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Cytotoxic drugs - Biotech, Pharma and Life Science Channel

23:17 EDT 25th August 2016 | BioPortfolio

PubMed Articles [5753 Associated PubMed Articles listed on BioPortfolio]

Sexual abstinence: What is the understanding and views of secondary school learners in a semi-rural area of North West Province, South Africa?

Among strategies to prevent HIV, other sexually transmitted infections (STIs) and unwanted pregnancies, are programs that promote sexual abstinence among adolescents. However, literature suggests that...

(177)Lu-labelled macrocyclic bisphosphonates for targeting bone metastasis in cancer treatment.

Metastatic bone lesion is a common syndrome of many cancer diseases in an advanced state. The major symptom is severe pain, spinal cord compression, and pathological fracture, associated with an obvio...

Multi-responsive magnetic microsphere of poly(N-isopropylacrylamide)/carboxymethylchitosan hydrogel for drug controlled release.

Multi-responsive composite microspheres were synthesized via an in situ free radical polymerization of thermo-responsive poly(N-isopropylacrylamide) (poly(NIPAAm)) in the presence of carboxymethylchit...

Magnetic field-responsive release of transforming growth factor beta 1 from heparin-modified alginate ferrogels.

Stimuli-responsive polymeric systems have been widely used for various drug delivery and tissue engineering applications. Magnetic stimulation can be also exploited to regulate the release of pharmace...

One-pot green synthesis of luminescent gold nanoparticles using imidazole derivative of chitosan.

Water soluble luminescent gold nanoparticles with average size 2.3nm were for the first time synthesized by completely green method of Au(III) reduction using chitosan derivative-biocompatible nontoxi...

Novel aqueous chitosan-based dispersions as efficient drug delivery systems for topical use. Rheological, textural and release studies.

The use of a novel cross-linked thiolated chitosan (CTS) was investigated as the main component of aqueous dispersions (at 1% and 3% w/v) for topical drug delivery systems. The nonionic theophiline (T...

Influence of natural and synthetic crosslinking reagents on the structural and mechanical properties of chitosan-based hybrid hydrogels.

The objective of this work was to correlate the physical and chemical properties of chitosan/poly(vinyl alcohol)/genipin (CS/PVA/GEN) and chitosan/poly(vinyl alcohol)/glutaraldehyde (CS/PVA/GA) hydrog...

Synthesis of novel amphiphilic hyaluronan containing-aromatic fatty acids for fabrication of polymeric micelles.

Novel hydrophobized hyaluronan (HA) derivatives, containing ω-phenylalkanoic acids (ω-PAA, 4-phenylbutyric acid, 6-phenylhexanoic, 8-phenyloctanoic or 11-tolylundecanoic acids) were prepared by este...

The antihyperlipidemic activities of enzymatic and acidic intracellular polysaccharides by Termitomyces albuminosus.

Two polysaccharides, EIPS and AIPS were obtained by the hydrolysis of IPS from Termitomyces albuminosus, and their pharmacological effects on blood lipid profiles metabolism and oxidative stress were ...

Polyethylene glycol-conjugated chondroitin sulfate A derivative nanoparticles for tumor-targeted delivery of anticancer drugs.

Polyethylene glycol (PEG)-decorated chondroitin sulfate A-deoxycholic acid (CSD) nanoparticles (NPs) were fabricated for the selective delivery of doxorubicin (DOX) to ovarian cancer. CSD-PEG was synt...

News Articles [5849 Associated News Articles listed on BioPortfolio]

Novan Files for IPO to Finance ‘Nitric Oxide on Demand’ Skin Drugs

Novan, a company researching ways to harness nitric oxide for drugmaking, has filed for an initial public offering to fund clinical work on treatments for an array of skin conditions. Durham, NC-based...

Illegal street drugs, not prescriptions, now powering opioid abuse, study finds

Addicts abusing fentanyl are increasingly taking versions of the drug manufactured illicitly, rather than diverted prescription drugs, two new reports find.

