Cytotoxic drugs - Biotech, Pharma and Life Science Channel

01:25 EDT 4th August 2015 | BioPortfolio

PubMed Articles [5724 Associated PubMed Articles listed on BioPortfolio]

Maximum flow approach to prioritize potential drug targets of Mycobacterium tuberculosis H37Rv from protein-protein interaction network.

In spite of the implementations of several strategies, tuberculosis (TB) is overwhelmingly a serious global public health problem causing millions of infections and deaths every year. This is mainly d...

The cost-effectiveness of celecoxib versus non-steroidal anti-inflammatory drugs plus proton-pump inhibitors in the treatment of osteoarthritis in Saudi Arabia.

Cyclooxygenase (COX)-2 inhibitors including celecoxib are as effective as non-selective non-steroidal anti-inflammatory drugs (ns-NSAIDs) in the treatment of osteoarthritis (OA) and have less gastroin...

Isolation, purification and characterization of novel antimicrobial compound 7-methoxy-2,2-dimethyl-4-octa-4',6'-dienyl-2H-napthalene-1-one from Penicillium sp. and its cytotoxicity studies.

Fungus isolated from soil has been evaluated for its antimicrobial activity which showed broad spectrum antimicrobial activity against all the pathogenic microorganisms used. Optimization was done by ...

Production and characterization of chitosan/gelatin/β-TCP scaffolds for improved bone tissue regeneration.

Recently, bone tissue engineering emerged as a viable therapeutic alternative, comprising bone implants and new personalized scaffolds to be used in bone replacement and regeneration. In this study, b...

Bioactivity and cell proliferation in radiopaque gel-derived CaO-P2O5-SiO2-ZrO2 glass and glass-ceramic powders.

In this study, 10mol% ZrO2 was added to a 27CaO-5P2O5-68SiO2 (mol%) base composition synthesized via a simple sol-gel method. This composition is similar to that of a frequently investigated bioactive...

Silver nanoparticles with antimicrobial activities against Streptococcus mutans and their cytotoxic effect.

Microbial resistance represents a challenge for the scientific community to develop new bioactive compounds. The goal of this research was to evaluate the antimicrobial activity of silver nanoparticle...

A modified emulsion gelation technique to improve buoyancy of hydrogel tablets for floating drug delivery systems.

The use of buoyant or floating hydrogel tablets is of particular interest in the sustained release of drugs to the stomach. They have an ability to slow the release rates of drugs by prolonging their ...

Collagen based film with well epithelial and stromal regeneration as corneal repair materials: Improving mechanical property by crosslinking with citric acid.

Corneal disease can lead to vision loss. It has become the second greatest cause of blindness in the world, and keratoplasty is considered as an effective treatment method. This paper presents the cro...

Alternative approach of cell encapsulation by Volvox spheres.

Volvox sphere is a bio-mimicking concept of a biomaterial structure design able to encapsulate chemicals, drugs and/or cells. The aim of this study was to prepare Volvox spheres encapsulating AML12 li...

Chitin dipentanoate as the new technologically usable biomaterial.

In this article, the synthesis of novel biopolymer, chitin dipentanoate (Di-O-Valeryl Chitin, DVCH) has been described. DVCH is a chitin derivative esterified with two valeryl groups at positions 3 an...

News Articles [5075 Associated News Articles listed on BioPortfolio]

Weight loss warning linked to dementia drugs class

Cholinesterase inhibitors could result in potentially harmful weight loss among patients taking them for Alzheimer’s disease, according to US researchers.

In a first, drug using 3D printing technology gets FDA nod

Aug 3 (Reuters) - The U.S. Food and Drug Administration has, for the first time, approved a drug that uses 3D printing technology, paving the way for potential customization of drugs to suit patients'...

Roche, Others Probed in Romanian Corruption Case

Swiss pharmaceuticals company Roche confirmed that it is being investigated by anti-corruption prosecutors looking for evidence that drug companies offered doctors vacations and other incentives in ex...

Common dementia drugs could cause harmful weight loss

Drugs commonly used to treat dementia could result in harmful weight loss, according to UC San Francisco…

Chronic insomnia sufferers may find relief with half of standard pill dose

The roughly nine million Americans who rely on prescription sleeping pills to treat chronic insomnia may be able to get relief from as little as half of the drugs, and may even be helped by taking pla...

Oasmia Pharmaceutical AB: Oasmia Pharmaceutical Extends Form F-1/A Registration Statement to Include New Key Material Data and Final Full-Year Financials

New York, NY - August 3, 2015 - Oasmia Pharmaceutical AB, a developer of a new generation of drugs within human and veterinary oncology, today announced that it is extending its proposed initial pu...

AstraZeneca and Isis Pharma in $65m drugs collaboration

Isis Pharmaceuticals and AstraZeneca have announced a strategic collaboration to discover and develop antisense therapies for cardiovascular, metabolic and renal diseases. The new collaboration builds...

A brain-training game could improve cognition problems in schizophrenia patients

Drugs might not necessarily be the answer to improve conditions for patients with schizophrenia.

AstraZeneca, Isis Pharmaceuticals to Develop Antisense Drugs for Cardiovascular, Metabolic and Renal Diseases

Isis Pharmaceuticals, Inc. and AstraZeneca today announced a strategic collaboration to discover and develop antisense therapies for cardiovascular, metabolic and renal diseases. The new collaboration...

Lawsuit Accuses CVS of Overcharging for Generic Drugs

Health Corp. deliberately overcharged some pharmacy customers for generic drugs by submitting claims to their insurance companies at inflated prices, according to a lawsuit filed Thursday in federal c...

