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Cytotoxic drugs - Biotech, Pharma and Life Science Channel

18:54 EDT 29th July 2014 | BioPortfolio

PubMed Articles [5713 Associated PubMed Articles listed on BioPortfolio]

In brief: Khedzela - a new brand of desvenlafaxine.

New oral anticogulants for acute venous thromboembolism.

Simeprevir (Olysio) for chronic hepatitis c.

Qualitative screening of 116 veterinary drugs in feed by liquid chromatography-high resolution mass spectrometry: Potential application to quantitative analysis.

Veterinarian and human pharmaceuticals may be intentionally added to animal feed to enhance animal production. Monitoring these substances is necessary for protecting the consumers. In this work, a sc...

Effect of irradiated sodium alginate and phosphorus on biomass and artemisinin production in Artemisia annua.

It is now being realized that irradiation products of natural bioactive agents can also be beneficially utilized to impart value addition in agriculture by converting these bioactive agents into more...

Structure-property relationships and biocompatibility of carbohydrate crosslinked polyurethanes.

Biocompatible and biodegradable polyurethanes (PUs) based on castor oil and polypropylene glycols (PPGs) were prepared using various carbohydrate crosslinkers: monosaccharide (glucose), disaccharide (...

Porous silicon-cyclodextrin based polymer composites for drug delivery applications.

One of the main applications of porous silicon (PSi) in biomedicine is drug release, either as a single material or as a part of a composite. PSi composites are attractive candidates for drug delivery...

Controlling the complexation of polysaccharides into multi-functional colloidal assemblies for nanomedicine.

The controlled assembly of oppositely charged polysaccharides led to colloids stable in physiological media, capable of encapsulating a molecular drug and of sorbing proteins at their interface. Two t...

Contribution of the NO-detoxifying enzymes HmpA, NorV and NrfA to nitrosative stress protection of Salmonella Typhimurium in raw sausages.

The antimicrobial action of the curing agent sodium nitrite (NaNO2) in raw sausage fermentation is thought to mainly depend on the release of cytotoxic nitric oxide (NO) at acidic pH. Salmonella Typhi...

Seasonal changes in antibiotics, antidepressants/psychiatric drugs, antihistamines and lipid regulators in a wastewater treatment plant.

Seasonal changes in the concentration of 21 pharmaceuticals in a wastewater treatment plant (WWTP) in České Budějovice were investigated over 12months. The target compounds were 10 antibiotics, 4 a...

News Articles [5605 Associated News Articles listed on BioPortfolio]

Surgery: β-Blockers—still a trusted ally or time for retirement?

Uncertainty surrounds the benefit of β-blocker treatment in various clinical settings. The researchers in a new retrospective analysis of preoperative β-blocker use in CABG surgery now add to the de...

UPDATE 3-Pfizer leaves investors guessing on intentions for Astra

(Adds CEO, CFO, analyst comments, details on experimental drugs, paragraphs 4-15)

Banner Health Joins Excelera® Specialty Pharmacy Network

ExceleraRx Corp. announced that Banner Health, one of the nation’s largest health systems, has joined the Excelera national specialty pharmacy network. Minneapolis, MINN (PRWEB) July 29, 2014 Excel...

Ziopharm: Pipeline Expansion And Data Updates To Drive Near-Term Upside

By Michael Vascocu: There are still many big catalysts ahead and closer to the end of the year that will propel the stock price much higher Back in May, I wrote a very thorough article on the potent...

Merck beats forecasts as newer drugs offset generics

(Reuters) - Merck & Co reported better-than-expected quarterly results, with sales of newer drugs mostly offsetting declining sales of drugs facing generic competition. The No. 2 U.S. drugmaker on...

Earnings at Pfizer tank but still just beat expectations

Taking the brunt of generic competition to former blockbuster drugs, US pharma giant Pfizer posted a massive 79.4% drop in second-quarter 2014 earnings.

