Damage - Biotech, Pharma and Life Science Channel
PubMed Articles
The overproduction of reactive oxygen species (ROS) has been implicated in the development of neurodegenerative diseases such as Parkinson's disease (PD) and Alzheimer's disease (AD). Previous studies...
We examined the relation between DNA damage and the clonogenic potential of 3 human cell lines, HepG2, HT29 and A549, treated with bare 20nm or 200nm silver nanoparticles (AgNPs). The endpoints examin...
This study investigated power density and relevant information related to light-curing units used in private dental offices in Changchun City, China. The power density of 196 light-curing units used i...
Aims: The current study aim was to elucidate the anti-hypoglycemic role and mechanism of inducible nitric oxide synthase (iNOS) under inflammatory stress. Methods: Liver inflammatory stress was induce...
Role of AMPK in UVB-induced DNA damage repair and growth control.
Skin cancer is the most common cancer in the United States, while DNA-damaging ultraviolet B (UVB) radiation from the sun remains the major environmental risk factor. Reducing skin cancer incidence is...
The root of Paeonia lactiflora Pall (family Ranunculaceae) or peony root, a herbal medicine, possesses therapeutic potential for neurodegenerative diseases. The isomers paeoniflorin (PF) and albiflori...
Intraepithelial γδ T lymphocytes (γδ IEL) have important roles in repair of tissue damage at epithelial sites, such as skin and intestine. Molecules that orchestrate these γδ T-cell functions ar...
5-Lipoxygenase Inhibitor Zileuton Inhibits Neuronal Apoptosis Following Focal Cerebral Ischemia.
Previous studies from our laboratory demonstrated that zileuton, a selective 5-lipoxygenase (5-LOX) inhibitor, attenuates ischemic brain damage in rats of focal cerebral ischemia. Enormous evidences s...
Brain pacemaker (BPM) systems are similar to cardiac pacemaker (CPM). On CPM, damage caused by ionizing radiation may lead to failure of the device. We report here a clinical situation of a patient tr...
Purpose: In a previous paper, we showed that chemiluminescence from radical recombination (initiated by lipid peroxidation and propagated by polyunsaturated fatty acids [PUFA]) has a bleaching effect...
News Articles
Glucosamine Linked to Increased Intraocular Pressure
Glucosamine supplementation was linked to significant, reversible increases in intraocular pressure in a small study, but the investigators could not exclude the potential for permanent damage. Meds...
Bochum's medics use autologous cord blood to treat infantile cerebral palsy
Bochum's medics have succeeded in treating cerebral palsy with autologous cord blood. Following a cardiac arrest with severe brain damage, a 2.5 year old boy had been in a persistent vegetative state...
Antidepressant Cymbalta May Reduce Pain from Chemotherapy-Induced Peripheral Neuropathy
The antidepressant Cymbalta® (duloxetine) appears to reduce the numbness and tingling associated with taxane or platinum-based chemotherapy, according to the results of a study published in the Journ...
Aberdeen researchers in new stem cell research into osteoarthritis
Medical research charity Arthritis Research UK has awarded £184,000 to a team of researchers at the University of Aberdeen to study stem cells found naturally present in people’s joints in...
The firm is actively filing Tylenol lawsuits on behalf of those who allegedly suffered liver damage and other serious complications related to their use of Tylenol. (PRWEB) May 23, 2013 The Rottenste...
Skinceuticals Phloretin CF Serum corrects existing damage by stimulating the synthesis of essential proteins, fibers, and accelerating cell turnover. This item can be found at skincaremarket.net. Brea...
Neuropathy Nerve Damage Can Now Be Reversed With Neuracel
Boise, Idaho (PRWEB) May 23, 2013 Diabetes is one of the worst diseases on its own, but it can become a nuisance when patients are unfortunate enough to become victims of peripheral neuropathy as w...
Medics have succeeded in treating cerebral palsy with autologous cord blood. Following a cardiac arrest with severe brain damage, a two-and-a-half year old boy had been in a persistent vegetative stat...
Controlling Schizophrenia Gene Could Help Tame The Disease
Brett Smith for redOrbit.com - Your Universe Online Geneticists at the Medical College of Georgia at Georgia Regents University have identified a key regulatory gene that appears to play a role in...
Events
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Companies
DecImmune Therapeutics was founded by Michael Carroll PhD (The Immune Disease Institute, Harvard Medical School), and Francis Moore Jr. MD (Brigham and Womenâs Hospital, Harv...
Hycult Biotech is a leader in the fields of immunology and cell biology, we develop, produce and market antibodies, antibody based products and more specifically immunoassays for...
Pulse Health was established in 2006 to deliver breakthrough breath technologies that can better identify health risks through the superior measurement of key biomarkers. Pulse He...
Osprey Medical is a privately held company located in Eden Prairie, Minnesota. The Company is dedicated to the treatment and prevention of ailments originating from the inter-rela...
