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Cytotoxic drugs - Biotech, Pharma and Life Science Channel

17:09 EDT 28th June 2017 | BioPortfolio

PubMed Articles [5762 Associated PubMed Articles listed on BioPortfolio]

Fullerene C60 Penetration into Leukemic Cells and Its Photoinduced Cytotoxic Effects.

Fullerene C60 as a representative of carbon nanocompounds is suggested to be promising agent for application in photodynamic therapy due to its unique physicochemical properties. The goal of this stud...

Methanethiosulfonate derivatives as ligands of the STAT3-SH2 domain.

With the aim to discover new STAT3 direct inhibitors, potentially useful as anticancer agents, a set of methanethiosulfonate drug hybrids were synthesized. The in vitro tests showed that all the thios...

Synthesis of new pyridothienopyrimidinone derivatives as Pim-1 inhibitors.

Four series of pyridothienopyrimidin-4-one derivatives were designed and prepared to improve the pim-1 inhibitory activity of the previously reported thieno[2,3-b]pyridines. Significant improvement in...

Biosynthesis, Characterization, and Bioactivities Evaluation of Silver and Gold Nanoparticles Mediated by the Roots of Chinese Herbal Angelica pubescens Maxim.

A facile synthesis and biological applications of silver (DH-AgNps) and gold nanoparticles (DH-AuNps) mediated by the aqueous extract of Angelicae Pubescentis Radix (Du Huo) are explored. Du Huo is a ...

Non-invasive Photodynamic Therapy in Brain Cancer by Use of Tb(3+)-Doped LaF3 Nanoparticles in Combination with Photosensitizer Through X-ray Irradiation: A Proof-of-Concept Study.

The use of photodynamic therapy (PDT) in the treatment of brain cancer has produced exciting results in clinical trials over the past decade. PDT is based on the concept that a photosensitizer exposed...

Erratum to: Aldo-ketoreductase 1 (AKR1) improves seed longevity in tobacco and rice by detoxifying reactive cytotoxic compounds generated during ageing.

Molecular targets of dietary phytochemicals for possible prevention and therapy of uterine fibroids: Focus on fibrosis.

Uterine fibroids (myomas or leiomyomas) are common benign tumors of reproductive aged women. Fibroids are clinically apparent in 20-50% of women, and cause abnormal uterine bleeding, abdominal pain an...

Drugging the Cancers Addicted to DNA Repair.

Defects in DNA repair can result in oncogenic genomic instability. Cancers occurring from DNA repair defects were once thought to be limited to rare inherited mutations (such as BRCA1 or 2). It now ap...

Nanocarriers as treatment modalities for hypertension.

Hypertension, a worldwide epidemic at present, is not a disease in itself rather it is an important risk factor for serious cardiovascular disorders including myocardial infarction, stroke, heart fail...

In vitro and in vivo investigation for optimization of niosomal ability for sustainment and bioavailability enhancement of diltiazem after nasal administration.

Diltiazem hydrochloride (DTZ) is a calcium channel antagonist depicted by extensive first pass metabolism and low oral bioavailability. The aim of this work was to develop niosomes for potential nasal...

News Articles [6297 Associated News Articles listed on BioPortfolio]

Renal Stones/CalculiGlobal API Manufacturers, Marketed and Phase III Drugs Landscape, 2017 [Report Updated: 30052017] Prices from USD $1700

DelveInsight's Report, Renal Stones/CalculiGlobal API Manufacturers, Marketed and Phase III Drugs Landscape, 2016, provides comprehensive insights about the marketed drugs, drug sales, Phase III pipel...

Phosphoinositide 3Kinase Alpha PI3K Alpha Inhibitors Pipeline Insights, 2017 [Report Updated: 30052017] Prices from USD $1063

DelveInsight's, Phosphoinositide 3Kinase Alpha PI3K Alpha InhibitorsPipeline Insights, 2017, report provides in depth insights on the pipeline drugs and their development activities around the Phospho...