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Companies [252 Associated Companies listed on BioPortfolio]

CEL-SCI

CEL-SCI Corporation (AMEX: CVM), a biotechnology company, was formed in 1983. CEL-SCI is involved in the research and development of drugs and vaccines for the treatment of cancer and infectious disea...

Seres Therapeutics, Inc.

Seres Therapeutics, Inc. is a leading microbiome therapeutics platform company developing a novel class of biological drugs that are designed to treat disease by restoring the fun...

Hanmi Pharmaceutical co., Ltd.

Hanmi Pharmaceutical is a Korea-based pharmaceutical company. The Company invests over 20 percent of its sales in R&D and has over 20 programs consisting of the novel long acting ...

Center for Infectious Disease Research

Center for Infectious Disease Research is the largest independent, non-profit organization in the U.S. focused solely on infectious disease research. Our mission is to make transf...

Tanner Pharma Group

For over 15 years, Tanner Pharma Group has provided highly specialized pharmaceutical services to its partners around the world. Leading pharmaceutical and biotech companies partn...

Thetis Pharmaceuticals, LLC

Thetis Pharmaceuticals is a privately held biopharmaceutical company applying its expertise in amino-lipid chemistry to discover and develop innovative drugs for the treatment of ...

Iris Pharma

Iris Pharma is a Contract Research Organizations (CROs) providing drug development services to Research Institutes, Pharmaceutical or Biotechnology Industries, to support the preclinical development a...

Proteo Biotech AG

The company researches, develops and markets compounds for biological and medical research as well as for use as pharmaceuticals. The main focus is on anti-inflammatory drugs, in ...

Immune Design Corp.

Immune Design is a clinical-stage immunotherapy company employing next-generation in vivo approaches to enable the body’s immune system to fight disease. The company’s t...

MedDay

MedDay is a privately held biotechnology company developing new drugs for nervous system disorders. The company was founded in 2011 by Frédéric Sedel, MD, PhD (Chief Executi...

Clinical Trials [434 Associated Clinical Trials listed on BioPortfolio]

Multivirus-specific Cytotoxic T Lymphocytes (mCTL)

PIDD represent an expanding group of genetic disorders that compromise immunity against bacteria, viruses, and fungi. The most severe forms of PIDD cause profound susceptibility to opport...

S-1, Cisplatin-based Chemoradiotherapy, Induction Chemotherapy, Locally Advanced Gastric Adenocarcinoma

Currently, for further improved survival outcome, new cytotoxic compounds such as irinotecan and docetaxel have been combined with 5-FU/cisplatin. However, triplet regimen often burdened w...

BK Specific Cytotoxic T Lymphocytes (CTL) Lines for Stem Cell Transplant (SCT) Recipients

The goal of this clinical research study is to learn if giving cytotoxic T lymphocytes (CTLs) to patients who have had a stem cell transplant can help to control BK viral infection. Resea...

Preventive Strategies in Colorectal Carcinogenesis Production and Meat Processing

Colorectal Cancer is, in non-smokers for both sex, first cause of cancers mortality in Western country. The main risk factors associated with colorectal cancer depend of lifestyle, and pr...

Isolated Thoracic Perfusion (ITP-F) for MPM

This is an observational study of isolated thoracic perfusion with subsequent hemofiltration to lower the concentration of the cytotoxic drugs as a locoregional therapeutic strategy in mal...

Phase I Study of an Oncofetal Antigen Multi-Peptide Immunotherapy in Subjects With Hematologic Cancer

The study is designed to evaluate safety, immunogenicity, and preliminary anti-tumor activity of a multi-peptide immunotherapy (BB-MPI-03) at three peptide+adjuvant dose levels. The peptid...

Evaluating SINE KPT-330 in Treating Patients With Melanoma That Cannot Be Removed By Surgery

This phase I clinical trial studies the side effects of selinexor in treating patients with melanoma that cannot be removed by surgery. Drugs used in chemotherapy, such as selinexor, may s...

Study for the Evaluation of Vemurafenib ( Zelboraf® ) and Ipilimumab ( Yervoy® ) in Combination With DNE3 Therapy to Patients With Metastatic Melanoma

Vemurafenib ( Zelboraf) inhibits BRAF- mutated kinase activation code 600. Ipilimumab ( Yervoy) is a monoclonal antibody that binds to a cytotoxic T - lymphocyte antigen 4 (CTLA- 4). ...

An Observational Study in Clinical Practice Management of Patients With Biological Drugs in Monotherapy

This observational multicenter study will evaluate the management of disease and safety in clinical practice in patients with moderate to severe rheumatoid arthritis receiving any biologic...

Comparison of the Effects of Two Glaucoma Drugs Over 24 Hours (0507A-137)(COMPLETED)

This study is comparing 2 medications for glaucoma and how effective they are at controlling glaucoma over the course of an entire day.

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Medical and Biotech [MESH] Definitions

A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.

A cytokine which resembles IL-1 structurally and IL-12 functionally. It enhances the cytotoxic activity of NK CELLS and CYTOTOXIC T-LYMPHOCYTES, and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity.

Methods of investigating the effectiveness of anticancer cytotoxic drugs and biologic inhibitors. These include in vitro cell-kill models and cytostatic dye exclusion tests as well as in vivo measurement of tumor growth parameters in laboratory animals.

A critical subpopulation of regulatory T-lymphocytes involved in MHC Class I-restricted interactions. They include both cytotoxic T-lymphocytes (T-LYMPHOCYTES, CYTOTOXIC) and CD8+ suppressor T-lymphocytes.

Drugs used by veterinarians in the treatment of animal diseases. The veterinarian's pharmacological armamentarium is the counterpart of drugs treating human diseases, with dosage and administration adjusted to the size, weight, disease, and idiosyncrasies of the species. In the United States most drugs are subject to federal regulations with special reference to the safety of drugs and residues in edible animal products.


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