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Disease progression - Biotech, Pharma and Life Science Channel

03:17 EDT 16th April 2014 | BioPortfolio

PubMed Articles [12833 Associated PubMed Articles listed on BioPortfolio]

Preventing and controlling zoonotic tuberculosis: a One Health approach.

The expression One Health refers to the unified human and veterinary approach to zoonoses, an approach that used to be identified with Medicine throughout the 20th Century. Zoonotic tuberculosis (TB),...

Positioning therapy for Crohn's disease.

The therapy of Crohn's disease is constantly evolving. It is widely recognized that clinical assessment does not stage disease activity accurately and that endoscopic healing is associated with improv...

Aspirin Desensitization: Useful Treatment for Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) in Aspirin-Exacerbated Respiratory Disease (AERD)?

Aspirin intolerance syndrome is due to disturbances in the arachidonic acid metabolism implicating both the lipoxygenase and cyclooxygenase pathways. This results in imbalances of eicosanoid, leukotri...

A modified split Hopkinson torsional bar system for correlated study of τ-γ relations, shear localization and microstructural evolution.

The conventional split Hopkinson torsional bar (SHTB) system consists of two bars, which can successfully produce the data for the construction of dynamic torsional shear stress and strain relationshi...

Influence of temperature on infection, growth, and mycotoxin production by Fusarium langsethiae and F. sporotrichioides in durum wheat.

Information concerning the temperature requirements of the species causing Fusarium head blight of small grains is essential for understanding which species cause the disease in different areas and ye...

New antiplatelet agents prescribed to patients with ischemic heart disease: implications for treatment of stroke.

Stroke continues to be a significant public health problem worldwide. Despite a number of clinical trials testing various therapeutic agents, we are still left with a small armamentarium of options. A...

Current treatment and management of dystrophinopathies.

• Duchenne muscular dystrophy (DMD), the most common and severe type of dystrophinopathy, is a progressive disease affecting primordially skeletal and cardiac muscle. A coordinated multidisciplinary...

Induction Therapy with Combination TNF Inhibitor and Methotrexate in Early Rheumatoid Arthritis.

With the introduction of more objective disease activity measures and the development of biological therapies, there were dramatic changes in the treatment of rheumatoid arthritis (RA). The combinatio...

Patient involvement in outcome measures for psoriatic arthritis.

Psoriatic arthritis (PsA) is a heterogeneous inflammatory arthritis with a varied clinical phenotype. There has been considerable international collaboration over recent years to develop and prioritis...

Surgical salvage of recurrent cancer of the head and neck.

The therapeutic options and prognosis for recurrent squamous cell carcinoma of the upper aerodigestive tract vary greatly depending on site, extent of disease, and previous treatment. Surgical salvage...

News Articles [8340 Associated News Articles listed on BioPortfolio]

Wilson Therapeutics Secures $40 Million Private Financing To Advance Late Stage Development Program For Wilson's Disease

STOCKHOLM, April 16, 2014 /PRNewswire/ -- Wilson Therapeutics, a biopharmaceutical company, today announced that it has closed a $40 million Series B financing co-led by new investors, Abingworth...

Researchers identify mechanism that explains reason for persistence of hepatitis C virus

Researchers at the University of California, San Diego School of Medicine have identified a mechanism that explains why people with the hepatitis C virus get liver disease and why the virus is able to...

Dr. Afshin Vahadi of Lone Star Dental Center Now Offers Laser Gum Disease Treatment in Frisco, TX

Dr. Afshin Vahadi of Lone Star Dental Center is now offering gum disease treatment in Frisco, TX. Given the widespread nature of gum disease, many Americans are likely experiencing the signs of gum di...

Genetically modified neural stem cells offer potential treatment for Alzheimer's disease

UC Irvine neurobiologists have found that genetically modified neural stem cells show positive results when transplanted into the brains of mice with the symptoms and pathology of Alzheimer's disease....

Diabetes and pre-diabetes cases in the U.S. have nearly doubled since 1988

Cases of diabetes and pre-diabetes in the United States have nearly doubled since 1988, suggests new research from the Johns Hopkins Bloomberg School of Public Health, with obesity apparently to blame...

Akebia completes enrollment in ongoing 200-patient Phase 2b study of AKB-6548

Akebia Therapeutics, Inc., a biopharmaceutical company focused on the development of novel proprietary therapeutics based on hypoxia-inducible factor (HIF) biology and the commercialization of these p...

Measurement of calcium in coronary arteries can predict heart disease risk

With growing evidence that a measurement of the buildup of calcium in coronary arteries can predict heart disease risk, Los Angeles Biomedical Research Institute (LA BioMed) researchers found that the...

Variation in Rates of Autoimmune Thyroid Disease by Race/Ethnicity in US Military Personnel

The relationship between Graves disease and race/ethnicity is undefined. Based on thyroid antibody prevalence, the rates of Hashimoto thyroiditis may be highest in whites and lowest in blacks.

CDC: Hospital Antibiotic Use Promotes Resistance Checklist Can Improve Practices

Antibiotic prescribing in hospitals is inconsistent and often inappropriate—contributing to the emergence of antibiotic resistance, according to an analysis of hospital antibiotic prescribing by the...

Some Progress in Effort to Reduce Hospital-Acquired Infections

Hospital-acquired infections remain a pressing public health threat, affecting 1 in 25 hospitalized patients in 2011, according to the US Centers for Disease Control and Prevention (CDC). But some pro...

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Companies [267 Associated Companies listed on BioPortfolio]

The Happy Huntleys

The Happy Huntleys originally formed as Jon’s walk team for The ALS Association Golden West Chapter’s Los Angeles County Walk to Defeat ALS®. It evolved into a platfo...

