Cholesterol - Biotech, Pharma and Life Science Channel
Cholesterol is a waxy steroid metabolite found in the cell membranes and transported in the blood plasma. It is an important structural component of mammalian cell membranes, where it is establishes proper membrane permeability and fluidity. Cholesterol also aides the process of bile acids, steroid hormones, and Vitamin D manufacture. Although mainly made by animals, plants and fungi also make small amounts of cholesterol.
Despite these important biological roles, a high level of cholesterol in the blood serum is a risk factor for cardiovascular disease, which is the biggest killer worldwide.
There are a range of cholesterol-lowering medications such as statins to reduce high cholesterol and protect patients from cardiovascular disease.
Source; Adapted from Wikipedia
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News Articles
ERA-EDTA CONGRESS 2013: Late Breaking Clinical Trials
ISTANBUL, May 21, 2013 /PRNewswire/ -- The congress of the ERA-EDTA (European Renal Association - European Dialysis and Transplant Association) is the biggest congress in Europe on nephrol...
Job stress may raise our 'bad cholesterol' levels
'A stressful job really can kill you – by raising your cholesterol,' reports the Mail Online website. This headline is based on Spanish research that looked at the relationship between job stress a...
Mylan Launches Generic Tricor® Tablets
PITTSBURGH, May 17, 2013 /PRNewswire/ -- Mylan Inc. (Nasdaq: MYL) today announced that its subsidiary Mylan Pharmaceuticals Inc. has shipped Fenofibrate Tablets, 48 mg and 145 mg. Mylan Pharmaceutical...
AmeriHealth NJ Expands Suite of Interactive Health Infographics
AmeriHealth NJ today released three new interactive health infographics that focus on diabetes, cholesterol and HIV/AIDS. The company’s series of infographics, w...
WOONSOCKET, R.I., May 14, 2013 /PRNewswire/ -- High cholesterol is one of the major risk factors for coronary heart disease, heart attack and stroke,[1] which can be well managed with a...
Decades of Improving Cholesterol Levels Abruptly Ended in 2008, PLOS ONE Study Finds
MADISON, N.J., May 13, 2013 /PRNewswire/ -- Decades of declines in LDL cholesterol blood levels, a key marker of death risk from heart disease, abruptly ended in 2008, and may have stalled since,...
With Doping Cloud Lifted, BuckPower Deer Antler Velvet Sales up 84% at GNC Retail Stores
Sales skyrocket as Vijay Singh saga continues With professional athletes use of deer antler velvet as a performance enhancement supplement again in the spotlight, more consume...
WASHINGTON, May 8, 2013 /PRNewswire/ -- Heart attacks are the leading cause of on-duty firefighter fatalities, with more than half of all firefighter fatalities attributed to them.[1] In an e...
LIPTRUZET Approved for Patients with Primary or Mixed Hyperlipidemia, as an Adjunct to Diet When Diet Alone Is Not Enough Merck (NYSE:MRK), known as MSD outside the United Sta...
LIPTRUZET Approved for Patients with Primary or Mixed Hyperlipidemia, as an Adjunct to Diet When Diet Alone Is Not Enough Merck (NYSE:MRK), known as MSD outside the United Sta...
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Companies
Plandaí Biotechnology, Inc. intends to transform the world of nutraceuticals by making available extracts from live plant material that deliver the highest levels of bioavailability curr...
TheAmerican Association of Clinical Endocrinologists (AACE)
The American Association of Clinical Endocrinologists (AACE) represents more than 6,500 endocrinologists in the United States and abroad. AACE is the largest association of clinic...
VitalRemedyMD was founded by Seth J. Baum, MD, FACC, FACPM, FAHA, FNLA, a leading and practicing preventive cardiologist and cholesterol expert, to offer condition-specific nutrit...
The American Association of Clinical Endocrinologists
The American Association of Clinical Endocrinologists (AACE) represents more than 6,500 endocrinologists in the United States and abroad. AACE is the largest association of clinic...
Entelos, Inc. (www.entelos.com) is a life sciences company applying next-generation predictive technologies across multiple markets in R&D, healthcare and finance to dramat...
Alverix is a leader in providing next-generation instrument and connectivity platforms for diagnostic Point-of-Care (POC) testing. Building upon a 30-year legacy within Hewlett Pa...
XenaCare Holdings, Inc. engages in branding, formulation, marketing, and distribution of nutrition supplement products primarily in the United States. In addition to Cobroxin, for...
Nuvilex, Inc. is a âGreenâ products company. The Companyâs current products include: Cinnergenâ¢, which promotes a healthy glucose metabolism; Cinnecholâ¢,...
Limerick BioPharma (http://www.limerickbio.com) is developing small molecule modulators of cell membrane-bound transporters to rid cells of unwanted toxins. By activating cellular...
Imperative Health (formerly known as MiLife) is a spin-out from Unilever Corporate Research (UCR), focused on providing ground-breaking health management technology solutions to a...
Clinical Trials
Randomized Trial of Imaging Versus Risk Factor-Based Therapy for Plaque Regression
Background: - Atherosclerosis (thickening of the artery walls caused by cholesterol and other deposits) commonly occurs in the heart vessels and carotid (neck) arteries of adults. This i...
This study will evaluate the effects of 2 different dose levels of anacetrapib on low-density lipoprotein-cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) in participan...
Internet Diabetes Self-Management Workshop
The purpose of this study is to determine of the effectiveness of an Internet based Diabetes Self-Management workshop for people with type II diabetes. Half of the people who complete the...
