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Adrenergic modifiers - Biotech, Pharma and Life Science Channel

11:14 EST 12th February 2016 | BioPortfolio

PubMed Articles [345 Associated PubMed Articles listed on BioPortfolio]

Lipoprotein (a): a Unique Independent Risk Factor for Coronary Artery Disease.

The current epidemic affecting Indians is coronary artery disease (CAD), and is currently one of the most common causes of mortality and morbidity in developed and developing countries. The higher rat...

Effect of selective β-adrenoceptor blockade and surgical resection of the celiac-superior mesenteric ganglion complex on delayed liquid gastric emptying induced by dipyrone, 4-aminoantipyrine, and antipyrine in rats.

There is evidence for participation of peripheral β-adrenoceptors in delayed liquid gastric emptying (GE) induced in rats by dipyrone (Dp), 4-aminoantipyrine (AA), and antipyrine (At). The present st...

A Screen for Modifiers of Cilia Phenotypes Reveals Novel MKS Alleles and Uncovers a Specific Genetic Interaction between osm-3 and nphp-4.

Nephronophthisis (NPHP) is a ciliopathy in which genetic modifiers may underlie the variable penetrance of clinical features. To identify modifiers, a screen was conducted on C. elegans nphp-4(tm925) ...

SnapShot: Stress and Disease.

Perturbation of an organism's homeostasis by stress can trigger biological or behavioral adaptation and accelerate onset and course of several diseases. Signaling triggered by norepinephrine or epinep...

Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer.

An increasingly recognized resistance mechanism to androgen receptor (AR)-directed therapy in prostate cancer involves epithelial plasticity, in which tumor cells demonstrate low to absent AR expressi...

Transfusion-Related Acute Lung Injury: Transfusion, Platelets and Biological Response Modifiers.

Transfusion-related acute lung injury (TRALI) may be induced by plasma, platelet concentrates and red blood cell concentrates. The mechanism leading to TRALI is thought to involve two steps. The primi...

GRK2 upregulation creates a positive feedback loop for catecholamine production in chromaffin cells.

Elevated sympathetic nervous system (SNS) activity aggravates several diseases, including heart failure (HF). The molecular cause(s) underlying this SNS hyperactivity are not known. We have previously...

Genomic Modifiers of Natural Killer Cells, Immune Responsiveness and Lymphoid Tissue Remodeling Together Increase Host Resistance to Viral Infection.

The MHC class I Dk molecule supplies vital host resistance during murine cytomegalovirus (MCMV) infection. Natural killer (NK) cells expressing the Ly49G2 inhibitory receptor, which specifically binds...

Calmodulin kinase II inhibition limits the pro-arrhythmic Ca2+ waves induced by cAMP-phosphodiesterase inhibitors.

A major concern of using PDE inhibitors in heart failure (HF) is their potential to increase mortality by inducing arrhythmias. By diminishing cAMP hydrolysis, they promote PKA activity under β-adren...

A systematic review and meta-analysis on the longitudinal relationship between eating pathology and depression.

Undertake a meta-analysis to provide a quantitative synthesis of longitudinal studies that assessed the direction of effects between eating pathology and depression. A second aim was to use meta-regre...

News Articles [51 Associated News Articles listed on BioPortfolio]

Shire Partner, Shionogi, Submits New Drug Application in Japan for ADHD Treatment for Children

LEXINGTON, Massachusetts, February 10, 2016 /PRNewswire/ -- This press release is intended for U.S. and EU audiences only.  A separate press release has been prepared for use in Japan.  W...

Newly Published Head-to-Head Data Show STIOLTO RESPIMAT Improved Lung Function Across Range of Measures

RIDGEFIELD, Conn., Feb. 9, 2016 /PRNewswire/ -- Boehringer Ingelheim Pharmaceuticals, Inc. today announced the publication of data that show STIOLTO RESPIMAT improved lung function across a range of m...

National Billing Center Announces Addition of Evaluation & Management Tools to Its Coding Automation Software

PITTSBURGH, Feb. 9, 2016 /PRNewswire/ -- The National Billing Center, a provider of clinical documentation and reimbursement software and services, today announced its upcoming release of EM-CAT,...

Growing Demand for Organic Meat Driving the Global Medicinal Feed Additives Market, Says Technavio

According to the latest market study by Technavio, the market size of the global medicinal feed additives market is predicted to reach close to USD 5 billion in revenue by 2020. ...

Backbone NMR reveals allosteric signal transduction networks in the β1-adrenergic receptor

G protein-coupled receptors (GPCRs) are physiologically important transmembrane signalling proteins that trigger intracellular responses upon binding of extracellular ligands. Despite recent breakthro...

Judges Announced for the 28th DuPont Awards for Packaging Innovation

Enter Now to ‘Wow’ Industry Thought Leaders (PRWEB) February 04, 2016 DuPont Packaging has assembled a distinguished panel of packaging experts in design, research and manufacturing roles, repres...

