Cytotoxic drugs - Biotech, Pharma and Life Science Channel

07:27 EDT 16th September 2014 | BioPortfolio

PubMed Articles [5731 Associated PubMed Articles listed on BioPortfolio]

In brief: Khedzela - a new brand of desvenlafaxine.

New oral anticogulants for acute venous thromboembolism.

Simeprevir (Olysio) for chronic hepatitis c.

How to Treat Erectile Dysfunction in Men with Diabetes: from Pathophysiology to Treatment.

Erectile dysfunction (ED) is highly prevalent affecting at least 50 % of men with diabetes mellitus (DM). DM may cause ED through a number of pathophysiological pathways. These include neuropathy, en...

Qualitative screening of 116 veterinary drugs in feed by liquid chromatography-high resolution mass spectrometry: Potential application to quantitative analysis.

Veterinarian and human pharmaceuticals may be intentionally added to animal feed to enhance animal production. Monitoring these substances is necessary for protecting the consumers. In this work, a sc...

Hepatobiliary/Pancreas Pathology: SY11-2 CHOLANGIOCARCINOMA WITH RESPECT TO IGG4 REACTION.

IgG4-related diseases including IgG4-related sclerosing cholangitis are characterized by the increased level of serum IgG4 and the marked infiltration of IgG4+ plasma cells in affected organs. However...

Infectious Diseases and Tropical Disease Pathology: SY16-3 PYTHIOSIS: AN ENDEMIC FATAL INFECTIOUS DISEASE.

Pythiosis is a life threatening infectious disease of humans and animals living in tropical and subtropical areas of the world. The causative agent is the fungus-like microorganism Pythium insidiosum,...

Neuropathology: SY21-2 MUCOR FUNGAL ENCEPHALITIS: CASE PRESENTATION.

Mucormycosis is a rare and often fatal infection caused by fungi of the Mucorales order, commonly affecting immunocompromised patients and adults with diabetic ketoacidosis. Infants are infected throu...

Potential Applications of Pharmacogenomics to Heart Failure Therapies.

Pharmacogenomics explores one drug's varying effects on different patient genotypes. A better understanding of genomic variation's contribution to drug response can impact 4 arenas in heart failure (H...

Case Management in a DUI Lab: Effect on Drugs Reported.

An evaluation of an internal laboratory decision to implement a protocol for limiting drug testing based on ethanol concentration in laboratory analysis for driving under the influence (DUI) cases is ...

News Articles [5481 Associated News Articles listed on BioPortfolio]

Genisphere Closes $2 Million to Accelerate Development of Targeted Drug Delivery Platform

Pharma and Academic Collaborations for Targeted Delivery of Small Drugs, Biologics and Nucleic Acids Reaches 25 Genisphere LLC, provider of the 3DNA® nanotechnology pl...

Veterinary Pharmacy, Diamondback Drugs, Selects the Grand Prize Winner in Their Annual Max Memorial Essay Contest

Texas A&M Veterinary Medicine and Biomedical Sciences student Therese Gavin takes top honors in Diamondback Drugs annual essay contest. Scottsdale, Arizona (PRWEB) September 16, 2014 Recognizing ...

Merck KGaA agrees to market Lupin drugs in emerging countries

FRANKFURT (Reuters) - German drugmaker Merck KGaA said it struck a deal with Lupin Limited to market some of the Indian drugmaker's cardiovascular and diabetes treatments in emerging markets.

Dr Reddy's polypill beats strong after FDA panel view

Polypill developers can take heart that the route to the US market may have become feasible after the US FDA's Cardiovascular and Renal Drugs Advisory Committee offered cautious support to such fixed ...

Patients with particular genetic variation more prone to drug-induced pancreatitis

Doctors have discovered that patients with a particular genetic variation are four times more likely to develop pancreatitis if they are prescribed a widely used group of drugs.

Hope Of Low Priced Drugs Kindle As Gilead Teams Up With Indian Firms

Gilead’s much-hyped partnerships with Indian drug makers to sell cut price versions of its blockbuster hepatitis C treatment Sovaldi opens up a huge market opportunity.

Benefits of blood pressure lowering drugs for low risk patients 'still open to question'

Dr Stephen Martin and colleagues argue that this strategy is failing patients and wasting healthcare resources. They call for a re-examination of the threshold and urge clinicians to be cautious about...

GHIT Fund announces new grants to tackle malaria, chagas disease and dengue

The Global Health Innovative Technology Fund, a new public health partnership that is bringing Japanese know-how and investment to the global fight against infectious diseases, today announced seven g...

U.S. Report Says Indian Drug Makers Sell Inferior Drugs In Africa

A report by a U.S. conservative think tank accuses Indian drug manufacturers of selling poor-quality drugs in Africa, based on a test of 1,470 samples.

Exploring a New Approval Process for Continued Excipient Innovation

New excipients and improvements to existing excipients are needed to facilitate access to new drugs for patients.

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Companies [229 Associated Companies listed on BioPortfolio]

Retina Associates of Florida

Retina Associates is a state-of-the art diagnostic and treatment center as well as a leading clinical research center for macular degeneration and other retinal diseases. Its phys...

BioFilm, Ltd.

Founded in 2003 as a subsidiary of Devro plc., BioFilm is the largest Thin Dissolving Film (TDF) producer in Europe, with their GMP certified manufacturing and packaging facility ...

Catalent, Inc.

Catalent, Inc. is the leading global provider of advanced delivery technologies and development solutions for drugs, biologics and consumer health products. With over 80 years ser...

Biosceptre

Biosceptre has identified a pan-cancer target, present in many cancer types, and importantly not found in healthy tissue. Early research and initial evidence suggest that drugs di...