Pulmonary FibrosisGlobal API Manufacturers, Marketed and Phase III Drugs Landscape, 2017 [Report Updated: 30052017] Prices from USD $1700

DelveInsight's Report, Pulmonary FibrosisGlobal API Manufacturers, Marketed and Phase III Drugs Landscape, 2016, provides comprehensive insights about the marketed drugs, drug sales, Phase III pipelin...

Src Tyrosine Kinase Inhibitors Pipeline Insights, 2017 [Report Updated: 30052017] Prices from USD $1063

DelveInsight's, Src Tyrosine Kinase InhibitorsPipeline Insights, 2017, report provides in depth insights on the pipeline drugs and their development activities around the Src Tyrosine Kinase Inhibitor...

Regenacy Promotes Simon Jones to CEO, Walter Ogier Stays on Board

Regenacy Pharmaceuticals has promoted Simon Jones to president and CEO of the clinical-stage drug developer. Jones had served as chief operating officer and senior vice president of preclinical develo...

Trypsin Inhibitors Pipeline Insights, 2017 [Report Updated: 30052017] Prices from USD $1063

DelveInsight's, Trypsin InhibitorsPipeline Insights, 2017, report provides in depth insights on the pipeline drugs and their development activities around the Trypsin Inhibitors. The DelveInsight's Re...

Diabetic Neuropathic PainGlobal API Manufacturers, Marketed and Phase III Drugs Landscape, 2017 [Report Updated: 30052017] Prices from USD $1700

DelveInsight's Report, Diabetic Neuropathic PainGlobal API Manufacturers, Marketed and Phase III Drugs Landscape, 2016, provides comprehensive insights about the marketed drugs, drug sales, Phase III ...

San Diego Team Tests Delivery Mode for Potential HIV Vaccine

NewsHIV has faded from the headlines, mainly because the development of antiretroviral drugs has turned AIDS into a chronic, manageable disease.

Fungal InfectionsGlobal API Manufacturers, Marketed and Phase III Drugs Landscape, 2017 [Report Updated: 30052017] Prices from USD $1700

DelveInsight's Report, Fungal InfectionsGlobal API Manufacturers, Marketed and Phase III Drugs Landscape, 2016, provides comprehensive insights about the marketed drugs, drug sales, Phase III pipeline...

Colorectal CancerGlobal API Manufacturers, Marketed and Phase III Drugs Landscape, 2017 [Report Updated: 30052017] Prices from USD $1700

DelveInsight's Report, Colorectal CancerGlobal API Manufacturers, Marketed and Phase III Drugs Landscape, 2016, provides comprehensive insights about the marketed drugs, drug sales, Phase III pipeline...

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Companies [273 Associated Companies listed on BioPortfolio]

Repare Therapeutics Inc.

Repare is developing new, precision oncology drugs for patients that target specific vulnerabilities of tumor cells. Its approach integrates insights from several fields of cell b...

Modra Pharmaceuticals

Modra Pharmaceuticals is contributing to modern cancer treatment options by improving the delivery and bioavailability of chemotherapy, the backbone of oncology regimens today. Th...

Tanner Pharma Group

For over 15 years, Tanner Pharma Group has provided highly specialized pharmaceutical services to its partners around the world. Leading pharmaceutical and biotech companies partn...

Abreos Biosciences

Abreos Biosciences is focused on ligand binding assays for biologic and biosimilar drug development, activity validation, authentication, and precision dosing, as well as massivel...

ImmunoGen

ImmunoGen, Inc. develops pharmaceuticals, primarily for the treatment of cancer. The Company's product candidates arecalled tumor-activated prodrugs ("TAPs") and are based on its proprietary immunocon...

Rare Disease Communications

Rare Disease Communications® is a healthcare communications and media company focused on the rare disease community and dedicated to raising awareness of rare diseases and orph...

Rasna Therapeutics, Inc.

Rasna Therapeutics, Inc. is a development stage biotechnology company focused primarily on the high unmet need that exists for leukemias. Rasna’s primary indication is acute ...

BioAxone BioSciences, Inc.

BioAxone BioSciences is a clinical-stage biotechnology company developing innovative drugs to restore neurological function for patients with Spinal Cord Injuries (SCI) and other ...

Rasna Therapeutics , Inc.