Aerpio Therapeutics, Inc.

Aerpio Therapeutics, Inc. is a clinical‐stage biopharmaceutical company focused on advancing innovative therapies for the treatment of diabetic eye disease and inflammatory b...

Intelligent Medical Objects

IMO provides the most widely accepted medical terminology solution for the development, management, and licensing of medical vocabularies and software applications at healthcare o...

Allegro Diagnostics Corp.

Allegro Diagnostics’ molecular testing platform utilizes gene expression of normal epithelial cells in the respiratory tract to detect early signs of lung cancer and diseases...

Catabasis Pharmaceuticals Inc.

Catabasis is a clinical-stage company dedicated to the discovery and development of innovative medicines to treat inflammatory and metabolic diseases. The company's drug developme...

Premier Biomedical, Inc.

Premier Biomedical, Inc. is a research-based company that intends to discover and develop medical treatments for humans, specifically targeting the treatment of Alzheimer's Diseas...

International Union Against Tuberculosis and Lung Disease

Exosome Diagnostics, Inc.

Exosome Diagnostics is a developer of proprietary molecular diagnostic tests with applications in oncology and metabolic disease. The company's core technology is based on the discovery that circulat...

Fibrotech Therapeutics

Fibrotech is an Australian biopharmaceutical company developing a new class of drugs to prevent a massive health burden associated with fibrosis (tissue scarring). The Company dev...

Blockade Medical L.L.C.

Blockade Medical is a privately held medical device company focused on expanding the endovascular management of hemorrhagic stroke and related disease of the neurovascular system....

Clinical Trials [2704 Associated Clinical Trials listed on BioPortfolio]

Dose Escalation of Hypofractionated Radiation Therapy in Patients With Metastatic Cancer

Patients with metastatic cancer are generally treated with chemotherapy, which has improved median survival compared to best supportive care. Despite this, patients continue to have persi...

A Study of RO5083945 in Combination With FOLFIRI Versus FOLFIRI Plus Cetuximab or FOLFIRI Alone as Second Line Treatment in Patients With Metastatic Colorectal Cancer

This randomized, multicenter, open label study will evaluate the safety and efficacy of RO5083945 in combination with FOLFIRI as compared to FOLFIRI plus cetuximab or FOLFIRI alone as seco...

Study to Assess the Seroprevalence of Anti-Tat Antibodies in HIV-infected Patients

Tat is a key HIV regulatory protein produced very early after infection, prior to virus integration, and necessary for viral gene expression, cell-to-cell virus transmission and disease pr...

Vitamin K to Attenuate Coronary Artery Calcification in Hemodialysis Patients

The purpose of this study is to see if vitamin K supplementation three times per week reduces the progression of coronary artery calcification over 12 months in dialysis patients compared...

FG-4592 (ASP1517) in the Treatment of Anemia in Chronic Kidney Disease Patients Not Requiring Dialysis

This study is conducted to treat anemia in patients with chronic kidney disease. Anemia is a reduced number of red blood cells or hemoglobin. Hemoglobin is important for the transport of o...

Adipose Derived Cells for Chronic Obstructive Pulmonary Disease

The intent of this clinical study is to answer the questions: 1) Is the proposed treatment safe and 2) Is treatment effective in improving the disease pathology of patients with diagnosed...

A Study of Prasugrel in Pediatric Participants With Sickle Cell Disease (SCD)

The main purpose of the study is to evaluate the efficacy and safety of the study drug known as prasugrel for the reduction of Vaso-Occlusive Crisis events in pediatric participants with s...

Trial of Superiority of Stereotactic Body Radiation Therapy in Patients With Breast Cancer

The previous reported phase I study allows us to prospectively define the optimal total dose in different metastatic locations (88). However, several questions are still unanswered such as...

Impact on Reducing the Incidence of Low Serum Calcium by Providing Educational Materials on the Need to Take Daily Supplemental Calcium and Vitamin D to Patients With Paget's Disease Treated With Reclast®

This study will evaluate the impact of investigator and patient education and educational materials to foster calcium and vitamin D supplementation to mitigate the potential for hypocalcem...

A Randomised Placebo Controlled Study of OXN PR for Severe Parkinson's Disease Associated Pain

To demonstrate superiority of OXN PR compared to placebo with respect to analgesic efficacy in subjects with chronic severe pain associated with Parkinson's disease (PD), as assessed by av...

Medical and Biotech [MESH] Definitions

The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.

A slowly progressive autoimmune demyelinating disease of peripheral nerves and nerve roots. Clinical manifestations include weakness and sensory loss in the extremities and enlargement of peripheral nerves. The course may be relapsing-remitting or demonstrate a step-wise progression. Protein is usually elevated in the spinal fluid and cranial nerves are typically spared. GUILLAIN-BARRE SYNDROME features a relatively rapid progression of disease which distinguishes it from this condition. (Adams et al., Principles of Neurology, 6th ed, p1337)

Treatments with drugs which interact with or block synthesis of specific cellular components characteristic of the individual's disease in order to stop or interrupt the specific biochemical dysfunction involved in progression of the disease.

A repeat operation for the same condition in the same patient due to disease progression or recurrence, or as followup to failed previous surgery.

A selective, irreversible inhibitor of Type B monoamine oxidase. It is used in newly diagnosed patients with Parkinson's disease. It may slow progression of the clinical disease and delay the requirement for levodopa therapy. It also may be given with levodopa upon onset of disability. (From AMA Drug Evaluations Annual, 1994, p385) The compound without isomeric designation is Deprenyl.

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