Obagi Medical Products is a specialty pharmaceutical company that develops, markets and sells, and is a leading provider of, proprietary topical aesthetic and therapeutic prescrip...
ShockWatch has specialized in damage prevention since 1976, offering shipping and handling monitors, environmental monitors and equipment monitors for use in thousands of applicat...
OXIS International, Inc. develops technologies and products to research, diagnose, treat and prevent diseases of oxidative stress/inflammation associated with damage from free rad...
Based in Alpharetta, Ga., Carticept Medical, Inc. is a privately held medical device company established in 2005 to develop innovative solutions for patients with osteoarthritis o...
HydroCision (http://www.hydrocision.com) is the leading developer, manufacturer, and marketer of fluidjet-based surgical tools for minimally invasive spine surgery. HydroCision's proprietary Fluidjet...
WHO WE ARE Oxyrane UK Limited is a biopharmaceutical company dedicated to the development of novel and biosuperior enzyme replacement therapies (ERT) to treat lysosomal storage diseases, a class o...
Clinical Trials
Tc-99m Renography and Cisplatin-Induced Nephrotoxicity
Cisplatin is a heavy-metal complex widely used in the treatment of a variety of malignancies, including small cell and non-small cell lung cancer, ovarian, bladder, head and neck, esophage...
Prediction of Acute Rejection in Renal Transplant
Acute rejection is still a major risk factor affecting the prognosis of kidney transplant patients. Alloreactive cells of the recipient infiltrate the kidney graft and cause inflammatory r...
Pilot Study of Mycophenolate Mofetil in Congenital Uropathies
Congenital or hereditary structural anomalies of the genitourinary tract account for approximately half of all cases of end stage renal disease in the pediatric population. Despite optimal...
N-Acetylcysteine for Preventing Renal Injury After Cardiac Surgery
Cardiac surgery improves the survival and quality of life of people with heart disease. Nonetheless, several complications continue to adversely affect outcomes following cardiac surgery....
Safety Study of Individualised Radiation Dose Determination for Lung Cancer Patients.
Radiotherapy is treatment of choice for inoperable lung cancer. Research has shown that the local control rate is low and the radiation often causes pneumonitis and/or esophagitis. To pre...
Pre-hospital Administration of Thrombolytic Therapy With Urgent Culprit Artery Revascularization
The PATCAR study has been designed to test the hypothesis that the strategy of pre-hospital use of a "clot busting" (thrombolytic) drug followed with emergent heart catheterization includi...
Vitamin E and Male Infertility
The goal of this study is to determine whether there is a correlation between the levels of Vitamin E in sperm and sperm DNA fragmentation. Previous research has shown that damage to the...
Develop Biomarkers for Assessing RA Joint Erosion
With the current therapeutic focus in rheumatoid arthritis (RA) shifting from symptom control to actual disease modification there is a growing demand for more objective and sensitive ways...
Stenting in Renal Dysfunction Caused by Atherosclerotic Renal Artery Stenosis
Background: Atherosclerotic renal artery stenosis (ARAS) is associated with progressive loss of renal function and is one of the most important causes of renal failure in the elderly. Cur...
Compassionate Use of Defibrotide for Patients With Veno-occlusive Disease of the Liver
Veno-occlusive disease (VOD) of the liver is a significant complication for some patients undergoing hematopoietic stem cell transplantation. This disease is thought to be a toxicity secon...
Videos
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Medical and Biotech [MESH] Definitions
Receptors, Formyl Peptide
A family of G-protein-coupled receptors that was originally identified by its ability to bind N-formyl peptides such as N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE. Since N-formyl peptides are found in MITOCHONDRIA and BACTERIA, this class of receptors is believed to play a role in mediating cellular responses to cellular damage and bacterial invasion. However, non-formylated peptide ligands have also been found for this receptor class.
Nanotubes, Peptide
NANOTUBES formed from cyclic peptides (PEPTIDES, CYCLIC). Alternating D and L linkages create planar rings that self assemble by stacking into nanotubes. They can form pores through CELL MEMBRANE causing damage to cells.
Hearing Loss, Mixed Conductive-sensorineural
Hearing loss due to damage or impairment of both the conductive elements (HEARING LOSS, CONDUCTIVE) and the sensorineural elements (HEARING LOSS, SENSORINEURAL) of the ear.
Dna Repair-deficiency Disorders
Disorders resulting from defective DNA REPAIR processes or the associated cellular responses to DNA DAMAGE.
Nijmegen Breakage Syndrome
A chromosome instability syndrome resulting from a defective response to DNA double-strand breaks. In addition to characteristic FACIES and MICROCEPHALY, patients have a range of findings including RADIOSENSITIVITY, immunodeficiency, increased cancer risk, and growth retardation. Causative mutations occur in the NBS1 gene, located on human chromosome 8q21. NBS1 codes for nibrin, the key regulator protein of the R/M/N (RAD50/MRE11/NBS1) protein complex which senses and mediates cellular response to DNA DAMAGE caused by IONIZING RADIATION.