Canada’s Health Minister moves on safe prescribing practices for drugs prone to abuse

Canada’s Minister of Health, Rona Ambrose, has issued a national Call for Proposals to improve the prescribing practices for prescription drugs that have a high risk of abuse or addiction.

What Are Theravance's GSK Drugs Really Worth?

By Early Retiree:With Theravance (NASDAQ:THRX) plunging back to its June lows and investors panicking about GlaxoSmithKline's (NYSE:GSK) prospects in the respiratory market segment, the stock is worth...

Pharma Clinical Trials Market in China: Authorities for Drug New Study Now Available at MarketReportsOnline.com

MarketReportsOnline.com adds "Latest Guidebook for Conducting Pharma Clinical Trials in China: From Regulations to Practice (2014 Edition)" report to its research store. Dallas, Texas (PRWEB...

New blockbuster drugs to more than triple acute coronary syndrome treatment market value by 2023, says GlobalData

The launch of several drugs with “extraordinary blockbuster potential” will cause the acute coronary syndrome treatment market to more than triple in value...

Events [0 Results]

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Companies [223 Associated Companies listed on BioPortfolio]

Biosceptre

Biosceptre has identified a pan-cancer target, present in many cancer types, and importantly not found in healthy tissue. Early research and initial evidence suggest that drugs di...

Hydra Biosciences, Inc.

Hydra Biosciences is a privately-held biopharmaceutical company based in Cambridge, Massachusetts, and develops drugs to treat pain, inflammation, anxiety and other diseases using...

DesignMedix, Inc.

DesignMedix, Inc. was founded in 2008 to develop drugs to overcome drug resistance. The company’s initial focus is on oral drugs to treat malaria, which kills over 600,000 pe...

Ichor Medical Systems, Inc.

Ichor Medical Systems’ TriGrid™ Delivery System (TriGrid) is the first integrated and fully automated device for electroporation-mediated DNA administration in humans. I...

Sonrgy, Inc.

Sonrgy is a preclinical stage biotechnology company based in San Diego, California that is developing a targeted chemotherapy delivery platform to improve survival and quality of...

Zocere, Inc.

Headquartered in Albuquerque, New Mexico, Zocere, Inc., is a startup pharmaceutical company developing injectable, neuroprotectant drugs intended to combat stroke and other neurol...

Carmot Therapeutics

Carmot is pioneering a transformative drug discovery approach, Chemotype Evolution, to identify superior therapeutics for human diseases. Chemotype Evolution is a proprietary tech...

CancerCare Co-Payment Foundation

The CancerCare® Co-Payment Assistance Foundation (CCAF) is a nonprofit 501(c)(3) organization dedicated to helping people afford co-payments for chemotherapy and targeted treat...

Concert Pharmaceuticals Inc.

Concert Pharmaceuticals is a clinical stage biotechnology company with a broad development pipeline targeting renal disease, CNS disorders, inflammation and hematologic disorders....

Etubics Corporation

Etubics Corporation, based in Seattle, Wash., is a clinical stage bio-pharmaceutical company, which has developed a proprietary platform technology consisting of a next generation...

Clinical Trials [281 Associated Clinical Trials listed on BioPortfolio]

Evaluation of the Safety and Tolerance of Immunotherapy With Autologous, Ex-Vivo Expanded, HIV-Specific Cytotoxic T-Cells in HIV-Infected Patients With CD4+ Counts Between 100-400/mm3

To determine the safety, tolerance, and feasibility of adoptive immunotherapy with autologous cytotoxic T-lymphocytes (CTLs) in HIV-infected patients with CD4 counts between 100 and 400; t...

A Study of Cytotoxic T Lymphocyte (CTL) Therapy in HIV-Infected Patients

To define the safety of cytotoxic T lymphocytes (CTLs) generated from sibling-supplied dendritic cells and lymphocytes and infused into an HIV-infected patient. To determine the efficacy o...

