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Adrenergic modifiers - Biotech, Pharma and Life Science Channel

05:25 EDT 24th April 2017 | BioPortfolio

PubMed Articles [313 Associated PubMed Articles listed on BioPortfolio]

Associations among left ventricular systolic function, tachycardia, and cardiac preload in septic patients.

In sepsis, tachycardia may indicate low preload, adrenergic stimulation, or both. Adrenergic overstimulation is associated with septic cardiomyopathy. We sought to determine whether tachycardia was as...

Epigenetics of reproductive infertility.

Infertility is a complex pathophysiological condition. It may caused by specific or multiple physical and physiological factors, including abnormalities in homeostasis, hormonal imbalances and genetic...

Sex-difference in expression and function of beta-adrenoceptors in macrovessels: role of the endothelium.

Estrogen modulates adrenergic reactivity of macrovessels, resulting in weaker α-adrenergic vasoconstriction in females than males. However, the mechanisms governing this important sex-specific differ...

Analyzing Glycopeptide Isomers by Combining Differential Mobility Spectrometry with Electron- and Collision-Based Tandem Mass Spectrometry.

Differential mobility spectrometry (DMS) has been employed to separate isomeric species in several studies. Under the right conditions, factors such as separation voltage, temperature, the presence of...

Structural and Functional Analysis of a β2-Adrenergic Receptor Complex with GRK5.

The phosphorylation of agonist-occupied G-protein-coupled receptors (GPCRs) by GPCR kinases (GRKs) functions to turn off G-protein signaling and turn on arrestin-mediated signaling. While a structural...

The magnitude of ivacaftor effects on fluid secretion via R117H-CFTR channels: Human in vivo measurements.

We optically measured effects of orally available ivacaftor (Kalydeco®) on sweat rates of identified glands in 3 R117H subjects, each having a unique set of additional mutations, and compared them wi...

Enteral tranexamic acid attenuates vasopressor resistance and changes in α1-adrenergic receptor expression in hemorrhagic shock.

Irreversible hemorrhagic shock is characterized by hyporesponsiveness to vasopressor and fluid therapy. Little is known, however, about the mechanisms that contribute to this phenomenon. Previous stud...

Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis.

Adaptive thermogenesis is the process of heat generation in response to cold stimulation. It is under the control of the sympathetic nervous system, whose chief effector is the catecholamine norepinep...

Divergence and evolution of assortative mating in a polygenic trait model of speciation with gene flow.

Assortative mating is an important driver of speciation in populations with gene flow and is predicted to evolve under certain conditions in few-locus models. However, the evolution of assortment is l...

1-(4-(18)FFluorobenzyl)-4-((tetrahydrofuran-2-yl)methyl)piperazine: A novel suitable radioligand with low lipophilicity for imaging sigma-1 receptors in the brain.

We have designed and synthesized novel piperazine compounds with low lipophilicity as σ1 receptor ligands. 1-(4-Fluorobenzyl)-4-((tetrahydrofuran-2-yl)methyl)piperazine (10) possessed low nanomolar ...

News Articles [50 Associated News Articles listed on BioPortfolio]

Cause of Stroke Immunodeficiency Uncovered

As if the devastating effects on the brain after having a stroke weren’t enough, new research from investigators at the Roslin, located on the University of Edinburgh's Easter Bush Campus, point...

Teva simultaneously launches AirDuo RespiClick and its authorized generic

Brian BerkDrugs are used for the treatment of asthma in patients aged 12 years and older who are uncontrolled on an inhaled corticosteroid or whose disease severity clearly warrants the use of an ICS/...

Mono-unsaturated fatty acids link H3K4me3 modifiers to C. elegans lifespan

A deficiency in H3K4me3 methyltransferase causes accumulation of mono-unsaturated fatty acids, which is important for lifespan extension in C. elegans and could be relevant in mammals.

Surface chemistry: Giving catalysts a hand

Using chiral modifiers on the surfaces of heterogeneous catalysts is a potentially fruitful route to practical stereoselective chemistry. Now, a study of the dynamics of prochiral adsorbates on modifi...

IBM Watson Health Adopts SNOMED CT

CAMBRIDGE, Mass., March 30, 2017 /PRNewswire/ -- SNOMED International and IBM (NYSE: IBM) Watson Health today announced that Watson Health will adopt SNOMED CT (Clinical Terms) for use in Watson ...

INTUNIV® (Guanfacine Hydrochloride Prolonged Release), a Non-stimulant for the Treatment of ADHD, Receives Approval in Japan

ZUG, Switzerland, March 30, 2017 /PRNewswire/ -- A New Non-stimulant Clinical Option for Children and Adolescents From 6 to 17 Years old With ADHD  Shire plc (LSE: SHP, NASDAQ: SHPG) toda...

Ink Additives Market by Type Rheology Modifiers, Slip/Rub Materials, Defoamers, Dispersants, Technology Waterbased, SolventBased, Process, Application Packaging, Publishing, Commercial Printing, Region Global Forecast to 2021 [Updated: 13032017] Prices f

The ink additives market is projected to register a CAGR of 4.9% during the forecast period in terms of value The global ink additives market is projected to reach USD 793.6 million by 2021, at a CAGR...

