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Botulinum Toxin A Merz - Biotech, Pharma and Life Science Channel

23:56 EDT 16th April 2014 | BioPortfolio

PubMed Articles [458 Associated PubMed Articles listed on BioPortfolio]

Time-resolved cellular effects induced by TcdA from Clostridium difficile.

The anaerobe Clostridium difficile is a common pathogen that causes infection of the colon leading to diarrhea or pseudomembranous colitis. Its major virulence factors are toxin A (TcdA) and toxin B (...

Ibuprofen associated acute vanishing bile duct syndrome and toxic epidermal necrolysis in an infant.

Acute vanishing bile duct syndrome, a rare but rapidly progressive destruction of the intrahepatic bile ducts with unknown pathogenesis, is most often a drug- or toxin-related. Toxic epidermal necroly...

Recombinant TAT-Gelonin Fusion Toxin: Synthesis and Characterization of Heparin/Protamine-Regulated Cell Transduction.

Protein toxins, such as gelonin, are highly desirable anti-cancer drug candidates due to their unparalleled potency and repetitive reaction mechanism in inhibiting protein translation. However, for it...

Host-derived, pore-forming toxin-like protein and trefoil factor complex protects the host against microbial infection.

Aerolysins are virulence factors belonging to the bacterial β-pore-forming toxin superfamily. Surprisingly, numerous aerolysin-like proteins exist in vertebrates, but their biological functions are u...

Evolutionary pathway to increased virulence and epidemic group A Streptococcus disease derived from 3,615 genome sequences.

We sequenced the genomes of 3,615 strains of serotype Emm protein 1 (M1) group A Streptococcus to unravel the nature and timing of molecular events contributing to the emergence, dissemination, and ge...

A Biased Non-Gαi OXE-R Antagonist Demonstrates That Gαi Protein Subunit Is Not Directly Involved in Neutrophil, Eosinophil, and Monocyte Activation by 5-Oxo-ETE.

Gαi-coupled chemoattractant receptors, such as the 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-oxo-ETE) receptor (OXE-R), are able to switch on Gαiβγ protein-dependent and β-arrestin-related sig...

Staphylococcus aureus Alpha-Toxin Mediates General and Cell Type-Specific Changes in Metabolite Concentrations of Immortalized Human Airway Epithelial Cells.

Staphylococcus aureus alpha-toxin (Hla) is a potent pore-forming cytotoxin that plays an important role in the pathogenesis of S. aureus infections, including pneumonia. The impact of Hla on the dynam...

Immunity factors for two related tRNA(Gln) targeting killer toxins distinguish cognate and non-cognate toxic subunits.

The cytoplasmic virus-like element pWR1A from Debaryomyces robertsiae encodes a toxin (DrT) with similarities to the Pichia acaciae killer toxin PaT, which acts by importing a toxin subunit (PaOrf2) w...

Significance of interleukin-13 receptor alpha 2-targeted glioblastoma therapy.

Glioblastoma multiforme (GBM) remains one of the most lethal primary brain tumors despite surgical and therapeutic advancements. Targeted therapies of neoplastic diseases, including GBM, have received...

Structure, Molecular Modeling and Function of the First Potassium Channel Blocker, Urotoxin, Isolated from the Venom of the Australian Scorpion Urodacus Yaschenkoi.

This communication reports the structural and functional characterization of urotoxin, the first K(+) channel toxin isolated from the venom of the Australian scorpion Urodacus yaschenkoi. It is a basi...

News Articles [211 Associated News Articles listed on BioPortfolio]

Gate for bacterial toxins found in cells

A molecule that smuggles toxins from intestinal pathogens into human cells has been discovered by scientists. "In order to prevent the toxin from entering the cell, it is necessary to find the recepto...

Gate for bacterial toxins found

(University of Freiburg) Prof. Dr. Dr. Klaus Aktories and Dr. Panagiotis Papatheodorou from the University of Freiburg have discovered the receptor responsible for smuggling the toxin of the bacterium...

Applied BioCode to Present Poster at CVS on Multiplex Gastrointestinal Pathogen Detection with a User Friendly, High Throughput System

Applied BioCode announced today that its abstract for a poster on “Multiplex Gastrointestinal Pathogen Detection with a User Friendly, High Throughput System” has been accepte...

Top-of-Mind Companies in Facial Injectable and Laser/Energy Device Markets Are Similar in Europe and Asia

BURLINGTON, Mass., April 15, 2014 /PRNewswire/ -- Decision Resources Group, in collaboration with IMCAS (International Master Course on Aging Skin), finds that the top-of-mind companies in e...

Kibow Biotech of Newtown Square, Pennsylvania -- First Dietary Supplement Company, Nominated to Participate in the "Buzz of BIO"- Pipelines of Promise Category at the 2014 BIO International Convention.

NEWTOWN SQUARE, Pa., April 15, 2014 /PRNewswire/ -- Kibow Biotech is pleased to participate in the Buzz of BIO for the 2014 BIO International Convention. Hosted by the Biotechnology Industry Organizat...

Ipsen presents first set of results on Phase III clinical study of Dysport

Ipsen has reported the first set of results on Phase III clinical study of Dysport, an injectable form of botulinum toxin type A (BoNT-A), in the treatment of adults suffering from upper limb spastici...

Listeria monocytogenes exploits efferocytosis to promote cell-to-cell spread

Efferocytosis, the process by which dying or dead cells are removed by phagocytosis, has an important role in development, tissue homeostasis and innate immunity. Efferocytosis is mediated, in part, b...

