Bancroftian and Brugian Lymphatic Filariasis - Biotech, Pharma and Life Science Channel
PubMed Articles
Tandem antioxidant enzymes confer synergistic protective responses in experimental filariasis.
Helminth parasites use antioxidant defence strategies for survival during oxidative stress due to free radicals in the host. Accordingly, tissue-dwelling filarial parasites counteract host responses b...
Heparanase promotes lymphangiogenesis and tumor invasion in pancreatic neuroendocrine tumors.
Heparan sulfate proteoglycans are an important and abundant component of the extracellular matrix, which undergo substantial remodeling throughout tumorigenesis via the enzymatic activity of heparanas...
Helichrysum has long been used medicinally, proving to be beneficial in treatment of acne, asthma, bronchitis and circulatory problems, and lymphatic system diseases. The objective of this research wa...
Regulation of endothelial cell differentiation and specification.
The circulatory system is the first organ system to develop in the vertebrate embryo and is critical throughout gestation for the delivery of oxygen and nutrients to, as well as removal of metabolic w...
Venous edema of the limb presents several challenges to clinicians, particularly with regard to its definition, pathophysiology and measurement, as well as those relating to its management. Compressio...
Mapping superficial lymphatic territories in the rabbit.
Little is known about the anatomy of the lymphatic system in the rabbit with regard to relationships between the lymphatic vessel and lymph node. According to our previous studies in human cadavers an...
Dynamics of lymphatic regeneration and flow patterns after lymph node dissection.
Knowledge about the mechanisms of regeneration of the lymphatic vasculature after surgical trauma is essential for the development of strategies for the prevention and therapy of lymphedema. However,...
New diagnostic agent approved for lymphatic mapping.
Spectratype analysis of clonal T cell expansion in murine experimental stroke.
T lymphocytes are major contributors to post-ischemic neuroinflammation following ischemic stroke. However, the mode of postischemic T cell activation remains a controversial issue. Therefore, this st...
Tumor-associated lymphatic endothelial cell promotes invasion of cervical cancer cells.
The most common way for cervical cancer to spread is through the lymphatic system. Tumor-associated lymphatic endothelial cell (TLEC) has been considered to play a crucial role in metastasis of certai...
News Articles
‒ Six presentations and sponsored lymphatic mapping symposium highlight results from Lymphoseek® clinical trials ‒ Navidea Biopharmaceuticals, Inc. (NYSE MKT: NAVB), a bi...
Improved Detection Of Elephantiasis Worm Infection
A new diagnostic test for a worm infection that can lead to severe enlargement and deformities of the legs and genitals is far more sensitive than the currently used test, according to results of a fi...
Research Highlights From The American Journal Of Tropical Medicine And Hygiene, May 2013
1.) New Rapid Diagnostic Test for Worm Infection Provides Substantial Improvement Over Current Standard According to New African Field Study Provides Compass to Guide Public Health Efforts to Halt Deb...
New diagnostic test for lymphatic filariasis
A new diagnostic test for a worm infection that can lead to severe enlargement and deformities of the legs and genitals is far more sensitive than the currently used test, according to results of a fi...
Dr. Christopher Michael Craft Joins the Exclusive Haute MD Network
Dr. Christopher Michael Craft has been welcomed as the newest member of the Haute MD Network. Miami, FL (PRWEB) May 20, 2013 An exclusive invitation-only group, Haute MD members represent the best do...
When tumours metastasise, they can block lymphatic vessels, as researchers from ETH Zurich have discovered using a new method. The lymphatic fluid subsequently has to find a new path through the tissu...
Cancer Metastasis Promoted By Tumor-Activated Protein
Researchers at the University of California, San Diego School of Medicine and UC San Diego Moores Cancer Center report that cancers physically alter cells in the lymphatic system - a network of vessel...
Cancers physically alter cells in lymphatic system to promote the spread of disease
Researchers at the University of California, San Diego School of Medicine and UC San Diego Moores Cancer Center report that cancers physically alter cells in the lymphatic system - a network of vessel...
Tumor-activated protein promotes cancer spread
(University of California - San Diego) Researchers at the University of California, San Diego School of Medicine and UC San Diego Moores Cancer Center report that cancers physically alter cells in the...
