Cytotoxic drugs - Biotech, Pharma and Life Science Channel

17:25 EST 18th December 2014 | BioPortfolio

PubMed Articles [5826 Associated PubMed Articles listed on BioPortfolio]

Simple SPE-HPLC determination of some common drugs and herbicides of environmental concern by pulsed amperometry.

In this work the electrochemical behavior of substances of environmental concern [bentazone, atrazine, carbamazepine, phenytoin and its metabolite 5-(4-hydroxyphenyl)-5-phenylhydantoin, HPPH] on a gla...

Nanostructure imaging mass spectrometry: the role of fluorocarbons in metabolite analysis and yoctomole level sensitivity.

Nanostructure imaging mass spectrometry (NIMS) has become an effective technology for generating ions in the gas phase, providing high sensitivity and imaging capabilities for small molecules, metabol...

Simultaneous pharmacokinetic and pharmacodynamic analysis of 5α-reductase inhibitors and androgens by liquid chromatography tandem mass spectrometry.

Benign prostatic hyperplasia and prostate cancer can be treated with the 5α-reductase inhibitors, finasteride and dutasteride, when pharmacodynamic biomarkers are useful in assessing response. A nove...

Fast determination of 40 drugs in water using large volume direct injection liquid chromatography-tandem mass spectrometry.

This work describes a rapid analytical method based on direct sample injection of water samples for the simultaneous identification/quantification of 40 emerging compounds, including pharmaceuticals a...

Sequential hollow-fiber liquid phase microextraction for the determination of rosiglitazone and metformin hydrochloride (anti-diabetic drugs) in biological fluids.

A new analytical method for the simultaneous determination of the antidiabetic drugs rosiglitazone (ROS) and metformin hydrochloride (MH) with marked differences in their affinity towards organic solv...

Combination of poly(diallyldimethylammonium chloride) and hydroxypropyl-γ-cyclodextrin for high-speed enantioseparation of phenothiazines by capillary electrophoresis.

High-speed capillary electrophoresis (CE) enables the simple, rapid, and inexpensive analysis of large sets of chiral samples in the pharmaceutical industry. Hence, we developed a novel method for sep...

Murine models in the evaluation of heparan sulfate-based anticoagulants.

Evaluating anticoagulants in animal thrombosis models is a standard component of preclinical drug testing. Mice are frequently used for these initial evaluations because a variety of thrombosis models...

Validated capillary electrophoretic assays for disaccharide composition analysis of galactosaminoglycans in biologic samples and drugs/nutraceuticals.

Capillary electrophoresis is a separation technique with high resolving power and sensitivity with applications in glycosaminoglycan analysis. In this chapter, we present validated protocols for deter...

Current role of chemotherapy and bone marrow transplantation in multiple sclerosis.

The range of available treatment options for patients with multiple sclerosis (MS) has expanded tremendously in recent years, adding further complexity to the therapeutic decision-making process. The ...

Effect of Preoperative Biologic Drugs on Complications and Function After Restorative Proctocolectomy with Primary Ileal Pouch Formation: Systematic Review and Meta-analysis.

Debate exists concerning the presumed risk of postoperative complications in patients with ulcerative colitis (UC) receiving preoperative infliximab (IFX). Meta-analyses are contrasting because of man...

News Articles [5389 Associated News Articles listed on BioPortfolio]

Teen contraband cigarette use linked to other drugs

Reuters Health - Compared to those who don’t smoke illicit tobacco, kids who do are more likely to try other illegal drugs like cocaine, heroin and amphetamines, according to a recent Canadian study...

NIH: Repurposing may be Ebola savior; 53 drugs identified

There may be 53 existing compounds that could be repurposed for use against Ebola, scientists revealed in a new report.

Study identifies 53 approved drugs that may block Ebola

Study identifies 53 approved drugs that may block Ebola

IMS Institute Identifies Innovative Payment Models for Pharmaceuticals at Forbes Healthcare Summit

Advances Discussion on How Big Data Can Drive Understanding of Patient Treatment, Costs and Outcomes New approaches for determining how much drugs should cost, and for ...

NMS Labs and StopDUID.org Sponsor Update of 50 States DUI Law Compilation

Working in conjunction with StopDUID.org, NMS Labs has released an updated compilation of the laws in all 50 states dealing with alcohol impaired driving and driving under ...

Merck acquires OncoEthix for up to $375 mln to boost cancer drug pipeline

Merck (NYSE:MRK), the second-biggest U.S. drugmaker, agreed to buy OncoEthix, a Swiss biotech company developing cancer drugs, for up to $375 million. Shares gained. The purchase is part of Merck&rsqu...

Federal Grand Jury Indicts 14 People Linked To 2012 Meningitis Outbreak

The indictments were handed down against company officials, pharmacists and technicians who worked for the Massachusetts company responsible for tainted drugs that led to 64 deaths.

Post Silk Road - Another Online Drug Den Now Dominates the DarkNet

WASHINGTON, Dec. 18, 2014 /PRNewswire-USNewswire/ -- Since last month's FBI shutdown of online drug marketplace Silk Road, the site now known as the leading online black market for illegal drug...

UPDATE 1-Rite Aid raises full-year forecast after strong third quarter

Dec 18 (Reuters) - Rite Aid Corp, the third largest U.S. drugstore chain, raised its full-year earnings forecast after cutting it twice this year as higher sales of prescription drugs pushed up its pr...

New Generation of Cancer Drugs Granted European Approval

A new drug for ovarian cancer, developed by researchers at the University of Cambridge and AstraZeneca, has today become the first of new class of drugs, known as PARP-inhibitors, to be granted approv...

