Azole Antifungals - Biotech, Pharma and Life Science Channel
PubMed Articles
New azole antagonists with high affinity for the P2Y1 receptor.
Five-membered-ring heterocyclic urea mimics have been found to be potent and selective antagonists of the P2Y1 receptor. SAR of the various heterocyclic replacements is presented, as well as side-chai...
A series of benzenesulfonamides incorporating cyanoacrylamide moieties (tyrphostine analogs) were assayed as inhibitors of the β-carbonic anhydrase (CA, EC 4.2.1.1) from Saccharomyces cerevisiae, ScC...
Invasive fungal infections have increased significantly in the past few decades because of the increase in high-risk populations. To investigate the distribution and drug susceptibilities of such infe...
Synthesis, physical properties and self-assembly behavior of azole-fused pyrene derivatives.
A novel selenadiazole-fused pyrene derivative was successfully synthesized and characterized. Its single structure is almost planar and adopts a sandwich-herringbone packing model. The self-assembly b...
Proteomic survey of the Streptomyces coelicolor nucleoid.
Nucleoid-associated proteins (NAPs) are small, highly abundant transcriptional regulators with low sequence specificity which are involved in multiple DNA-related processes including gene expression,...
The Antifungal Occidiofungin Triggers an Apoptotic Mechanism of Cell Death in Yeast.
Occidiofungin is a nonribosomally synthesized cyclic peptide having a base mass of 1200 Da. It is naturally produced by the soil bacterium Burkholderia contaminans MS14 and possesses potent broad-spec...
To investigate spontaneous reporting relationships between representative antifungal agents and congestive heart failure (CHF)-related adverse events (AE) we performed multiple disproportionality anal...
Nanoelectrospray ionisation mass spectrometry (nanoESI MS) of intact protein complexes was used to study CYP121, one of the twenty cytochrome P450s in Mycobacterium tuberculosis (Mtb) and an enzyme th...
Azole resistance in Aspergillus is emerging in European and Asian countries. As azoles are mainstay of therapy in the management of aspergillosis, azole resistance has serious implications in patient...
Triplet energy tuning from 2.48 eV to 2.94 eV by just a simple change of heteroatom in the ligand structure of Be complexes was studied using azole based triplet host materials. Three Be organometalli...
News Articles
Novo A/S (Hellerup, Denmark) will acquire infectious disease company Xellia Pharmaceuticals A/S (Oslo, Norway) from private equity firm 3i Group for about $700 million. In 2008, 3i acquired Xellia, wh...
No Clear Favorite for Topical Treatment of Dermatophytosis
Most antifungals provide mycologic cure of dermatophytosis, although maintenance of cure may be best with butenafine or amorolfine, researchers from Brazil report. Reuters Health Information
Lawrence, KS, March 26, 2013 --(PR.com)-- The University of Kansas continues to move innovations from the laboratory to the marketplace. As part of this effort, five KU researchers have been awarded...
Blog Syn: An Idea Whose Time Has Come?
Here's something I've been following for the last couple of weeks in the chemical blogging world, and now it's up on its own site: "Blog Syn", an initiative of the well-known chemblogger See Arr Oh. T...
Combined fluoroquinolone and azole use associated with QT prolongation
NEW YORK (Reuters Health) - One in five hematology patients treated with a fluoroquinolone-azole combination may develop significant QT prolongation, Mayo Clinic researchers report.
MethylGene Completes Enrollment in Phase II Trial of MGCD290
MONTREAL, CANADA -- (Marketwire) -- 12/19/12 -- MethylGene Inc. (TSX: MYG) today announced that it has completed enrollment in its multi-center, randomized, double-blind, placebo-controlled trial (Tr...
Merz, Inc. (U.S. affiliate of Merz Pharma Group) today announced the completion of the acquisition of ONMEL™ (itraconazole), an azole antifungal that is indicated for the oral t...
Vr Laboratories Selects Hsg2001 As Lead Development Candidate For Candida Albicans Program
Bonita Springs, Fla., Nov. 16, 2012 /PRNewswire-iReach/ -- VR Laboratories LLC today announced they have selected a lead product candidate based on preclinical activity to target Candida albicans (C....
Ashworth College Launches Certified Pharmacy Technician Career Training Program
Ashworth College announced the addition of Certified Pharmacy Technician (http://www.ashworthcollege.edu/) to its roster of online career training programs. At the conclusion of the program, graduates...
Ferrer takes novel antifungal into Phase III
The private Spanish pharmaceutical company Ferrer is to begin a Phase III study early next year for what it hopes will be a best–in-class topical azole antifungal, arasertaconazole, for vulvovag...
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AMR's Hospital Anti-Infectives Insight Series: Gram-Negative Infections analyzes hospital antifungal prescribing patterns using AMR's comprehensive and highly detailed clinical data in conjunction wit...
Clinical Trials
RATIONALE: Antifungals, such as caspofungin acetate, may be effective in treating fungal infections caused by chemotherapy or stem cell transplant. PURPOSE: This phase II trial is studyin...
RATIONALE: Antifungals, such as voriconazole and itraconazole, may be effective in preventing fungal infections in patients who are undergoing allogeneic stem cell transplantation....
Invasive aspergillosis is a type of fungal infection typically identified in very sick patients (for example, patients with cancer or who have had a bone marrow or organ transplant). This...
RATIONALE: Antifungals such as ravuconazole may be effective in preventing fungal infections in patients undergoing chemotherapy and stem cell transplantation. PURPOSE: Phase I/II trial t...
Invasive fungal infections are often life-threatening in persons with immunocompromise. Persons with prolonged neutropenia secondary to cytotoxic chemotherapies are at high risk for these...
Voriconazole vs. Amphotericin B in the Treatment of Invasive Aspergillosis
Invasive aspergillosis is a fungal disease which is increasing in incidence with the increase in immunocompromised persons in our population. Persons with prolonged neutropenia secondary...
Antifungal Use in Oncohematological Neutropenic Patients
Primary purpose: Frequency of use of broad-spectrum antifungals in the episode of neutropenia. Secondary purposes:To determine the safety and toxicity measure by: 1. Frequency of...
Objectives Primary Objectives: - Pilot Study: A preliminary assessment of the exposure and safety of oral A-60444 in post-stem cell transplant patients with RSV infection....
Empirical antifungal treatment is the gold standard for patients who are neutropenic and have persistent fever under broad-spectrum antibiotics. The rational is that fungal infections are...
Anidulafungin is an antifungal agent of the echinocandin class which is highly active in vitro against fluconazole resistant Candida species. The efficacy of anidulafungin has demonstrated...
Videos
The Role of Azoles
Developed and produced for http://www.MechanismsinMedicine.com Animation Description: Fungi are eukaryotic organisms which possess a unique cell wall and cel...
Medical and Biotech [MESH] Definitions
14-alpha Demethylase Inhibitors
Compounds that specifically inhibit STEROL 14-DEMETHYLASE. A variety of azole-derived ANTIFUNGAL AGENTS act through this mechanism.
