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Botulinum Toxin A Merz - Biotech, Pharma and Life Science Channel

09:40 EDT 30th September 2016 | BioPortfolio

PubMed Articles [624 Associated PubMed Articles listed on BioPortfolio]

Consensus Recommendations for Combined Aesthetic Interventions Using Botulinum Toxin, Fillers, and Microfocused Ultrasound in the Neck, Décolletage, Hands, and Other Areas of the Body.

The popularity of aesthetic procedures in the face has led to greater disparity between treated areas and those that still show evidence of true age. Although many areas of the body often require mult...

Induction of mucosal immune responses against Helicobacter pylori infection after sublingual and intragastric route of immunization.

There is a current lack of effective mucosal vaccines against major gastroenteric pathogens and particularly against Helicobacter pylori, a chronic infection that can lead to peptic ulcers and gastric...

Dietary zinc alters the microbiota and decreases resistance to Clostridium difficile infection.

Clostridium difficile is the most commonly reported nosocomial pathogen in the United States and is an urgent public health concern worldwide. Over the past decade, incidence, severity and costs assoc...

Venom Evolution: Gene Loss Shapes Phenotypic Adaptation.

Snake venoms are variable protein mixtures with a multitude of bioactivities. New work shows, surprisingly, that it is the loss of toxin-encoding genes that strongly influences venom function in rattl...

Differential Rickettsial Transcription in Bloodfeeding and Non-Bloodfeeding Arthropod Hosts.

Crucial factors influencing the epidemiology of Rickettsia felis rickettsiosis include pathogenesis and transmission. Detection of R. felis DNA in a number of arthropod species has been reported, with...

A Rationally Designed TNF-α Epitope-Scaffold Immunogen Induces Sustained Antibody Response and Alleviates Collagen-Induced Arthritis in Mice.

The TNF-α biological inhibitors have significantly improved the clinical outcomes of many autoimmune diseases, in particular rheumatoid arthritis. However, the practical uses are limited due to high ...

Virulence and biodegradation potential of dynamic microbial communities associated with decaying Cladophora in Great Lakes.

Cladophora mats that accumulate and decompose along shorelines of the Great Lakes create potential threats to the health of humans and wildlife. The decaying algae create a low oxygen and redox potent...

Proposed homology of the dorsomedial subdivision and V-shaped layer of the avian hippocampus to Ammon's horn and dentate gyrus, respectively.

The avian hippocampal formation differs considerably from that of mammals both in terms of position and cytoarchitecture. On the basis of fiber connections in pigeons, however, we previously proposed ...

Crystal Structure of the Escherichia coli Fic Toxin-Like Protein in Complex with Its Cognate Antitoxin.

FIC domain proteins mediate post-translational modifications of target proteins, which typically results in their inactivation. Depending on the conservation of crucial active site residues, the FIC f...

Phenogenotypic Characterization of Escherichia coli O157:H7 Strains Isolated from Cattle at Slaughter.

Shiga toxin-producing Escherichia coli (STEC) O157:H7 was isolated from 30 (4%) of 744 cattle hide swab samples collected at Estonian slaughterhouses within a 3-year monitoring program of zoonotic pat...

News Articles [206 Associated News Articles listed on BioPortfolio]

Experts demonstrate 'advances and refinements' in neuromodulators for facial rejuvenation

Plastic surgeons have a range of effective products and minimally invasive techniques for patients seeking to reverse the signs of facial aging. A review and update on facial rejuvenation using botuli...

It may not be a boy when dad’s been exposed to dioxin

(Reuters Health) - Men exposed to dioxin, a chemical once common in herbicides, may be less likely to father boys than peers who didn’t come in contact with this toxin, a recent study suggests.

Structure of the BinAB toxin revealed

Could we get rid of mosquitoes without polluting the environment? Yes, we can, say researchers. The BinAB toxin, produced in crystal form by a bacterium, specifically kills the larvae of Culex and Ano...

X-rays Reveal New Path in Battle Against Mosquito Borne Illness

The new information provides clues to how scientists could design a composite toxin that would work against a broader range of mosquito species, including Aedes

De novo phasing with X-ray laser reveals mosquito larvicide BinAB structure

The structure of the bacterial toxin BinAB, which is used to combat mosquito-borne diseases, reveals pH-sensitive switches and carbohydrate-binding modules that may contribute to the larvicidal functi...

Frizzled proteins are colonic epithelial receptors for C. difficile toxin B

Here, a genome-wide CRISPR–Cas9 screen is used to identify the Wnt receptors frizzled as physiologically relevant Clostridium difficile toxin B receptors, providing new therapeutic targets for treat...

Researchers reveal how dangerous intestinal toxin enters cells

BOSTON, Sept. 28, 2016 /PRNewswire-USNewswire/ -- Researchers have identified a key target in fighting the emerging, life-threatening gastrointestinal infection Clostridium difficile. The work, led by...

New Discovery May Benefit Farmers Worldwide

Researchers at the University of Guelph, Canada, are announcing a discovery that could benefit millions of subsistence farmers and livestock in developing countries. The team has shown, for the first ...

Leading Scientific Experts in Food Safety, Plant Safety and Infectious Diseases Join Bio Tech Leader PathSensors’ Advisory Board

Top Scientists To Guide Company’s Development of Bio Sensor Solutions for Medical, Bio-Security, Plant Safety and Food Safety Baltimore, Maryland (PRWEB) September 27, 2016 Bio tech firm, PathSenso...

