Choroidal metastases - Biotech, Pharma and Life Science Channel
PubMed Articles
PR (PRDI-BF1 and RIZ) domain containing proteins (PRDM) have been indicated to play important roles in several human cancers. The objectives of this study were to determine the frequency and prognosti...
Ocular manifestations of Churg-Strauss syndrome : Review article and case report.
This paper summarizes the possible ocular manifestations of Churg-Straus syndrome (CCS) from the literature and presents an unusual case report from routine clinical practice with conjunctival granulo...
Malignant meningitis presenting as pseudotumor cerebri.
Malignant leptomeningitis can present as the clinical syndrome of pseudotumor cerebri due to infiltration of arachnoid villi in the superior sagittal sinus. We show that malignant pachymeningitis can...
The American Cancer Society estimated 1.5 million new cancer cases in the United States in 2012. Although the exact number is not known, it is estimated that brain metastases occur in 20-40% of cancer...
Cultivation-dependent plasticity of melanoma phenotype.
Malignant melanoma is a highly aggressive tumor with increasing incidence and high mortality. The importance of immunohistochemistry in diagnosis of the primary tumor and in early identification of me...
PURPOSE: The response of colorectal liver metastases to the cytotoxic agent irinotecan varies widely. Attempts to correlate tumour metabolism with response have been mixed. This study investigated the...
The ErbB receptor family has been implicated in brain metastases (BM) formation in various cancer types and specific targeted therapies are available. We investigated the overexpression of EGFR, HER2...
The efficacy of protein-based therapeutics with indications in the treatment of lymphatic diseases is expected to be improved by enhancing lymphatic disposition. This study was therefore aimed at exam...
BH3 mimetics reduce adhesion and migration of hepatoblastoma and hepatocellular carcinoma cells.
Advanced stages of tumour and development of metastases are the two major problems in treating liver tumours such as hepatoblastoma (HB) and hepatocellular carcinoma (HCC), in paediatric patients. Mod...
A simple survival score for patients with brain metastases from breast cancer.
BACKGROUND AND PURPOSE: Personalized cancer treatment considers the patient's survival prognosis. Therefore, it is important to be able to estimate the patient's survival time, particularly in a palli...
News Articles
New drug proving effective in attacking advanced prostate cancer
INDIANAPOLIS, June 17, 2013 /PRNewswire-USNewswire/ -- Franciscan St. Francis Health Cancer Center today (June 17) is the first medical facility in Indiana to use a new drug to treat men with advanced...
Diabetics who use meters to monitor their glucose have better control over disease
(The Mount Sinai Hospital / Mount Sinai School of Medicine) Mount Sinai researchers will demonstrate new data on diabetes self-management, as well as the role of prostastic acid phosphatase in Prostat...
Ocular perfusion pressure and choroidal thickness in eyes with polypoidal choroidal vasculopathy, wet-age-related macular degeneration, and normals Eye advance online publication, June 14 2013....
Amgen’s Xgeva Gains FDA Nod For Use In Rare Bone Tumor
Approval of denosumab for giant cell tumor of the bone comes more than a year after Amgen’s failed bid to add a more commercially significant indication for prevention of bone metastases in patients...
Narrower Margin OK for Resection of Colorectal Liver Metastases
When resecting colorectal liver metastases, a 1-mm margin should be the standard of care, instead of a 1-cm margin, according to researchers at two major liver resection centers in the UK. Reuters H...
MR-Guided, Focused Ultrasound Targeted at Bone Metastases Helps Aleve Pain
A high-dose of ultrasound targeted to painful bone metastases appears to rapidly bring patients relief, and with largely bearable side...
Prostate Enzyme Enables Detection Of Metastases During Molecular Imaging
No matter where they have hidden, metastatic prostate cancer cells still express some of the same signaling as normal prostate cells; in some cases even more so, as with the PSMA enzyme. Harnessing th...
Prostate cancer: Lymph node metastases: not always the same prognosis
The presence of lymph node metastases is one of the most important prognostic factors after radical prostatectomy. However, not all patients with node-positive prostate cancer have the same risk of ca...
Molecular imaging enlists prostate enzyme to detect metastases
(Society of Nuclear Medicine) No matter where they have hidden, metastatic prostate cancer cells still express some of the same signaling as normal prostate cells; in some cases even more so, as with...
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Companies
OncoMed is a clinical development-stage biopharmaceutical company focused on discovering and developing first-in-class monoclonal antibody therapeutics targeting cancer stem cells, or CSCs. Our appr...
