Adrenergic modifiers - Biotech, Pharma and Life Science Channel

03:15 EDT 24th May 2015 | BioPortfolio

PubMed Articles [367 Associated PubMed Articles listed on BioPortfolio]

Preservation properties of in situ modified CaCO3-chitosan composite coatings.

To improve the dispersibility, hydrophilia constraints of primitive particle size, and reduce the economic cost, in situ modified CaCO3-chitosan composite coatings were prepared by tape-casting with d...

Polymorphisms in Oxytocin and α1a Adrenergic Receptor Genes and Their Effects on Production Traits in Dairy Buffaloes.

The use of molecular markers may auxiliary the buffalo breeding. The oxytocin (OXT) and the adrenergic receptor α1A (ADRA1A) may be involved in milk ejection in ruminants. The aim of this study was t...

The Broad-Spectrum Antiviral Protein ZAP Restricts Human Retrotransposition.

Intrinsic immunity describes the set of recently discovered but poorly understood cellular mechanisms that specifically target viral pathogens. Their discovery derives in large part from intensive stu...

Molecular characterization of genes modifying the age at onset in Huntington's Disease in Uruguayan patients.

Huntington's Disease (HD) is an hereditary neurodegenerative disorder. The genetic cause is an expansion of CAG repeats located in the IT15 gene. Though the number of CAG repeats ((CAG)n) can largely ...

Biobehavioral and neuroendocrine correlates of antioxidant enzyme activity in ovarian carcinoma.

Increased levels of reactive oxygen species (ROS) such as superoxide anions and hydrogen peroxide have been reported in many cancer cells and they have been implicated in carcinogenesis and tumor prog...

Central and peripheral antinociceptive activity of 3-(2-oxopropyl)-3-hydroxy-2-oxindoles.

Convolutamydine A has been shown to develop a significant antinociceptive effect. Here we demonstrated that new analogues (5-iodo-3-(2-oxopropyl)-3-hydroxy-2-oxindole (5-Iisa), 5-fluoro-3-(2-oxopropyl...

Systemic Regulation of RAS/MAPK Signaling by the Serotonin Metabolite 5-HIAA.

Human cancer is caused by the interplay of mutations in oncogenes and tumor suppressor genes and inherited variations in cancer susceptibility genes. While many of the tumor initiating mutations are w...

A Population Based Study of the Genetic Association between Catecholamine Gene Variants and Spontaneous Low-Frequency Fluctuations in Reaction Time.

The catecholamines dopamine and noradrenaline have been implicated in spontaneous low-frequency fluctuations in reaction time, which are associated with attention deficit hyperactivity disorder (ADHD)...

Identification of a novel class of covalent modifiers of hemoglobin as potential antisickling agents.

Aromatic aldehydes and ethacrynic acid (ECA) exhibit antipolymerization properties that are beneficial for sickle cell disease therapy. Based on the ECA pharmacophore and its atomic interaction with h...

Copy number variants including RAS pathway genes-How much RASopathy is in the phenotype?

The RASopathies comprise a group of clinically overlapping developmental syndromes the common pathogenetic basis of which is dysregulated signal flow through the RAS-MAPK pathway. Mutations in several...

News Articles [35 Associated News Articles listed on BioPortfolio]

Sunovion Announces Health Outcomes Data that Support the Consideration of Brovana® (arformoterol tartrate) Inhalation Solution for the Maintenance Treatment of COPD at the American Thoracic Society (ATS) 2015 Annual Meeting

Sunovion Pharmaceuticals Inc. (Sunovion) today announced the results of two health outcomes studies and a placebo controlled randomized trial presented at the American Thoracic So...

Beta1-adrenergic receptor-mediated dilation of rat cerebral artery requires Shaker-type KV1 channels on PSD95 scaffold

The Roles of Dopamine and α1-Adrenergic Receptors in Cocaine Preferences in Female and Male Rats

Myocardial MiR-30 downregulation triggered by doxorubicin drives alterations in β-adrenergic signaling and enhances apoptosis

Sunovion to Present New Clinical Analysis and Health Outcomes Data Supporting Use of BROVANA in Patients with Moderate-to-Severe COPD at the 110th American Thoracic Society (ATS) Annual Meeting

Sunovion Pharmaceuticals Inc. (Sunovion) announced today that new analyses of clinical and health outcomes data for Brovana® (arformoterol tartrate) Inhalation Solution will be p...

FDA approves Breo Ellipta for adults, not children

FDA approved an sNDA on Thursday for Breo Ellipta fluticasone furoate/vilanterol from GlaxoSmithKline plc (LSE:GSK; NYSE:GSK) and Theravance Inc. (NASDAQ:THRX) to treat asthma in adults. The agency is...

