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Cytotoxic drugs - Biotech, Pharma and Life Science Channel

04:10 EDT 1st July 2016 | BioPortfolio

PubMed Articles [5864 Associated PubMed Articles listed on BioPortfolio]

Sexual abstinence: What is the understanding and views of secondary school learners in a semi-rural area of North West Province, South Africa?

Among strategies to prevent HIV, other sexually transmitted infections (STIs) and unwanted pregnancies, are programs that promote sexual abstinence among adolescents. However, literature suggests that...

(177)Lu-labelled macrocyclic bisphosphonates for targeting bone metastasis in cancer treatment.

Metastatic bone lesion is a common syndrome of many cancer diseases in an advanced state. The major symptom is severe pain, spinal cord compression, and pathological fracture, associated with an obvio...

Biological evaluation of N-2-hydroxypropyl trimethyl ammonium chloride chitosan as a carrier for the delivery of live Newcastle disease vaccine.

Mucosal immune system plays a very important role in antiviral immune response. We prepared Newcastle disease viruses (NDV) encapsulated in N-2-hydroxypropyl trimethyl ammonium chloride chitosan (N-2-...

Modification biological activity of S and R forms of Proteus mirabilis and Burkholderia cepacia lipopolysaccharides by carrageenans.

The modification of biological features of S and R forms of Proteus mirabilis and Burkholderia cepacia LPS by kappa/iota and kappa/beta carrageenans was shown in Limulus activation test, ELISA, human ...

Preparation and evaluation of naringenin-loaded sulfobutylether-β-cyclodextrin/chitosan nanoparticles for ocular drug delivery.

The aim of this study was to prepare and characterize the naringenin-loaded sulfobutylether-β-cyclodextrin/chitosan nanoparticles (Nag-CD/CS-NPs) and evaluate their potential for the topical ophthalm...

Formation of nanoporous aerogels from wheat starch.

Biodegradable nanoporous aerogels were obtained from wheat starch using a simple and green method based on supercritical carbon dioxide (SC-CO2) drying. Effects of processing parameters (temperature, ...

Gums' based delivery systems: Review on cashew gum and its derivatives.

The development of delivery systems using natural polymers such as gums offers distinct advantages, such as, biocompatibility, biodegradability, and cost effectiveness. Cashew gum (CG) has rheological...

Syntheses and characterization of amphiphilic quaternary ammonium chitosan derivatives.

Amphiphilic chitosan derivatives possess improved physico-chemical properties and could be used as carriers in drug delivery systems. The aim of this study was to investigate the behaviour of an amphi...

The Impact of Psychoactive Drugs on Seizures and Antiepileptic Drugs.

Psychiatric comorbidities are very common in patients with epilepsy, and in fact, a bidirectional relationship between epilepsy and some psychiatric disorders have been identified. However, despite th...

Using Literature-Based Discovery to Explain Adverse Drug Effects.

We report on our research in using literature-based discovery (LBD) to provide pharmacological and/or pharmacogenomic explanations for reported adverse drug effects. The goal of LBD is to generate nov...

News Articles [5651 Associated News Articles listed on BioPortfolio]

Drugs for treating alcohol dependence in England cost nearly {pound}4m in 2014

Prescriptions for treating alcohol dependence in England reached 196 000 in 2014 and cost £3.93m (€4.73m; $5.27m), nearly double the number 10 years ago when prescriptions totalled 109 000 and ...

Pharmaceutical Research: Development and Characterization of the Paclitaxel loaded Riboflavin and Thiamine Conjugated Carbon Nanotubes for Cancer Treatment

Type: Original PaperPurposeIn the present investigation, we prepared and evaluated the paclitaxel loaded riboflavin and thiamine conjugated multi walled carbon nanotubes (PTX-Rf-MWCNTs and PTX-Tm-MWCN...

Pharmaceutical Research: Combination Nanopreparations of a Novel Proapoptotic Drug – NCL-240, TRAIL and siRNA

Type: Original PaperPurposeTo develop a multifunctional nanoparticle system carrying a combination of pro-apoptotic drug, NCL-240, TRAIL [tumor necrosis factor-α (TNF-α)-related apoptosis-inducing l...