Membrane insertion of a Tc toxin in near-atomic detail

A cryo-EM structure of toxin component TcdA1 embedded in lipid nanodiscs reveals details of the mechanism used by this bacterial toxin to insert into the host cell membrane.

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Companies [11 Associated Companies listed on BioPortfolio]

Merz Pharma GmbH & Co. KGaA

Merz Neurosciences

Merz Neurosciences is a division of Merz North America, a specialty healthcare company that develops and commercializes treatment solutions in aesthetics, dermatology and neurosci...

Merz Inc.

Pharmaleads

Pharmaleads is a research company focussed on the custom design of substrates and inhibitors of zinc metallopeptidases and proteases. Pharmaleads has already developed molecules for ECE, NEP, ACE, APN...

OCuSOFT, Inc.

OCuSOFT, Inc. is a privately-held Richmond, TX USA-based ophthalmic research, development and supply company with an established reputation for innovation, particularly in the are...

Merz North America, Inc.

Merz North America is a specialty healthcare company that develops and commercializes innovative treatment solutions in medical and aesthetic dermatology, and neurology in the U.S...

Merz North America

Merz North America is a specialty healthcare company that develops and commercializes innovative treatment solutions in aesthetics, dermatology and neurology in the U.S. and Canad...

Merz, Inc.

Merz, Inc. is a focused specialty healthcare company that is responsible for developing and commercializing innovative products and solutions in neurology, medical aesthetics, and...

Molecular Templates

Molecular Templates is a biopharmaceutical company focused on the discovery and development of targeted biologic therapeutics using its novel Engineered Toxin Bodies (ETB) platfor...

Merz Aesthetics

Merz Aesthetics, the new business unit of Merz Pharma Group, is a leader in the global aesthetic medicine market. With a 100-year history of compassion and innovation in healthcare, Merz Aesthetics i...

Clinical Trials [303 Associated Clinical Trials listed on BioPortfolio]

A Pilot Study of the Effect of Botulinum Toxin Type a (Dysport®, Abobotulinum Toxin A) Injection on Changes in Musculotendinous Length and Dynamics of Hamstring Muscles During Gait in Children With Spastic Cerebral Palsy Walking With Excessive Knee Flexi

This is a longitudinal, prospective, and open-label interventional study in a single center. We will investigate the effect of single injection in each patient. This study was designed to ...

Deep Brain Stimulation Surgery for Focal Hand Dystonia

Researchers want to test a procedure called deep brain simulation (DBS) to treat focal hand dystonia (FHD). A device called a neurostimulator is placed in the chest. It is attached to wire...

Comparison of Botulinum Toxin Injections in Forearm FLexor Plus EXtensor Muscles Versus Flexor Muscles Alone for the Treatment of Essential Hand Tremor (FLEX-D ET)

To compare the efficacy of botulinum toxin (BoNT) injections in forearm flexors plus extensor muscles versus flexors alone for the treatment of essential hand tremor (ET).

Botulinum Toxin A Single Blind Split-Face Randomized Pilot Study

A 16-week single-blind, split-face, randomized study. Each patient served as their own control, receiving onabotulinumtoxinA and abobotulinumtoxinA randomized to either the left or right s...

Computer Modelling of the Cervical Spine Movements in Cervical Dystonia

Cervical dystonia (CD) is a syndrome characterized by sustained and/or phasic involuntary neck muscle activity causing abnormal head postures and movements. It is the most frequent form of...

Randomised, Evaluation-blinded, Crossover, Controlled Study Assessing Dynamic Hand Splinting in Adults With Post-stroke Hemiplegia (Orthox)

Upper limb spasticity is currently mainly managed with local toxin treatments. Recent studies suggested combining botulinum toxin injections with splinting to optimise rehabilitation in sp...

Early Postoperative Prevention and Treatment of Median Sternotomy Scars With Botulinum Toxin Type A Injection

Linear hypertrophic scar is a common surgical problem that can be difficult to manage, especially for the median sternotomy scar. Despite high demand for the early intervention to prevent ...

Validation of the Zigzag Tracking Task Test for the Evaluation of Handwriting Difficulties in Writer's Cramp

Writer's cramp (WC) is a task specific dystonia that occurs from the moment patient starts writing. It leads to partial or complete inability to use the hand only during the handwriting ge...

Human Challenge Model With ST-only Enterotoxigenic Escherichia Coli

Heat stable toxin (ST) producing ETEC strains are important causes of childhood diarrhea in many countries. Vaccine candidates targeting ST are in development. A human challenge model usin...

A Pilot Study of the Effects of Botulinum Toxin in the Treatment of Provoked Vestibulodynia

The main objective of this study is to compare the efficacy of botulinum toxin injections on vestibulodynia pain compared to a group treated with a placebo.

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Medical and Biotech [MESH] Definitions

Subtype of CLOSTRIDIUM BOTULINUM that produces botulinum toxin type C which is neurotoxic to ANIMALS, especially CATTLE, but not humans. It causes dissociation of ACTIN FILAMENTS.

Subtype of CLOSTRIDIUM BOTULINUM that produces botulinum toxin type D which is neurotoxic to ANIMALS, especially CATTLE, but not humans.

Subtype of CLOSTRIDIUM BOTULINUM that produces BOTULINUM TOXIN TYPE A which is neurotoxic to humans and animals.

Subtype of CLOSTRIDIUM BOTULINUM that produces botulinum toxin type B which is neurotoxic to humans and animals.

Subtype of CLOSTRIDIUM BOTULINUM that produces botulinum toxin type E which is neurotoxic to humans and animals.

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