Alzheimer's Disease - Biotech, Pharma and Life Science Channel
Of all the types of Dementia, Alzheimer's disease is the most common, affecting around 465,000 people in the UK.
Neurons in the brain die, becuase 'plaques' and 'tangles' (mis-folded proteins) form in the brain. People with Alzheimer's also have a shortage of some the neurotransmitter, acetylcholine, in their brains. Alzheimer's is a progressive disease. Symptoms include; memory lapses, aphasia, confusion and mood swings.
There may be a genetic background to Alzheimer's, particulary in the cases of early onset. This is being investigated by scientists. The ApoE4 gene variant is suggestive of a much higher chance of developing Alzheimer's disease. Other risk factors include injury to the head, smoking and high blood pressure or cholesterol levels.
The treatment for Alzheimers focuses on managing the symptoms, as there is currently no cure. Some medications increased the depleted supply of Acetylcholine, such as donepezil hydrochloride, rivastigmine and galantamine. Ebixa (trade name for the drug memantine) was launched in the UK in 2002, and is used in the moderate and severe stages of the disease. In addition to drugs, the antioxidant vitamins C and D may help.
Source; Alzheimer's Society, UK
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Medical and Biotech [MESH] Definitions
Casuistry
A method of ETHICAL ANALYSIS that emphasizes practical problem solving through examining individual cases that are considered to be representative; sometimes used to denote specious argument or rationalization. Differentiate from casuistics, which is the recording and study of cases and disease.
Incidental Findings
Unanticipated information discovered in the course of testing or medical care. Used in discussions of information that may have social or psychological consequences, such as when it is learned that a child's biological father is someone other than the putative father, or that a person tested for one disease or disorder has, or is at risk for, something else.
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