A Phase I/II Double-Blind Controlled Trial to Determine the Safety and Immunogenicity of HIV-1 MN rgp160 Immuno AG Vaccine Therapy in HIV-Infected Individuals With Greater Than or Equal to 500/mm3 CD4+ T Cells and 200-400/mm3 CD4+ T Cells

To evaluate the safety and immunogenicity of HIV-1 MN rgp160 (Immuno-AG) in HIV-infected patients. To evaluate the immunogenicity of HIV-1 MN rgp160 immunogen by lymphocyte proliferation,...

A Study on Possible Interactions Between Protease Inhibitors (Anti-HIV Drugs) and Drugs Which Lower the Level of Fat in Your Blood

The purpose of this study is to find out whether taking protease inhibitors (anti-HIV drugs) together with lipid-lowering drugs (drugs which lower the amount of fat in the blood) has an ef...

A Phase I Trial of HIV-1 C4-V3 Polyvalent Peptide Vaccine in HIV-1 Infected Persons

To determine the safety of immunization with HIV-1 C4-V3 polyvalent peptide vaccine in HIV-infected persons. To determine the proportion of study participants immunized who develop new spe...

A Phase I Safety and Immunogenicity Study of HIV p17/p24:Ty-VLP in HIV-1 Seronegative Subjects

To evaluate the safety and immunogenicity of HIV p17/p24:Ty-VLP (virus-like particles) vaccine in uninfected volunteers. Specifically, to determine whether the vaccine formulated with and...

A Study to Evaluate the Effects of Anti-HIV Drugs in HIV-Positive Patients Who Also Have Hepatitis C Infection

This study evaluates patients infected with both HIV and Hepatitis C virus (HCV) who are receiving anti-HIV drugs. The purpose of this study is to learn more about HCV infection in patien...

A Multi-Institutional Phase II Study of Cyclophosphamide, Paclitaxel, Cisplatin With G-CSF for Patients With Newly Diagnosed Advanced Stage Ovarian Cancer

A supra-additive cytotoxic effect was seen when CAI and paclitaxel were given to human ovarian cancer cells sequentially in tissue culture. We have demonstrated that CAI given for 8 days...

Subcutaneously Administered Interleukin-12 Therapy in HIV-Infected Patients With Disseminated Mycobacterium Avium Complex Infection

Disseminated infection with Mycobacteria avium complex (MAC) is one of the most common systemic bacterial infections in advanced stages of the acquired immunodeficiency syndrome (AIDS). C...

Mycophenolate Mofetil to Treat Wegener's Granulomatosis and Related Vascular Inflammatory Conditions

This study will examine the safety and effectiveness of the drug mycophenolate mofetil (MPM) in treating Wegener's granulomatosis and related inflammatory vessel diseases. Blood vessel inf...

Medical and Biotech [MESH] Definitions

A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.

A cytokine which resembles IL-1 structurally and IL-12 functionally. It enhances the cytotoxic activity of NK CELLS and CYTOTOXIC T-LYMPHOCYTES, and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity.

Methods of investigating the effectiveness of anticancer cytotoxic drugs and biologic inhibitors. These include in vitro cell-kill models and cytostatic dye exclusion tests as well as in vivo measurement of tumor growth parameters in laboratory animals.

A critical subpopulation of regulatory T-lymphocytes involved in MHC Class I-restricted interactions. They include both cytotoxic T-lymphocytes (T-LYMPHOCYTES, CYTOTOXIC) and CD8+ suppressor T-lymphocytes.

Drugs used by veterinarians in the treatment of animal diseases. The veterinarian's pharmacological armamentarium is the counterpart of drugs treating human diseases, with dosage and administration adjusted to the size, weight, disease, and idiosyncrasies of the species. In the United States most drugs are subject to federal regulations with special reference to the safety of drugs and residues in edible animal products.

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