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Adrenergic modifiers - Biotech, Pharma and Life Science Channel

12:11 EDT 5th May 2016 | BioPortfolio

PubMed Articles [356 Associated PubMed Articles listed on BioPortfolio]

Alpha2-adrenergic agonists for the management of opioid withdrawal.

Withdrawal is a necessary step prior to drug-free treatment or as the endpoint of long-term substitution treatment.

Raynaud's phenomenon and digital ischaemia - pharmacologic approach and alternative treatment options.

The primary goal of therapy is to reduce the frequency and intensity of Raynaud's attacks and to minimize the related morbidity rather than to cure the underlying condition. Treatment strategies depen...

Influence of Naftopidil on Plasma Monoamine Levels and Lower Urinary Tract Symptoms Associated with Benign Prostatic Hyperplasia.

To clarify the influence of naftopidil, an α1D/A -adrenergic receptor antagonist, on the autonomic nervous system, we examined the relation between lower urinary tract symptoms (LUTS) and the plasma ...

Evolview v2: an online visualization and management tool for customized and annotated phylogenetic trees.

Evolview is an online visualization and management tool for customized and annotated phylogenetic trees. It allows users to visualize phylogenetic trees in various formats, customize the trees through...

The impact of metabotropic glutamate receptors into active neurodegenerative processes: A "dark side" in the development of new symptomatic treatments for neurologic and psychiatric disorders.

Metabotropic glutamate (mGlu) receptor ligands are under clinical development for the treatment of CNS disorders with high social and economic burden, such as schizophrenia, major depressive disorder ...

Postural hand tremor and incident hypertension in young to middle-aged adults: the Bogalusa heart study.

Hand tremor and blood pressure (BP) are both increased by adrenergic stimulation and reduced by β-blockade, indicating that they may share a common underlying pathophysiology.

A novel asymmetric membrane osmotic pump capsule with in situ formed delivery orifices for controlled release of gliclazide solid dispersion system.

In this study, a novel asymmetric membrane osmotic pump capsule of gliclazide (GLC) solid dispersion was developed to achieve a controlled drug release. The capsule shells were obtained by wet phase i...

HBK-7 - A new xanthone derivative and a 5-HT1A receptor antagonist with antidepressant-like properties.

Xanthone derivatives possess many biological properties, including neuroprotective, antioxidant or antidepressant-like. In this study we aimed to investigate antidepressant- and anxiolytic-like proper...

Cross-fostering reduces obesity induced by early exposure to monosodium glutamate in male rats.

Maternal obesity programmes a range of metabolic disturbances for the offspring later in life. Moreover, environmental changes during the suckling period can influence offspring development. Because b...

Cognitive Test Scores in UK Biobank: Data Reduction in 480,416 Participants and Longitudinal Stability in 20,346 Participants.

UK Biobank includes 502,649 middle- and older-aged adults from the general population who have undergone detailed phenotypic assessment. The majority of participants completed tests of cognitive funct...

News Articles [53 Associated News Articles listed on BioPortfolio]

Early Mitochondrial Stress Alters Epigenetics, Secures Lifelong Health Benefits

A little adversity builds character, or so the saying goes. True or not, the saying does seem an apt description of a developmental phenomenon that shapes gene expression. While it knows nothing of ...

Value of Adrenergic Blockade in Acute Severe TBI Questioned

Adrenergic blockade with propranolol and clonidine did not increase ventilator-free days after severe traumatic brain injury, a new study shows. Medscape Medical News

FDA approves AZ's Bevespi Aerosphere for COPD

AstraZeneca plc (LSE:AZN; NYSE:AZN) said FDA approved Bevespi Aerosphere (PT003) for long-term maintenance treatment of airflow obstruction in patients with chronic obstructive pulmonary disease. Beve...

BEVESPI AEROSPHERE(TM) Approved by the US FDA for Patients With COPD

WILMINGTON, DE--(Marketwired - April 25, 2016) -  AstraZeneca today announced that the US Food and Drug Administration has approved BEVESPI AEROSPHERE (glycopyrrolate and formoterol fumarate) inhalat...

