Cytomegalovirus CMV Vaccines - Biotech, Pharma and Life Science Channel
Cytomegalovirus (CMV) is a ubiquitous herpesvirus that persists indefinitely after primary infection. CMV is the most common opportunistic infection after solid organ transplantation. The incidence of clinically apparent infection ranges from 20-60%. The mortality rate from CMV infection is as high as 90% if it is left untreated. CMV disease (i.e., CMV syndrome with CMV viremia) may present as infection with signs and symptoms of fever, malaise, leukopenia, or documented CMV invasive disease into organs. CMV disease is classified as being both a tissue invasive problem and a syndrome. Tissue-invasive disease often affects the allograft (e.g., mild hepatitis and mild respiratory involvement to severe pneumonitis are common in patients with liver and lung transplants, respectively), although various other organs (e.g., the kidneys, intestines, retinas) may be affected.
At present, a limited number of drugs is approved for treatment or prevention of CMV disease, such as ganciclovir, or hyperimmune globulin preparations, but no specific CMV vaccine is approved. The present Competitor Analysis describes the R&D pipeline of new molecular entities including vaccines, monoclonal antibodies, peptides, cellular therapy approaches and small molecules in clinical and preclinical development for prophylaxis and treatment of CMV disease.
Source; Research and Markets (Competitor Analysis)
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News Articles
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Companies
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Xenetic is a leading UK-based biopharmaceutical company providing leading-edge expertise in the development of a whole new generation of drugs and vaccines. Working with some of the largest pharma...
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Clinical Trials
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Medical and Biotech [MESH] Definitions
Tuberculosis Vaccines
Vaccines or candidate vaccines used to prevent or treat TUBERCULOSIS.
Ebola Vaccines
Vaccines or candidate vaccines used to prevent EBOLA HEMORRHAGIC FEVER.
Dengue Vaccines
Vaccines or candidate vaccines used to prevent infection with DENGUE VIRUS. These include live-attenuated, subunit, DNA, and inactivated vaccines.
West Nile Virus Vaccines
Vaccines or candidate vaccines used to prevent infection with WEST NILE VIRUS.
Electrochemotherapy
A treatment modality that uses pulsed electrical currents to permeabilize cell membranes (ELECTROPORATION) and thereby enhance the uptake of chemotherapeutic agents, vaccines, or genes into the body's cells.
