Dendritic Cell Vaccine Personalized BiovaxID - Biotech, Pharma and Life Science Channel
PubMed Articles
It is well accepted that Ag-induced B cell differentiation often results in the generation of exceptionally long-lived plasma cells. Much of the work supporting this viewpoint stems from studies focus...
Insulin resistance (IR) and pancreatic β-cell dysfunction lead to type 2 diabetes mellitus (DM). We tested whether risk factors would differ for DM that was preceded predominantly by IR, β-cell dysf...
Adoptive cell therapy with tumor-infiltrating lymphocytes (TILs) represents an effective treatment for patients with metastatic melanoma. However, most of the Ag targets recognized by effective melano...
The Proto-Oncogene c-myc Regulates Antibody Secretion and Ig Class Switch Recombination.
The immune response involves the generation of Ab-secreting cells and memory B cells through a process called terminal B lymphocyte differentiation. This program requires the transcriptional repressor...
CD40 Mediates Downregulation of CD32B on Specific Memory B Cell Populations in Rheumatoid Arthritis.
Altered B cell function is important in the pathogenesis of rheumatoid arthritis (RA). In this report, we show that patients with active RA have an increased frequency of CD32B low/neg cells in the CD...
Dendritic cells (DCs) have been shown to play a major role in oral tolerance, and this function has been associated with their ability to produce anti-inflammatory cytokines and to induce suppressive...
Canonical and noncanonical wnt proteins program dendritic cell responses for tolerance.
Ag-presenting dendritic cells (DCs) interpret environmental signals to orchestrate local and systemic immune responses. They govern the balance between tolerance and inflammation at epithelial surface...
The bacille Calmette-Guérin vaccine provides very efficient protection in standard animal models of Mycobacterium tuberculosis challenge. We show in this article that although bacille Calmette-Guéri...
The H2-A(g7) (A(g7)) MHC class II (MHCII) allele is required for type 1 diabetes (T1D) in NOD mice. A(g7) not only has a unique peptide-binding profile, it was reported to exhibit biochemical defects,...
Critical Roles of a Dendritic Cell Subset Expressing a Chemokine Receptor, XCR1.
Dendritic cells (DCs) consist of various subsets that play crucial roles in linking innate and adaptive immunity. In the murine spleen, CD8α(+) DCs exhibit a propensity to ingest dying/dead cells, pr...
News Articles
Japan Ministry Still Puzzled By Adverse HPV Vaccine Reactions
Japan's suspension of a program urging cervical-cancer vaccinations continues as the health ministry struggles to understand the causes of adverse side effects that led to the response.
Brazil Plans Own Making Of H1N1 Vaccine To Avoid Private-Sector Pitfalls
Brazil's Ministry of Health plans to produce its own H1N1 influenza vaccine to avoid the pitfalls of relying on the private sector constantly challenged by a changing economic landscape.
Senescent cells spread the word: non-cell autonomous propagation of cellular senescence
Senescent cells spread the word: non-cell autonomous propagation of cellular senescenceOncogene-induced senescence has been thought to operate cell autonomously. New data establish ‘paracrine senesc...
Paediatric rheumatology: HPV vaccine safe and effective in patients with JIA
Transplantation: Alefacept does not reduce risk of T-cell-mediated rejection
Protein Being Studied To Fight Cancer; May Cause Toxicity In Cardiac Cells
A study by researchers at Skaggs School of Pharmacy and Pharmaceutical Sciences and the Department of Pharmacology at the University of California, San Diego, shows that a protein called MCL-1, which...
Adipocyte differentiation is affected by media height above the cell layer
Markers of systemic inflammation predict survival in patients with advanced renal cell cancer
Events
7TH LYOPHILIZATION AMERICAS CONFERENCE
Achieving optimum lyophilization processes. Where is the future of lyophilization heading?
The summit will address the latest developments in the biomarker arena from discovery to translation to commercialization.
Infectious Diseases World Summit 2013
3 Tracks: 10th Anti-Infectives Partnering and Deal-Making 11th Vaccines Research & Development: All Things Considered 2nd Influenza Research & Development
The European Society for Translational Medicine (EUSTM) and the Centre de Recherche Public – Santé (CRP-Santé)
Cancer Vaccines will provide attendees with a complete view of the cancer immunotherapy field. Focusing on the discovery of new vaccines, developments in target identification
Select Biosciences' 4th annual Single Cell Analysis Summit 2013 will build on the overwhelming success of the previous Single Cell events.