Coronary heart disease (CHD) is the most common cause of death in the United States. A common term for CHD is "blocked arteries." People with CHD or "blocked arteries" often have high bl...
Effect of Valsartan on Carotid Artery Disease
Atherosclerosis or 'hardening of the arteries' is a process that ultimately leads to the development of heart attacks, strokes, poor circulation, and death. Millions of Americans are affe...
Effect of Statins on Oxidative Stress and Endothelial Progenitor Cells
Individuals with a high cholesterol level, diabetes or metabolic syndrome (collection of abnormalities such as high blood pressure, high triglyceride levels [fat], obesity, high blood gluc...
Lipoproteins are large complexes of molecules that transport lipids (primarily triglycerides and cholesterol) through the blood. The intestine has traditionally been viewed as a 'passive'...
The Torcetrapib project was terminated on December 2, 2006 due to safety findings. To evaluate the efficacy and safety of the lipid drug torcetrapib/atorvastatin in subjects with a rare g...
Comparison of Two Approaches to Weight Loss Follow-Up Study
This is a follow-up research study to determine if there are any differences in the long-term maintenance of two diet groups, the Atkins’ diet (low-carbohydrate) or the LEARN program (lo...
Bexarotene Treatment in Schizophrenia
In this proposed study, we aim to investigate the effects of Bexarotene (Targretin; LGD1069; 4-[1-{5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl} ethenyl] benzoic acid) on severi...
PubMed Articles
Our objective was to evaluate the effectiveness of implementing standardized guidelines to mitigate metabolic and bone side effects of androgen deprivation therapy (ADT) in men with non-metastatic pro...
Dyslipidemia is a common contributory cause of cardiovascular disease. Vaccinium arctostaphylos L. (Caucasian whortleberry) fruit is rich of anthocyanins. Anthocyanins may exert cardioprotective effec...
BACKGROUND: Statins are among the most prescribed drugs worldwide to reduce the risk of cardiovascular events. Interindividual variability in drug response is a major clinical problem and is of concer...
The rise in childhood obesity has lead to an increased number of children with lipid abnormalities and the predominance of a combined dyslipidemic pattern characterized by a moderate-to-severe elevati...
Part of the efficacy of statins in the prevention of cardiovascular events can be attributed to their blood pressure-lowering effect, but clinical trials primarily designed to investigate this effect...
Background: Among patients with coronary artery disease (CAD), high-density lipoprotein cholesterol (HDL-C) is a cardiac protective factor. In contrast, body mass index (BMI) is inversely related to...
We studied the effects of 2 different dosages of highmolecular- weight poly-gamma-glutamic acid (hm gamma-PGA) derived from Bacillus subtilis chungkookjang on lipid metabolism in a high-fructose diet-...
Antimicrobial peptides (AMPs) could become the next generation antibiotic compounds which can overcome bacterial resistance by disrupting cell membranes and it is essential to determine the factors un...
Molecular dynamics simulations of bilayer systems consisting of varying proportions of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC), cholesterol (Chol), and intrinsically fluorescent Chol a...
A new electrochemical biosensor with enhanced sensitivity was developed for detection of cholesterol by using platinum-palladium-chitosan-graphene hybrid nanocomposites (PtPd-CS-GS) functionalized gla...
Videos
Understanding Cholesterol (Cholesterol #1)
Cholesterol isn't inherently "bad," but too much of it can cause a plethora of problems! Keep watching for the cholesterol basics.Watch More Health Videos at...
Medical and Biotech [MESH] Definitions
Gallstones
Solid crystalline precipitates in the BILIARY TRACT, usually formed in the GALLBLADDER, resulting in the condition of CHOLELITHIASIS. Gallstones, derived from the BILE, consist mainly of calcium, cholesterol, or bilirubin.
Cytochrome-b(5) Reductase
A FLAVOPROTEIN oxidoreductase that occurs both as a soluble enzyme and a membrane-bound enzyme due to ALTERNATIVE SPLICING of a single mRNA. The soluble form is present mainly in ERYTHROCYTES and is involved in the reduction of METHEMOGLOBIN. The membrane-bound form of the enzyme is found primarily in the ENDOPLASMIC RETICULUM and outer mitochondrial membrane, where it participates in the desaturation of FATTY ACIDS; CHOLESTEROL biosynthesis and drug metabolism. A deficiency in the enzyme can result in METHEMOGLOBINEMIA.
Dyslipidemias
Abnormalities in the serum levels of LIPIDS, including overproduction or deficiency. Abnormal serum lipid profiles may include high total CHOLESTEROL, high TRIGLYCERIDES, low HIGH DENSITY LIPOPROTEIN CHOLESTEROL, and elevated LOW DENSITY LIPOPROTEIN CHOLESTEROL.
Atherosclerosis
Thickening and loss of elasticity of the walls of medium and large muscular ARTERIES with lesions in the innermost layer of the artery (ARTERIAL INTIMA). This disease process of atherogenesis includes the retention of cholesterol-rich LIPOPROTEINS and their binding to PROTEOGLYCANS in the arterial intima, generation of proinflammatory molecules that recruit MACROPHAGES to the subendothelial space, formation of FOAM CELLS, and eventual calcification of the arterial wall. These arterial plaques (atheromas) contain CARBOHYDRATES; BLOOD; and CALCIUM.
Squalene Monooxygenase
The second enzyme in the committed pathway for CHOLESTEROL biosynthesis, this enzyme catalyzes the first oxygenation step in the biosynthesis of STEROLS and is thought to be a rate limiting enzyme in this pathway. Specifically, this enzyme catalyzes the conversion of SQUALENE to (S)-squalene-2,3-epoxide.
