Botulinum Toxin A Merz - Biotech, Pharma and Life Science Channel

19:26 EDT 21st April 2015 | BioPortfolio

PubMed Articles [689 Associated PubMed Articles listed on BioPortfolio]

Capsaicin, resiniferatoxin and botulinum toxin-A - a trip down memory lane.

A Toxin-Binding Alkaline Phosphatase Fragment Synergizes Bt Toxin Cry1Ac against Susceptible and Resistant Helicoverpa armigera.

Evolution of resistance by insects threatens the continued success of pest control using insecticidal crystal (Cry) proteins from the bacterium Bacillus thuringiensis (Bt) in sprays and transgenic pla...

Identification of Toxemia in Patients with Clostridium difficile Infection.

Toxemia can develop in Clostridium difficile-infected animals, and correlates with severe and fulminant disease outcomes. Circumstantial evidence suggests that toxemia may occur in patients with C. di...

Toxin-Induced Necroptosis Is a Major Mechanism of Staphylococcus aureus Lung Damage.

Staphylococcus aureus USA300 strains cause a highly inflammatory necrotizing pneumonia. The virulence of this strain has been attributed to its expression of multiple toxins that have diverse targets ...

Architecture of the botulinum neurotoxin complex: a molecular machine for protection and delivery.

Botulinum neurotoxins (BoNTs) are extremely poisonous protein toxins that cause the fatal paralytic disease botulism. They are naturally produced in bacteria with several nontoxic neurotoxin-associate...

Rational design of adjuvant for skin delivery: conjugation of synthetic β-glucan Dectin-1 agonist to protein antigen.

The potential benefits of skin delivery of vaccines derive from the presence of a densely connected network of antigen presenting cells in the skin layer, most significantly represented by Langerhans ...

Soluble T-Cell Receptors Produced in Human Cells for Targeted Delivery.

Recently, technology has become available to generate soluble T-cell receptors (sTCRs) that contain the antigen recognition part. In contrast to antibodies, sTCRs recognize intracellular in addition t...

MAPK Signaling Pathway Alters Expression of Midgut ALP and ABCC Genes and Causes Resistance to Bacillus thuringiensis Cry1Ac Toxin in Diamondback Moth.

Insecticidal crystal toxins derived from the soil bacterium Bacillus thuringiensis (Bt) are widely used as biopesticide sprays or expressed in transgenic crops to control insect pests. However, large-...

Membrane transporters in self resistance of Cercospora nicotianae to the photoactivated toxin cercosporin.

The goal of this work is to characterize membrane transporter genes in Cercospora fungi required for autoresistance to the photoactivated, active-oxygen-generating toxin cercosporin they produce for i...

Association of decreased mRNA expression of multidrug and toxin extrusion protein 1 in peripheral blood cells with the development of flutamide-induced liver injury.

The anti-prostate cancer drug flutamide occasionally causes hepatotoxicity, and predictive biomarkers of flutamide-induced liver injury (FILI) are needed to improve safety of this drug. The aim of thi...

News Articles [216 Associated News Articles listed on BioPortfolio]

National Institute for Occupational Safety and Health Partners with Protea Biosciences

NIOSH utilizes mass spectrometry imaging tools for workplace toxin inhalation studies Protea Biosciences Group, Inc. announced that the National Institute for Occupational Safety and Health (NIOSH) ha...

Merz Neurosciences to Present Key Clinical Data at the Annual Meeting of the American Academy of Neurology (AAN)

Merz Neurosciences, a division of Merz North America (U.S. affiliate of the global Merz Pharma Group), announces that it will present top-line data from its Phase 3 PURE: Post-str...

Allan Kurtz D.O. and Morton Hyson M.D. Named To Med-X, Inc. Board of Directors

DENVER, April 20, 2015 /PRNewswire/ -- Med-X, Inc. announced today the appointments of Allan L. Kurtz D.O. and Morton I. Hyson M.D. to its Board of Directors. "Dr. Kurtz's great deal of knowled...

Expression of the Streptococcus pneumoniae yoeB Chromosomal toxin gene causes Cell Death in the model plant Arabidopsis thaliana

Background: Bacterial toxin-antitoxin systems usually comprise of a pair of genes encoding a stable toxin and its cognate labile antitoxin and are located in the chromosome or in plasmids of several b...

Merz Neurosciences Announces New Data Presentations at the 2015 American Academy of Neurology (AAN) Annual Meeting

Merz Neurosciences, a division of Merz North America (US affiliate of the global Merz Pharma Group), announced today that the below three poster presentations will be shown...

Dyskinesia Review H1 2015 Reports on Pipeline, Global Clinical Trials

DALLAS, April 17, 2015 /PRNewswire/ -- LifeScienceIndustryResearch.com adds Dyskinesia - Pipeline Review, H1 2015 and Dyskinesia Global Clinical Trials Review, H1, 2015 market research reports of 201...

Botox Makes Unnverving Journey into Our Nervous System

New research might bring a frown to even the most heavily botoxed faces, with scientists finding how some of the potent toxin used for cosmetic surgery escapes into the central nervous system. Resear...

Molecular Templates Presents Preclinical Data on De-Immunized Engineered Toxin Bodies (ETB) with Novel Immuno-Oncology Capabilities at the 2015 AACR Annual Meeting

Presentation includes report on the development of CD38- and HER2-targeting lead drug candidates that incorporate the Company’s proprietary de-immunization and nove...

