Cocaine - Biotech, Pharma and Life Science Channel
PubMed Articles
The aim of the present studies was to evaluate cocaine-induced changes in the concentrations of different redox forms of cysteine (Cys) and homocysteine (Hcy), and products of anaerobic Cys metabolism...
HIV and substance use are inextricably intertwined. One-sixth of people living with HIV/AIDS (PLWHA) transition through the correctional system annually. There is paucity of evidence on the impact of...
Acute effects of resveratrol to enhance cocaine-induced dopamine neurotransmission in the striatum.
Resveratrol is known as an activator of SIRT1, which leads to the deacetylation of histone and non-histone protein substrates, but also has other pharmacological profiles such as the inhibition of mon...
The μ-opioid receptor (MOR) binds exogenous and endogenous opioids and is known to mediate the rewarding effects of drugs of abuse. Numerous genetic studies have sought to identify common genetic var...
Cocaine addiction is a major problem for which there is no approved pharmacotherapy. We have developed a vaccine to cocaine (dAd5GNE), based on the cocaine analog GNE linked to the capsid proteins of...
Probing Active Cocaine Vaccination Performance through Catalytic and Noncatalytic Hapten Design.
Presently, there are no FDA-approved medications to treat cocaine addiction. Active vaccination has emerged as one approach to intervene through the rapid sequestering of the circulating drug, thus te...
RATIONALE: Whereas cannabinoid CB1 receptors have long been known to contribute to the rewarding effects and dependence liability of many drugs of abuse, recent studies have implicated the involvement...
The orbitofrontal cortex regulates outcome-based decision-making via the lateral striatum.
The orbitofrontal cortex (oPFC) sends substantial projections to the ventrolateral striatum and aspects of the nucleus accumbens that are, functionally, poorly understood. This is despite probable cor...
In search of the true dosage: Statistics applied to the analysis of the cocaine.
A method of separation by gas chromatography with a flame ionization detector was developed for quantifying cocaine in powders seized by the police. The method was validated by studying parameters of...
This communication reports the blood concentrations of alcohol and drugs from 376 cases of alleged driving under the influence of drugs analysed at the Forensic Science Service Chorley and London labo...
News Articles
Doping-Use of social drugs on the rise in Aussie Rules
MELBOURNE, May 16 (Reuters) - The use of social drugs like cocaine and methamphetamines is on the rise in Australian Rules football with 26 positive tests and a similar number of confessions of use la...
Prefrontal synaptic markers of cocaine addiction-like behavior in rats
Anti-Cocaine vaccine successfully tested in primates
A novel anti-cocaine vaccine has been successfully tested in primates, bringing researchers closer to launching clinical trials with the vaccine in humans. The research was [...]
Human Testing Of Anti-Cocaine Vaccine Likely Within A Year
Researchers at Weill Cornell Medical College have successfully tested their novel anti-cocaine vaccine in primates, bringing them closer to launching human clinical trials. Their study, published onli...
Cocaine Use May Make Brain Bleeds Deadlier (CME/CE)
(MedPage Today) -- Patients presenting with aneurysmal subarachnoid hemorrhage are more likely to die in the hospital if they've recently used cocaine, researchers found.
Cocaine Vaccine Close To Human Clinical Trials
A novel anti-cocaine vaccine has been successfully tested in primates, suggesting that human clinical trials are not far off, according to new research by Weill Cornell Medical College. The finding, p...
Biotie puts cocaine dependence drug into Phase II
Biotie puts cocaine dependence drug into Phase II
Researchers successfully test new anti-cocaine vaccine in primates
Researchers at Weill Cornell Medical College have successfully tested their novel anti-cocaine vaccine in primates, bringing them closer to launching human clinical trials.
Experimental Cocaine Vaccine Effective On Mice, Primates
Brett Smith for redOrbit.com – Your Universe Online Although trends are pointing to a decrease in recent years, cocaine use is still a major problem in the US, with 1.5 million users in 2010 – ac...
