Botulinum Toxin A Merz - Biotech, Pharma and Life Science Channel
PubMed Articles
Increased autophagic vacuoles (AVs) occur in injured or degenerating neurons, under both developmental and pathological situations. Although an induced autophagy has been shown in inflammation respons...
Flu-like Symptoms and Associated Immunological Response Following Therapy with Botulinum Toxins.
We aimed to define the frequency and risk factors associated with flu-like symptoms (FLS) and other systemic symptoms following treatment with botulinum toxins (BoNT) and correlate them with the immun...
In Greece, Shiga toxin-producing Escherichia coli (STEC) have only been sporadically reported. The objective of this study was to estimate the prevalence of STEC and Escherichia coli O157:H7 in farm a...
The Developmental Regulators, FlbB and FlbE, are Involved in the Virulence of Aspergillus fumigatus.
Several upstream activators required for proper activation of brlA are involved in the development, vegetative growth, toxin production, and pathogenesis of Aspergillus fumigatus. In this study, we ch...
PURPOSE: The peptide-based delivery system constitutes a potent approach to overcome the limitations of drug delivery in vitro and in vivo. We recently proposed a novel peptide RDP, which enables brai...
Botulinum toxin for conditions of the female pelvis: comment.
To evaluate the anti-proliferative and apoptogenic activity of ethyl acetate extract from the leaves of Memecylon edule (EtAc-LME) in MKN-74, NUGC gastric cancer cells and non cancerous gastric mucous...
OBJECTIVES: Conventional isolation of epidermis from the dermis and disruption of epidermal sheets to liberate the cells, are performed using proteolytic enzymes such as thermolysin or collagenase. Se...
BACKGROUND: Relapse after treatment for idiopathic achalasia is common and long-term outcome data are limited. AIM: To determine the cumulative relapse rate and long-term outcome after pneumatic dilat...
This review describes the preclinical mechanisms that may underlie the increased therapeutic benefit of combination therapy-with the N-methyl-D-aspartate receptor antagonist, memantine, and an acetylc...
News Articles
Validation of a new photogrammetric technique to monitor the treatment effect of Botulinum toxin in synkinesis Eye advance online publication, May 17 2013. doi:10.1038/eye.2013.91 Authors:...
Researchers Mine The Botulinum Genome In The Hope Of Disarming This Deadly Foe
The toxin that causes botulism is the most potent that we know of. Eating an amount of toxin just 1000th the weight of a grain of salt can be fatal, which is why so much effort has been put into keepi...
IFR scientists mine the genome of C. botulinum to reveal new information about toxin genes
The toxin that causes botulism is the most potent that we know of. Eating an amount of toxin just 1000th the weight of a grain of salt can be fatal, which is why so much effort has been put into keepi...
Type: Original PaperPurposeThe peptide-based delivery system constitutes a potent approach to overcome the limitations of drug delivery in vitro and in vivo. We recently proposed a novel peptide RDP,...
Charm Sciences Announces Six WET® (Water Extraction Technology) Mycotoxin Tests
Charm WET uses bottled water, instead of ethanol or methanol, to extract mycotoxins. Lawrence, MA (PRWEB) May 14, 2013 A breakthrough Charm® technology, WET, has been expanded to include the fol...
TORONTO, May 14, 2013 /PRNewswire/ -- According to Millennium Research Group (MRG), the global authority on medical technology market intelligence, Allergan continues to dominate the global...
(Norwich BioScience Institutes) Scientists at the Institute of Food Research have been mining the genome of C. botulinum to uncover new information about the toxin genes that produce the potent toxin...
New research in The Lancet reports that just four pathogens—rotavirus, Cryptosporidium, enterotoxigenic Escherichia coli producing heat-stable toxin, and Shigella—are causing most cases of moderat...
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Companies
Merz North America is a specialty healthcare company that develops and commercializes innovative treatment solutions in aesthetics, dermatology and neurology in the U.S. and Canad...
