Analgesic Nephropathy - Biotech, Pharma and Life Science Channel
PubMed Articles
Are nonesterified Fatty acids protective in chronic allograft nephropathy?
At therapeutic doses, acetaminophen (APAP) is a safe and effective analgesic. However, overdose of APAP is the principal cause of acute liver failure in the West. Binding of the reactive metabolite of...
Neovascularization in diabetes and its complications. Unraveling the angiogenic paradox.
Diabetes mellitus (DM) is a chronic metabolic disease characterized by the presence of hyperglycemia, which can lead to many complications over time. These complications, such as nephropathy, retinopa...
Skin vasodilation and analgesic effect of a topical nitric oxide-releasing hydrogel.
New approaches based on topical treatments are needed for treating pain and impaired dermal blood flow. We used a topical Pluronic F127 hydrogel containing S-nitrosoglutathione (GSNO) as a prodrug to...
OBJECTIVE: Chronic hepatitis B virus (HBV) carrier status has a critical impact on clinical management of patients with IgA nephropathy (IgAN) who are treated with corticosteroids, because corticoster...
Association between serum ferritin and microalbuminuria in Type 2 diabetes in Taiwan.
AIMS: Serum ferritin has been found closely related with diabetes and glucose metabolism, but its impact on diabetic nephropathy remains unknown. This study aimed to explore the association between se...
BACKGROUND: Proximal femoral fractures are common in elderly patients. Recently, use of regional blockade has gained popularity as a means of relieving pain among this patient population. Among the pr...
BACKGROUND: In recent years, tonsillectomy and steroid pulse (TSP) therapy have been widely performed in Japan. However, there is no consensus about the treatment protocol and indication. METHODS: In...
OBJECTIVE: To compare the analgesic efficacy of bupivacaine, bupivacaine + morphine, or bupivacaine + dexmedetomidine administered epidurally in dogs undergoing pelvic limb orthopedic surgery. STU...
Catalytic mechanism of Angiotensin-converting enzyme and effects of the chloride ion.
The angiotensin-converting enzyme (ACE) exhibits critical functions in the conversion of angiotensin I to angiotensin II and the degradation of bradykinin and other vasoactive peptides. As a result, t...
News Articles
SAN DIEGO, June 17, 2013 /PRNewswire/ -- Purdue Pharma L.P. will present a poster describing the changes in abuse of OxyContin® and immediate-release oxycodone in rural Kentucky fo...
SAN DIEGO, June 14, 2013 /PRNewswire/ -- Imprimis Pharmaceuticals, Inc. (NASDAQ:IMMY), which is focused on the commercialization of compounded drug formulations, today announced CEO Mark L. Baum will...
Introducing Goody’s® Headache Relief Shot™
Fast-Acting Liquid Formula Comes in Convenient One-Shot Bottles Goody’s®, the brand known for its fast-acting headache powder, is introducing an innovative new pain relieve...
Osprey Medical Inc. PRESERV Clinical Trial Update
In March 2013, Osprey Medical announced commencement of its US registration directed pivotal IDE clinical study of the CINCOR™ system with the first patient enrolle...
Zogenix cuts 55 jobs, awaits FDA Zohydro decision
Zogenix will reduce its 148-employee work force by 37%, cutting 55 jobs as the San Diego-based company awaits a US FDA decision on approval for the chronic pain drug Zohydro ER. FDA staff and the agen...
NALP3-mediated inflammation is a principal cause of progressive renal failure in oxalate nephropathy
Opioid Analgesics—Risky Drugs, Not Risky Patients Opioid Analgesics
From 1999 to 2010 the number of people in the United States dying annually from opioid analgesic–related overdoses quadrupled, from 4030 to 16 651. Patients' predisposition to overdose could not ha...
Atrasentan Reduces Albuminuria and Cholesterol
In patients with type 2 diabetes and nephropathy, the selective endothelin-receptor antagonist reduces albuminuria and cholesterol, new research suggests, but will this translate into cardiorenal prot...
Events
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Companies
Promedior has developed a novel drug discovery platform to regulate the monocyte-derived cell populations that play key roles in fibrotic, inflammatory and autoimmune diseases. By...
CorMedix Inc. is a pharmaceutical company that seeks to in-license, develop and commercialize therapeutic products for the prevention and treatment of cardiac and renal dysfunctio...
