Biosuperior Antibodies - Biotech, Pharma and Life Science Channel
After biosimilar versions of therapeutic proteins have become reality in Europe and in the US, now it’s the turn of therapeutic antibodies to be in the line of fire. Patents of the first wave of therapeutic antibodies are beginning to expire over the next few years. With 2009 combined sales of US$ 35.5 bln for only six pharmacologic classes, therapeutic antibodies are quite an attractive field for companies to embark on with biosimilar or biobetter/biosuperior antibodies. Apart from the economic attractiveness, it is also the validated target of therapeutic antibodies which attracts technology companies to create and develop improved versions of established therapeutic antibodies against CD20, Her2, VEGF, TNF, EGF-R and TNF. Further players in this field are Big Pharma companies trying to defend their market with next generation molecules, as well as biopharmaceutical companies from “off-patent” countries with the intention to offer valuable therapeutics at locally affordable prices.
News Articles
Autoantibodies may form basis of lupus diagnostic test
Scientists believe a new diagnostic test for lupus could be developed by looking for the presence of certain antibodies in the blood.Antibodies are proteins manufactured by the immune system to help i...
BioFront Technologies Receives Funding Through Florida Institute Seed Capital Accelerator Program
Company Based on Technology Developed at Florida State University The Institute for the Commercialization of Public Research (the Institute) announced today that it has finali...
Arsanis Nominates Preclinical Candidate for Staphylococcus aureus Program
Receives additional grant support to expand its infectious disease antibody pipeline Arsanis Biosciences GmbH, a biotechnology company developing anti-infective human m...
SAN DIEGO, May 22, 2013 /PRNewswire/ -- Prometheus Laboratories Inc., a specialty pharmaceutical and diagnostic company, announced today the eighteen abstracts relating to its proprietary diagnostic p...
Oligomerix, Inc. Completes Series B Financing
NEW YORK, May 22, 2013 /PRNewswire/ -- Oligomerix, Inc., a privately held company pioneering the development of disease modifying therapeutics for Alzheimer's disease (AD) and related neurodegene...
Scientists identify marker for severe rheumatoid arthritis
Researchers in the US have identified specific proteins in the blood of people with an aggressive form of rheumatoid arthritis, a discovery that could pave the way for a new diagnostic test and novel...
The Start-up Company Will Develop Therapeutic Antibodies against Novel Targets in the Fields of Cancer and Inflammation Regulatory News: Transgene SA (Euronext...
FARMINGTON, Conn., May 17, 2013 /PRNewswire-iReach/ -- The escalation of new biological drugs, including antibodies and recombinant proteins, is placing renewed emphasis on alternate delivery te...
NEW YORK, May 16, 2013 /PRNewswire/ -- Actinium Pharmaceuticals, Inc. (OTCBB: ATNM), a biopharmaceutical company that develops innovative targeted payload immunotherapeutics for treatment of adva...
AnaptysBio Awarded U.S. Government Contract To Develop Anti-Ricin Antibodies
SAN DIEGO, May 16, 2013 /PRNewswire/ -- AnaptysBio, Inc., a privately-held therapeutic antibody company, today announced the receipt of a contract award from the U.S. government for the developme...
Events
6TH ANNUAL RECOMBINANT ANTIBODIES Conference
An insight into novel therapeutics and future technologies
Companies
Source BioScience LifeSciences
Source BioScience LifeSciences are European leaders in DNA sequencing, genomic services, bioinformatic analyses and offers a comprehensive portfolio of genomic reagents and antibodies. Source Bio...
OncoMed Pharmaceuticals is a clinical-stage company that discovers and develops novel therapeutics targeting cancer stem cells, the cells believed to be capable of driving tumor growth, recurrence and...
Onconova, based in Newtown, PA and Lawrenceville, NJ, discovers and develops novel patent- protected small molecule therapeutic agents for cancer, radiation protection and hematol...
Itero Biopharmaceuticals, Inc.
Itero Biopharmaceuticals, Inc. is a specialty biopharmaceutical company focused on the development and commercialization of protein therapeutics that offer significant clinical an...
CytomX Therapeutics is an early stage biotechnology company developing Probodiesâ¢, or proteolytically-activated antibodies. Probodies combine the well-established power and s...
Rockland Immunochemicals has supported the biopharma and diagnostic industries for over 40 years with antibodies and antibody based toolsâ¢Â for basic research, assay develo...
Hycult Biotech is a leader in the fields of immunology and cell biology, we develop, produce and market antibodies, antibody based products and more specifically immunoassays for...
Virdante Pharmaceuticals is developing safer and more effective drugs for autoimmune and inflammatory diseases. Our products incorporate a proprietary âSialic Switchâ te...
Ironwood Pharmaceuticals, Inc. & Protagonist Therapeutics, Inc.
Protagonist Therapeutics is a privately held biotechnology company pursuing the discovery and development of disulfide rich peptides (DRPs) as well differentiated alternati...
Arsanis is committed to the development of monoclonal antibody therapeutics against severe infectious diseases that cannot be controlled with currently available medical treatment...
Clinical Trials
Haploidentical Stem Cell Transplantation for Patients With Hematologic Malignancies
Blood and marrow stem cell transplant has improved the outcome for patients with high-risk hematologic malignancies. However, most patients do not have an appropriate HLA (immune type) ma...