Celgene acquires Quanticel Pharmaceuticals

Celgene and Quanticel Pharmaceuticals announced a definitive share purchase agreement under which Celgene will acquire Quanticel. Through the agreement, Celgene will have full access to Quanticel’s ...

Celgene exercises option to acquire Quanticel

Celgene Corp. (NASDAQ:CELG) exercised its option to acquire Quanticel Pharmaceuticals Inc. (San Francisco, Calif.) for $100 million up front. Celgene gains Quanticel's platform to perform single-cell ...

Betoptic side effects

The summary of product characteristics for Betoptic (betaxolol; Novartis) eye drops now warns of occasional reports of mydriasis resulting from concomitant use of ophthalmic beta-blockers and adrenali...

Aerie's Rocket misfires in glaucoma

Aerie Pharmaceuticals Inc. (NASDAQ:AERI) fell $23.01 (65%) to $12.38 in after hours trading Thursday after it said Rhopressa (AR-13324) missed the primary endpoint of the Phase III Rocket 1 trial to t...

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Companies [2 Associated Companies listed on BioPortfolio]

Innate Immunotherapeutics Limited

Innate Immunotherapeutics Limited is a public unlisted biopharmaceutical company based in Auckland, New Zealand. The company is focused on the development of a new generation of i...

Innate Therapeutics Limited

Innate Therapeutics Limited is a public unlisted biopharmaceutical company based in Auckland. The company is focused on the development of a new generation of immune response modi...

Clinical Trials [89 Associated Clinical Trials listed on BioPortfolio]

Therapeutic Response Evaluation and Adherence Trial (TREAT)

The primary objectives of this prospective study of hydroxyurea for children with sickle cell anemia are 1) Develop and prospectively evaluate a population pharmacokinetic/pharmacodynamics...

Pharmacogenetic Trial of Doxazosin for Treatment of Cocaine Abuse

Cocaine use disorders affect approximately 1.5 million Americans annually. Currently, there are no US Food and Drug Administration approved medications for treatment of cocaine dependence;...

Perioperative Propranolol in Patients With Post Traumatic Stress Disorder (PTSD)

Understanding what treatments may facilitate perioperative care of Veterans with posttraumatic stress disorder (PTSD) is of great importance to the U.S. health care system. Patients with ...

Use of an Oral Beta-2 Agonist in Persons With Spinal Cord Injury

The primary purpose of this study is to determine the effect of administration of the oral beta-2 adrenergic agonist, albuterol, on respiratory muscle strength in individuals with cervical...

Genetically Targeted Therapy for the Prevention of Symptomatic Atrial Fibrillation in Patients With Heart Failure

This study is being done to compare the effects of bucindolol hydrochloride (bucindolol) to metoprolol succinate (Toprol-XL) on the recurrence of symptomatic atrial fibrillation/atrial flu...

Darbepoetin Alfa in Anemic Low or Intermediate-1 Risk MDS Subjects

This is a Phase 3, multicenter, randomised, double-blind, placebo-controlled trial of darbepoetin alfa 500 μg administered once every 3 weeks (Q3W) to approximately 141 low or intermediat...

TAKO-TSUBO Cardiomyopathy and Genetic

This is a case-control association study with multicentric prospective recruitment. Tako-TSUBO cardiomyopathy is a new clinical entity mimicking an acute coronary syndrome. It is characte...

Molecular Immunohematology in Ethiopian Sub-Populations

Alloimmunization to blood products in transfused patients is a recognized management challenge in the clinical setting. In particular the ethnic and racial specificity of RBC antigens and ...

Combination of Dronabinol and Clonidine for Cannabis Dependence in Patients With Schizophrenia

Cannabis use disorders are an important public health problem in the United States, but no effective pharmacotherapies are available to treat these disorders. People with schizophrenia ar...

Terlipressin + Albumin Versus Midodrine + Octreotide in the Treatment of Hepatorenal Syndrome

From 1999, several studies have showed that the use of vasoconstrictors in association with albumin are effective in the treatment of hepatorenal syndrome (HRS). The rationale of the use o...

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Medical and Biotech [MESH] Definitions

Drugs that act on adrenergic receptors or affect the life cycle of adrenergic transmitters. Included here are adrenergic agonists and antagonists and agents that affect the synthesis, storage, uptake, metabolism, or release of adrenergic transmitters.

Drugs that bind to but do not activate ADRENERGIC RECEPTORS. Adrenergic antagonists block the actions of the endogenous adrenergic transmitters EPINEPHRINE and NOREPINEPHRINE.

A subclass of beta-adrenergic receptors (RECEPTORS, ADRENERGIC, BETA). beta-3 Adrenergic receptors are the predominant beta-adrenergic receptor type expressed in white and brown ADIPOCYTES and are involved in modulating ENERGY METABOLISM and THERMOGENESIS.

Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.

Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.

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