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Cytotoxic drugs - Biotech, Pharma and Life Science Channel

08:27 EST 9th December 2016 | BioPortfolio

PubMed Articles [5813 Associated PubMed Articles listed on BioPortfolio]

Epithelial-to-Mesenchymal Transition in Paclitaxel-Resistant Ovarian Cancer Cells Is Downregulated by Luteolin.

Ovarian cancer (OVCA) is the deadliest of all gynecological cancers which is attributed to late presentation, persistence, and development of chemoresistance. The objectives were to evaluate the assoc...

Flavopiridol: An Old Drug With New Perspectives? Implication for Development of New Drugs.

Glioblastoma, the most common brain tumor, is characterized by high proliferation rate, invasion, angiogenesis, and chemo- and radio-resistance. One of most remarkable feature of glioblastoma is the s...

Eliciting Epitope-Specific CD8+ T Cell Response by Immunization with Microbial Protein Antigens Formulated with α-Galactosylceramide: Theory, Practice, and Protocols.

CD8+ cytotoxic T lymphocytes confer protection against infectious diseases caused by viruses, bacteria, and parasites. Hence, significant efforts have been invested into devising ways to generate CD8+...

High-Throughput N-Glycan Analysis with Rapid Magnetic Bead-Based Sample Preparation.

N-glycan profiling of therapeutic glycoproteins is essential to ensure the activity and efficacy of these promising new-generation drugs. The N-linked glycan moieties of these entities highly affect c...

Gammaretroviral Production and T Cell Transduction to Genetically Retarget Primary T Cells Against Cancer.

Adoptive T cell therapy has demonstrated tremendous outcomes against treatment-refractory leukemias and solid tumor malignancies. As opposed to industry-developed drugs that are manufactured and dispe...

Association of the Cholinergic Muscarinic M2 Receptor with Autonomic Nervous System Activity in Patients with Schizophrenia on High-Dose Antipsychotics.

Patients with schizophrenia have abnormal autonomic nervous system (ANS) activity compared with the general population. One reason for this difference is the muscarinic affinity for antipsychotic drug...

New anti-IL-23 drugs raise hopes for psoriasis plaque clearance.

Intracellular allosteric antagonism of the CCR9 receptor.

Chemokines and their G-protein-coupled receptors play a diverse role in immune defence by controlling the migration, activation and survival of immune cells. They are also involved in viral entry, tum...

Evaluating the potential of the GFAP-KLH immune tolerizing vaccine for type 1 diabetes in mice.

Glial fibrillary acidic protein (GFAP), expressed in peri-islet Schwann cells, is a novel target for the treatment of type 1 diabetes mellitus (T1DM). We designed a GFAP immune tolerizing vaccine that...

Characteristics, sources, and cytotoxicity of atmospheric polycyclic aromatic hydrocarbons in urban roadside areas of Hangzhou, China.

The primary objective of this study is to understand the profiles, sources and cytotoxic effects of atmospheric polycyclic aromatic hydrocarbons (PAHs), which are closely related to urban air contamin...

News Articles [5732 Associated News Articles listed on BioPortfolio]

Cellular engineering for therapeutic protein production: product quality, host modification, and process improvement

Recombinant proteins offer many therapeutic advantages unavailable in traditional small molecule drugs, but the need for cellular versus chemical synthesis complicates production. Avenues for producin...

FDA issues final guidance on pharmacology labelling

The US Food and Drug Administration (FDA) on 2 December 2016 published final guidance for completing the clinical pharmacology section of labelling for human prescription drugs, which includes origina...

Demonstrating biosimilarity in the EU

How has the European Medicines Agency (EMA) changed its requirements for biosimilars since it first approved biosimilars in 2006? This is a question Dr Martina Weise, Head of the Licensing Division at...

Florida Plant to Manufacture Vaccines Against Bioterrorism

NewsA plant that manufactures vaccines and drugs to protect soldiers from chemical and biological attacks has opened in north Florida.

Arvinas Presents Data on Oral Estrogen Receptor PROTAC Degrader at 2016 San Antonio Breast Cancer Symposium

NEW HAVEN, Conn., Dec. 9, 2016 /PRNewswire/ -- Arvinas LLC, a private biotechnology company creating a new class of drugs known as PROTACs, which function via targeted protein degradation, today ...

HER2Negative Breast Cancer 5EU Drug Forecast and Market Analysis to 2023 Prices from USD $6995

HER2Negative Breast Cancer 5EU Drug Forecast and Market Analysis to 2023SummaryBreast cancer is the second most common cancer in the world and the most common cancer in women worldwide. This report f...

Switzerland Diagnostics Market Forecasts: Blood Banking, Cancer Diagnostics, Clinical Chemistry, Coagulation, Drugs of Abuse, Endocrine Function, Flow Cytometry, Hematology, Immunoproteins, Infectious Diseases, Molecular Diagnostics, TDM Prices from USD $

This new report from VPG Market Research provides granular analysis of the Switzerland diagnostic testing market, including volume and sales forecasts by test for the following market segments:nbsp;nb...

Mandarin Capital Pays $17 Million for Majority Stake in Italian CMO

Mandarin Capital Partners, a China private equity firm, paid $17.4 million to acquire a majority stake in an Italian CMO, Mipharm SpA of Milan. Mipharm specializes in making generic drugs and has trad...

Cancer Research Technology pioneer fund announces investment in blood cancer drugs

Press release The Cancer Research Technology (CRT) Pioneer Fund today announced an investment to develop a promising new class of drugs for blood cancer. "This announcement marks the ninth investm...

Health Tech 2016: A Year To Recalibrate

Among the key health technology lessons that 2016 has reinforced: biology is fiendishly complex; data ≠ insight; impacting health–whether making new drugs or meaningfully changing behavior – is ...

