Cleft Palate and Cleft Lip - Biotech, Pharma and Life Science Channel
Cleft means 'split' or 'separation', and in Cleft Palate and Lip, the palate and lip are split respectively. This occurs as a congenital abnormality because during development in the womb, the face develops in sections which fuse together. In every 1 in 700 pregnancies, this fusion does not not occur properly, causes Cleft Palate or Lip.
A cleft lip is a condition that creates an opening in the upper lip between the mouth and nose. It looks as though there is a split in the lip. It can range from a slight notch in the colored portion of the lip to complete separation in one or both sides of the lip extending up and into the nose. Cleft lip can be unilateral or bilateral. A cleft palate occurs when the roof of the mouth has not joined completely. A cleft palate can range from just an opening at the back of the soft palate to a nearly complete separation of the roof of the mouth (affecting the soft and hard palate).
Surgery can help repair some on the structure.
Source; Adapted from CLAPA (UK)
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News Articles
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NEW YORK, April 16, 2013 /PRNewswire/ -- Smile Train, the world's largest cleft lip and palate charity, has announced today that San Francisco 49ers Tackle Joe Staley will act as ambassa...
NEW YORK and NORFOLK, Va., April 10, 2013 /PRNewswire-USNewswire/ -- Smile Train and Operation Smile, the two leading cleft care charities in the world, are launching Rwanda Smiles a groundbreaki...
Dr. J Sponsors Real Medicine Foundation's Presence at the 2013 LA Marathon
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NEW YORK, April 3, 2013 /PRNewswire/ -- Smile Train, the world's largest cleft lip and palate charity, has announced today a partnership with the New York Islanders in celebration of National Facial P...
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The Shriners is a fraternity based on fun, fellowship and the principles of brotherly love, truth and relief. We promote strong family values, fraternal and social interact...
Shriners Hospitals for Children - Boston
Shriners Hospitals for Children® is changing lives every day through innovative pediatric specialty care, world-class research and outstanding medical education. Our health car...
Clinical Trials
A Study to Examine the Relationship Between Sleep Apnea and Cleft Lip/Palate
The study is to examine the relationship between sleep apnea and neurocognitive behaviors in children with cleft lip/palate. Describe the incidence and severity of obstructive sleep apnea...
Short-term Behavioral Effects of Cholesterol Therapy in Smith-Lemli-Opitz Syndrome
This 10-week study will evaluate and compare behavior changes in children with Smith-Lemli-Opitz syndrome (SLOS) who are taking cholesterol supplementation versus those who are not on chol...
Study of Mycobacterial Infections
This study will examine the symptoms, course of disease and treatment of non-tuberculous mycobacterial (NTM) infections, as well as the genetics involved in these infections. Patients with...
This study will examine the experiences of parents who decided to continue a pregnancy after receiving a prenatal diagnosis of holopresencephaly (HPE). HPE results from a genetic defect t...
Ultrasound Evaluation of Tongue Movements in Speech and Swallowing
This study will assess the use of ultrasound-a test that uses sound waves to produce images-as a diagnostic tool for evaluating speech and swallowing. The following categories of individu...
Intraoral Grafting of Ex Vivo Produced Oral Mucosal Composites
The purpose of this study is to see if we can develop a good graft for oral mucosal tissue that is like the top of the mouth in a "test tube" that could be used successfully in humans. We...
Primary Objective: To determine if amifostine in combination with IMRT can mitigate the decrease in production of saliva by the submandibular and sublingual salivary glands in patients wi...
This study will describe the use of an intervention, developed by an organization called Positive Exposure, to improve self-perceptions among adolescents and young adults who may encounter...
Study of Effects of Sutures on Results of Palate Surgery for Obstructive Sleep Apnea
In this study we will examine whether suture repair of the palate, or roof of mouth, has any effect on results of palate surgery performed for treatment of obstructive sleep apnea.
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PubMed Articles
Synaptic vesicle exocytosis: Molecular mechanisms and clinical implications.