Comprehensive genomic profiling of orbital and ocular adnexal lymphomas identifies frequent alterations in MYD88 and chromatin modifiers: new routes to targeted therapies

Inhibition of β2-adrenergic receptor reduces triple-negative breast cancer brain metastases

Blocking adrenaline receptors on breast cancers stymies their spread to the brain

Genetic variation in the alpha1B-adrenergic receptor and vascular response

Genetic variation: New tool to map genetic modifiers of transcription factor–gene target connections

Plans for Phase 3 smoking cessation trial underway

Drug development company Invion (ASX:IVX) has met with the Division of Anesthesia, Analgesia, and Addiction Products (DAAAP) of the US Food and Drug Administration (FDA) to discuss Phase 3 plans for d...

Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1

Brown and beige adipose tissues can dissipate chemical energy as heat through thermogenic respiration, which requires uncoupling protein 1 (UCP1). Thermogenesis from these adipocytes can combat obesit...

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Companies [3 Associated Companies listed on BioPortfolio]

Partikula LLC

Partikula is a preclinical stage biotechnology company focused on developing novel therapies for cancer and other diseases based on platform chemistry technologies, including its ...

Innate Immunotherapeutics Limited

Innate Immunotherapeutics Limited is a public unlisted biopharmaceutical company based in Auckland, New Zealand. The company is focused on the development of a new generation of i...

Innate Therapeutics Limited

Innate Therapeutics Limited is a public unlisted biopharmaceutical company based in Auckland. The company is focused on the development of a new generation of immune response modi...

Clinical Trials [116 Associated Clinical Trials listed on BioPortfolio]

Cardiac Output Changes in Cesarean Section

Since 2011, phenylephrine was recommended as the preferred drug to maintain blood pressure in obstetric anesthesia.Phenylephrine, an α adrenoceptor agonist, can induce peripheral vasocons...

Norepinephrine Exerts an Inotropic Effect at the Early Phase of Human Septic Shock

Norepinephrine (NE) is a potent vasopressor used in septic shock to reverse hypotension. Early infusion of NE was associated with a favorable clinical outcome in a large cohort of patients...

Pilot - Peri-operative Beta Blockade

Perioperative cardiac adverse events [heart injuries caused by general anesthesia and surgical procedures] are a significant public health issue, with more than 60,000 deaths per annum in ...

Unravelling Effectiveness of a Nurse-led Behavior Change Intervention to Enhance Physical Activity in Patients

A two-armed, cluster randomized controlled trial will be conducted comparing the Activate intervention with care as usual in 26 general practices in the Netherlands, in which approximately...

Correlation Between the Polymorphism ofβ2 AR and the Labor Progress After Labor Analgesia

Labor and delivery is a unique physiological experience of women. Inappropriate length of labor progress during vaginal delivery may produce great risks for mother and fetus. Especially th...

Bilirubin Binding Capacity to Assess Bilirubin Load in Preterm Infants

Most preterm newborns are managed by phototherapy to reverse hyperbilirubinemia with the intent to prevent bilirubin neurotoxicity. A threshold-based relationship between a specific total ...

POTS Adrenergic Ab (CIHR Aims #1&2)

Objective: In this pilot study, we will test the hypothesis that patients with POTS (age 18-60 years) will have a higher percentage of functional antibodies to adrenergic receptors compare...

The IFR Colon Model

The aim of this project is to establish a list of volunteers willing and able to donate stool samples for use in the model colon so as to facilitate research directed toward understanding ...

Assessing the Efficacy and Safety of Metformin in Treatment of Moderate Psoriasis

Psoriasis vulgaris is a common, chronic, relapsing skin disease characterized by predominant involvement of skin, nails and joints. Recent advances in its patho-physiology have shifted the...

Utility of Olanzapine in the Treatment of Opioid Withdrawal in the ED

Withdrawal from opioids is a clinical scenario that emergency department physicians encounter frequently. Patients who present with opioid withdrawal display symptoms such as agitation, an...

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Medical and Biotech [MESH] Definitions

Drugs that act on adrenergic receptors or affect the life cycle of adrenergic transmitters. Included here are adrenergic agonists and antagonists and agents that affect the synthesis, storage, uptake, metabolism, or release of adrenergic transmitters.

Drugs that bind to but do not activate ADRENERGIC RECEPTORS. Adrenergic antagonists block the actions of the endogenous adrenergic transmitters EPINEPHRINE and NOREPINEPHRINE.

A subclass of beta-adrenergic receptors (RECEPTORS, ADRENERGIC, BETA). beta-3 Adrenergic receptors are the predominant beta-adrenergic receptor type expressed in white and brown ADIPOCYTES and are involved in modulating ENERGY METABOLISM and THERMOGENESIS.

Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.

Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.

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