Muhammad Ali Parkinson Center Salutes Celebrity Fight Night with Dramatic Expansion

PHOENIX, April 10, 2014 /PRNewswire/ -- On the eve of the 20th anniversary of Celebrity Fight Night, the Muhammad Ali Parkinson Center is unveiling an extensive expansion that doctors s...

U.S. Market for Pain Management Devices Will Reach Nearly $2.7 Billion by 2022

BURLINGTON, Mass., April 9, 2014 /PRNewswire/ -- Decision Resources Group finds that the United States market for pain management devices will expand to reach a value of nearly $2.7 billion by 2022. T...

Sientra Appoints Charlie Huiner as Chief Strategy and Corporate Development Officer

Medical Aesthetics company that serves plastic surgeons adds medical technology industry veteran to drive expansion and strategic growth Sientra, Inc. (Sientra), a privately-h...

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Companies [6 Associated Companies listed on BioPortfolio]

DentaSpa

DentaSpa™ is one of the nation’s leading Botulinum Toxin, dermal fillers and injectables business education companies tailored exclusively for dental practitioners. Dent...

Merz North America, Inc.

Merz North America is a specialty healthcare company that develops and commercializes innovative treatment solutions in medical and aesthetic dermatology, and neurology in the U.S...

Merz North America

Merz North America is a specialty healthcare company that develops and commercializes innovative treatment solutions in aesthetics, dermatology and neurology in the U.S. and Canad...

Merz, Inc.

Merz, Inc. is a focused specialty healthcare company that is responsible for developing and commercializing innovative products and solutions in neurology, medical aesthetics, and...

Molecular Templates

Molecular Templates is a biopharmaceutical company focused on the discovery and development of targeted biologic therapeutics using its novel Engineered Toxin Bodies (ETB) platfor...

Pharmaleads

Pharmaleads is a research company focussed on the custom design of substrates and inhibitors of zinc metallopeptidases and proteases. Pharmaleads has already developed molecules for ECE, NEP, ACE, APN...

Clinical Trials [199 Associated Clinical Trials listed on BioPortfolio]

Efficacy and Safety Study of Botulinum Toxin Type A Against Placebo to Treat Spasticity in the Arm After a Stroke

The purpose of this study is to determine whether injections of Botulinum toxin type A into muscles of the upper limb are effective in treating spasticity in patients after stroke.

The Use of Botulinum Toxin A in Two-Stage Tissue Expander/ Implant Breast Reconstruction

Breast reconstruction is a common procedure with over 86,000 breast reconstruction procedures performed in the United States in 2009. This is a 1.5-fold increase since 2007. Of these breas...

Effect of Botulinum Toxin to Hallux Valgus in Addition to Total Contact Insole

The investigators propose a new therapeutic approach by injecting Botulinum Toxin Type A (BTA) to the oblique and transverse heads of adductor muscle of the great toe. BTA works by binding...

Neuropathic Pain Study With Botulinum Toxin A in Spinal Cord Injury Patients

The purpose of this study is to determine whether botulinum toxin A is effective in the treatment of neuropathic pain in spinal cord injury patients.

Host Immune Response to Clostridium Difficile Infection in Inflammatory Bowel Disease Patients

The inflammatory bowel diseases (IBD), ulcerative colitis (UC) and Crohn's disease (CD) are chronic conditions affecting approximately 1.4 million Americans. The burden of Clostridium dif...

Botox as a Treatment for Chronic Male Pelvic Pain Syndrome

Chronic pelvic pain syndrome (CPPS) is thought to affect approximately 8% of men aged 18 and older. Patients with this condition experience pain in the perineum, the genitalia, and the rec...

Botox as a Treatment for Interstitial Cystitis in Women

Patients with interstitial cystitis have been well documented to have pelvic floor muscle tenderness as well as pain on bladder distension. Some investigators have even suggested that pel...

Vanderbilt University Spasticity Management Program Evaluation Plan

People with severe developmental disabilities frequently have comorbidities that make providing care to them more difficult. Spasticity is one such comorbidity. It produces increased muscl...

Follow-up Study on the Antibody Response to Hepatitis B, Acellular Pertussis Toxin and Inactivated Poliovirus Antigens 1 Month After the 4th Hexavac® Vaccination in Healthy Children, Who Participated in NeisVac-C Study 216

The primary aim of the study is to show that the antibody response to hepatitis B, acellular pertussis toxin and inactivated poliovirus antigens after the 4th vaccination with Hexavac® is...

A Double-Blind, Randomized Control Trial Comparing Botulinum Toxin Type A (Botox) and Placebo in the Treatment of Idiopathic Clubfoot

The purpose of this study is to continue the work from the previous review study and determine the effectiveness of Botox in treating patients with idiopathic clubfoot by comparing outcome...

Medical and Biotech [MESH] Definitions

Subtype of CLOSTRIDIUM BOTULINUM that produces botulinum toxin type C which is neurotoxic to ANIMALS, especially CATTLE, but not humans. It causes dissociation of ACTIN FILAMENTS.

Subtype of CLOSTRIDIUM BOTULINUM that produces botulinum toxin type D which is neurotoxic to ANIMALS, especially CATTLE, but not humans.

Subtype of CLOSTRIDIUM BOTULINUM that produces BOTULINUM TOXIN TYPE A which is neurotoxic to humans and animals.

Subtype of CLOSTRIDIUM BOTULINUM that produces botulinum toxin type B which is neurotoxic to humans and animals.

Subtype of CLOSTRIDIUM BOTULINUM that produces botulinum toxin type E which is neurotoxic to humans and animals.

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