High drug prices result of government protection in US

The high cost of prescription drugs in the United States is the result of drug manufacturers being granted government-protected monopolies, according to data published in JAMA Internal Medicine.“The...

Seattle’s Potential Solution for Heroin Epidemic: Places for Legal Drug Use

A city task force endorsed the idea of safe consumption facilities, which would allow addicts to take drugs without fear of being arrested.

Amphetamines Polluting Some Urban Streams: Study

THURSDAY, Aug. 25, 2016 -- Medications and illegal drugs are polluting streams in and around at least one major U.S. city, new research reveals. Scientists say this pollution comes with ecological con...

Immunology: Cytotoxic T cells that escape exhaustion

T cells of the immune system mount antiviral responses, but if a response fails, a chronic viral infection can develop. It now seems that a T-cell subset in lymphoid immune tissues can control chronic...

HER2 expression identifies dynamic functional states within circulating breast cancer cells

Circulating tumour cells in women with advanced oestrogen-receptor (ER)-positive/human epidermal growth factor receptor 2 (HER2)-negative breast cancer acquire a HER2-positive subpopulation after mult...

Structural basis for inhibition of a voltage-gated Ca2+ channel by Ca2+ antagonist drugs

Ca2+ antagonist drugs are widely used in therapy of cardiovascular disorders. Three chemical classes of drugs bind to three separate, but allosterically interacting, receptor sites on CaV1.2 channels,...

Shire leads the fallers as £3.7bn is wiped from drugs sector after Clinton blast

A total of £3.7bn was wiped off the value of the UK’s major drugs stocks after comments by presidential hopeful Hilary Clinton that hinted a crackdown on the major pharmas for what the Americans ca...

Does pessimism worsen side effects from breast cancer drugs?

A new study suggests that with an attitude adjustment women getting hormone treatments from breast cancer might experience fewer or milder side effects.

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Companies [276 Associated Companies listed on BioPortfolio]

Reset Therapeutics, Inc.

Reset, a discovery-stage biopharma company co-founded by leaders in the field of circadian biology and Bay City Capital, is developing first-in-class approaches to treating diseas...

SciFluor Life Sciences, Inc.

SciFluor Life Sciences is a drug discovery company developing a best-in-class portfolio of partnership-ready therapeutic drugs strategically capitalizing on the transformational p...

Altan Pharma Limited

Altan Pharma Ltd. is a privately held, specialty pharmaceutical company that develops, manufactures and commercialises injectable drugs for the hospital and other provider segm...

Ensemble Therapeutics

EnsemblinsTM are a new class of synthetic macrocycles developed by Ensemble using its proprietary chemistry platforms, including DNA-Programmed ChemistryTM. Macrocyc...

XenoPort

We are a biopharmaceutical company focused on developing a portfolio of internally discovered product candidates for the potential treatment of central nervous system (CNS) disorders. We also have a p...

Verseon

Verseon is a technology-based pharmaceutical company that employs its proprietary computational drug discovery platform to develop novel therapeutics for today’s challenging ...

Enable Injections

Founded February 2010 by medical device industry veterans, Cincinnati, OH-based Enable Injections develops and manufactures devices that allow easy, comfortable patient self-admin...

Icagen, Inc.

Icagen, Inc. is a biopharmaceutical company based in Research Triangle Park, North Carolina, focused on the discovery, development and commercialization of novel orally-administered small molecule...

CureDuchenne Ventures LLC

CureDuchenne Ventures LLC collaborates with pharmaceutical and biotechnology companies to facilitate the development of drugs to treat Duchenne muscular dystrophy. CureDuchenne Ve...

XL-protein GmbH

XL-protein is a privately owned biopharmaceutical company based in Freising, Germany, which exploits its proprietary PASylation® technology to develop biologics with extended p...

