Adrenergic modifiers - Biotech, Pharma and Life Science Channel

14:00 EDT 20th September 2014 | BioPortfolio

PubMed Articles [362 Associated PubMed Articles listed on BioPortfolio]

Evidence for Fibroblast Growth Factor-2 as a Mediator of Amphetamine-Enhanced Motor Improvement following Stroke.

Previously we have shown that addition of amphetamine to physical therapy results in enhanced motor improvement following stroke in rats, which was associated with the formation of new motor pathways ...

Search for β2 Adrenergic Receptor Ligands by Virtual Screening via Grid Computing and Investigation of Binding Modes by Docking and Molecular Dynamics Simulations.

We designed a program called MolGridCal that can be used to screen small molecule database in grid computing on basis of JPPF grid environment. Based on MolGridCal program, we proposed an integrated s...

A comprehensive review and update on the biologic treatment of adult noninfectious uveitis: part II.

Introduction: Treatment of adult, noninfectious uveitis remains a major challenge for ophthalmologists around the world, especially in regard to recalcitrant cases. It is reported to comprise approxim...

Genotranscriptomic meta-analysis of the Polycomb gene CBX2 in human cancers: initial evidence of an oncogenic role.

Background:Polycomb group (PcG) proteins are histone modifiers known to transcriptionally silence key tumour suppressor genes in multiple human cancers. The chromobox proteins (CBX2, 4, 6, 7, and 8) a...

Epoxidized Soybean Oil/ZnO Biocomposites for Soft Tissue Applications: Preparation and Characterization.

Biocompatible and biodegradable nanocomposites comprising epoxidized soybean oil (ESO) as matrix, zinc oxide (ZnO) nanoparticles as reinforcements and 4-dimethylaminopyridine (DMAP) as a catalyst have...

The effect of nocturnal wear of complete denture on sleep and oral health related quality of life: study protocol for a randomized controlled trial.

Edentulism and sleep disturbance are chronic conditions that are common in older people and have serious adverse consequences for their functioning and quality of life. Edentulism can disturb sleep th...

Anchored protein kinase A signalling in cardiac cellular electrophysiology.

The cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA) is an elementary molecule involved in both acute and chronic modulation of cardiac function. Substantial research in recent yea...

Pak1 Is Required to Maintain Ventricular Ca2+ Homeostasis and Electrophysiological Stability through SERCA2a Regulation in Mice.

-Impaired sarcoplasmic reticular (SR) Ca(2+) uptake resulting from decreased SR Ca(2+)-ATPase type 2a (SERCA2a) expression or activity is characteristic of heart failure (HF) with its associated ventr...

An Integrative Genomic Approach Identifies Multiple Genes Involved in Cardiac Collagen Deposition.

-With aging and in cardiac disease, fibrosis due to collagen deposition is increased, impairing contractility and providing a substrate for arrhythmia. In this study we set out to identify genetic mod...

Caveolin Contributes to the Modulation of Basal and β-Adrenoceptor Stimulated Function of the Adult Rat Ventricular Myocyte by Simvastatin: A Novel Pleiotropic Effect.

The number of people taking statins is increasing across the globe, highlighting the importance of fully understanding statins' effects on the cardiovascular system. The beneficial impact of statins e...

News Articles [78 Associated News Articles listed on BioPortfolio]

Demystifying NCCI Edits and Hidden Medicare Coding Guidance

Expert speaker Dr. Duane C. Abbey is taking an audio conference on NCCI Edits and hidden Medicare coding guidance on behalf of AudioEducator.com. Durham, NC (PRWEB) September 19, 2014 The CMS develop...

LabCorp/ARCA biopharma GENETIC-AF Poster Presented at the 18th Annual Scientific Meeting of the Heart Failure Society of America

ARCA biopharma, Inc. (ARCA) (Nasdaq: ABIO), a biopharmaceutical company developing genetically-targeted therapies for cardiovascular diseases, today announced that a joint Laborat...

Evidence of genetic link to PTSD in soldiers exposed to childhood trauma

(Columbia University's Mailman School of Public Health) While abnormalities in the adrenergic and noradrenergic systems, both integral in the fight-or-flight response, are thought to play a role in th...

Research Down Syndrome Announces 2014/2015 Grant Awards to Fund Down Syndrome Cognitive Research

Research Down Syndrome is among the leading sources of funding of research directed toward developing treatments to improve memory, learning and communication in persons with Down syndrome. Research i...

LabCorp/ARCA biopharma GENETIC-AF Poster Selected for Presentation at the 18th Annual Scientific Meeting of the Heart Failure Society of America

ARCA biopharma, Inc. (Nasdaq: ABIO), a biopharmaceutical company developing genetically-targeted therapies for cardiovascular diseases, today announced that a joint Laboratory Cor...

Vicus Therapeutics Announces Phase II Data Demonstrating Overall Survival Benefit with VT-122 Plus Sorafenib in Patients with Advanced Hepatocellular Carcinoma

Eleven-month Increase in Median OS Reported with VT-122 plus Sorafenib, Compared to Sorafenib Alone. Data Presented at International Liver Cancer Association Conference. MORRISTOWN, N.J (PRWEB) Septem...

