Channels: Page 2
BioPortfolio's Channels offers visitors a single point of access to life science and healthcare subjects, technologies, products and services. For example ImmTAC developed by Immunocore, PolyXen developed by Xenetic Biosciences. Each dedicated Channel web page provides highly specific information sourced from BioPortfolio's unique collection of databases - news stories, corporate directory, clinical trials, medical and scientific information.
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Showing Channels 26–50 of 4,400+
PKC (protein kinase C) http://www.bioportfolio.com/channels/serine-threonine-protein-kinase-c-pkc is a kinase enzyme and a protein molecule that can change the format of other proteins through chemical reactions called phosphorylation on individual amino...
APC stands for adenomatous polyposis coli, a form of colorectal cancer and is a tumour suppressor
APC stands for adenomatous polyposis coli, a form of colorectal cancer and is a tumour suppressor. When APC it mutated, it can cause this particular type of colorectal cancer. When not present in its correct form, APC is correlated with increased risk of...
Ras is the first protein in the apoptosis cascade
Ras is the first protein in the apoptosis cascade, activated by tyrosine kinase receptors in response to growth factor stimulation from the extra cellular matrix. Ras is an oncogene, meaning it promotes cell cycle activity, driving cell replication, the...
Myc is the protein encoded by the MYC gene that activates the cell cycle
Myc is the protein encoded by the MYC gene that activates the cell cycle. It promotes cell replication through genetic coding for p14, inhibiting MDM2 and preventing the degradation of the pro-apoptotic protein p53. When mutated, the gene may be ampli...
Endocrine Disrupting Chemicals (EDCs)
Endocrine disrupting chemicals (EDCs) consist of a diverse group of industrial chemicals and pharmacological agents. Evidence is accumulating that environmental chemicals (ECs) including endocrine-disrupting compounds (EDCs) can alter female repro...
Metabotropic Glutamate Receptor 4 (mGluR4)
Metabotropic glutamate receptor 4 is a protein that in humans is encoded by the GRM4 gene. Together with GRM6, GRM7 and GRM8 it belongs to group III of the metabotropic glutamate receptor family. Group III receptors are linked to the inhibition of t...
Antibody-drug conjugates are designed to combine the specificity of antibodies directed against tumor-associated targets with potent cytotoxity. Upon internalization of the ADC, the antibody-bound cytotoxins are released intracellularly, leading to elimi...
Cholesteryl Ester Transfer Protein (CETP)
The Cholesteryl Ester Transfer Protein (CETP) facilitates the transfer of cholesterol from HDL to other lipoproteins including LDL, in exchange for triglycerides. The CETP mediated transfer of cholesterol into LDL particles results into maturation of tho...
What is new in prostate cancer research and development?
Key research areas in relation to Prostate Cancer are discussed below. Brief descriptions are supported by hyperlinks to the most relevant research papers and current affairs news reports and blog postings - follow these links for more detailed inf...
Lysosomal storage disorders (LSDs)
Lysosomal storage disorders (LSDs) represent a group of about 50 genetic disorders caused by deficiencies of lysosomal proteins. Most involve genetic mutations causing loss of function of key catabolic enzymes residing in the lysosome that are involved i...
The most common system to evaluate and describe prostate cancer currently in use is the Gleason grading system. After a biopsy, the pathologist assigns a primary grade from 1 to 5, with 5 being the most aggressive, to the pattern of cancer cells occupyin...
Technical Background Tumor necrosis factor (TNF) is a substance made by your body's immune system. People with inflammatory diseases such as rheumatoid arthritis, plaque psoriasis, psoriatic arthritis, juvenile idiopathic arthritis, and ankylosing...
Technical background: HUMIRA is a tumor necrosis factor (TNF) blocker - further details can be viewed: Tumor Necrosis Factor TNF Cytokine Tumour Necrosis Factor (TNF) Mechanism of Action: Adalimumab is a recombinant human anti-TNF mono...
Despite the humorous name, hedgehog signalling cascades are central to embryonic development and has been implicated in the development of a number of diseases, including cancer. The downstream cascades of the Hedgehog pathway have considerable overlap...
Wnt is an anti-apoptotic ligand for the Fz (frizzled) receptor on cell membranes
Wnt is an anti-apoptotic ligand for the Fz (frizzled) receptor on cell membranes, meaning it attaches to the Fz receptor and prevents cell death (in effect with other cellular stimuli). Wnt molecules are a family of proteins that act as a paracrine stimu...
p53 - protein 53 - tumor protein 53
The p53 molecule is centrally important to the apoptosis pathway, and found in many cell pathways leading to apoptosis. As a tumour suppressor protein, its downstream compounds act to prevent apoptosis and cell death. This is significant in that is makes...
Caspases are a family of enzymes with very specific characteristics that can be used in almost every biological pathway in the body. The knock-on effects of the action of caspases keep us alive, initiating many vital cellular pathways. Interestingly, cas...
Cytokine Tumour Necrosis Factor (TNF)
TNF is a compound that is classified as a cytokine which plays a central role in the cellular mechanisms of apoptosis or cell death. However, there are a number of different kinds of TNF, just under twenty, but the family of molecules have very similar a...
Top 50 Biopharma Products 2011
Ronald A. Rader, president of the Biotechnology Information Institute provided Contract Pharma a list of the Top 57 Biopharma Products by 2011 revenues (in millions). Mr. Rader subscribes to the same criteria as Contract Pharma — that biopharmaceut...
Plasmid Land: The Plasmid Cloning Game
When the average person asks, “What is a plasmid?” we sometimes struggle to give them a basic answer. Plasmids are circular fragments of double-stranded DNA that can replicate independently of chromosomal DNA. Today, scientists can easily stu...
ATX-MS-1467 for patients with multiple sclerosis (MS)
ATX-MS-1467 is a novel treatment that was developed with the aim of working with the immune system to treat the underlying cause of disease rather than just treating the symptoms or suppressing the entire immune system, and thus restore immunological bal...
Veryan has developed three dimensional (3D) stent technology based upon a helical shape that may be applied to a self-expanding stent platform. The initial objective was to investigate the presence of, and effects arising from, secondary flows in a 3D...
Rivaroxaban is the most broadly indicated novel oral anticoagulant and is marketed under the brand name Xarelto®. To date, Xarelto has been approved for use in the following indications across the venous arterial thromboembolic (VAT) space: The...
Venous Arterial Thromboembolism
Thrombosis is the formation of a blood clot inside a blood vessel, blocking a vein (venous thrombosis) or artery (arterial thrombosis). Venous Arterial Thromboembolism (VAT) is caused when some or all of a clot detaches and is moved within the blood stre...
Macitentan (Opsumit®) is a novel dual endothelin receptor antagonist (ERA) that resulted from a tailored drug discovery process with the target to develop an ERA optimized for efficacy and safety [2]. Macitentan has a number of potentially key benefi...
