Diseases caused by nontyphoidal Salmonella sp - Biotech, Pharma and Life Science Channel
PubMed Articles
Dehydroxymethylepoxyquinomicin (DHMEQ) is a low-m.w. compound that strongly inhibits NF-κB. Previous reports showed that DHMEQ directly binds to specific cysteine residues of NF-κB subunits and ther...
SOCS3 Regulates BAFF in Human Enterocytes under Ribosomal Stress.
Although the activation of B cells in the gastrointestinal tract is of great importance in the context of immunity to pathogens and mucosal inflammatory diseases, little is known about the mechanisms...
The ability of vaccines to induce T cell responses is crucial for preventing diseases caused by viruses or bacteria. Nanoparticles (NPs) are considered an efficient tool for inducing potent immune res...
Intestinal organoids as tissue surrogates for toxicological and pharmacological studies.
Recently developed cell culture protocols have allowed for the derivation of multi-cellular structures dubbed intestinal "organoids" from embryonic stem cells (ESCs), induced pluripotent stem cells (I...
Assessing the damage caused by Deepwater Horizon: Not just another Exxon Valdez.
In light of the high stakes of the Deepwater Horizon civil trial and the important precedent-setting role that the case will have on the assessment of future marine disasters, the methodologies underp...
There is a clear evidence that environmental pollutants, such as benzo[a]pyrene (B[a]P), can have detrimental effects on the immune system, whereas the underlying mechanisms still remain elusive. Jurk...
Resistance to bacterial infectious diseases in rainbow trout (Oncorhynchus mykiss).
Individually tagged rainbow trout representing 15 full-sibling families were sequentially challenged twice with Aeromonas salmonicida causing furunculosis: first as cohabitation and then as injected i...
Emergence of serogroup X meningococcal disease in Africa: Need for a vaccine.
Neisseria meningitidis is responsible for the seasonal burden and recurrent epidemics of meningitis in an area of sub-Saharan Africa known as the meningitis belt. Historically, the majority of the cas...
Salmonella Typhimurium lacking the Znuabc transporter is attenuated and immunogenic in pigs.
Meat contamination by Salmonella spp. is emerging as a major cause of human enteric infections in industrialized countries. The attempts to reduce human cases of salmonellosis encompass pre- and post-...
Transcription by RNA polymerases can stimulate (-) DNA supercoiling both in vitro and in Escherichia coli topA strains. This phenomenon has been successfully explained by a "twin-supercoiled-domain" m...
News Articles
New study identifies possible treatment to block deposition of calcium in arterial wall
HGPS is a rare genetic disease that affects one in every 4-8 million births. The disease is caused by a spontaneous mutation in one of the two copies (alleles) of the gene LMNA, which codes for lamin...
Falling toilet seats: Rare but growing risk for boys
NEW YORK (Reuters Health) - Ouch: Boys know that toilet seats are an occupational hazard of potty training, but a new study suggests the number of genital injuries caused by falling toilet toppers is...
Niche drugmaker ViroPharma attracts takeover interest: sources
NEW YORK (Reuters) - ViroPharma Inc, a drug maker specializing in rare diseases, is attracting preliminary acquisition interest from several pharmaceutical companies, according to three people familia...
UPDATE 1-Niche drugmaker ViroPharma attracts takeover interest -sources
NEW YORK, June 17 (Reuters) - ViroPharma Inc, a drug maker specializing in rare diseases, is attracting preliminary acquisition interest from several pharmaceutical companies, according to three peopl...
Men 'caused menopause' by seeking younger women
Men's preference for younger partners has led to the development of the menopause in women, according to a recently published theory in PLOS Computational Biology....
Diet may affect Alzheimer's disease risk
The lipidation states (or modifications) in certain proteins in the brain that are related to the development of Alzheimer disease appear to differ depending on genotype and cognitive diseases, and le...
Eyelid Disorder Controlled with Botulinum Toxin (CME/CE)
SYDNEY (MedPage Today) -- Patients with blepharospasm related to Parkinson's disease, an involuntary closure of the eyelid caused by spasms of the ocular muscles, can get relief with injections of bot...
Study of dietary intervention examines proteins in brain
The lipidation states (or modifications) in certain proteins in the brain that are related to the development of Alzheimer disease appear to differ depending on genotype and cognitive diseases, and le...
Is genetic testing worth the money?
But while it’s true that genetic testing can provide important information for diagnosing, treating and, in Jolie’s case, even preventing diseases, it’s not always clear which tests are really...
Scientist and surgeon dissects “pig paper”
David H. Gorski, a distinguished scientist and surgeon specializing in breast cancer, is also a redoubtable opponent of pseudoscience. In a blog posting, “More bad science in the service of ant...
Events
Recent years have seen huge growth in orphan drug development, but also a time of increased pressure as many leading blockbuster drugs soon come off patent.
Infectious Diseases World Summit 2013
3 Tracks: 10th Anti-Infectives Partnering and Deal-Making 11th Vaccines Research & Development: All Things Considered 2nd Influenza Research & Development
Welcome to Molecular Medicine Congress and exhibition.
The CNS Diseases World Summit 2013 brings together the leading experts across the industry and academia to discuss the latest research and developments in the CNS field.
