Dopamine - Biotech, Pharma and Life Science Channel
PubMed Articles
A selective and sensitive ultra-performance liquid chromatography-electrospray ionization tandem mass spectrometry (UPLC-MS) method was developed for the simultaneous determination of ten biogenic ami...
Substituted methcathinones differ in transporter and receptor interactions.
The use of synthetic methcathinones, components of "bath salts," is a world-wide health concern. These compounds, structurally similar to methamphetamine (METH) and 3,4-methylendioxymethamphetamine (M...
Norepinephrine potentiates proinflammatory responses of human vaginal epithelial cells.
The vaginal epithelium provides a barrier to pathogens and recruits immune defenses through the secretion of cytokines and chemokines. Several studies have shown that mucosal sites are innervated by n...
BACKGROUND: Therapy with ergot-derivative dopamine agonists (ergot-DAs) is suspected to cause or promote the development of insufficiency and regurgitation in previously normal cardiac valves. Thus, w...
PURPOSE: To elucidate the role of metabolism in the pharmacokinetics and pharmacodynamics of intranasal loxapine in conscious animals. METHODS: At pre-determined time points after intranasal or oral l...
It has been suggested that minor alkaloids in plants play a role in the biological and neuronal actions of nicotine. We hypothesized that these molecules modulate the effect of nicotine on the activit...
Explosive overpressure brain injury (OBI) impacts the lives of both military and civilian population. We hypothesize that a single exposure to OBI results in increased hypothalamic expression of oxida...
Electroconvulsive therapy (ECT) treats depression by repeated administration of seizure-inducing electrical stimuli. To assess the effects of repeated electroconvulsive shocks (ECS), an animal model o...
Treatment with dopamine agonists in patients with prolactinomas has been associated with weight loss in short term studies. However, long-term studies on weight changes are lacking. Taq1A is a restric...
Current treatment options for hyperprolactinemia.
Introduction: Hyperprolactinemia is a prevalent cause of oligo-amenorrhea, and prolactinomas are the most common type of functional pituitary tumor. Untreated hyperprolactinemia can lead to bone loss...
News Articles
Using positron emission tomography (PET) imaging of the brain, researchers have identified a sweet spot that operates in a disorderly way when simple sugars are introduced to people with insulin resis...
High sugar intake linked to low dopamine release in insulin-resistant patients
(Medical Xpress)—Using positron emission tomography (PET) imaging of the brain, researchers have identified a sweet spot that operates in a disorderly way when simple sugars are introduced to people...
Sugar ingestion associated with low dopamine release in patients with insulin resistance
Using positron emission tomography (PET) imaging of the brain, researchers have identified a sweet spot that operates in a disorderly way when simple sugars are introduced to people with insulin resis...
High sugar intake linked to low dopamine release in insulin resistant patients
A PET study indicates that overeating and weight gain contributing to onset of diabetes could be related to a deficit in reward circuits in the brain.
The Biology Behind Restless Leg Syndrome
A protein profile of people with restless leg syndrome (RLS), identifies factors behind disrupted sleep, cardiovascular dysfunction and pain finds research in BioMed Central's open access journal Flui...
Type: Original PaperPurposeTo elucidate the role of metabolism in the pharmacokinetics and pharmacodynamics of intranasal loxapine in conscious animals.MethodsAt pre-determined time points after intra...
Buy These 3 Biotechs To Corner The Parkinson's Disease Market
By Jason Napodano: By Jason Napodano, CFA This is a mission directive to all business development officers for large-cap pharmaceutical companies on how to build a potential world-class franchise i...
Company Showcases Innovative Hardware, Software and Radiopharmaceutical Solutions GE Healthcare today announced that results from three company studies utilizing DaTsca...
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Companies
Deplin is a prescription medical food for the dietary management of suboptimal L-methylfolate levels in patients with depression. Up to 70 percent of people who suffer from depression may have a spec...
The Malibu Beach Recovery Center® is a residential drug and alcohol treatment program licensed and certified by the State of California. The Center uses a unique neuro-b...
Neurovance has been spun out of Euthymics Bioscience, Inc. to advance EB-1020, a norepinephrine and dopamine-preferring reuptake inhibitor for ADHD. In addition to EB-1020, Neurov...