The AAPS Journal: Effect of Gastric Fluid Volume on the In Vitro Dissolution and In Vivo Absorption of BCS Class II Drugs: a Case Study with Nifedipine

Type: Original PaperNifedipine is a BCS Class II drug used for treatment of hypertension and preterm labor. Large inter-patient variability in nifedipine absorption results in variable exposure among ...

Gilead and Massachusetts agree to rebates for hep C drugs

Massachusetts had threatened to sue the drug firm over the costs of its hepatitis C treatments. The commonwealth will now receive rebates for most of its residents who are infected…

UPDATE 2-U.S. doctors, hospitals paid billions by drug, device makers - gov't

NEW YORK, June 30 (Reuters) - Doctors and hospitals in the United States received $7.52 billion in payments and ownership and investment interests from the makers of drugs and medical devices in 2015,...

#jobs #lifescience The Wyss Institute for Biologically Inspired Engineering at Harvard University : Free Event: Mechanotherapeutics: From Drugs to Wearables

// Free Event, Registration Required: The Wyss Institute for Biologically Inspired Engineering at Harvard University : Harvard Wyss Institute’s 7th annual symposium is September 20, 2016 in Bost...

FDA's Breakthrough Bar May Be Set Too Low, Jenkins Says

Office of New Drugs Director recommends that EMA be careful how its sets the bar for its similar PRIME program to ensure it remains meaningful.

USFDA Backs Approval of Jardiance for Cardiovascular Indication

Endocrinologic and Metabolic Drugs Advisory Committee votes in favour of cardiovascular mortality benefit for Jardiance for adults with type 2 diabetes. The post USFDA Backs Approval of Jardiance for ...

Announcing Insulin Potentiation Low Dose Chemotherapy (IPT) for Cancer Treatment at National Integrated Health Associates

National Integrated Health Associates (NIHA) has added Targeted Low Dose Insulin Potentiation Therapy (TLD/IPT) as part of the integrative cancer care and treatment program. TLD/IPT targets chemothera...

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Companies [276 Associated Companies listed on BioPortfolio]

Reset Therapeutics, Inc.

Reset, a discovery-stage biopharma company co-founded by leaders in the field of circadian biology and Bay City Capital, is developing first-in-class approaches to treating diseas...

SciFluor Life Sciences, Inc.

SciFluor Life Sciences is a drug discovery company developing a best-in-class portfolio of partnership-ready therapeutic drugs strategically capitalizing on the transformational p...

Altan Pharma Limited

Altan Pharma Ltd. is a privately held, specialty pharmaceutical company that develops, manufactures and commercialises injectable drugs for the hospital and other provider segm...

Ensemble Therapeutics

EnsemblinsTM are a new class of synthetic macrocycles developed by Ensemble using its proprietary chemistry platforms, including DNA-Programmed ChemistryTM. Macrocyc...

XenoPort

We are a biopharmaceutical company focused on developing a portfolio of internally discovered product candidates for the potential treatment of central nervous system (CNS) disorders. We also have a p...

Verseon

Verseon is a technology-based pharmaceutical company that employs its proprietary computational drug discovery platform to develop novel therapeutics for today’s challenging ...

Enable Injections

Founded February 2010 by medical device industry veterans, Cincinnati, OH-based Enable Injections develops and manufactures devices that allow easy, comfortable patient self-admin...

Icagen, Inc.

Icagen, Inc. is a biopharmaceutical company based in Research Triangle Park, North Carolina, focused on the discovery, development and commercialization of novel orally-administered small molecule...

CureDuchenne Ventures LLC

CureDuchenne Ventures LLC collaborates with pharmaceutical and biotechnology companies to facilitate the development of drugs to treat Duchenne muscular dystrophy. CureDuchenne Ve...

XL-protein GmbH

XL-protein is a privately owned biopharmaceutical company based in Freising, Germany, which exploits its proprietary PASylation® technology to develop biologics with extended p...