Privately held CardioLogical Solutions is an emerging medical technology company focused on developing novel accessory devices for interventional cardiology procedures. For exampl...
EpiCept is focused on the development and commercialization of pharmaceutical products for the treatment of cancer and pain. The Company's lead product is Ceplene®, which has b...
Clinical Trials
The Effect of the Forced Diuresis With Matched Hydration in Reducing Acute Kidney Injury During TAVI
Evaluating whether forced diuresis with matched hydration will reduce the risk of contrast induced nephropathy in patients undergoing Trancatheter Aortic Valve Implantation (TAVI).
Intra-operative Ketamine Infusions in Opioid-dependent Patients With Chronic Lower Back Pain
Noxious stimuli occurring intraoperatively and postoperatively generate central sensitization, decreasing pain thresholds and ultimately increasing analgesic requirements. The pathophysiol...
Nephrotic Syndrome Study Network
Minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), and Membranous nephropathy (MN), generate an enormous individual and societal financial burden, accounting for appr...
Renal Effects of Two Iodinated Contrast Media in Patients at Risk Undergoing Computed Tomography
It is well known that X-ray contrast media can affect kidney function in some patients, especially when administered intra-arterially, and patients who already suffer from reduced kidney f...
Chronic transplant nephropathy and cardiovascular death are the main reasons for loss of transplanted organs after kidney transplantation. Vascular changes, induced by hypertension and/or...
Statins in Proteinuric Nephropathies
End stage renal disease (ESRD) is rapidly growing worldwide. Patients with ESRD have increased morbidity and mortality mostly because of a dramatic excess of cardiovascular disease. Thus,...
The purpose of this study is to determine whether treatment with sirolimus, in combination with low-dose tacrolimus and prednisone, is effective for the treatment of chronic allograft neph...
Study of Fentanyl-Propofol-EMLA of L.M.X4 Technique for Bone Marrow Aspiration
St. Jude Children's Research Hospital is studying the best ways to prevent pain during and after procedures such as bone marrow aspiration and lumbar puncture with intrathecal (in the spin...
Prevention of Contrast-Induced Nephropathy
Patients with pre-existing kidney disease are at high risk of acute renal failure when exposed to radio-contrast dyes, for example during a cardiac angiogram. The investigators hypothesiz...
A number of blood pressure lowering drugs in the class known as angiotensin receptor blockers (ARB) have been shown to slow the decline in kidney function of patients with type 2 diabetes,...
Videos
WHAT IS ANALGESIC NEPHROPATHY
These videos are designed for medical students studying for the USMLE step 1. Feel free to comment and suggest what you would like to see in the future, and ...
Medical and Biotech [MESH] Definitions
Aristolochic Acids
Nitro-phenanthrenes occurring in ARISTOLOCHIACEAE and other plants. They derive from stephanine (APORPHINES) by oxidative ring cleavage. The nitro group is a reactive alkylator (ALKYLATING AGENTS) that binds to biological macromolecules. Ingestion by humans is associated with nephropathy (NEPHRITIS). There is no relationship to the similar named aristolochene (SESQUITERPENES).
Opiate Alkaloids
Alkaloids found in OPIUM from PAPAVER that induce analgesic and narcotic effects by action upon OPIOID RECEPTORS.
Potassium Deficiency
A condition due to decreased dietary intake of potassium, as in starvation or failure to administer in intravenous solutions, or to gastrointestinal loss in diarrhea, chronic laxative abuse, vomiting, gastric suction, or bowel diversion. Severe potassium deficiency may produce muscular weakness and lead to paralysis and respiratory failure. Muscular malfunction may result in hypoventilation, paralytic ileus, hypotension, muscle twitches, tetany, and rhabomyolysis. Nephropathy from potassium deficit impairs the concentrating mechanism, producing polyuria and decreased maximal urinary concentrating ability with secondary polydipsia. (Merck Manual, 16th ed)
Prenazone
A pyrazole that has analgesic, anti-inflammatory, and antipyretic properties. It has been used in mild to moderate pain, fever, and inflammation associated with musculoskeletal and joint disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p15)
Promedol
A narcotic analgesic similar to MEPERIDINE; it exists in four stereoisomers, two of which, the beta (isopromedol) and the gamma (trimeperidine) are active.
