Botulinum Toxin A Merz - Biotech, Pharma and Life Science Channel

06:20 EDT 1st November 2014 | BioPortfolio

PubMed Articles [687 Associated PubMed Articles listed on BioPortfolio]

CYN determination in tissues from freshwater fish by LC-MS/MS: Validation and application in tissues from subchronically exposed tilapia (Oreochromis niloticus).

Harmful cyanobacterial blooms are occurring in eutrophic freshwater lakes and reservoirs throughout the world and, because of the production of toxins such as cylindrospermopsin (CYN), they can presen...

Enhanced detection of the algal toxin PbTx-2 in marine waters by atmospheric pressure chemical ionization mass spectrometry.

Karenia brevis, a marine dinoflagellate, biosynthesizes a unique class of polyether toxins called brevetoxins that produce significant health, environmental and economic impacts in and along coastal w...

Applications of Musculoskeletal Ultrasonography in Pediatric Patients.

Ultrasonography is an excellent adjunct to other musculoskeletal imaging tools utilized in the pediatric population and in some instances offers advantages over CT and MRI. It permits dynamic examinat...

Anatomical Considerations Regarding the Location and Boundary of the Depressor Anguli Oris Muscle with Reference to Botulinum Toxin Injection.

Hyperactivity of the depressor anguli oris muscle can lead to a drooping of the mouth corner, which can give a sad, tired, or almost angry look in some patients. Botulinum toxin type A has recently be...

Molecular dynamics simulations of wild type and mutants of botulinum neurotoxin A complexed with synaptic vesicle protein 2C.

Botulinum neurotoxins (BoNTs) are known as the most poisonous biological substances, and they are also used to treat a wide range of medical conditions as well as in the cosmetic applications. Recentl...

Quantitation of multiple mycotoxins and cyanogenic glucosides in cassava samples from Tanzania and Rwanda by an LC-MS/MS based multi-toxin method.

A multi-mycotoxin method based on liquid chromatography/tandem mass spectrometry (LC-MS/MS) was used for a mycotoxin survey in 627 samples of processed cassava collected from different districts acros...

A novel prodrug-like fusion toxin with protease-sensitive bioorthogonal PEGylation for tumor targeting.

Highly potent biotoxins like Pseudomonas exotoxin A (ETA) are attractive payloads for tumor targeting. However, despite replacement of the natural cell-binding domain of ETA by tumor-selective antibod...

Functional Characterization of Sticholysin I and W111C Mutant Reveals the Sequence of the Actinoporin's Pore Assembly.

The use of pore-forming toxins in the construction of immunotoxins against tumour cells is an alternative for cancer therapy. In this protein family one of the most potent toxins are the actinoporins,...

Effect of Intravesical Botulinum Neurotoxin-A Injection on Detrusor Hyperreflexia in Spinal Cord Injured Patients.

Purpose: To evaluate the effects of Botulinum Toxin A injection into the detrusor muscle on various voiding parameters in spinal cord injured patients with neurogenic detrusor hyperreflexia Materials ...

Systemically Administered IgG Anti-Toxin Antibodies Protect the Colonic Mucosa during Infection with Clostridium difficile in the Piglet Model.

The use of anti-toxin human monoclonal antibodies (HMab) as treatment for C. difficile infection has been investigated in animal models and human clinical trials as an alternative to or in combination...

News Articles [197 Associated News Articles listed on BioPortfolio]

Hyaluronic Acid Products Market (Single-Injection, Three-Injection Cycle and Five-Injection Cycle) - Global Industry Analysis, Size, Share, Growth, Trends and Forecast, 2013 - 2019

LONDON, Oct. 30, 2014 /PRNewswire/ -- Hyaluronic acid (HA) is a glycosaminoglycan that helps in transportation of nutrients through the body and facilitate water retention in body tissue. It is natura...

