Amphetamines - Biotech, Pharma and Life Science Channel
PubMed Articles
A solid-phase microextraction (SPME) method for the determination of five amphetamine type stimulants (ATSs) in water and urine samples is presented. Analytes were simultaneously derivatized with iso-...
Fatal acute methamphetamine (MA) poisoning in cases of internal drug trafficking is rarely described in the literature. This case study reports an MA 'body packer' who died from fatal methamphetamine...
Monoaminergic dysregulation is implicated in attention-deficit/hyperactivity disorder (ADHD), and methylphenidate and amphetamines are the most frequently prescribed pharmacological agents for treatin...
Time to Abandon the Self-Medication Hypothesis in Patients with Psychiatric Disorders.
Background: The Self-Medication Hypothesis (SMH) of addictive disorders as articulated by Edward Khantzian in his seminal 1985 paper postulates that individuals with psychiatric disorders use substanc...
Pharmacological characterization of designer cathinones in vitro.
Background and purpose: Designer β-keto amphetamines (e.g., cathinones, "bath salts," and "research chemicals") have become popular recreational drugs, but their pharmacology is poorly characterized....
OBJECTIVE: To describe patterns of simultaneous polysubstance use (SPU) among Danish 3,4-methylenedioxymethamphetamine (MDMA) ("Ecstasy") and hallucinogen users. METHODS: A cross-sectional survey of 9...
Profile of infants born to drug-using mothers: A state-wide audit.
Aims: To ascertain the characteristics and short-term outcomes of infants born to illicit drug-using mothers in public hospitals in the state of New South Wales and the Australian Capital Territory...
Anti-obesity drugs: a review about their effects and their safety.
Introduction: Amphetamines, rimonabant and sibutramine licenses as anti-obesity drugs have been withdrawn because of their adverse effects. In fact, orlistat is the only available long-term treatment...
The pharmacological treatment of obesity: Past, present and future.
Currently, obesity presents one of the biggest health problems. Management strategies for weight reduction in obese individuals include changes in life style such as exercise and diet, behavioral ther...
Pharmacotherapy of attention-deficit hyperactivity disorder in adolescents.
Attention-deficit hyperactivity disorder (ADHD) is a common neurobehavioural disorder in children and adolescents, consisting of developmentally inappropriate levels of inattention and/or hyperactivit...
News Articles
Ten Percent Of Teens Use Study Drugs Yet Most Parents Aren't Aware
Many teens across the country are using "study drugs" to give them an academic advantage and help them achieve better results in school. The University of Michigan Mitt Children's Hospital National P...
CANTON, Mass., May 17, 2013 /PRNewswire/ -- Collegium Pharmaceutical, Inc., a specialty pharmaceutical company, today announced that the Company's President and CEO, Michael Heffernan, will present th...
CANTON, Mass., May 8, 2013 /PRNewswire/ -- Collegium Pharmaceutical, Inc., a specialty pharmaceutical company focused on the development of innovative treatments for chronic pain, today announc...
PHILADELPHIA, May 1, 2013 /PRNewswire/ -- Shire plc (LSE: SHP, NASDAQ: SHPGY), the global specialty biopharmaceutical company, today announced that the US Food and Drug Administration (FDA) approved...
Roadside Breath Testing For Drugs A Step Closer
A group of researchers from Sweden have provided further evidence that illegal drugs can be detected in the breath, opening up the possibility of a roadside breathalyzer test to detect substances such...
Scientists Develop Breathalyzer That Can ‘Smell’ Drugs
Brett Smith for redOrbit.com – Your Universe Online For years, roadside breathalyzer tests have been an accurate and effective way to determine the blood alcohol level of a motorist and new resear...
Breath study brings roadside drug testing closer
A group of researchers from Sweden have provided further evidence that illegal drugs can be detected in the breath, opening up the possibility of a roadside breathalyzer test to detect substances such...
(PRWEB) April 24, 2013 When drugs like Spice, Kratom and Bath Salts first started gaining popularity in the United States, they didn't show up on traditional drug tests. People began to use th...
Are primary psychotic disorder and psychosis precipitated by amphetamines two separate phenomena? In this review, the authors propose a new model for understanding the dynamics of their relationship....
Collegium Pharmaceutical Names Douglas Carlson to Vice President of Business Development
CANTON, Mass., April 3, 2013 /PRNewswire/ -- Collegium Pharmaceutical, Inc., a specialty pharmaceutical company focused on the development of innovative treatments for chronic pain, has hired Dou...
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Clinical Trials
Improvement of Use Dependent Plasticity in Chronic Stroke Patients
This study will examine the role of an amphetamine in improving the effect that electrical nerve stimulation has over brain flexibility associated with motor training in patients who exper...
The purpose of this research study is to learn about the effects of a medication called Vyvanse on the heart (cardiovascular system). The U.S. Food and Drug Administration (FDA) has approv...
A Pilot Trial of Modafinil for Treatment of Methamphetamine Dependence
Patients treated for methamphetamine dependence have high rates of relapse, and no pharmacotherapy has yet been demonstrated to be efficacious. Modafinil (d, l-2-[(diphenylmethyl) sulfinyl...
To enhance our capacity to correctly choose the appropriate medication for ADHD patients on the first try based on the presence of a particular variant of a gene that could be identified o...
Videos
Amphetamines and the Brain
20% of regular amphetamine users tested under the age of 30 have been found to have an 'abnormality of the brain'. At that age, it should be less than 1%. Fi...
Medical and Biotech [MESH] Definitions
Designer Drugs
Drugs designed and synthesized, often for illegal street use, by modification of existing drug structures (e.g., amphetamines). Of special interest are MPTP (a reverse ester of meperidine), MDA (3,4-methylenedioxyamphetamine), and MDMA (3,4-methylenedioxymethamphetamine). Many drugs act on the aminergic system, the physiologically active biogenic amines.
Adrenergic Uptake Inhibitors
Drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants (ANTIDEPRESSIVE AGENTS, TRICYCLIC) and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin.
Amphetamine-related Disorders
Disorders related or resulting from use of amphetamines.
Amphetamines
Analogs or derivatives of AMPHETAMINE. Many are sympathomimetics and central nervous system stimulators causing excitation, vasopressin, bronchodilation, and to varying degrees, anorexia, analepsis, nasal decongestion, and some smooth muscle relaxation.
Cocaine
An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.
