Anticoagulant drugs - Biotech, Pharma and Life Science Channel
PubMed Articles
TL-118-anti-angiogenic treatment in pancreatic cancer: a case report.
Pancreatic cancer is one of the most aggressive malignant tumors. In recent years, little progress has been made in understanding and treatment of the disease. The two most commonly used chemotherapy...
Thymidylate synthase (TSase) produces the sole intracellular de novo source of thymidine (i.e., the DNA base T) and thus is a common target for antibiotic and anticancer drugs. Mg(2+) has been reporte...
Multidrug resistance has been a critical issue in current chemotherapy. In Escherichia coli , a major efflux pump responsible for the multidrug resistance contains a transporter AcrB. Crystallographic...
Publication Bias, with a Focus on Psychiatry: Causes and Solutions.
Publication bias undermines the integrity of the evidence base by inflating apparent drug efficacy and minimizing drug harms, thus skewing the risk-benefit ratio. This paper reviews the topic of publi...
BACKGROUND AND OBJECTIVE: It is well recognized that many antihypertensive drugs exhibit large interindividual variability in effect and that this wide range of patient response to antihypertensive dr...
PURPOSE: To measure the adherence and persistence of patients with acute coronary syndrome (ACS) initiating prasugrel after percutaneous coronary intervention (PCI). METHODS: Using the Thomson Reuters...
Evaluation and Management of Acquired Methemoglobinemia Associated with Topical Benzocaine Use.
Benzocaine is a widely used topical oropharyngeal anesthetic and has been reported to cause methemoglobinemia. We discuss benzocaine-induced methemoglobinemia and review the causes, presentation, and...
Aortic thrombus and multiple embolisms during a Mycoplasma pneumoniae infection.
We report the case of a patient who presented with a thrombus of the aortic arch complicated with splenic, renal and peroneal artery embolisms, associated with transient lupus anticoagulant, during a...
Drug-related visits to the emergency department in a Spanish university hospital.
Background Negative outcomes of medications (NOMs) are a major public health problem that impact on patients' quality of life. As many NOMs are avoidable, it is necessary to determine their causes in...
Background In 2008 recommendations were launched to prevent medication-related hospital admissions in the Netherlands. Elderly patients using several drugs on a chronic basis were among the target gro...
News Articles
Experts Say Revamp Needed for Diabetes Drug Development
Obesity drugs, too, require a new approach to approval, say doctors, because both diabetes and obesity are chronic conditions with much attendant comorbidity, which often requires lifelong therapy...
India sets guidelines to meet EU drug import rules
May 23 (Reuters) - The Indian government said on Thursday it had set guidelines for pharmaceutical makers to comply with a European Union directive on standards for import of bulk drugs into the EU th...
Isis Pharmaceuticals to Present at the Deutsche Bank 38th Annual dbAccess Health Care Conference
CARLSBAD, Calif., May 23, 2013 /PRNewswire/ -- Isis Pharmaceuticals, Inc. (NASDAQ: ISIS), the leader in antisense therapeutics, today announced that management will present a company overview at the D...
Medical research charity Arthritis Research UK has awarded a team of researchers at Cardiff University a grant of £200,000 to investigate new drugs to treat early onset osteoarthritis. The team will...
GSK, US HHS team up to develop drugs against antibiotic resistance and bioterrorism
GlaxoSmithKline (GSK) has teamed up with Biomedical Advanced Research and Development Authority (BARDA), part of the US Department of Health and Human Services (HHS), to develop drugs against antibiot...
Russia Seeks Foreign Partnerships For Pharma, Medical Device Growth
Drugs and medical devices are the subject of several efforts Russia is making to attract international partnerships to help the country achieve several goals, including one to produce nearly half such...
Small molecule inhibition of the KRAS–PDEδ interaction impairs oncogenic KRAS signalling
The KRAS oncogene product is considered a major target in anticancer drug discovery. However, direct interference with KRAS signalling has not yet led to clinically useful drugs. Correct localization...
Cancer: Drug for an 'undruggable' protein
Scientists have long aimed to develop drugs against the cancer-associated protein KRAS, but without success. An approach that targets the oncoprotein's cellular localization reignites lost enthusiasm.
Grapefruit-Derived Nanovectors Provide A Secret Weapon In Medical Drug Delivery
University of Louisville researchers have uncovered how to create nanoparticles using natural lipids derived from grapefruit, and have discovered how to use them as drug delivery vehicles. UofL scient...
New funding for Cardiff researchers to develop new drugs to treat osteoarthritis
Medical research charity Arthritis Research UK has awarded a team of researchers at Cardiff University a grant of £200,000 to investigate new drugs to treat early onset osteoarthritis. The team...
Events
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Companies
Perosphere is a specialty pharmaceutical company that identifies and develops new chemical entities and other therapeutics that can be used as ârescueâ drugs. For more i...