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Companies [237 Associated Companies listed on BioPortfolio]

Proteo Biotech AG

The company researches, develops and markets compounds for biological and medical research as well as for use as pharmaceuticals. The main focus is on anti-inflammatory drugs, in ...

RaNA Therapeutics, Inc.

RaNA Therapeutics is pioneering the discovery of a new class of medicines that target RNA to selectively activate protein expression within the body’s own cells. RaNA’s ...

PharmaEngine, Inc.

PharmaEngine, Inc. is a biopharmaceutical company established in Taipei, Taiwan in 2003. The company focuses on the development of new drugs to treat cancer and Asian prevalent di...

ScripsAmerica, Inc.

ScripsAmerica, Inc. is a supplier of prescription, OTC and nutraceutical drugs, delivering pharmaceutical products to a wide range of end users across the health care industry. En...

NEMUS Bioscience, Inc.

The Company is a biopharmaceutical company, headquartered in Costa Mesa, California, focused on the discovery, development, and commercialization of cannabis-based therapeutics fo...

RetroSense Therapeutics, LLC

RetroSense Therapeutics is a privately-held biotechnology company developing life-enhancing gene therapies designed to restore vision in patients suffering from blindness due to r...

Synta Pharmaceuticals

Synta Pharmaceuticals is a biopharmaceutical company focused on discovering, developing, and commercializing products for extending and enhancing the lives of patients with severe medical conditions. ...

BBB Therapeutics

BBB Therapeutics is pioneering innovative therapeutics to treat severe brain disorders for which there are currently limited treatment options. We are advancing a clinical pipelin...

Cosmederm Bioscience

Cosmederm Bioscience is a specialty pharmaceutical company focused on dermatology and pain management. The Company currently operates in the areas of aesthetic medicine with its R...

Cerecor Inc.

Driven by an innovative team of industry experts and leading scientists, Cerecor aspires to develop neuroscience drugs that will make a difference. We are committed to improving t...

Clinical Trials [320 Associated Clinical Trials listed on BioPortfolio]

Combination of gp96-Ig Vaccine, Theophylline and Oxygen for the Treatment of Patients With Advanced, Relapsed or Metastatic Non-Small Cell Lung Cancer

NSCLC tumors are appropriate targets for active immunotherapy, because they are non-immunogenic, which indicates that NSCLC does not stimulate a spontaneous immune response. NSCLC t...

Multi-Tracer PET in Early Phase Trials

The treatment of cancer is increasingly aimed at molecular targets derived from studies of the oncogenes and tumor suppressors known to be involved in the development of human cancers. The...

The Effects of the Drugs Used in Hypotensive Anaesthesia on Cochlea

The aim of this study is to find the Effects of Anesthetics Used in Hypotensive Anesthesia on Stapes Reflex and Distortion Product Auto Acoustic Emission.

Ph II Cabazitaxel/Ifosfamide DD Liposarcoma

Soft tissue sarcomas (STS) are a rare group of malignant heterogenous tumors (> 50 histological subtypes, including liposarcoma, the commonest subtype of STS) with distinct genetic, pathol...

Assessment of Ovarian Reserve in Women With Rheumatologic Diseases

Our infertility unit has started a clinic for women with rheumatological diseases. those women are prone to infertility problems and it might be due to their illness or cytotoxic treatmen...

Expanded Access Program With Nivolumab (BMS-936558) in Combination With Ipilimumab (Yervoy®) in Anti-CTLA-4 Treatment-Naïve Subjects With Unresectable or Metastatic Melanoma (CheckMate 218)

The purpose of this study is to provide treatment with Nivolumab in combination with Ipilimumab and to assess the safety and tolerability of this combination in subjects who are anti-cytot...

When to Start Anti-HIV Drugs in Patients With Opportunistic Infections

The purpose of this study is to evaluate the effect of starting anti-HIV drugs in HIV infected patients who are being treated for opportunistic infections (OIs). This study will follow tw...

Evaluation of Non-cytotoxic Suramin as a Chemosensitizer in Non-small Cell Lung Cancer

The purpose of this study is to evaluate the benefit of adding suramin at a non-cytotoxic dose to carboplatin and docetaxel regimen in the treatment of chemo-naïve patients with non-small...

An Observational Study of Induction Therapy With Fuzeon (Enfuvirtide) in Combination With Antiretroviral Drugs in Patients With HIV-1 Infection

This multicenter, retrospective, observational study will evaluate the therapeut ic effectiveness of a strategy of induction with Fuzeon (enfuvirtide) within an optimized regimen of antire...

A Study of Two Approved Drugs in the Treatment of Postoperative Dental Pain (0966-182)

The purpose of this study is to compare the safety and effectiveness of two approved drugs in the treatment of pain following dental surgery.

Medical and Biotech [MESH] Definitions

A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.

A cytokine which resembles IL-1 structurally and IL-12 functionally. It enhances the cytotoxic activity of NK CELLS and CYTOTOXIC T-LYMPHOCYTES, and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity.

Methods of investigating the effectiveness of anticancer cytotoxic drugs and biologic inhibitors. These include in vitro cell-kill models and cytostatic dye exclusion tests as well as in vivo measurement of tumor growth parameters in laboratory animals.

A critical subpopulation of regulatory T-lymphocytes involved in MHC Class I-restricted interactions. They include both cytotoxic T-lymphocytes (T-LYMPHOCYTES, CYTOTOXIC) and CD8+ suppressor T-lymphocytes.

Drugs used by veterinarians in the treatment of animal diseases. The veterinarian's pharmacological armamentarium is the counterpart of drugs treating human diseases, with dosage and administration adjusted to the size, weight, disease, and idiosyncrasies of the species. In the United States most drugs are subject to federal regulations with special reference to the safety of drugs and residues in edible animal products.

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