Dengue Virus Vaccines - Biotech, Pharma and Life Science Channel
It is estimated that about 100 million cases of infection by Dengue virus occur each year and that nearly half the world’s population is at risk of Dengue virus infection. At present, no vaccines are available to prevent infection with mosquito-borne Dengue virus. There are four serotypes of Dengue virus, and neutralizing antibodies are serotype-specific with the risk of sequential infections. Although immunity against a specific serotype is life-long, but previous infection with one serotype is a risk factor for a more severe form of Dengue (Dengue hemorrhagic fever) upon subsequent infection with another serotype, thus emphasizing the need for a tetravalent vaccine against all four serotpyes of Dengue virus.
A number of vaccines have entered clinical development, two of them (live, attenuated forms) already in large scale trials. Newer vaccines are recombinant subunit or vector-delivered DNA forms. Most of them are tetravalent vaccines aimed at all four serotypes of Dengue virus.
News Articles
NanoViricides, Inc. (OTC: NNVC) (the "Company"), has filed its quarterly report with the Securities and Exchange Commission on Wednesday, May 15th, in a timely fashion. The...
iBio Technology Produces Vaccine Candidate for Recently Emerged H7N9 Influenza
NEWARK, Del., May 22, 2013 /PRNewswire/ -- PRNewswire – iBio, Inc. (NYSE MKT: IBIO) today announced the production of a vaccine candidate for the newly emerged H7N9 influenza virus by an indepen...
Soligenix Announces Issuance of US Patent for its ThermoVax™ Technology
PRINCETON, N.J., May 22, 2013 /PRNewswire/ -- Soligenix, Inc. (OTCQB: SNGX) (Soligenix or the Company), a clinical stage biopharmaceutical company focused on developing products to treat inflamma...
Alnylam to Webcast Presentation at Deutsche Bank 38th Annual dbAccess Health Care Conference
Alnylam Pharmaceuticals, Inc. (Nasdaq: ALNY), a leading RNAi therapeutics company, today announced that management will present a company overview at the Deutsche Bank 38th...
Company’s Virtual Conjugate Vaccine Program Shows Promise Liquidia Technologies today announced that its collaborative agreement with PATH, a global health nonprofit organiz...
Baby Boomers Urged to Get Tested for Hepatitis C Virus
KANSAS CITY, Mo., May 21, 2013 /PRNewswire-USNewswire/ -- If you're a baby boomer, you may not know that odds are high that you're carrying the hepatitis C virus, putting yourself at risk for illness...
Oxitec Report 96% Suppression of the Dengue Mosquito in Brazilian Trials
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OAKLAND, Calif., May 20, 2013 /PRNewswire/ -- Whole-cell pertussis vaccines were more effective at protecting against pertussis than acellular pertussis vaccines during a large recent outb...
New SARS-Like Coronavirus Suspected at New York Hospital
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Events
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Companies
Zoetis (zÅ-EH-tis) is the leading animal health company, dedicated to supporting its customers and their businesses. Building on a 60-year history as the animal health business...
TRANSGENE is a leading integrated gene therapy company, dedicated to the discovery and development of gene delivery technologies and gene therapy products for the treatment of acquired and inherited d...
Merck is a global healthcare leader working to help the world be well. Merck is known as MSD outside the United States and Canada. Through our prescription medicines, vaccines, biologic therapies, a...
Xenetic is a leading UK-based biopharmaceutical company providing leading-edge expertise in the development of a whole new generation of drugs and vaccines. Working with some of the largest pharma...
VGTI Florida is the Florida-funded expansion of Oregon Health & Science University's highly successful Vaccine and Gene Therapy Institute. Research at the facility will focus on v...
Cell Medica is a clinical stage cellular therapeutics company engaged in the development and delivery of cellular immunotherapy treatment strategies for infectious disease and can...
Etubics Corporation, based in Seattle, Wash., is a clinical stage bio-pharmaceutical company, which has developed a proprietary platform technology consisting of a next generation...
Enanta Phatmaceuticals ARE A RESEARCH AND DEVELOPMENT-FOCUSED BIOTECHNOLOGY COMPANY that uses its robust chemistry-driven approach and drug discovery capabilities to create small molecule drugs in t...
Fraunhofer USA CMB, a division of Fraunhofer USA, Inc., is a not-for-profit research organization whose mission is to develop safe and effective vaccines targeting infectious dise...
Profectus BioSciences, Inc. is a technology based vaccine company devoted to the treatment and prevention of chronic viral diseases with a goal of reducing morbidity and mo...
Clinical Trials
Immune Response to Hepatitis C Virus
This study will identify and characterize immune factors involved in hepatitis C infection and elimination of the virus. Individual responses to hepatitis C infection vary; some people ar...
RATIONALE: Vaccines made from a person's white blood cells may help the body build an effective immune response. PURPOSE: This phase I trial is studying the side effects of vaccine therap...
The primary purpose of this study is to determine the pharmacokinetic properties (what the body does to maraviroc) and to determine a suitable dosing schedule of maraviroc in HIV-1 infecte...