Merz, Inc. is a focused specialty healthcare company that is responsible for developing and commercializing innovative products and solutions in neurology, medical aesthetics, and...
Molecular Templates is a biopharmaceutical company focused on the discovery and development of targeted biologic therapeutics using its novel Engineered Toxin Bodies (ETB) platfor...
Pharmaleads is a research company focussed on the custom design of substrates and inhibitors of zinc metallopeptidases and proteases. Pharmaleads has already developed molecules for ECE, NEP, ACE, APN...
Clinical Trials
The purpose of this study is to determine whether injections of Botulinum toxin type A into muscles of the upper limb are effective in treating spasticity in patients after stroke.
Neuropathic Pain Study With Botulinum Toxin A in Spinal Cord Injury Patients
The purpose of this study is to determine whether botulinum toxin A is effective in the treatment of neuropathic pain in spinal cord injury patients.
The Use of Botulinum Toxin A in Two-Stage Tissue Expander/ Implant Breast Reconstruction
Breast reconstruction is a common procedure with over 86,000 breast reconstruction procedures performed in the United States in 2009. This is a 1.5-fold increase since 2007. Of these breas...
Host Immune Response to Clostridium Difficile Infection in Inflammatory Bowel Disease Patients
The inflammatory bowel diseases (IBD), ulcerative colitis (UC) and Crohn's disease (CD) are chronic conditions affecting approximately 1.4 million Americans. The burden of Clostridium dif...
Botox as a Treatment for Chronic Male Pelvic Pain Syndrome
Chronic pelvic pain syndrome (CPPS) is thought to affect approximately 8% of men aged 18 and older. Patients with this condition experience pain in the perineum, the genitalia, and the rec...
Botox as a Treatment for Interstitial Cystitis in Women
Patients with interstitial cystitis have been well documented to have pelvic floor muscle tenderness as well as pain on bladder distension. Some investigators have even suggested that pel...
Vanderbilt University Spasticity Management Program Evaluation Plan
People with severe developmental disabilities frequently have comorbidities that make providing care to them more difficult. Spasticity is one such comorbidity. It produces increased muscl...
The primary aim of the study is to show that the antibody response to hepatitis B, acellular pertussis toxin and inactivated poliovirus antigens after the 4th vaccination with Hexavac® is...
The purpose of this study is to continue the work from the previous review study and determine the effectiveness of Botox in treating patients with idiopathic clubfoot by comparing outcome...
Deep Brain Stimulation to Treat Cervical Dystonia
This study will evaluate the effectiveness of deep brain stimulation (DBS) for treating primary dystonia. Patients with dystonia have muscle spasms that cause uncontrolled twisting and rep...
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Xeomin 100IU is a botulinum toxin that is used to treat adults with cervical dystonia and blepharospasm. It has been used around the world since 2005 and was...
Medical and Biotech [MESH] Definitions
Pertussis Toxin
One of the virulence factors produced by BORDETELLA PERTUSSIS. It is a multimeric protein composed of five subunits S1 - S5. S1 contains mono ADPribose transferase activity.
Adenylate Cyclase Toxin
One of the virulence factors produced by virulent BORDETELLA organisms. It is a bifunctional protein with both ADENYLATE CYCLASE and hemolysin components.
Clostridium Botulinum Type A
Subtype of CLOSTRIDIUM BOTULINUM that produces BOTULINUM TOXIN TYPE A which is neurotoxic to humans and animals.
Clostridium Botulinum Type B
Subtype of CLOSTRIDIUM BOTULINUM that produces botulinum toxin type B which is neurotoxic to humans and animals.
Clostridium Botulinum Type C
Subtype of CLOSTRIDIUM BOTULINUM that produces botulinum toxin type C which is neurotoxic to ANIMALS, especially CATTLE, but not humans. It causes dissociation of ACTIN FILAMENTS.
