alpha-adrenergic blocker in preventing post-operative urinary retention. A previous...

Beta Blockade in in Traumatic Brain Injury

The purpose of this study is test the effect of beta-adrenergic blockade on mortality in patients with traumatic brain injury with the hypothesis being that the addition of beta blockade t...

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Medical and Biotech [MESH] Definitions

Drugs that act on adrenergic receptors or affect the life cycle of adrenergic transmitters. Included here are adrenergic agonists and antagonists and agents that affect the synthesis, storage, uptake, metabolism, or release of adrenergic transmitters.

Drugs that bind to but do not activate ADRENERGIC RECEPTORS. Adrenergic antagonists block the actions of the endogenous adrenergic transmitters EPINEPHRINE and NOREPINEPHRINE.

A subclass of beta-adrenergic receptors (RECEPTORS, ADRENERGIC, BETA). beta-3 Adrenergic receptors are the predominant beta-adrenergic receptor type expressed in white and brown ADIPOCYTES and are involved in modulating ENERGY METABOLISM and THERMOGENESIS.

Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.

Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.

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