FDA reviewers question nebivolol/valsartan benefit

FDA reviewers questioned whether a fixed-dose combination of nebivolol and valsartan from Actavis plc (NYSE:ACT) provides a "clinically meaningful" benefit in patients with hypertension. The reviewers...

Craneware Launches Reference Plus™ to Simplify Chargemaster Management for Critical Access and Independent Community Hospitals

ATLANTA, Sept. 2, 2014 /PRNewswire/ -- Craneware, Inc., the healthcare market leader in automated revenue integrity solutions, today announced the launch of Reference Plus™, a tool that simplifi...

Vasopressin more effective for cardiopulmonary resuscitation

Epinephrine has been shown to be a first-choice drug for cardiopulmonary resuscitation. Nevertheless, its β-adrenergic effect probably increases myocardial oxygen consumption and leads to severe card...

Alpha-adrenergic treatment improves QoL in obese LUTS men

Alpha-adrenergic medication can significantly improve the quality of life of obese men with lower urinary tract symptoms, show study findings.

Events [0 Results]

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Companies [2 Associated Companies listed on BioPortfolio]

Innate Immunotherapeutics Limited

Innate Immunotherapeutics Limited is a public unlisted biopharmaceutical company based in Auckland, New Zealand. The company is focused on the development of a new generation of i...

Innate Therapeutics Limited

Innate Therapeutics Limited is a public unlisted biopharmaceutical company based in Auckland. The company is focused on the development of a new generation of immune response modi...

Clinical Trials [79 Associated Clinical Trials listed on BioPortfolio]

Study to Evaluate Esmolol (Brevibloc) to Manage Cardiac Function in Patients With Subarachnoid Hemorrhage

The purpose of this study is to evaluate the clinical effect of esmolol treatment on cardiac function and electrophysiology; to assess the effects of esmolol treatment on serum adrenergic ...

Atrial Fibrillation Follow-Up Investigation of Rhythm Management (AFFIRM)

To compare two standard treatment strategies for atrial fibrillation: ventricular rate control and anticoagulation vs. rhythm control and anticoagulation.

Study of Alpha-2 Adrenergic Receptor Dysfunction in Regional Lipoatrophy

OBJECTIVES: I. Determine the response in plasma norepinephrine concentration and plasma glycerol to the agonist (clonidine) and the antagonist (yohimbine) of the alpha-2 adrenergic recept...

Occluded Artery Trial (OAT)

The purpose of this study is to determine whether opening an occluded infarcted artery 3-28 days after an acute myocardial infarction in high-risk asymptomatic patients reduces the composi...

Active Immunotherapy Of Metastatic Renal Cell Carcinoma Using Autologous Dendritic Cells Transfected With Autologous Total Tumor RNA

The feasibility and dose-limiting toxicity of administering escalating doses of dendritic cells transfected with autologous renal cell carcinoma RNA DC(DCRCC-RNA) will be defined. As a sec...

Brain Receptors in Sympathetic Nervous System Regulation

The purpose of this study is to investigate the role of brain receptors called alpha2-adrenoreceptors in regulating the sympathetic nervous system, which maintains the supply of blood and ...

Gene Modifiers of Cystic Fibrosis Lung Disease

Ths purpose of this study is to examine genetic modifiers of the severity of cystic fibrosis lung disease.

Genetics and Cardiovascular Reactivity in Young Twins

To evaluate the effects of genetic variants in all of the nine adrenergic receptor subtype genes, alone or in combination, on cardiovascular reactivity and other quantitative cardiovascula...

Trial to Compare Alfuzosin Versus Placebo in the Treatment of Chronic Prostatitis/Chronic Pelvic Pain Syndrome

The purpose of this randomized clinical trial is to evaluate the efficacy and safety of the alpha adrenergic blocker Alfuzosin (Uroxatral) in men with relatively new onset of chronic prost...

The Role of Norepinephrine in Emotional Processing

This study will examine the role of a brain chemical called norepinephrine in thinking, decision-making, and emotional processing. After norepinephrine is released from a brain cell, it bi...

Videos

Medical and Biotech [MESH] Definitions

Drugs that act on adrenergic receptors or affect the life cycle of adrenergic transmitters. Included here are adrenergic agonists and antagonists and agents that affect the synthesis, storage, uptake, metabolism, or release of adrenergic transmitters.

Drugs that bind to but do not activate ADRENERGIC RECEPTORS. Adrenergic antagonists block the actions of the endogenous adrenergic transmitters EPINEPHRINE and NOREPINEPHRINE.

A subclass of beta-adrenergic receptors (RECEPTORS, ADRENERGIC, BETA). beta-3 Adrenergic receptors are the predominant beta-adrenergic receptor type expressed in white and brown ADIPOCYTES and are involved in modulating ENERGY METABOLISM and THERMOGENESIS.

Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.

Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.

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