Clinical Trials [863 Associated Clinical Trials listed on BioPortfolio]

Interest of Routine Screening for Hepatitis B and C in Patients Receiving Chemotherapy for Solid Tumors

Immunosuppression induced by cancer treatment increases the risk of hepatitis B virus (HBV) and hepatitis C virus (HCV) reactivations. These viral reactivations may be asymptomatic but can...

Chemoembolization of Non-resectable Non-metastatic Hepatocellular Carcinoma Using Embolization Microspheres

Chemoembolization is a recognized treatment strategy for hepatocellular carcinoma (HCC) - classical chemoembolization consists in injecting an emulsion of an anticancer agent in L...

Multiple Target Antigen Stimulating Cell Therapy (MASCT-I) Treatment for Advanced Evil Solid Tumor

Multiple Target Antigen Stimulating Cell Therapy (MASCT-I) is a new immunotherapy that dendritic cells(DC) was induced from autologous peripheral blood. The DC can then be loaded with anti...

Direct Antiviral Agents for Hepatitis C Virus-associated Cryoglobulinaemia Vasculitis

Cryoglobulinemia are responsible for systemic vasculitis, and the most frequently targeted organs are the skin, joints, kidney and peripheral nervous system. Cryoglobulinemia vasculitides ...

Evaluation of Changes in Consumption of Drugs and Substances After Incarceration

To improve the management and risk reduction, it is essential to understand the evolution of the consumption of psychoactive substances, medicated or not in detention; it does not have at ...

Cancer Patients' Performance Status Assessed Using Cardiopulmonary Exercise Testing and Wearable Data Generation

The primary objective of this study is to establish the feasibility and value of physical fitness assessment within patients receiving cytotoxic chemotherapy. If successful, this project w...

Combined Infusion of Cytotoxic T-Lymphocytes and Vaccination

To assess the safety and biological efficacy of prophylactically administered donor-derived multi-infection specific cytotoxic T lymphocytes (CTLs) (targeting cytomegalovirus (CMV), Adenov...

Evaluation and Modeling of the G-CSF Effect on the Evolution of Neutrophils During Chemotherapy Based on Eribulin

The anti-cancer cytotoxic chemotherapy is often the cause of neutropenia of grade IV or febrile neutropenia. Those neutropenia, in addition to being a comorbidity factor, result in dose re...

Pembrolizumab, Paclitaxel, and Carboplatin in Patients With Advanced Stage Epithelial Ovarian Cancer (EOC).

The investigators hypothesize that tumor cell killing by cytotoxic chemotherapy exposes the immune system to high levels of tumor antigens.The combination of Paclitaxel/Carboplatin and Pem...

Study of Allogeneic EBV-CTLs in EBV-Associated Lymphomas and Lymphoproliferative Disorders

This is a multicenter expanded access protocol to provide human leukocyte antigen (HLA) partially-matched third-party allogeneic EBV-CTLs for the treatment of EBV lymphomas or Lymphoprolif...

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Medical and Biotech [MESH] Definitions

A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.

A cytokine which resembles IL-1 structurally and IL-12 functionally. It enhances the cytotoxic activity of NK CELLS and CYTOTOXIC T-LYMPHOCYTES, and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity.

Methods of investigating the effectiveness of anticancer cytotoxic drugs and biologic inhibitors. These include in vitro cell-kill models and cytostatic dye exclusion tests as well as in vivo measurement of tumor growth parameters in laboratory animals.

A critical subpopulation of regulatory T-lymphocytes involved in MHC Class I-restricted interactions. They include both cytotoxic T-lymphocytes (T-LYMPHOCYTES, CYTOTOXIC) and CD8+ suppressor T-lymphocytes.

Drugs used by veterinarians in the treatment of animal diseases. The veterinarian's pharmacological armamentarium is the counterpart of drugs treating human diseases, with dosage and administration adjusted to the size, weight, disease, and idiosyncrasies of the species. In the United States most drugs are subject to federal regulations with special reference to the safety of drugs and residues in edible animal products.

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