Therapeutic Proteins International

Therapeutic Proteins International, LLC (TPI) is a fully integrated manufacturer of biosimilar recombinant protein products. TPI’s vision is to produce high quality, life-alt...

Sephos Biotherapeutics

Sephos Biotherapeutics is a privately owned company focused on designing drugs for the treatment of cancer stem cells where the structure and biological activity of the drugs have...

BIOCAD

Based in St. Petersburg, Russia, joint-stock company BIOCAD is a leading Russian private biopharmaceutical company, specializing in the research, development and manufacture of ge...

DesignMedix, Inc.

DesignMedix, Inc. was founded in 2008 to develop drugs to overcome drug resistance. The company’s initial focus is on oral drugs to treat malaria, which kills over 600,000 pe...

Zarbee’s Naturals

Founded in 2008 by pediatrician Dr. Zak Zarbock, Zarbee’s Naturals manufactures the nation’s #1 natural cough syrup and a complete line of “family-safe” health...

Ichor Medical Systems, Inc.

Ichor Medical Systems’ TriGrid™ Delivery System (TriGrid) is the first integrated and fully automated device for electroporation-mediated DNA administration in humans. I...

Clinical Trials [283 Associated Clinical Trials listed on BioPortfolio]

HER2 Imaging Study to Identify HER2 Positive Metastatic Breast Cancer Patient Unlikely to Benefit From T-DM1

T-DM1 , which is a highly innovative but also expensive antiHER2 agent consisting in the coupling of the humanised monoclonal antibody trastuzumab with a cytotoxic agent (maytansine deriva...

A Phase I/II Double-Blind Controlled Trial to Determine the Safety and Immunogenicity of HIV-1 MN rgp160 Immuno AG Vaccine Therapy in HIV-Infected Individuals With Greater Than or Equal to 500/mm3 CD4+ T Cells and 200-400/mm3 CD4+ T Cells

To evaluate the safety and immunogenicity of HIV-1 MN rgp160 (Immuno-AG) in HIV-infected patients. To evaluate the immunogenicity of HIV-1 MN rgp160 immunogen by lymphocyte proliferation, ...

Evaluation of the Safety and Tolerance of Immunotherapy With Autologous, Ex-Vivo Expanded, HIV-Specific Cytotoxic T-Cells in HIV-Infected Patients With CD4+ Counts Between 100-400/mm3

To determine the safety, tolerance, and feasibility of adoptive immunotherapy with autologous cytotoxic T-lymphocytes (CTLs) in HIV-infected patients with CD4 counts between 100 and 400; t...

A Study of Cytotoxic T Lymphocyte (CTL) Therapy in HIV-Infected Patients

To define the safety of cytotoxic T lymphocytes (CTLs) generated from sibling-supplied dendritic cells and lymphocytes and infused into an HIV-infected patient. To determine the efficacy o...

A Study on Possible Interactions Between Protease Inhibitors (Anti-HIV Drugs) and Drugs Which Lower the Level of Fat in Your Blood

The purpose of this study is to find out whether taking protease inhibitors (anti-HIV drugs) together with lipid-lowering drugs (drugs which lower the amount of fat in the blood) has an ef...

A Phase I Trial of HIV-1 C4-V3 Polyvalent Peptide Vaccine in HIV-1 Infected Persons

To determine the safety of immunization with HIV-1 C4-V3 polyvalent peptide vaccine in HIV-infected persons. To determine the proportion of study participants immunized who develop new spe...

A Phase I Safety and Immunogenicity Study of HIV p17/p24:Ty-VLP in HIV-1 Seronegative Subjects

To evaluate the safety and immunogenicity of HIV p17/p24:Ty-VLP (virus-like particles) vaccine in uninfected volunteers. Specifically, to determine whether the vaccine formulated with and ...

A Multi-Institutional Phase II Study of Cyclophosphamide, Paclitaxel, Cisplatin With G-CSF for Patients With Newly Diagnosed Advanced Stage Ovarian Cancer

A supra-additive cytotoxic effect was seen when CAI and paclitaxel were given to human ovarian cancer cells sequentially in tissue culture. We have demonstrated that CAI given for 8 days ...

Treatment of T-Large Granular Lymphocyte (T-LGL) Lymphoproliferative Disorders With Cyclosporine

T Cell Large Granular Lymphocyte (T-LGL) Lymphoproliferative Disorders are a heterogeneous group of uncommon diseases which may involve a polyclonal or a monoclonal T cell population, whic...

Mycophenolate Mofetil to Treat Wegener's Granulomatosis and Related Vascular Inflammatory Conditions

This study will examine the safety and effectiveness of the drug mycophenolate mofetil (MPM) in treating Wegener's granulomatosis and related inflammatory vessel diseases. Blood vessel inf...

Medical and Biotech [MESH] Definitions

A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.

A cytokine which resembles IL-1 structurally and IL-12 functionally. It enhances the cytotoxic activity of NK CELLS and CYTOTOXIC T-LYMPHOCYTES, and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity.

Methods of investigating the effectiveness of anticancer cytotoxic drugs and biologic inhibitors. These include in vitro cell-kill models and cytostatic dye exclusion tests as well as in vivo measurement of tumor growth parameters in laboratory animals.

A critical subpopulation of regulatory T-lymphocytes involved in MHC Class I-restricted interactions. They include both cytotoxic T-lymphocytes (T-LYMPHOCYTES, CYTOTOXIC) and CD8+ suppressor T-lymphocytes.

Drugs used by veterinarians in the treatment of animal diseases. The veterinarian's pharmacological armamentarium is the counterpart of drugs treating human diseases, with dosage and administration adjusted to the size, weight, disease, and idiosyncrasies of the species. In the United States most drugs are subject to federal regulations with special reference to the safety of drugs and residues in edible animal products.

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