Bone morphogenetic protein rhBMP - Biotech, Pharma and Life Science Channel
Bone morphogenetic protein 2 (rhBMP-2) is approved by the Food and Drug Administration for anterior lumbar interbody fusion and for acute open tibial fractures; rhBMP-7, on the other hand, is approved for long bone defects and has received a humanitarian device exemption for revision posterolateral lumbar operations and recalcitrant long bone unions. The commercial success of BMP-2 has spurred the clinical evaluation in many other subsets of bone defects and the research into new growth factors and scaffolds. The first products were also approved for use in dental implantation procedures extending the scope of indications for bone and dental growth factors.
In contrast to the more advanced clinical stage development pipeline of bone and dental growth factors, the use of growth factors for cartilage and tendon or soft tissue repair still is preclinical representing a niche with a competitive advantage for the players in the field. While traditional growth factors are proteins, new molecules stimulating or accelerating growth of bone, dental, cartilage or soft tissue also are engineered peptides, antibodies, small molecules or even plasmids. Among the growth stimulators are the BMPs, GDFs, PDGF, PTH receptor agonists, FGF and many more. In many cases, selection of the appropriate scaffold for delivery of the growth stimulating molecules is essential for the success of the therapy.
News Articles
Aberdeen researchers in new stem cell research into osteoarthritis
Medical research charity Arthritis Research UK has awarded £184,000 to a team of researchers at the University of Aberdeen to study stem cells found naturally present in people’s joints in...
KFx Medical Corporation announced that it received Notice of Allowance of claims for its application entitled: SYSTEM AND METHOD FOR ATTACHING SOFT TISSUE TO BONE used in knotless...
RTI Biologics Inc. (RTI) (Nasdaq:RTIX), a leading provider of orthopedic and other biologic implants, is pleased to announce that the company has passed the five million ma...
Biomet, Inc., a global leader in the manufacture of orthopaedic and biotechnology products, announces the presentation of research that included an evaluation of patient satisfact...
Celgene Announces U.S. FDA Grants Priority Review for ABRAXANE® sNDA in Advanced Pancreatic Cancer
European Medicines Agency Accepts Regulatory Submission of Type II Variation for ABRAXANE for the Treatment of Advanced Pancreatic Cancer Celgene International Sàrl, a subsid...
Cycle Stuff Direct Looks at Cycle Fitness Nutrition
SOUTHAMPTON, England, May 23, 2013 /PRNewswire/ -- Everyone knows that cycling is fantastic for our overall fitness and health, but what about nutrition and how it has an impact on cycle training? Al...
New funding for Cardiff researchers to develop new drugs to treat osteoarthritis
Medical research charity Arthritis Research UK has awarded a team of researchers at Cardiff University a grant of £200,000 to investigate new drugs to treat early onset osteoarthritis. The team...
At-risk women 'underestimate likelihood of fractures'
Postmenopausal women with conditions such as Parkinson's disease and multiple sclerosis (MS) tend to underestimate their risk of fractures, a study suggests.The bone-thinning disease osteoporosis...
Study suggests best ways to improve osteoporosis medication adherence
A review of previously published studies has highlighted the most effective ways to boost treatment adherence among people with the bone-thinning disease osteoporosis.Treatment adherence is an importa...
KFx Medical Corporation announced that it received Notice of Allowance of claims in two additional patent applications broadly covering its AppianFx anchors and anchors for use in...
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Companies
Founded in 1989 and with headquarters in Ann Arbor, Michigan, Aastrom Biosciences is dedicated to the development of stem cell treatments for critical cardiovascular diseases. Aastrom is currently e...
LABS, Inc., founded in 1979 as Immunological Associates of Denver, was one of the first transplant laboratories established in the United States. Today, as a taxable, non-profit c...
Blue Belt Technologies, Inc. has developed the next generation of âsmartâ surgical instruments with precision robotics for use initially in orthopedic procedures and the...
From its establishment in 1977, simply as a Distributor of diagnostic products, IDS has become a globally-recognised innovator and marketeer in the IVD industry.The Company is particularly well-known...
Cerapedics is a privately-held medical device company focused on developing and commercializing novel osteobiologic products based on its proprietary anorganic bone mineral (ABM)...
Health Discovery Corporation is a molecular diagnostics company that uses advanced mathematical techniques to analyze large amounts of data to uncover patterns that might otherwis...
Xenetic is a leading UK-based biopharmaceutical company providing leading-edge expertise in the development of a whole new generation of drugs and vaccines. Working with some of the largest pharma...
Cell Medica is a clinical stage cellular therapeutics company engaged in the development and delivery of cellular immunotherapy treatment strategies for infectious disease and can...
Itero Biopharmaceuticals, Inc.
Itero Biopharmaceuticals, Inc. is a specialty biopharmaceutical company focused on the development and commercialization of protein therapeutics that offer significant clinical an...
Salient Surgical Technologies, Inc.
Salient Surgical Technologies, Inc. (www.salientsurgical.com) is a medical technology company that develops and markets advanced energy devices for use in surgical procedures. Sal...
Clinical Trials
Pamidronate to Treat Osteogenesis Imperfecta in Children
This study will evaluate the effect of pamidronate-a drug that decreases bone resorption (breakdown)-on osteogenesis imperfecta. This is a genetic disorder of collagen, the major protein...
Collection of Samples and Data for the National Marrow Donor Program Repository
This protocol will collect blood samples and medical information from patients who have had a bone marrow transplant using cells from an unrelated donor identified through the National Mar...