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Companies [276 Associated Companies listed on BioPortfolio]

Reset Therapeutics, Inc.

Reset, a discovery-stage biopharma company co-founded by leaders in the field of circadian biology and Bay City Capital, is developing first-in-class approaches to treating diseas...

SciFluor Life Sciences, Inc.

SciFluor Life Sciences is a drug discovery company developing a best-in-class portfolio of partnership-ready therapeutic drugs strategically capitalizing on the transformational p...

Altan Pharma Limited

Altan Pharma Ltd. is a privately held, specialty pharmaceutical company that develops, manufactures and commercialises injectable drugs for the hospital and other provider segm...

Ensemble Therapeutics

EnsemblinsTM are a new class of synthetic macrocycles developed by Ensemble using its proprietary chemistry platforms, including DNA-Programmed ChemistryTM. Macrocyc...

XenoPort

We are a biopharmaceutical company focused on developing a portfolio of internally discovered product candidates for the potential treatment of central nervous system (CNS) disorders. We also have a p...

Verseon

Verseon is a technology-based pharmaceutical company that employs its proprietary computational drug discovery platform to develop novel therapeutics for today’s challenging ...

Enable Injections

Founded February 2010 by medical device industry veterans, Cincinnati, OH-based Enable Injections develops and manufactures devices that allow easy, comfortable patient self-admin...

Icagen, Inc.

Icagen, Inc. is a biopharmaceutical company based in Research Triangle Park, North Carolina, focused on the discovery, development and commercialization of novel orally-administered small molecule...

CureDuchenne Ventures LLC

CureDuchenne Ventures LLC collaborates with pharmaceutical and biotechnology companies to facilitate the development of drugs to treat Duchenne muscular dystrophy. CureDuchenne Ve...

XL-protein GmbH

XL-protein is a privately owned biopharmaceutical company based in Freising, Germany, which exploits its proprietary PASylation® technology to develop biologics with extended p...

Clinical Trials [1015 Associated Clinical Trials listed on BioPortfolio]

Impact of HLA-E Overexpression by Tumor Cells on the Biology of TIL in Colorectal Cancer

Accumulating evidences suggest that colorectal cancer (CRC) progression is not solely determined by the genetic abnormalities of the tumor cells but also by the host response. Indeed, rece...

Nivolumab With Epstein Barr Virus Specific T Cells (EB-VSTS), Relapsed/Refractory EBV Positive Lymphoma (PREVALE)

Subjects have a type of a lymph node cancer called Non-Hodgkin's Lymphoma (NHL) or lymphoproliferative disease (LPD), which affects their immunity, blood production, and can involve multip...

Self-monitoring and Reminder Texts to Increase Physical Activity After Cancer: a Pilot Randomized Controlled Trial

Epidemiologic data consistently indicate that colorectal cancer survivors can improve their quality-of-life and prognosis by engaging in physical activity. This study aims to build on this...

Treatment of Metastatic Melanoma With TSA-CTL(Tumor Specific Antigen-Induced Cytotoxic T Lymphocytes)

The primary purpose of this study is to evaluate the safety of TSA-CTL in the treatment of the advanced melanoma. The secondary purpose of this study is to evaluate preliminarily the effe...

Efficacy Study to Evaluate the Effect of New Antiviral Drugs on HCV Infection.

The purpose of this study is to determinate the AMH levels before and after antiviral therapy with Ombitasvir-Paritaprevir-Ritonavir and Dasabuvir in comparison with age-matched HCV-positi...

High Concentration of Sugar Solution Irrigation Promotes the Healing of Infected Wound

Surgeons easily get wound infections. Most wound infections will be cured by applying medicines and changing dressing in very short period of time. But some wounds are severely contaminate...

Integrated Treatment and Prevention for People Who Inject Drugs

The purpose of this study is to determine the feasibility of a future trial that will assess whether an integrated intervention combining psychosocial counseling and supported referrals fo...

Neuroimaging and Neuropsychological Outcomes in Urea Cycle Disorders

In proximal urea cycle disorders (UCD), particularly ornithine transcarbamylase deficiency (OTCD), hyperammonemia (HA) causes increased brain glutamine (Gln) which perturbation is thought ...

EC-MOTION : ExtraCorporeal Membrane Oxygenation and Therapeutic Drug Monitoring of Drugs of infectION

The objective of the study is to investigate the exposure difference between antibiotic studied patients in intensive care with Extracorporeal Membrane Oxygenation and patients without Ext...

Thiopurine Enhanced ALL Maintenance Therapy

Acute Lymphoblastic Leukaemia (ALL) is the most frequent cancer in children. The survival rate has improved significantly during the last decades, but the treatment still fails to cure 15 ...

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Medical and Biotech [MESH] Definitions

A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.

A cytokine which resembles IL-1 structurally and IL-12 functionally. It enhances the cytotoxic activity of NK CELLS and CYTOTOXIC T-LYMPHOCYTES, and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity.

Methods of investigating the effectiveness of anticancer cytotoxic drugs and biologic inhibitors. These include in vitro cell-kill models and cytostatic dye exclusion tests as well as in vivo measurement of tumor growth parameters in laboratory animals.

A critical subpopulation of regulatory T-lymphocytes involved in MHC Class I-restricted interactions. They include both cytotoxic T-lymphocytes (T-LYMPHOCYTES, CYTOTOXIC) and CD8+ suppressor T-lymphocytes.

Drugs used by veterinarians in the treatment of animal diseases. The veterinarian's pharmacological armamentarium is the counterpart of drugs treating human diseases, with dosage and administration adjusted to the size, weight, disease, and idiosyncrasies of the species. In the United States most drugs are subject to federal regulations with special reference to the safety of drugs and residues in edible animal products.

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