Companies
Resverlogix Corp. (TSX: RVX) is a clinical stage cardiovascular company with an epigenetic platform technology that modulates protein production. Resverlogix is developing RVX-208, a first-in-class...
Bristol-Myers Squibb Company and Simcere Pharmaceutical Group
Bristol-Myers Squibb is a global biopharmaceutical company whose mission is to discover, develop and deliver innovative medicines that help patients prevail over serious diseases....
NanoLogix is a biotechnology company focused primarily on medical diagnostics. Its products offer accelerated detection and identification of microorganisms present in infectious and non-infectious hu...
Kadimastem is a biotechnology company focusing on the development and industrial commercialization of products based on human pluripotent stem cells. Kadimastemâs technology...
The Moran Eye Center is the largest eye care and vision research center in the Intermountain West and is part of the University of Utah Hospitals and Clinics. With collaborators f...
NeuroMetrix is a science-based health care company transforming patient care through neurotechnology. To date, our focus has been primarily on the assessment of neuropathies. We a...
Bioness offers innovative Neuromodulation products designed to help certain individuals with central nervous system disorders and diseases such as Stroke, Multiple Sclerosis, Trau...
Ocular Therapeutix, Inc. is a privately held company based in Bedford, MA, focused on the development and commercialization of ophthalmic therapeutic products using its proprietar...
Medigene is a publicly listed (Frankfurt: MDG, prime standard) biotechnology company headquartered in Martinsried/Munich, Germany. Medigene is focused on the research and development of innovative d...
Astellas Pharma Inc., located in Tokyo, Japan, is a pharmaceutical company dedicated to improving the health of people around the world through the provision of innovative and reliable pharmaceuticals...
Clinical Trials
Fat Biology, Sleep Disorders, and Cardiovascular Disease
Endothelial dysfunction, or abnormal functioning of the lining of blood vessels, appears to be a key process in the development of cardiovascular disease. Endothelial dysfunction appears t...
Pilot Trial to Assess Effect of CNI Conversion of Efalizumab on T Reg Cells
The purpose of this pilot trial is to determine whether a conversion from calcineurin inhibitors (CNI) and mycophenolate mofetil (MMF) to a regimen consisting of efalizumab and sirolimus i...
Inhaled Nitric Oxide for Preventing Chronic Lung Disease in Premature Infants
To determine whether or not inhaled nitric oxide (iNO) safely decreases the incidence of chronic lung disease (CLD) in premature infants.
This study will evaluate whether the drug mifepristone can improve the symptoms of Cushing's syndrome in people with ectopic adrenal corticotrophin hormone (ACTH) secretion. Cushing's synd...
Nephrotic Syndrome Study Network
Minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), and Membranous nephropathy (MN), generate an enormous individual and societal financial burden, accounting for appr...
This is a Phase III, multicenter, open-label study of RI-002 administered as an intravenous infusion of RI-002 (IGIV) every 21 or 28 days in approximately 60 subjects with Primary Immunode...
RATIONALE: Drugs used in chemotherapy, such as paclitaxel, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Nutriti...
Primary Care Management/Action Plans for Advanced Chronic Diseases
Patients living with advanced chronic diseases (ACD), such as congestive heart failure (CHF) and chronic obstructive lung disease (COPD) present substantial care and economic challenges fo...
Double Bedtime Dosing During Immediate-Release Morphine Administration to Cancer Patients
This is a double -blind randomized crossover study to provide evidence for the expert advice based recommendation of the Expert Working Group of the European Association for Palliative Car...
Research Network for Neonatal Diseases Induced by Tissular Fetomaternal Alloimmunization
Problems of compatibility between a mother and her child are frequent. The most well-known case can be illustrated by the fetomaternal blood group incompatibility (rhesus factor) which can...
Videos
Medical and Biotech [MESH] Definitions
Andrology
A scientific or medical discipline concerning the study of male reproductive biology, diseases of the male genital organs, and male infertility. Major areas of interest include ENDOCRINOLOGY; SPERMATOGENESIS; semen analysis; FERTILIZATION; CONTRACEPTION; and CRYOPRESERVATION.
Hyperuricemia
Excessive URIC ACID or urate in blood as defined by its solubility in plasma at 37 degrees C; greater than 0.42mmol per liter (7.0mg/dL) in men or 0.36mmol per liter (6.0mg/dL) in women. This condition is caused by overproduction of uric acid or impaired renal clearance. Hyperuricemia can be acquired, drug-induced or genetically determined (LESCH-NYHAN SYNDROME). It is associated with HYPERTENSION and GOUT.
Insomnia, Fatal Familial
An autosomal dominant disorder characterized by degeneration of the THALAMUS and progressive insomnia. It is caused by a mutation in the prion protein (PRIONS).
Reproductive Health Services
Health care services related to human REPRODUCTION and diseases of the reproductive system. Services are provided to both sexes and usually by physicians in the medical or the surgical specialities such as REPRODUCTIVE MEDICINE; ANDROLOGY; GYNECOLOGY; OBSTETRICS; and PERINATOLOGY.
Streptococcus Milleri Group
A subset of VIRIDANS STREPTOCOCCI, but the species in this group differ in their hemolytic pattern and diseases caused. These species are often beta-hemolytic and produce pyogenic infections.