Rasna Therapeutics, Inc. is a biotechnology company focused primarily on the high unmet need that exists for leukemias. Rasna’s primary indication is acute myeloid leukemia (...

Evestra Inc.

Evestra Inc. is an emerging biopharmaceutical research and development company with a therapeutic focus in women’s healthcare. Evestra’s competitive advantage is based o...

Clinical Trials [1259 Associated Clinical Trials listed on BioPortfolio]

COMparison Between All immunoTherapies for Multiple Sclerosis.

The overarching goal of this study is to determine whether rituximab (RTX) offers effectiveness and safety advantages over other commonly used approved Disease-Modifying Drugs (DMT) in the...

TAA Specific Cytotoxic T Lymphocytes in Patients With Pancreatic Cancer

Patients who have pancreatic cancer that has has come back or has not gone away after treatment, including the standard treatment for this disease or patients who are not eligible for or h...

Standard Chemotherapy vs Immunotherapie in 2nd Line Treatment of MSI Colorectal Mestastatic Cancer

Immune chekpoints (ICI) are evaluated in many digestive cancers. Certain types of cancer appear to be rather refractory to ICI such as colorectal cancers (CRC). However, the MSI CRC repres...

Ibuprofen, Paracetamol Versus Placebo on Pain During Local Anesthetic Injection (RCT)

The Effect of Ibuprofen, Paracetamol versus Placebo on Pain during Local Anesthetic Injection and Following Dental Extraction in Primary Molars: A Randomized clinical trial

Research on the Clinical Effect of Xuefu Zhuyu Decoction in Treating Unstable Angina.

This study evaluates the clinical efficacy of Xuefu Zhuyu Decoction in the treatment of unstable angina pectoris. All of the patients will be divided into 2 arms randomly. One of the arms ...

Research on the Clinical Effect of Shuanghe Decoction in Treating Unstable Angina.

This study evaluates the clinical efficacy of Shuanghe Decoction in the treatment of unstable angina. All of the patients will be divided into 2 arms randomly. One of the arms will be trea...

Effect of Gualou Xiebai Banxia Decoction With Danshen Decoction in Treating Unstable Angina.

This study evaluates the clinical efficacy of Gualou Xiebai Banxia Decoction compounded with Danshen Decoction in the treatment of unstable angina pectoris. All of the patients will be div...

Evaluation of Thyroid Abnormity Incidence and Thyroid Toxicity During Chemotherapy Among Newly Diagnosed Breast Cancer

Breast cancer is one of the most common cancers in China. Even though advances in the field of breast cancer therapeutics, chemotherapy remains the mainstay therapeutic modality. The cytot...

Pattern of Skin Manifestations in Chronic Hepatitis c Virus Patients Before and After Direct Acting Anti Viral Drugs

- Hepatitis C is an infectious disease caused by the hepatitis C virus (HCV) that primarily affects the liver. It is one of the main causes of chronic liver diseases worldwide ....

Pharmacokinetics of Paracetamol and Antiepileptic Drugs After Sleeve Gastrectomy

Sleeve gastrectomy may affect drug pharmacokinetics in several potential ways. We will measure pharmakokinetics of paracetamol and antiepileptic drugs before and 6 months after sleeve gast...

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Medical and Biotech [MESH] Definitions

A cytokine which resembles IL-1 structurally and IL-12 functionally. It enhances the cytotoxic activity of NK CELLS and CYTOTOXIC T-LYMPHOCYTES, and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity.

A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.

Methods of investigating the effectiveness of anticancer cytotoxic drugs and biologic inhibitors. These include in vitro cell-kill models and cytostatic dye exclusion tests as well as in vivo measurement of tumor growth parameters in laboratory animals.

A critical subpopulation of regulatory T-lymphocytes involved in MHC Class I-restricted interactions. They include both cytotoxic T-lymphocytes (T-LYMPHOCYTES, CYTOTOXIC) and CD8+ suppressor T-lymphocytes.

The phenomenon of target cell destruction by immunologically active effector cells. It may be brought about directly by sensitized T-lymphocytes or by lymphoid or myeloid "killer" cells, or it may be mediated by cytotoxic antibody, cytotoxic factor released by lymphoid cells, or complement.

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