Improving the Immune System With Human IL-7 Vaccine in Older Subjects Who Have Had Chemotherapy
Background: - Drugs given to treat cancer (chemotherapy) can weaken the human immune system. But it can also become weaker because of aging. Interleukin (IL)-7, a molecule produced natura...
This Post Marketing Surveillance study will be performed as an open-label, prospective, non-interventional, uncontrolled study in Human immunodeficit Virus-1 (HIV-1) infected patients. Dat...
TMC435-TiDP16-C112 - Interaction Trial With Antidepressants
The purpose of this study is to investigate the effect of steady-state concentrations of TMC435 150mg q.d. (once a day) on the steady-state pharmacokinetics of escitalopram 10 mg q.d., and...
A Multiple Dose Study of MK-5172 in Hepatitis C-Infected Participants (MK-5172-010 AM1)
This study will compare hepatic pharmacokinetics (PK) derived from liver tissue to plasma PK after administration of MK-5172 to participants with chronic hepatitis C virus (HCV) infection....
HRN-003 STUDY SYNOPSIS OBJECTIVE: To compare the Sustained Virologic Response (SVR) of PEGIntron plus ribavirin among patients receiving a fixed dose of PEGIntron versus weighted-adjusted...
Genotype 1 hepatitis C virus (HCV) patients who did not respond (did not lose virus during treatment) or relapsed (virus went away on treatment but came back after treatment was stopped) a...
Study of the Pharmacokinetic Action of Amantadine and Ribavirin in Chronic Hepatitis C. CINAM
Peg interferon and ribavirin currently represent the standard approved association for treating patients infected with hepatitis C virus (HCV) . The adjunction of amantadine is expected to...
PubMed Articles
Treatment for hepatitis C virus-induced portal hypertension in leukemic children.
Children with acute leukemia are at high risk of hepatitis C infection, either by immunosuppression secondary to chemotherapy or by multiple transfusions of blood products during the course of the dis...
JAK/STAT signalling is essential for anti-viral immunity, making IFN-α an obvious anti-viral therapeutic. However, many HCV+ patients fail treatment, indicating that the virus blocks successful IFN-...
Xiao-Qing-Long-Tang (XQLT, TJ-19, Sho-seiryu-to, so-cheong-ryong-tang) has been used against acute airway diseases for thousands of year in ancient China. Most of the acute airway illnesses are caused...
Cinnamomum cassia Blume is a popular traditional Chinese herbal medicine that has been used to manage respiratory tract disease, including common cold and chronic bronchitis for thousand years. Human...
The role of plasma Epstein-Barr virus DNA in the management of recurrent nasopharyngeal carcinoma.
Background: To study the role of plasma Epstein-Barr virus (EBV) DNA in patients with recurrent nasopharyngeal carcinoma (NPC) after previous chemoradiation Study design: prospective Methods: Sixty pa...
Granulocyte-macrophage colony-stimulating factor (GM-CSF) secreting cellular tumor vaccines contribute to the induction of potent antitumor immune responses in murine models and patients suffering fro...
Breast feeding and immunoprophylaxis efficacy of mother-to-child transmission of hepatitis B virus.
Abstract Objective: This study was designed to explore if hepatitis B virus (HBV) may be transmitted via breast milk through mother-to-child transmission (MTCT), and assay the immunoprophylaxis effica...
BACKGROUND: Epstein-Barr virus-associated smooth muscle tumors (EBV SMT) in adult kidney transplant recipients (KTR) are rare. The aims of this study are to document the clinical features, types of tr...
Purification of infective baculoviruses by monoliths.
A chromatographic process based on monoliths for purification of infective baculovirus without prior concentration step has been established. Baculovirus produced in Spodoptera frugiperda cells (Sf-9)...
Sofosbuvir for previously untreated chronic hepatitis C infection.
In phase 2 trials, the nucleotide polymerase inhibitor sofosbuvir was effective in previously untreated patients with chronic hepatitis C virus (HCV) genotype 1, 2, or 3 infection.
Videos
First dengue fever vaccine passes clinical trial in Thailand
Dengue fever annually infects as many as 230 million people around the world. French company Sanofi Pasteur recently announced a large-scale trial in Thailan...
Medical and Biotech [MESH] Definitions
Tuberculosis Vaccines
Vaccines or candidate vaccines used to prevent or treat TUBERCULOSIS.
Hepatitis A Antigens
Antigens produced by various strains of HEPATITIS A VIRUS such as the human hepatitis A virus (HEPATITIS A VIRUS, HUMAN).
Hepatitis Delta Antigens
Antigens produced by various strains of HEPATITIS D VIRUS.
Virus Inactivation
Inactivation of viruses by non-immune related techniques. They include extremes of pH, HEAT treatment, ultraviolet radiation, IONIZING RADIATION; DESICCATION; ANTISEPTICS; DISINFECTANTS; organic solvents, and DETERGENTS.
Balb 3t3 Cells
Cell lines developed from disaggregated BALB/c mouse embryos. They are extremely sensitive to CONTACT INHIBITION, and highly susceptible to transformation by SV40 VIRUS and murine sarcoma virus (SARCOMA VIRUSES, MURINE).