Botox makes unnerving journey into our nervous system

New research might bring a frown to even the most heavily botoxed faces, with scientists finding how some of the potent toxin used for cosmetic surgery escapes into the central nervous system.

Clostridium botulinum neurotoxin type A (Xeomin) for sialorrhoea associated with adult Parkinson’s disease and paediatric cerebral palsy

Clostridium botulinum neurotoxin type A (Xeomin) is a purified botulinum toxin type A, which acts as a neuromuscular blocking agent by inhibiting acetylcholine release. It is intended to treat sialorr...

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Companies [8 Associated Companies listed on BioPortfolio]

OCuSOFT, Inc.

OCuSOFT, Inc. is a privately-held Richmond, TX USA-based ophthalmic research, development and supply company with an established reputation for innovation, particularly in the are...

Merz North America, Inc.

Merz North America is a specialty healthcare company that develops and commercializes innovative treatment solutions in medical and aesthetic dermatology, and neurology in the U.S...

Merz North America

Merz North America is a specialty healthcare company that develops and commercializes innovative treatment solutions in aesthetics, dermatology and neurology in the U.S. and Canad...

Merz, Inc.

Merz, Inc. is a focused specialty healthcare company that is responsible for developing and commercializing innovative products and solutions in neurology, medical aesthetics, and...

Pharmaleads

Pharmaleads is a research company focussed on the custom design of substrates and inhibitors of zinc metallopeptidases and proteases. Pharmaleads has already developed molecules for ECE, NEP, ACE, APN...

Molecular Templates

Molecular Templates is a biopharmaceutical company focused on the discovery and development of targeted biologic therapeutics using its novel Engineered Toxin Bodies (ETB) platfor...

Merz Aesthetics

Merz Aesthetics, the new business unit of Merz Pharma Group, is a leader in the global aesthetic medicine market. With a 100-year history of compassion and innovation in healthcare, Merz Aesthetics i...

DentaSpa

DentaSpa™ is one of the nation’s leading Botulinum Toxin, dermal fillers and injectables business education companies tailored exclusively for dental practitioners. Dent...

Clinical Trials [225 Associated Clinical Trials listed on BioPortfolio]

Safety and Efficacy of Botulinum Toxin Type A (BOTOX®) to Treat Chronic Migraine in Korea

This study is a Post-Marketing Surveillance study in Korea to evaluate the safety and efficacy of botulinum toxin Type A to treat Chronic Migraine in clinical practice.

Botulinum Toxin for the Treatment of Trigeminal Neuralgia

IncobotulinumtoxinA (Xeomin®) is a neurotoxin which inhibits the release of certain chemicals at the nerve terminals. It blocks cholinergic transmission at the neuromuscular junction by...

BOTOX® Treatment in Pediatric Upper Limb Spasticity

This study will evaluate the safety and efficacy of BOTOX® (botulinum toxin Type A) in pediatric patients with upper limb spasticity.

Efficacy and Safety Study of Botulinum Toxin Type A Against Placebo to Treat Abnormal Contraction or Twitch of the Eyelid

This phase 3 study will serve to collect efficacy and safety data of two different doses of NT 201 in subjects suffering from Bilateral Blephorasm (BEB) who are BTX treatment-naïve. In t...

Apitox, Honeybee Toxin for Pain and Inflammation of Osteoarthritis

The study will identify the efficacy of Apitox, purified honeybee toxin, in 330 patients with diagnosed osteoarthritis of the knee. The subjects will be evaluated for relief of pain using...

Botulinum Toxin Injection to Prevent Ventricular Arrhythmias

The aim of this prospective non-randomized study was to assess the efficacy and safety of endomyocardial botulinum toxin injection in left ventricle for preventing ventricular arrhythmias.

Safety of Sublingual dmLT for ETEC

A Phase 1 dose escalating study of ETEC candidate vaccine to determine safety and immunogenicity of a multi-dose regimen in healthy adult volunteers. The study will be conducted at Cincinn...

Botox Injection in Treatment of Chronic Migraine

Chronic migraine is in many cases a most disabling condition. Chronic migraine is defined as headaches for at least 15 days per month, of which 8 days have typical migraine features. In ma...

rTMS and Botulinum Toxin in Benign Essential Blepharospasm

Benign essential blepharospasm (BEB) is a functionally disabling focal dystonia. Botulinum neurotoxin (BoNT) therapy is suboptimal in many BEB patients. Repetitious transcranial magnetic s...

Botulinum Toxin Injection Versus Anal Myectomy in Management of Idiopathic Constipation

Chronic idiopathic constipation is most common cause of Constipation in childhood with numerous cases in Egypt. Numerous conservative measures were tried but many fail. Surgical options in...

Medical and Biotech [MESH] Definitions

Subtype of CLOSTRIDIUM BOTULINUM that produces botulinum toxin type C which is neurotoxic to ANIMALS, especially CATTLE, but not humans. It causes dissociation of ACTIN FILAMENTS.

Subtype of CLOSTRIDIUM BOTULINUM that produces botulinum toxin type D which is neurotoxic to ANIMALS, especially CATTLE, but not humans.

Subtype of CLOSTRIDIUM BOTULINUM that produces BOTULINUM TOXIN TYPE A which is neurotoxic to humans and animals.

Subtype of CLOSTRIDIUM BOTULINUM that produces botulinum toxin type B which is neurotoxic to humans and animals.

Subtype of CLOSTRIDIUM BOTULINUM that produces botulinum toxin type E which is neurotoxic to humans and animals.

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