The beta-1 adrenergic receptor and RAGE work together to break hearts

Cardiomyopathies result from a remodeling process that can be initiated by a variety of pathological stresses. Activation of the β-1 adrenergic receptor (β1AR) typically occurs in response to stress...

The β-1 adrenergic receptor and RAGE work together to break hearts

(Journal of Clinical Investigation) A new study in the inaugural issue of JCI Insight uncovers an interaction between β1AR and RAGE that mediates myocardial injury and progression to cardiomyopat...

Prenatal Exposure to Asthma Drugs May Boost Autism Risk

Exposure to beta-2-adrenergic receptor agonists in utero increased the risk of developing autism spectrum disorders, new research shows. Medscape Medical News

AAPS PharmSciTech: Development, Optimization, and Evaluation of Carvedilol-Loaded Solid Lipid Nanoparticles for Intranasal Drug Delivery

Type: Original PaperCarvedilol, a beta-adrenergic blocker, suffers from poor systemic availability (25%) due to first-pass metabolism. The aim of this work was to improve carvedilol bioavailability th...

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Companies [3 Associated Companies listed on BioPortfolio]

Partikula LLC

Partikula is a preclinical stage biotechnology company focused on developing novel therapies for cancer and other diseases based on platform chemistry technologies, including its ...

Innate Immunotherapeutics Limited

Innate Immunotherapeutics Limited is a public unlisted biopharmaceutical company based in Auckland, New Zealand. The company is focused on the development of a new generation of i...

Innate Therapeutics Limited

Innate Therapeutics Limited is a public unlisted biopharmaceutical company based in Auckland. The company is focused on the development of a new generation of immune response modi...

Clinical Trials [110 Associated Clinical Trials listed on BioPortfolio]

POTS Adrenergic Ab (CIHR Aims #1&2)

Objective: In this pilot study, we will test the hypothesis that patients with POTS (age 18-60 years) will have a higher percentage of functional antibodies to adrenergic receptors compare...

The IFR Colon Model

The aim of this project is to establish a list of volunteers willing and able to donate stool samples for use in the model colon so as to facilitate research directed toward understanding ...

Assessing the Efficacy and Safety of Metformin in Treatment of Moderate Psoriasis

Psoriasis vulgaris is a common, chronic, relapsing skin disease characterized by predominant involvement of skin, nails and joints. Recent advances in its patho-physiology have shifted the...

Utility of Olanzapine in the Treatment of Opioid Withdrawal in the ED

Withdrawal from opioids is a clinical scenario that emergency department physicians encounter frequently. Patients who present with opioid withdrawal display symptoms such as agitation, an...

Hemodynamic Effects of Dexmedetomidine in Septic Shock

The current treatment regimen of patients with septic shock requires a sufficient hemodynamic support aiming to preserve tissue oxygen requirements and perfusion. Therefore, aggressive flu...

A Study of Colesevelam in Fecal Incontinence

Fecal incontinence (FI) is a common symptom that can significantly impair quality of life. There is very limited, mostly uncontrolled, evidence to support the approaches currently used to ...

The Effect of Dexmedetomidine on Prevention of Postoperative Acute Kidney Injury in Patients Undergoing Aortic Surgery

Acute kidney injury(AKI) is a common and severe complication after the cardiac surgery. Postoperative AKI increases the in-hospital stay, intensive care unit(ICU) stay and postoperative mo...

Assessment of Efficacy of Mirabegron, a New beta3-adrenergic Receptor in the Prevention of Heart Failure

This study will assess the efficacy of mirabegron, a new beta3-adrenergic receptor in the prevention of heart failure. This is a two armed, prospective, randomized, placebo-controlled, mul...

Study of the Ease of Use and Correct Use of Placebo ELLIPTA® Inhaler in Subjects With Asthma

Asthma is a chronic disease of the lungs characterized by airway inflammation, bronchoconstriction and increased airway responsiveness. Inhaled corticosteroids (ICS), alone or in combinati...

cAMP Signaling and Muscle Adaptations

The role of cAMP signaling mediated by beta2-adrenergic stimulation with agonists has been well-studied in skeletal muscles of animals. Studies in humans are scant and the scope of the pre...

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Medical and Biotech [MESH] Definitions

Drugs that act on adrenergic receptors or affect the life cycle of adrenergic transmitters. Included here are adrenergic agonists and antagonists and agents that affect the synthesis, storage, uptake, metabolism, or release of adrenergic transmitters.

Drugs that bind to but do not activate ADRENERGIC RECEPTORS. Adrenergic antagonists block the actions of the endogenous adrenergic transmitters EPINEPHRINE and NOREPINEPHRINE.

A subclass of beta-adrenergic receptors (RECEPTORS, ADRENERGIC, BETA). beta-3 Adrenergic receptors are the predominant beta-adrenergic receptor type expressed in white and brown ADIPOCYTES and are involved in modulating ENERGY METABOLISM and THERMOGENESIS.

Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.

Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.

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