Chugai licenses ISPRI/OptiMatrix platform from EpiVax for de-risking biologics

PROVIDENCE, R.I., Oct. 30, 2014 /PRNewswire/ -- Chugai Pharmaceutical Co., Ltd. (Chugai), signed an agreement with Rhode Island-based biotechnology company, EpiVax, Inc., to incorporate EpiVax's ISPRI...

INNATE PHARMA PRESENTS TWO POSTERS ON PROPRIETARY BTG-ADC TECHNOLOGY AT THE WORLD ADC SUMMIT

Innate Pharma presents two posters on proprietary BTG-ADC technology at the world ADC summit: "Site-specific conjugation by BTG improves the therapeutic index of ADC in vivo": ht...

Mederma® Partners with Big Belli to bring Groundbreaking Pregnancy Documentary 40 Weeks to Life

New film from Big Belli LLC documents pregnancy journey in a week-by-week glimpse into the lives of real women who share pregnancy milestones and health information. NEW YORK, NY (PRWEB) October 28, 2...

A combination of targeted toxin technology and the piggyBac‐mediated gene transfer system enables efficient isolation of stable transfectants in nonhuman mammalian cells

Isolation of cells harboring exogenous DNA is typically achieved by the introduction of plasmids, but its efficiency remains still low. In this study, we developed a novel strategy to obtain stable tr...

Battling Brain Tumors with Toxin-Secreting Stem Cells

Proof-of-concept study highlights new therapeutic use of engineered human stem cellsRead more about Battling Brain Tumors with Toxin-Secreting Stem Cells Comments

Toxin-secreting stem cells treat brain tumors, in mice

A new way to use stem cells in the fight against brain cancer has been devised by researchers. A team led by a neuroscientist who recently demonstrated the value of stem cells loaded with cancer-killi...

Scientists engineer toxin-secreting stem cells to treat brain tumors

Harvard Stem Cell Institute scientists at Massachusetts General Hospital have devised a new way to use stem cells in the fight against brain cancer. A team led by neuroscientist Khalid Shah, MS, PhD, ...

Researchers to Present Data on Soliris® (eculizumab) as a Treatment for Patients with aHUS at ASN 2014 Annual Meeting

Alexion Pharmaceuticals, Inc. (NASDAQ:ALXN) today announced that researchers will present seven posters detailing findings from clinical studies of Soliris® (eculizumab) in patie...

IPEN: U.S. battles international ban on toxin used on utility poles that Health and Human Services calls a "carcinogen" & state lawmakers seek to eliminate in New York

ROME, Oct. 23, 2014 /PRNewswire-USNewswire/ -- The U.S. government is opposing international efforts to halt the global use of a toxic chemical, pentachlorophenol (PCP), used in the U.S. on wood utili...

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Companies [7 Associated Companies listed on BioPortfolio]

Merz North America, Inc.

Merz North America is a specialty healthcare company that develops and commercializes innovative treatment solutions in medical and aesthetic dermatology, and neurology in the U.S...

Merz North America

Merz North America is a specialty healthcare company that develops and commercializes innovative treatment solutions in aesthetics, dermatology and neurology in the U.S. and Canad...

Merz, Inc.

Merz, Inc. is a focused specialty healthcare company that is responsible for developing and commercializing innovative products and solutions in neurology, medical aesthetics, and...

Pharmaleads

Pharmaleads is a research company focussed on the custom design of substrates and inhibitors of zinc metallopeptidases and proteases. Pharmaleads has already developed molecules for ECE, NEP, ACE, APN...

Molecular Templates

Molecular Templates is a biopharmaceutical company focused on the discovery and development of targeted biologic therapeutics using its novel Engineered Toxin Bodies (ETB) platfor...

Merz Aesthetics

Merz Aesthetics, the new business unit of Merz Pharma Group, is a leader in the global aesthetic medicine market. With a 100-year history of compassion and innovation in healthcare, Merz Aesthetics i...