This is a phase 3, randomized, double-blind, placebo-controlled study to evaluate new or worsening lens opacifications in subjects with non-metastatic prostate cancer receiving denosumab f...
Ventricular Arrhythmias in Uremic Cardiomyopathy
There is a certain gene called sarcoplasmic reticulum gene (SERCA2a), which is found in heart muscle. This gene is also found in blood vessels and skin tissue. When active this gene builds...
Phase 2A Study of NPC-1C Chimeric Monoclonal Antibody to Treat Pancreatic and Colorectal Cancer
The purpose of the phase 2A component of this study is to determine if giving the immune molecule NPC-1C to individuals who have cancer of the pancreas or gastrointestinal tract (colon or...
Randomized Study of ON 01910.Na in Refractory Myelodysplastic Syndrome Patients With Excess Blasts
The primary objective of this study is to compare overall survival (OS) in patients receiving ON 01910.Na + best supportive care (BSC) to OS of patients receiving BSC in a population of pa...
Using TRAP to Evaluate the Effect of Zometa on Bone Metastasis Due to Lung Cancer
The purpose of this study is to evaluate a new blood test as a way to follow the effect of Zometa in treating bone metastases due to lung cancer.
Background: The interactive effects of resistance training and dietary protein on hormonal responses in overweight or obese adults are not clear and remain controversial. Investigators tes...
The purpose of this study is to evaluate the safety and efficacy of autologous bone marrow-derived stem cells("HYNR-CS inj"), through intrathecal delivery for the treatment in patients wit...
Zoledronic Acid in the Management of Patients With Asymptomatic/Early Stage Multiple Myeloma
Evidence for the beneficial effects of bisphosphonates on bone resorption in multiple myeloma has been reported extensively, showing reductions in skeletal events and improvement of severa...
PubMed Articles
Arrhythmias during and after zoledronic acid infusion patients with bone metastasis.
Zoledronic acid (ZA) is one of the important bisphosphonates which is widely used in bone metastatic cancer and osteoporotic patients. In a few studies, it has been reported that treatment with bispho...
Giant cell tumor (GCT) of bone is a benign but locally aggressive neoplasm of bone. However, molecular mechanisms underlying osteolysis in GCT have not been deeply understood. The aim of this study wa...
Expression and prognostic significance of GATA-binding protein 2 in colorectal cancer.
GATA-binding protein 2 (GATA2) is a nuclear transcription factor that plays a critical role in tumorigenesis. High levels of GATA2 expression are correlated with poor survival outcomes in many types o...
Prognostic evaluation of microRNA-210 expression in pediatric osteosarcoma.
MicroRNA-210 (miR-210) plays important roles in the regulation of cell growth, angiogenesis, and apoptosis in different cancer type. Previous study of miRNA expression profiling found that miR-210 was...
Clinical implications of CIP2A protein expression in breast cancer.
The aim of this work is to study the expression and regulatory effects of CIP2A protein in breast cancer and the correlation between CIP2A protein expression and the prognosis of breast cancer. The CI...
Application of five prognostic survival scores to primary myelofibrosis in 62 Brazilian patients.
Primary myelofibrosis (PM) is a Philadelphia-negative clonal hematopoietic stem cell disorder characterized by intense reactive changes of bone marrow stroma with collagen fibrosis, osteosclerosis and...
The breast cancer type 1 susceptibility gene (BRCA1) is a tumor suppressor gene, mutations or loss of which lead to genomic instability and breast cancer. BRCA1 protein is part of a large multi-protei...
ErbB3 silencing reduces osteosarcoma cell proliferation and tumor growth in vivo.
Osteosarcoma is the most common primary bone tumor in children and adults. Despite improved prognosis, resistance to chemotherapy remains responsible for failure of osteosarcoma treatment. The identif...
A novel mutation in the SLCO2A1 gene in a Chinese family with primary hypertrophic osteoarthropathy.
Primary hypertrophic osteoarthropathy (PHO) is a rare monogenetic disease that closely mimics hypertrophic osteoarthropathy secondary to pulmonary or other pathology. The study of PHO provides an oppo...
A novel mutation (R122Q) in the cathepsin K gene in a Chinese child with Pyknodysostosis.
Pyknodysostosis (OMIM 265800) is a rare, autosomal recessive sclerosing skeletal dysplasia as a consequence of the diminished capacity of osteoclasts to degrade organic bone matrix. Pyknodysostosis is...
Videos
A stop animation film about bone morphogenetic protein (BMP) and fracture healing
This is a stop animation film created as an educational tool to inform people about bone fractures, the process of repairing a fracture during surgery, as we...
Medical and Biotech [MESH] Definitions
Transferrin-binding Protein A
A subtype of bacterial transferrin-binding protein found in bacteria. It forms a cell surface receptor complex with TRANSFERRIN-BINDING PROTEIN B.
Transferrin-binding Protein B
A subtype of bacterial transferrin-binding protein found in bacteria. It forms a cell surface receptor complex with TRANSFERRIN-BINDING PROTEIN A.
Adaptor Protein Complex 1
A clathrin adaptor protein complex primarily involved in clathrin-related transport at the TRANS-GOLGI NETWORK.
Adaptor Protein Complex 2
An adaptor protein complex primarily involved in the formation of clathrin-related endocytotic vesicles (ENDOSOMES) at the CELL MEMBRANE.
Adaptor Protein Complex 3
An adaptor protein complex found primarily on perinuclear compartments.
