Chronic Lymphocytic Leukemia CLL - Biotech, Pharma and Life Science Channel
Chronic lymphocytic leukemia is a disease in which mature lymphocytes become cancerous and gradually replace normal cells in lymph nodes. CLL mainly affects elderly males in North America and Europe.
The number of cancerous mature lymphocytes increases first in the blood and lymph nodes. They then spread to the liver and spleen, both of which begin to enlarge. Cancerous lymphocytes also invade the bone marrow, where they crowd out normal cells, resulting in a decreased number of red blood cells, white blood cells, platelets and antibodies in the blood. There may also be autoimmune destruction of red blood cells and platelets.
CLL is normally a disorder of B lymphocytes, but there are other rarer types; Hairy cell leukemia (a slow-growing uncommon type of B-cell leukemia, produces a large number of abnormal white blood cells with distinctive hairlike projections), T-cell leukemia, Sézary syndrome (a rare type of T-cell leukemia in which cancerous T lymphocytes that start as a skin cancer called mycosis fungoides grow and divide more rapidly and enter the bloodstream, becoming leukemia cells).
The prognosis depend on how symptomatic the case is, but can be up to 20 year, but this cohort of patients are likely to develop other cancers. Treatment options include corticosteroids, chemotherapy drugs, and monoclonal antibodies. There is also symptomatic treatment of the anemia in some patients. Radiotherapy may also be used.
Source; Adapted from Merck Manuals
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Chronic Lymphocytic Leukemia (CLL)-Mayo Clinic
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American Public Health Association
Professional organization concerned with issues affecting personal and environmental health, including federal and state funding for health programs, programs related to chronic and infectious diseases, and professional education in public health.