DentaSpa

DentaSpa™ is one of the nation’s leading Botulinum Toxin, dermal fillers and injectables business education companies tailored exclusively for dental practitioners. Dent...

Clinical Trials [207 Associated Clinical Trials listed on BioPortfolio]

BOTOX® Open-Label Treatment in Pediatric Upper Limb Spasticity

This study will evaluate the long-term safety of BOTOX® (botulinum toxin Type A) for the treatment of pediatric upper limb spasticity.

Study of Botulinum Toxin and Recovery of Hand Function After Stroke

The purpose of this study is to determine whether injections of botulinum toxin (commonly known as BOTOX®) into the affected hand of Stroke patients, while targeting the muscles controlli...

Pain Perception of Children and Youth Receiving Non-sedated Botulinum Toxin-A Injections Using the Buzzy®

The use of Botulinum toxin injections (BoNT-A) has become a standard therapy for children and youth who suffer from stiffness of their muscles due to a neurological problem. These injectio...

Dose-response Study of Efficacy and Safety of Botulinum Toxin Type A to Treat Spasticity of the Arm(s) or of Arm(s) and Leg(s) in Cerebral Palsy

The purpose of this study is to determine whether injections of Botulinum toxin type A into muscles of one or both arms alone or in combination with injections into one or both legs are ef...

A Study of MK-6072 and MK-3415A in Participants Receiving Antibiotic Therapy for Clostridium Difficile Infection (MK-3415A-002)

MK-3415A is the combination of monoclonal antibodies to Clostridium (C.) difficile toxin A (MK-3415) and toxin B (MK-6072). This study will investigate whether: 1) treatment with MK-6072 o...

Onabotulinum Toxin Type A and Abobotulinum Toxin Type A Crow's Feet Rhytid Study

The objective of the study is to compare the time to onset of Dysport® versus Botox® in the treatment of lateral orbital rhytids ("crow's feet"). Thirty subjects were enrolled in the stu...

The Use of Botulinum Toxin A in Two-Stage Tissue Expander/ Implant Breast Reconstruction

Breast reconstruction is a common procedure with over 86,000 breast reconstruction procedures performed in the United States in 2009. This is a 1.5-fold increase since 2007. Of these breas...

Long Term Follow-up Study of Safety and Efficacy of Botulinum Toxin Type A for the Treatment of Patients With Idiopathic Overactive Bladder With Urinary Incontinence

The purpose of this study is to assess the long term safety and effectiveness of botulinum toxin type A in treating patients with idiopathic overactive bladder with urinary incontinence.

Safety Study of DWP-450 (Botulinum Purified Neurotoxin, Type A) Injection to Treat Glabellar Lines

The purpose of this study is to demonstrate the safety of multiple doses of DWP-450 (Botulinum purified neurotoxin, Type A) Injection in treatment of moderate to severe glabellar lines in ...

Safety and Efficacy Study of Botulinum Toxin for the Treatment of Glabellar Frown Lines

The primary objective of the study is to evaluate the efficacy in wrinkle reduction of a single treatment of three different doses of botulinum toxin compared to placebo, in the treatment ...

Medical and Biotech [MESH] Definitions

Subtype of CLOSTRIDIUM BOTULINUM that produces botulinum toxin type C which is neurotoxic to ANIMALS, especially CATTLE, but not humans. It causes dissociation of ACTIN FILAMENTS.

Subtype of CLOSTRIDIUM BOTULINUM that produces botulinum toxin type D which is neurotoxic to ANIMALS, especially CATTLE, but not humans.

Subtype of CLOSTRIDIUM BOTULINUM that produces BOTULINUM TOXIN TYPE A which is neurotoxic to humans and animals.

Subtype of CLOSTRIDIUM BOTULINUM that produces botulinum toxin type B which is neurotoxic to humans and animals.

Subtype of CLOSTRIDIUM BOTULINUM that produces botulinum toxin type E which is neurotoxic to humans and animals.

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