Visceral Pain Pipeline Review, H1 2017 [Updated: 15032017] Prices from USD $2000

Visceral Pain Pipeline Review, H1 2017SummaryGlobal Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Visceral Pain Pipeline Review, H1 2017, provides an overview of the V...

DuPont Performance Materials Announces High-Performance Materials for 3D Printing

Products Showcase at Additive Manufacturing Users Group Conference WILMINGTON, Del. (PRWEB) March 20, 2017 DuPont Performance Materials announces participation in the 3D printing industry at the Addi...

Pharmathen Pharmaceuticals SA Pharmaceuticals Healthcare Deals and Alliances Profile [Updated: 21022017] Prices from USD $250

SummaryPharmathen Pharmaceuticals SA Pharmathen is a pharmaceutical company that develops and markets generic products. The company's products include retinoid, serotonin and noradrenaline reuptake in...

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Companies [3 Associated Companies listed on BioPortfolio]

Partikula LLC

Partikula is a preclinical stage biotechnology company focused on developing novel therapies for cancer and other diseases based on platform chemistry technologies, including its ...

Innate Immunotherapeutics Limited

Innate Immunotherapeutics Limited is a public unlisted biopharmaceutical company based in Auckland, New Zealand. The company is focused on the development of a new generation of i...

Innate Therapeutics Limited

Innate Therapeutics Limited is a public unlisted biopharmaceutical company based in Auckland. The company is focused on the development of a new generation of immune response modi...

Clinical Trials [143 Associated Clinical Trials listed on BioPortfolio]

B2 Adrenergic Receptor Gene Polymorphism in Bronchial Asthma

The b2-adrenoceptor (b2AR) mediates the physiological responses in the airway, which include bronchodilation, bronchoprotection. The b2-adrenoceptor (b2AR) mediates the physiological respo...

Efficacy of Ketamine Infusion Compared With Traditional Anti-epileptic Agents in Refractory Status Epilepticus

The study will investigate the efficacy of the NMDA receptor antagonist ketamine as a first line agent in refractory status epilepticus versus traditional general anesthetic agents used fo...

Adrenergic System in Islet Transplantation

To determine the effect of sympathetic neural and hormonal (epinephrine) input on islet cell hormonal responses to insulin-induced hypoglycemia in type 1 diabetic recipients of intrahepati...

Dexmedetomidine Versus Magnesium Sulphate for Caesarean Delivery

Regional anesthesia has become more popular in cesarean deliveries because most of the parturients prefer being awake during the birth process. In addition, regional anesthesia may be a sa...

Physiological Responses and Adaptation of Brown Adipose Tissue to Chronic Treatment With Beta 3-Adrenergic Receptor Agonists

Background: Brown adipose tissue (BAT) is a type of fat in the body. It may prevent weight gain, improve insulin sensitivity, and reduce fatty liver. Researchers want to see if BAT helps ...

Ephedrine and Phenylephrine for Spinal Hypotension

Spinal anesthesia is widely used as the procedure of choice for cesarean delivery. In comparison to epidural anesthesia it is faster, easier to perform, patients are more comfortable, comp...

Trelegy ELLIPTA ® Inhaler: Qualitative Analysis and Subject Preference Survey

Three main classes of inhaled treatment exist for chronic obstructive pulmonary disease (COPD): Beta2-adrenergic agonists (which may be short (SABA) or long (LABA) acting), long-acting mus...

Cutaneous Autonomic Pilomotor Testing to Unveil the Role of Neuropathy Progression in Early Parkinson's Disease

In Parkinson's disease (PD), alpha-synuclein accumulation in cutaneous autonomic pilomotor and sudomotor nerve fibers has been linked to autonomic nervous system disturbances even in the e...

The Influence of Electronic and Traditional Cigarettes Smoking on Hemodynamic Parameters

It is intended to examine 50 healthy volunteers aged 18 - 60 years. 12-hour abstinence from tobacco smoke, alcohol or coffee before the experiment will be required. The exclusion criteria ...

Dexmedetomidine on Basal Ganglia Neuronal Activity in Parkinson's Disease

The implantation of a deep brain stimulator (DBS) is an established option to improve the symptoms of Parkinson's disease (PD) in patients that do not respond adequately to medical therapy...

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Medical and Biotech [MESH] Definitions

Drugs that act on adrenergic receptors or affect the life cycle of adrenergic transmitters. Included here are adrenergic agonists and antagonists and agents that affect the synthesis, storage, uptake, metabolism, or release of adrenergic transmitters.

Drugs that bind to but do not activate ADRENERGIC RECEPTORS. Adrenergic antagonists block the actions of the endogenous adrenergic transmitters EPINEPHRINE and NOREPINEPHRINE.

A subclass of beta-adrenergic receptors (RECEPTORS, ADRENERGIC, BETA). beta-3 Adrenergic receptors are the predominant beta-adrenergic receptor type expressed in white and brown ADIPOCYTES and are involved in modulating ENERGY METABOLISM and THERMOGENESIS.

Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.

Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.

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