Biotie announces start of clinical study with nepicastat (SYN117) in cocaine dependence
BIOTIE THERAPIES CORP. STOCK EXCHANGE RELEASE 10 May 2013 at 9.00 a.m. Biotie announces start of clinical study with nepicastat (SYN117) in cocaine dependence Biotie Therapies today anno...
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Companies
Embera NeuroTherapeutics, Inc.
Embera NeuroTherapeutics, Inc. is a development stage pharmaceutical company focused on treating a broad range of addictions and obesity where the major clinical challenge is a li...
Passages Malibu was founded in 2000 by father and son team Chris and Pax Prentiss as a result of a fatherâs unconditional love and ongoing concern for son Pax and his...
Clinical Trials
Naltrexone in Two Models of Psychosocial Treatments for Cocaine and Alcohol Dependence
The purpose of this study is to see whether naltrexone is safe and useful in preventing alcohol relapse, as well as in decreasing craving for alcohol in people with a diagnosis of alcohol...
Modafinil and Naltrexone to Reduce Cocaine and Alcohol Dependence
Modafinil is a medication that may enhance mood and increase energy in cocaine addicts, which may be useful in preventing cocaine relapse. Naltrexone is a medication that is currently used...
Seroprevalence of Kaposi's Sarcoma Herpes Virus in the United States
This study will investigate patterns of Kaposi's sarcoma herpes virus (KSHV) in the United States and its potential impact on the U.S. population. KSHV is a newly discovered virus that i...
Early Phase II Trials for Cocaine Medication Development - 1
The purpose of this study is to develop models for early Phase II testing of potential medications for cocaine dependence: amoxapine, risperidone and other agents. The study was a control...
Disulfiram for Cocaine Abuse in Methadone Patients
This competitive renewal examines further the influence of dopamine beta-hydroxylase enzyme activity on the clinical efficacy of the novel pharmacotherapy, disulfiram, for treating cocaine...
Assessment of Potential Interactions Between Intravenous Cocaine and Atomoxetine - 1
The purpose of this study is to assess potential interactions between intravenout (i.v.) cocaine and atomoxetine (Straterra) administered orally in four escalating doses.
Vouchers vs. Prizes for Cocaine-Dependent Methadone Patients - 2
The purpose of this study is to compare voucher-based contingency management (CM) procedures to a lower-cost CM system that provides opportunities to win prizes. Cocaine-dependent outpati...
Employment-Based Reinforcement to Motivate Drug Abstinence in the Treatment of Drug Addiction - 1
The primary purpose of the study is to determine if the central feature of the Therapeutic Workplace, the abstinence reinforcement contingency, is critical to initiate cocaine abstinence i...
Valproate Efficacy in Cocaine-Bipolar Comorbidity
This proposal will test the efficacy of a promising pharmacological approach for the treatment of comorbid cocaine dependence and bipolar disorder. We propose a randomized, double blind,...
Naltrexone in Two Models of Psychosocial Treatments for Cocaine and Alcohol Dependence - 1
The purpose of this study is to see whether naltrexone is safe and useful in preventing alcohol relapse, as well as in decreasing craving for alcohol in people with a diagnosis of alcohol...
Videos
Eric Clapton- Cocaine
Eric Clapton- Cocaine, from the album Slowhand.
Medical and Biotech [MESH] Definitions
Crack Cocaine
The purified, alkaloidal, extra-potent form of cocaine. It is smoked (free-based), injected intravenously, and orally ingested. Use of crack results in alterations in function of the cardiovascular system, the autonomic nervous system, the central nervous system, and the gastrointestinal system. The slang term "crack" was derived from the crackling sound made upon igniting of this form of cocaine for smoking.
Cocaine-related Disorders
Disorders related or resulting from use of cocaine.
Coca
Any of several South American shrubs of the Erythroxylon genus (and family) that yield COCAINE; the leaves are chewed with alum for CNS stimulation.
Cocaine
An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.
Mazindol
Tricyclic anorexigenic agent unrelated to and less toxic than AMPHETAMINE, but with some similar side effects. It inhibits uptake of catecholamines and blocks the binding of cocaine to the dopamine uptake transporter.