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Fetal uvula: navigating and lightening the soft palate using HDlive.
We can predict post palatoplasty velopharyngeal insufficiency in cleft palate patients.
Objective: To find an anatomical measurement of the cleft palate (or a calculated parameter) that predicts the occurrence of velopharyngeal insufficiency (VPI) after palatal cleft repair. Study Design...
Age-related Differences in Tongue-Palate Pressures for Strength and Swallowing Tasks.
The tongue plays a key role in the generation of pressures for transporting liquids and foods through the mouth in swallowing. Recent studies suggest that there is an age-related decline in tongue str...
Crystal structure of AcrB complexed with linezolid at 3.5 Å resolution.
AcrB is an inner membrane resistance-nodulation-cell division efflux pump and is part of the AcrAB-TolC tripartite efflux system. We have determined the crystal structure of AcrB with bound Linezolid...
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Infant faces elicit early, specific activity in the orbitofrontal cortex (OFC), a key cortical region for reward and affective processing. A test of the causal relationship between infant facial confi...
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mTOR kinase structure, mechanism and regulation.
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Videos
Bilateral Complete Cleft Lip & Palate, 12 month old baby.
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Medical and Biotech [MESH] Definitions
Palaeognathae
A superorder of large, mostly flightless birds, named for their distinctive PALATE morphology. It includes the orders Apterygiformes, Casuriiformes, Dinornithiformes, RHEIFORMES; STRUTHIONIFORMES and Tinamiformes.
Wolf-hirschhorn Syndrome
A syndrome caused by large deletions of the telomereic end of the short arm of CHROMOSOME 4 (4p) in Wolf-Hirchhorn syndrome critial regions (WHSCRs). Several candidate genes have been identified including WHSC1 and WHSCH2 which appear to be responsible for the core phenotype and in combination with other linked and unlinked genes determine the severity and inclusion of rarer phenotypes. Most cases have a characteristic cranio-facial defect often referred to as "Greek helmet face" - a combined result of MICROCEPHALY, broad forehead, prominent glabella, HYPERTELORISM, high arched eyebrows, short philtrum and micrognathia. In addition there is mental retardation, growth delays, EPILEPSY, and frequently a wide range of midline and skeletal defects, including HYPOSPADIAS; CONGENITAL HEART DEFECTS; CLEFT LIP; CLEFT PALATE; colobomata; CLUBFOOT; clinodactyly; SCOLIOSIS; and KYPHOSIS.
Campomelic Dysplasia
A congenital disorder of CHONDROGENESIS and OSTEOGENESIS characterized by hypoplasia of endochondral bones. In most cases there is a curvature of the long bones especially the TIBIA with dimpling of the skin over the bowed areas, malformation of the pelvis and spine, 11 pairs of ribs, hypoplastic scapulae, club feet, micrognathia, CLEFT PALATE, tracheobronchomalacia, and in some patients male-to-female sex reversal (SEX REVERSAL, GONADAL). Most patients die in the neonatal period of respiratory distress. Campomelic dysplasia is associated with haploinsufficiency of the SOX9 gene (SRY-related HMG-box gene 9).
Velopharyngeal Sphincter
A group of muscles attached to the SOFT PALATE (or velum) and the PHARYNX. They include the superior constrictor, the PALATOPHARYNGEUS, the levator veli palatini muscle, and the muscularis uvulae. This sphincter is situated between the oral and nasal cavities. A competent velopharyngeal sphincter is essential for normal speech and swallowing.
Loeys-dietz Syndrome
An autosomal dominant aneurysm with multisystem abnormalities caused by increased TGF-BETA signaling due to mutations in type I or II of TGF-BETA RECEPTOR. Additional craniofacial features include CLEFT PALATE; CRANIOSYNOSTOSIS; HYPERTELORISM; or bifid uvula. Phenotypes closely resemble MARFAN SYNDROME; Marfanoid craniosynostosis syndrome (Shprintzen-Goldberg syndrome); and EHLERS-DANLOS SYNDROME.