Aradigm Corporation and Grifols S.A.
Aradigm is an emerging specialty pharmaceutical company focused on the development and commercialization of drugs delivered by inhalation for the prevention and treatment of sever...
Monarch Medical Technologies is a privately held medical technology company founded by clinicians with a vision of dramatically improving hospital-based glucose management by repl...
R-Tech Ueno is a bio-venture company established in September 1989 for the purpose of marketing and R&D of drugs. Under leadership of the president, also a medical doctor, the company is developing ne...
Xenetic is a leading UK-based biopharmaceutical company providing leading-edge expertise in the development of a whole new generation of drugs and vaccines. Working with some of the largest pharma...
Verastem, Inc. is a private biopharmaceutical company focused on discovering and developing novel drugs that selectively target cancer stem cells. Cancer stem cells are an underly...
Etubics Corporation, based in Seattle, Wash., is a clinical stage bio-pharmaceutical company, which has developed a proprietary platform technology consisting of a next generation...
TPP is a UK-based, drug development company operating in the preclinical area of the drug discovery process. TPP in-licenses novel intellectual property (IP) from universities, re...
Ipsen is a global biopharmaceutical group, with sales exceeding 1 billion euros in 2009. The Group has total worldwide staff of more than 4,400 employees, of which nearly 900 cont...
GlycoMimetics is a privately held biotechnology company that capitalizes on advances in the field of glycobiology. The company uses rational design of small molecule drugs that mi...
Clinical Trials
A Study of Two Approved Drugs in the Treatment of Postoperative Dental Pain (0966-181)(COMPLETED)
The purpose of this study is to compare the safety and effectiveness of two approved drugs in the treatment of pain following dental surgery.
Evaluation of M118 in Percutaneous Coronary Intervention (EMINENCE)
The primary objective is to evaluate the safety and feasibility of using M118 as an anticoagulant in the target population of subjects with stable coronary artery disease (CAD) undergoing...
Blood clots in the leg veins, known as deep vein thrombosis, are important because they may travel to the lung (known as pulmonary embolism) and cause death. Blood clots are treated with...
Heparin Responses in Pediatric Patients Undergoing Cardiopulmonary Bypass.
Heparin is an anticoagulant or "blood thinner". Heparin is always given to patients undergoing open-heart surgery to prevent blood from clotting when a patient is placed on the heart-lung...
Apheresis to Obtain Plasma or White Blood Cells for Laboratory Studies
This study will collect blood plasma and white blood cells from individuals using a procedure called apheresis. Apheresis is a method of collecting larger quantities of certain blood compo...
RATIONALE: Androgens can cause the growth of prostate cancer cells. Drugs, such as goserelin, may stop the adrenal glands from making androgens. Drugs used in chemotherapy, such as docetax...
Pixantrone or Other Chemotherapy Drugs in Treating Patients With Relapsed Non-Hodgkin's Lymphoma
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. It is not yet known whether...
RATIONALE: Drugs used in chemotherapy, such as eflornithine, work in different ways to stop tumor cells from dividing so they stop growing or die. Androgens can stimulate the growth of pro...
RATIONALE: Androgens can stimulate the growth of prostate cancer cells. Drugs such as goserelin and leuprolide may fight prostate cancer by stopping the adrenal glands from producing andro...
This trial will include patients who have a heart condition called atrial fibrillation. Atrial fibrillation is an abnormal rhythm (irregular beat) in the heart. Patients with atrial fibri...
Videos
Haemostasis 3 - Anticoagulants & Thrombolytics
http://www.handwrittentutorials.com - This tutorial is the third in a series of three on the topic of Haemostasis. This video explores the actions of the ant...
Medical and Biotech [MESH] Definitions
Cinnamomum Aromaticum
A plant species of the genus CINNAMOMUM that contains CINNAMATES and has been used in traditional Chinese medicine (DRUGS, CHINESE HERBAL).
Epimedium
A plant genus of the family BERBERIDACEAE which is used in DRUGS, CHINESE HERBAL. Members contain flavonol glycosides including epimedins, icariin and noricariin.
Cuscuta
A plant genus of the family Cuscutaceae. It is a threadlike climbing parasitic plant that is used in DRUGS, CHINESE HERBAL.
Histamine H1 Antagonists, Non-sedating
A class of non-sedating drugs that bind to but do not activate histamine receptors (DRUG INVERSE AGONISM), thereby blocking the actions of histamine or histamine agonists. These antihistamines represent a heterogenous group of compounds with differing chemical structures, adverse effects, distribution, and metabolism. Compared to the early (first generation) antihistamines, these non-sedating antihistamines have greater receptor specificity, lower penetration of BLOOD-BRAIN BARRIER, and are less likely to cause drowsiness or psychomotor impairment.
Herb-drug Interactions
The effect of herbs, other PLANTS, or PLANT EXTRACTS on the activity, metabolism, or toxicity of drugs.