SELECTBIO CellTech2014 will feature an integrated program of tracks designed to fully describe the latest trends in analysis of cells, cell-based assays, and high-content phenotypic assays.
World Vaccine Congress Europe 2013
Where global vaccine stakeholders meet to do business
Cell Culture World Congress USA
North America’s commercial cell culture event
Advancing cord blood banking & therapeutics
Companies
International Medica Foundation
The International Medica Foundation, which has the rights to RotaShield, is a nonprofit foundation that focuses on ensuring that a safe, effective and affordable rotavirus...
Located in San Diego, California, Pathway Genomics owns and operates an onsite federally CLIA (Clinical Laboratory Improvement Amendments) certified and California state-licensed...
Verastem, Inc. (NASDAQ: VSTM) is a clinical-stage biopharmaceutical company focused on discovering and developing drugs to treat cancer by the targeted killing of cancer stem cells. Cancer stem cell...
Phyton Biotech, LLC is a global supplier of high quality paclitaxel and docetaxel API. The company has development and manufacturing facilities near Hamburg, Germany and Va...
DecisionSim⢠is a web-based virtual patient platform enabling healthcare providers, academic institutions and professional societies to cost-effectively develop, improve and...
WAISMANN METHOD® is pioneering opiate treatment based on a safe and proven protocol that utilizes the most advanced medical techniques available. A major center for opioid depe...
OncoMed is a clinical development-stage biopharmaceutical company focused on discovering and developing first-in-class monoclonal antibody therapeutics targeting cancer stem cells, or CSCs. Our appr...
DiaTech Oncology is a privately held clinical pathology laboratory that offers patient-specific chemotherapy testing to help oncologists determine the best cancer treatment plans...
Transgenomic is a global biotechnology company that provides unique products and services for automated high sensitivity genetic variation and mutation analysis. Their offerings include systems, produ...
Sequenta, Inc. is a privately held company developing and commercializing molecular diagnostic assays based on a proprietary sequencing approach to the profiling of T and B cell r...
Clinical Trials
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may...
This phase II trial is studying how well giving erlotinib together with celecoxib works in treating patients with recurrent stage IIIB or stage IV non-small cell lung cancer. Erlotinib and...
Low Dose Vaccine Study for Surgically Resected Pancreatic Cancer
To assess the response for subjects with pancreatic cancer that have undergone surgical resection and treatment with a vaccine given with or without chemotherapy and chemoradiation.
A study to assess whether the Northern Hemisphere 2009/2010 season influenza vaccine Inflexal V is as immunogenic as a locally sourced competitor vaccine in young children.
Stem Cell Collection With Ofatumumab
The goal of this clinical research study is to learn if it is possible to collect stem cells after ofatumumab and chemotherapy treatment. This study will also evaluate side-effects, number...
A Study of Pemetrexed and Gefitinib Versus Gefitinib in Non-Small Cell Lung Cancer (NSCLC)
The purpose of this study is to compare the combination of pemetrexed and gefitinib versus gefitinib alone, in terms of progression-free survival. This study is in participants who have st...
Study of the Safety and Immunogenicity of a Novel H5N1 Influenza Vaccine in Healthy Adults Age 18-49
The purpose of this study is to test an investigational vaccine known as "VAX161C." An "investigational" vaccine is one that is not licensed for commercial use in the by the United States...
This phase I trial studies the side effects and best dose of PI3K inhibitor BKM120 when given together with carboplatin and pemetrexed disodium in treating patients with stage IV non-small...
This trial is conducted in Europe and North America. The aim of this trial is to investigate if liraglutide treatment can increase the proportion of insulin-independent subjects one year a...
IMA901 in Patients Receiving Sunitinib for Advanced/Metastatic Renal Cell Carcinoma
The primary objective of the phase III study is to investigate whether IMA901 can prolong overall survival in patients with metastatic and/or locally advanced renal cell carcinoma (RCC) wh...
Videos
Medical and Biotech [MESH] Definitions
Chromosomes, Plant
Complex nucleoprotein structures which contain the genomic DNA and are part of the CELL NUCLEUS of PLANTS.
Mass Vaccination
Administration of a vaccine to large populations in order to elicit IMMUNITY.
Spectral Karyotyping
The simultaneous identification of all chromosomes from a cell by fluorescence in situ hybridization (IN SITU HYBRIDIZATION, FLUORESCENCE) with chromosome-specific florescent probes that are discerned by their different emission spectra.
Chromosomes, Mammalian
Complex nucleoprotein structures which contain the genomic DNA and are part of the CELL NUCLEUS of MAMMALS.
Stem Cell Transplantation
The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.