In 1949 Jane Cooke Wright began testing anticancer agents on human leukaemias and cancers of the lymphatic system, one of the first research scientists to do so. Chemotherapy was, at best, little......
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Clinical Trials
Evaluation of Antibacterial Soap for Treatment of Lymphedema in a Filariasis-Endemic Area
Introduction. Lymphatic filariasis is a devastating mosquito-transmitted parasitic disease that causes lymphedema or elephantiasis of the leg in 15 million persons, the majority of whom a...
RATIONALE: Fibrin sealant may decrease lymphedema following surgery to remove lymph nodes in the groin by helping to seal the lymphatic vessels. It is not yet known if fibrin sealant is ef...
Study of Picibanil (OK432) Sclerotherapy in Children With Macrocystic Lymphatic Malformations
OBJECTIVES: I. Determine the efficacy of picibanil sclerotherapy in children with macrocystic lymphangioma.
Lymphatic Mapping in Treating Patients With Stage I or Stage II Cancer of the Vulva
RATIONALE: Lymphatic mapping may improve the ability to detect cancer of the vulva. PURPOSE: This phase III trial is studying how well lymphatic mapping works in treating patients with st...
Study of Patients With Strongyloides Stercoralis Infection
This study will explore faster and easier ways to detect infection with the intestinal parasite Strongyloides stercoralis and learn more about the conditions under which it causes serious...
Host Response to Infection and Treatment in Filarial Diseases
This study will evaluate and treat patients with filarial infections to explore in depth the immunology of the disease, including susceptibility to infection, disease development, and resp...
Effect of Albendazole Dose on Treatment of Lymphatic Filariasis
This study is conducted in Kerala, India. It will determine whether a new treatment regimen of albendazole and diethylcarbamazine (DEC) for lymphatic filariasis can eliminate the disease m...
Evaluating the Use of Fibrin Tissue Adhesive in Melanoma Patients
Primary Objective: 1. To determine whether the use of a fibrin sealant applied to superficial groin soft tissues following node dissection can result in decreased cumulative postoperativ...
RATIONALE: Diagnostic procedures, such as visceral lymphatic mapping using isosulfan blue, may help find cancer of the pancreas, colon, stomach, small intestine, or gallbladder and find ou...
Medical Implications of Coinfection With Malaria and Filariasis Parasites
This study will examine the clinical, immunological and epidemiological effects of concurrent infections with P. falciparum and W. bancrofti or M. perstans (the parasites that cause malari...
Videos
Brugia malayi Filarial Nematode. L3 Larvae from an Infected Mosquito. video.wmv
Lymphatic filariasis, caused by nematode parasites Wuchereria bancrofti, Brugia malayi and B. timori spread by mosquito bites, is a leading cause of disabili...
Medical and Biotech [MESH] Definitions
Receptors, Vascular Endothelial Growth Factor
A family of closely related RECEPTOR PROTEIN-TYROSINE KINASES that bind vascular endothelial growth factors. They share a cluster of seven extracellular Ig-like domains which are important for ligand binding. They are highly expressed in vascular endothelial cells and are critical for the physiological and pathological growth, development and maintenance of blood and lymphatic vessels.
Vascular Endothelial Growth Factor Receptor-3
A vascular endothelial cell growth factor receptor whose expression is restricted primarily to adult lymphatic endothelium. VEGFR-3 preferentially binds the vascular endothelial growth factor C and vascular endothelial growth factor D and may be involved in the control of lymphangiogenesis.
Vascular Endothelial Growth Factors
A family of angiogenic proteins that are closely-related to VASCULAR ENDOTHELIAL GROWTH FACTOR A. They play an important role in the growth and differentiation of vascular as well as lymphatic endothelial cells.
Vascular Endothelial Growth Factor C
A vascular endothelial growth factor that specifically binds to VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2 and VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-3. In addition to being an angiogenic factor it can act on LYMPHATIC VESSELS to stimulate LYMPHANGIOGENESIS. It is similar in structure to VASCULAR ENDOTHELIAL GROWTH FACTOR D in that they both contain N- and C-terminal extensions that were not found in other VEGF family members.
Lymphangiogenesis
The formation of LYMPHATIC VESSELS.