Clinical Trials [797 Associated Clinical Trials listed on BioPortfolio]

Evaluation of Aerosolized Drugs Deposition During Mechanical Ventilation

Aerosol delivery through a ventilator is influenced by numerous factors from ventilator-related, circuit-related to device-related factors. Aerosolized drug delivery through a ventilator s...

Ph II Nintedanib or Intravenous Ifosfamide Advanced Metastatic STS Failed on Imatinib and Sunitinib

This is a prospective, multicentric, randomized, open label Phase II trial investigating whether the oral angiogenesis inhibitor nintedanib, as compared to the intravenous cytotoxic compou...

The Comparison of Outcomes of Antibiotic Drugs and Appendectomy (CODA) Trial

For the past 130 years, appendectomy has been the standard treatment for appendicitis. Recent studies from Europe have challenged the notion that surgery is the best option, showing that a...

Perioperative Antiplatelet Therapy in Patients With Drug-eluting Stent Undergoing Noncardiac Surgery

The purpose of this study is to evaluate the safety and effectiveness of perioperative antiplatelet therapy in patients with drug-eluting stent undergoing non-cardiac surgery.

Implementation of PPI Medication PGX Testing

USING GENETIC INFORMATION ABOUT THE INDIVIDUAL TO PICK THE RIGHT DRUG FOR THE RIGHT DISEASE AT THE RIGHT DOSE DEFINES PERSONALIZED MEDICINE. THIS PILOT STUDY SEEKS TO INSTITUTE PHARMACOGEN...

A Study to Investigate Efficacy and Safety of Cobimetinib Plus Atezolizumab and Atezolizumab Monotherapy Versus Regorafenib in Participants With Metastatic Colorectal Adenocarcinoma

This is a Phase III, multicenter, open-label, three-arm, randomized study in participants with unresectable locally advanced or metastatic colorectal cancer (CRC) who have received at leas...

DC1s-CTL Cellular Therapy for Renal Cell Carcinoma

This trial is to evaluate the safety and effectiveness of autologous type-1 polarized dendritic cell vaccines (patients' autologous DC1s loaded with multiple antigens CTL epitope peptide c...

Maturation of Follicles After Transplantation of Ovarian Tissue Into the Pelvic Wall and the Ovary

The purpose of this study is to determine whether the pelvic wall or the ovary represents a better location for the maturation of follicles in the context of ovarian transplantation after ...

Partially HLA-matched Third Party Antigen Specific T-cells for Infection Post-stem Cell or Solid Organ Transplantation

To assess the safety and biological efficacy of therapeutically administered most closely HLA-matched third party donor-derived specific cytotoxic T lymphocytes (CTLs) targeting cytomegalo...

Evaluation of Safety and Activity of an Anti-PDL1 Antibody (DURVALUMAB) Combined With CSF-1R TKI (PEXIDARTINIB) in Patients With Metastatic/Advanced Pancreatic or Colorectal Cancers

Colorectal cancer (CRC) and pancreatic ductal adenocarcinoma (PDAC) are the most common gastrointestinal cancers in Western countries and are both associated with significant morbidity and...

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Medical and Biotech [MESH] Definitions

A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.

A cytokine which resembles IL-1 structurally and IL-12 functionally. It enhances the cytotoxic activity of NK CELLS and CYTOTOXIC T-LYMPHOCYTES, and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity.

Methods of investigating the effectiveness of anticancer cytotoxic drugs and biologic inhibitors. These include in vitro cell-kill models and cytostatic dye exclusion tests as well as in vivo measurement of tumor growth parameters in laboratory animals.

A critical subpopulation of regulatory T-lymphocytes involved in MHC Class I-restricted interactions. They include both cytotoxic T-lymphocytes (T-LYMPHOCYTES, CYTOTOXIC) and CD8+ suppressor T-lymphocytes.

Drugs used by veterinarians in the treatment of animal diseases. The veterinarian's pharmacological armamentarium is the counterpart of drugs treating human diseases, with dosage and administration adjusted to the size, weight, disease, and idiosyncrasies of the species. In the United States most drugs are subject to federal regulations with special reference to the safety of drugs and residues in edible animal products.

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