Prexton Therapeutics has the mission to develop innovative drugs to improve the quality of life of people who suffer from Parkinson’s disease and other brain disorders. Prexton Therapeutics ha...
Rexahn Pharmaceuticals is a clinical stage biopharmaceutical company dedicated to the discovery, development and commercialization of innovative treatments for cancer, central nervous system disorders...
Clinical Trials
Coenzyme Q10 as a Symptomatic Treatment in Parkinson's Disease
This study was designed to evaluate the symptomatic effects of Coenzyme Q10 nanodispersed solution in middle-stage Parkinson's disease (PD) patients (Hoehn&Yahr II to III). The treatment p...
Dopamine (DA) is one of the main catecholamines in mammals. Its major role as a brain neurotransmitter is well known as well as its contribution to the development of pathologies, mainly a...
Efficacy and Safety of Asenapine With Placebo and Olanzapine (41021)(P05933)(COMPLETED)
Schizophrenia is a brain disease. The primary features of schizophrenia are characterized by Positive symptoms (symptoms that should not be there, inability to think clearly, to distinguis...
Efficacy and Safety of Asenapine With Placebo and Haloperidol (41023)(COMPLETED)
Schizophrenia is a brain disease. The primary features of schizophrenia are characterized by Positive symptoms (symptoms that should not be there, inability to think clearly, to distinguis...
Schizophrenia is a brain disease. The primary features of schizophrenia are characterized by Positive symptoms (symptoms that should not be there, inability to think clearly, to distinguis...
Efficacy and Safety of Asenapine With Placebo and Olanzapine (41022)(COMPLETED)
Schizophrenia is a brain disease. The primary features of schizophrenia are characterized by Positive symptoms (symptoms that should not be there, inability to think clearly, to distinguis...
Dopexamine and Norepinephrine Compared With Epinephrine Alone in Septic Shock
In septic shock, when volume resuscitation fails to restore mean arterial pressure, catecholamines such as dopamine, dobutamine, epinephrine, or norepinephrine are used, either alone or in...
Donor Dopamine and Initial Graft Function
Donor pre-treatment with dopamine reduces injury to the kidney graft with consequences on the clinical performance immediately after transplantation: Donor dopamine reduces the requirement...
Relationship of Dopamine to Cognitive Function in Parkinson's Disease
This study will examine how the brain chemical dopamine affects memory, reasoning, and other thought processes in people with Parkinson's disease with and without dementia and in healthy c...
Lisuride Patch to Treat Parkinson's Disease
This study will evaluate the effectiveness of a skin patch formulation of the dopamine agonist Lisuride in controlling parkinsonian symptoms and dyskinesias (involuntary movements) caused...
Videos
Dopamine Jackpot! Sapolsky on the Science of Pleasure
Complete video at: http://fora.tv/2011/02/15/Robert_Sapolsky_Are_Humans_Just_Another_Primate Robert Sapolsky, professor of biology and neurology at Stanford ...
Medical and Biotech [MESH] Definitions
Dopamine Plasma Membrane Transport Proteins
Sodium chloride-dependent neurotransmitter symporters located primarily on the PLASMA MEMBRANE of dopaminergic neurons. They remove DOPAMINE from the EXTRACELLULAR SPACE by high affinity reuptake into PRESYNAPTIC TERMINALS and are the target of DOPAMINE UPTAKE INHIBITORS.
Receptors, Dopamine D3
A subtype of dopamine D2 receptors that are highly expressed in the LIMBIC SYSTEM of the brain.
Receptors, Dopamine D4
A subtype of dopamine D2 receptors that has high affinity for the antipsychotic CLOZAPINE.
Receptors, Dopamine D5
A subtype of dopamine D1 receptors that has higher affinity for DOPAMINE and differentially couples to GTP-BINDING PROTEINS.
Dopamine And Camp-regulated Phosphoprotein 32
A phosphoprotein that was initially identified as a major target of DOPAMINE activated ADENYLYL CYCLASE in the CORPUS STRIATUM. It regulates the activities of PROTEIN PHOSPHATASE-1 and PROTEIN KINASE A, and it is a key mediator of the biochemical, electrophysiological, transcriptional, and behavioral effects of DOPAMINE.