Clearside Biomedical, based in Atlanta, is a clinical-stage ophthalmic pharmaceutical company developing and commercializing targeted therapeutics for the treatment of sight-threa...
YES is a grassroots organization that provides cancer patients with support, resources, options, education and hope in their fight against liver tumors. It is made up of sur...
Clearside Biomedical is an Atlanta-based, clinical phase ophthalmic pharmaceutical company improving drug performance through tissue-targeted microinjection into distinct compartm...
Clinical Trials
This study will test the investigational antibody, anti-OX40, in combination with stereotactic body radiation in breast cancer patients that have liver or lung metastases and have received...
Using TRAP to Evaluate the Effect of Zometa on Bone Metastasis Due to Lung Cancer
The purpose of this study is to evaluate a new blood test as a way to follow the effect of Zometa in treating bone metastases due to lung cancer.
A Study Of Nasopharyngeal Carcinoma (NPC) Treated With Celecoxib And ZD1839
EGFR and COX-2 are involved in tumorigenesis, angiogenesis and metastases and are frequently over expressed in NPC.COX-2 and EGFR inhibitors are active in NPC.There is synergistic action b...
The overall goal of this study is to determine how FDG-PET can be incorporated into the assessment of the axilla in the staging and treatment of women with early stage breast cancer....
The purpose of this study is to determine whether the addition of bevacizumab, to hepatic arterial therapy with floxuridine (FUDR) and dexamethasone (Dex) (regional chemotherapy), and eith...
Positron Emission Tomography (PET) Interest in the Follow Up of Colorectal Cancer Stage II and III
The follow up of colorectal cancer after curative surgery has to find loco-regional relapses or synchronous metastases, and to detect adenomas and new cancer on the rest of the colon. The...
Dexamethasone for Palliation - Brain Metastases
Brain metastases occur when cancer cells from the initial tumour site (for example, lung or breast) spread to the brain. This develops in approximately 10% - 30% of adults with cancer. Th...
Study of Low Dose CT in Sarcoma Patients
The primary outcome of this study is the detection of lung metastases comparing Low dose CT (LDCT) and Minimum dose CT (MnDCT) with CXR. Hypothesis 1. LDCT and MnDCT have similar...
Accelerated Partial Breast Irradiation Following Lumpectomy for Breast Cancer
To determine whether an accelerated course of radiotherapy delivered to the lumpectomy cavity plus margin using IORT as a single dose, intracavitary brachytherapy with the MammoSite device...
Stereotactic Radiotherapy (SRT) Liver
A minority of patients with colorectal liver metastases and hepatobiliary cancer (primary liver cancer) are candidates for surgery, but there are no curative treatment options for these pa...
Videos
Treatment of Choroidal Metastases From Breast and Lung Carcinoma With Radioactive Plaques
Nisha R Patel, MD, Parin Patel, Jacqueline Emrich, PhD, Lydia Komarnicky, MD. Drexel University College of Medicine.
Medical and Biotech [MESH] Definitions
Neck Dissection
Dissection in the neck to remove all disease tissues including cervical LYMPH NODES and to leave an adequate margin of normal tissue. This type of surgery is usually used in tumors or cervical metastases in the head and neck. The prototype of neck dissection is the radical neck dissection described by Crile in 1906.
Myopia, Degenerative
Excessive axial myopia associated with complications (especially posterior staphyloma and CHOROIDAL NEOVASCULARIZATION) that can lead to BLINDNESS.
Multiple Pulmonary Nodules
A number of small lung lesions characterized by small round masses of 2- to 3-mm in diameter. They are usually detected by chest CT scans (COMPUTED TOMOGRAPHY, X-RAY). Such nodules can be associated with metastases of malignancies inside or outside the lung, benign granulomas, or other lesions.
Wet Macular Degeneration
A form of RETINAL DEGENERATION in which abnormal CHOROIDAL NEOVASCULARIZATION occurs under the RETINA and MACULA LUTEA, causing bleeding and leaking of fluid. This leads to bulging and or lifting of the macula and the distortion or destruction of central vision.
Thymoma
A neoplasm originating from thymic tissue, usually benign, and frequently encapsulated. Although it is occasionally invasive, metastases are extremely rare. It consists of any type of thymic epithelial cell as well as lymphocytes that are usually abundant. Malignant lymphomas that involve the thymus, e.g., lymphosarcoma, Hodgkin's disease (previously termed granulomatous thymoma), should not be regarded as thymoma. (From Stedman, 25th ed)
