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Thrombopoiesis stimulating agents are under evaluation for treatment of idiopathic thrombocytopenic purpura (ITP) and for prevention of severe thrombocytopenia induced by chemotherapy.
Progression through the cell cycle is monitored by surveillance mechanisms known as cell cycle checkpoints. Dysfunction in cell cycle checkpoints leads to genomic instability and contributes to tumor progression. Checkpoint kinase 1 (CHK-1) plays a criti...
Subacute cutaneous lupus erythematosus (SCLE) is a nonscarring non–atrophy-producing photosensitive dermatosis. SCLE may occur in patients with systemic lupus erythematosus (SLE), Sjögren syndrome, and deficiency of the second component of com...
Viruses are implicated in the causes of some cancers, and may in time offer potential therapy for other forms of cancer. An oncovirus is a virus that can cause cancer. Worldwide, the WHO International Agency for Research on Cancer estimated that in 200...
CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker. This receptor is expressed by activated, but not by resting, T and B cells. It is a positive regulator of apoptosis, and also has been ...
Luteinizing hormone (LH), a gonadotropin, stimulates the gonads - in males, the testes, and in females, the ovaries. It is essential for reproduction, and secreted from cells in the anterior pituitary called gonadotrophs. In females, ovulation of mature ...
Immunotoxins are proteins that contain a toxin along with an antibody or growth factor that binds specifically to target cells. Nearly all protein toxins work by enzymatically inhibiting protein synthesis. For the immunotoxin to work, it must bind to and...
Varicella zoster virus (VZV) is one of eight herpes viruses known to infect humans (and other vertebrates). Varicella-zoster virus is known by many names, including: chickenpox virus, varicella virus, zoster virus, and human herpes virus type 3 (HHV-3). ...