Intensified Post Remission Therapy Containing PEG-Asparaginase
This study is for patients with recently diagnosed blood cancer, called acute lymphoblastic leukemia (ALL). The standard treatment for this disease consists of many chemotherapy drugs tha...
The purpose of this study is to assess the seropersistence of TBE antibodies in children and adolescents aged 1 to 15 years at the time of their first vaccination, 24 months and 34 months...
Rituximab in the Treatment of Graves' Disease
Aim: In a phase II pilot study encompassing 20 patients with Graves’ disease to evaluate the effect of rituximab: 1. Biochemically as assessed by markers of disease activity ( fr...
Immunotherapy of Cancer Using Donor Lymphocytes Labelled With in-Vitro Bispecific Antibodies.
Patients with resistant metastatic solid tumors failing all conventional modalities who are eligible for immunotherapy by bispecific antibodies. First step: NST Second step: Patients with...
Human thyroglobulin (Tg) is the most sensitive biochemical marker for recurrence of differentiated cancer (DTC), especially after the complete removal of thyroid tissue through surgery and...
RATIONALE: Estrogen can cause the growth of breast cancer cells. Hormone therapy using fulvestrant may fight breast cancer by lowering the amount of estrogen the body makes. Monoclonal ant...
Evaluation of a Third and Fourth Dose of StaphVAX® in Adults With End-Stage Renal Disease
This study is a continued evaluation of the immune response to StaphVAX , a Staphylococcus aureus type 5 and 8 capsular polysaccharide conjugate vaccine, in end-stage renal disease patient...
RATIONALE: Radiolabeled monoclonal antibodies, such as iodine I 131 monoclonal antibody TNT-1/B (^131I MOAB TNT-1/B), can find tumor cells and carry tumor-killing substances to them withou...
Trastuzumab in Treating Patients With Metastatic or Recurrent Salivary Gland Cancer
RATIONALE: Monoclonal antibodies, such as trastuzumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help...
PubMed Articles
We observed that IgM monoclonal antibodies and aggregates in mammalian cell culture supernatants were associated nonspecifically with nucleosomes, DNA, and histone proteins derived from nuclei of host...
Proteomic Analysis of Acetylation in Thermophilic Geobacillus kaustophilus.
Recent analysis of prokaryotic N(ε) -lysine-acetylated proteins highlights the post-translational regulation of a broad spectrum of cellular proteins. However, the exact role of acetylation remains u...
The research on fast screening methods for antibodies against zoonotic pathogens in slaughter animals is important for food safety in farming and meat-processing industries. As a proof-of-concept stud...
Effectiveness of Egg Yolk Antibody Against Shiga Toxin II Variant Toxicity In Vitro and In Vivo.
We prepared anti-Shiga toxin II variant (Stx2e) and anti-Stx2e B antibodies in chicken egg yolk and investigated their effectiveness in vitro and in vivo. Both Egg yolk antibodies (IgY) reduced the cy...
SUMMARY Crimean-Congo haemorrhagic fever (CCHF) is endemic in Turkey, and since 2004 many cases have been reported from different regions of Turkey. There are limited data about the seroprevalence of...
Introduction: Over the last decade the field of medicine has dramatically changed with the introduction of biological therapies, among which monoclonal antibodies play a pivotal role in the management...
Conventional immunization-based antibodies are not always applicable to monitor trace amounts of clinical biomarkers due to insufficient antigen-binding affinity. The development of in vitro affinity...
An immunochromatographic strip method, developed with the excretory-secretory antigens from muscle larvae (ML) of Trichinella spiralis labeled with colloidal gold, was used for the detection of anti-T...
Intestinal infection with Trichinella spiralis induces distinct, regional immune responses.
The aim of this study was to evaluate differences between the small and large intestines (SI and LI) with regard to colonization and immunity during infection with Trichinella spiralis. In orally infe...
In vivo studies of aquaporins 3 and 10 in human stratum corneum.
Aquaporins (AQPs) constitute one family of transmembrane proteins facilitating transport of water across cell membranes. Due to their specificity, AQPs have a broad spectrum of physiological functions...
Videos
Medical and Biotech [MESH] Definitions
Hepatitis A Antibodies
Antibodies to the HEPATITIS A ANTIGENS including antibodies to envelope, core, and non-structural proteins.
Lectins
Proteins that share the common characteristic of binding to carbohydrates. Some ANTIBODIES and carbohydrate-metabolizing proteins (ENZYMES) also bind to carbohydrates, however they are not considered lectins. PLANT LECTINS are carbohydrate-binding proteins that have been primarily identified by their hemagglutinating activity (HEMAGGLUTININS). However, a variety of lectins occur in animal species where they serve diverse array of functions through specific carbohydrate recognition.
Oligoclonal Bands
Multiple protein bands serving as markers of specific ANTIBODIES and detected by ELECTROPHORESIS of CEREBROSPINAL FLUID or serum. The bands are most often seen during inflammatory or immune processes and are found in most patients with MULTIPLE SCLEROSIS.
Antibodies, Phospho-specific
Antibodies directed against immunogen-coupled phosphorylated PEPTIDES corresponding to amino acids surrounding the PHOSPHORYLATION site. They are used to study proteins involved in SIGNAL TRANSDUCTION pathways. (From Methods Mol Biol 2000; 99:177-89)
Plantibodies
Recombinant antibodies produced in TRANSGENIC PLANTS. The plants serve as BIOREACTORS to produce the antibodies for medical use or industrial processes.
