Drug Discovery - news, views, blogs and reports - Biotech, Pharma and Life Science Channel
In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which drugs are discovered and/or designed.
In the past most drugs have been discovered either by identifying the active ingredient from traditional remedies or by serendipitous discovery. A new approach has been to understand how disease and infection are controlled at the molecular and physiological level and to target specific entities based on this knowledge.
The process of drug discovery involves the identification of candidates, synthesis, characterization, screening, and assays for therapeutic efficacy. Once a compound has shown its value in these tests, it will begin the process of drug development prior to clinical trials.
Despite advances in technology and understanding of biological systems, drug discovery is still a lengthy, "expensive, difficult, and inefficient process" with low rate of new therapeutic discover. Currently, the research and development cost of each new molecular entity (NME) is approximately US$1.8 billion.
Source: Wikipedia
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News Articles
Puma Biotechnology Comment on Trading Activity
Puma Biotechnology, Inc. (NYSE: PBYI), a development stage biopharmaceutical company, has been contacted by the New York Stock Exchange regarding today’s trading in the Company...
Additional macitentan (Opsumit) data in pulmonary arterial hypertension presented at ATS
Actelion Pharmaceuticals Ltd / Additional macitentan (Opsumit) data in pulmonary arterial hypertension presented at ATS . Processed and transmitted by Thomson Reuters ONE. The issuer is solely respo...
FDA seeks preliminary injunction against New York fish manufacturer
The U.S. Department of Justice, on behalf of the U.S. Food and Drug Administration (FDA), is seeking a preliminary injunction in the U.S. District Court for the Eastern District of New York against Ne...
– RNAi Therapeutics Targeting ALAS-1 Completely Block Production of Toxic Heme Biosynthesis Intermediates that Cause Symptoms and Disease Pathology – Alnylam...
Tech Council of Maryland Names GlycoMimetics CEO Rachel King as 2013 Executive of the Year
GlycoMimetics, Inc. announced today that the Tech Council of Maryland (TCM) named Rachel K. King, GlycoMimetics Chief Executive Officer, as the winner of its 2013 Executive...
MaxCyte CEO Doug Doerfler Named Chairman of the Tech Council of Maryland
Four Board Members Appointed to Leadership Positions The Tech Council of Maryland (TCM), the state’s largest technology trade association with more than 400 biotechno...
Mechelen, Belgium; 17 May 2013 - Galapagos NV (Euronext: GLPG) announced today that the operational and financial results achieved thus far in 2013 encourage the Company to retain full year 2013 Grou...
A*STAR and Cytos Bring Singapore's First Influenza Vaccine to Clinical Testing
SINGAPORE and ZURICH, May 17, 2013 /PRNewswire/ -- Singapore's Agency for Science, Technology and Research (A*STAR) and Switzerland's Cytos Biotechnology AG today announced that the first healthy vol...
Taro to Announce Results for Year Ended March 31, 2013
Taro Pharmaceutical Industries Ltd. (NYSE: TARO) (“Taro”) announced today that it plans to release its financial results for the quarter and year ended March 31, 2013 after ma...
Tetraphase Pharmaceuticals to Present at the Annual UBS Global Healthcare Conference
Tetraphase Pharmaceuticals, Inc. (NASDAQ: TTPH), a clinical-stage biopharmaceutical company developing a portfolio of potent new antibiotics designed to be effective against dange...
Events
Cancer Vaccines will provide attendees with a complete view of the cancer immunotherapy field. Focusing on the discovery of new vaccines, developments in target identification
Stem Cells & Regenerative Medicine Congress
North America’s commercial stem cells event
To Help you Improve and Optimise your Drug Submission Procedures
Welcome to ADME and Toxicology 2013 conference and exhibition.
This conference will discuss the wide range of cutting edge research being conducted using Microarray technologies in various scientific fields.
Academic Screening Workshop 2013
Genomic and Proteomics Research
Advancements in Genomics and Proteomics, together with integrating myriad disciplines from structural biology to computer sciences, have brought tremendous change in the drug discovery process over th...
Microfluidics & Lab on a Chip India
Miniaturization, requiring use of Microfluidics or Lab-on-a-Chip Technology has proven to have specific advantage in expediting early stages of drug discovery process.
Pharmaceutical industry is utilizing a plethora of novel approaches, techniques and technologies for Drug Design and Discovery.
Companies
Promedior has developed a novel drug discovery platform to regulate the monocyte-derived cell populations that play key roles in fibrotic, inflammatory and autoimmune diseases. By...
Bio-Path is developing a patented, liposomal drug delivery system and products developed at The University of Texas M. D. Anderson Cancer Center, with two clinical cancer drug can...
Sunovion is a leading pharmaceutical company dedicated to discovering, developing and commercializing therapeutic products that advance the science of medicine in the central nerv...
Health Discovery Corporation is a molecular diagnostics company that uses advanced mathematical techniques to analyze large amounts of data to uncover patterns that might otherwis...
Alnylam Pharmaceuticals, a leader in RNAi therapeutics, is a biopharmaceutical company developing novel therapeutics based on a breakthrough in biology known as RNA interference, or RNAi; a discovery...
LI-COR Biosciences is a leader in the design, manufacture, and marketing of integrated instrument systems for plant biology, biotechnology, drug discovery, and environmental research. LI-COR instrumen...
OvaScience is a life sciences company focused on the discovery, development and commercialization of new treatments for infertility. The Companyâs patented technology is base...
Tokai Pharmaceuticals is a U.S. biopharmaceutical company focused on developing new treatments for prostate cancer. The companyâs lead drug candidate, TOK-001, is the first i...
Certara is dedicated to improving human health through a broad spectrum of software products and services, from molecular discovery through clinical development, with special focu...
Alvine Pharmaceuticals, Inc. is a private, clinical-stage, specialty biopharmaceutical company located in San Carlos, CA, focused on the development of biologics targeting autoimm...
Clinical Trials
1/2-MC4R Genotype and Pediatric Antipsychotic Drug- Induced Weight Gain
We will conduct a 12-week, randomized open label study, comparing usual care (UC) antipsychotic treatment (aripiprazole, quetiapine, risperidone) with ziprasidone (ZIP) in children and ado...
The objective of the study is To verify the safety and efficacy of the MDT-4107 Drug-Eluting Coronary Stent in the treatment of de novo lesions in native coronary arteries with a reference...
The purpose of this investigation is to collect following data in patients given Nexium capsule (Nexium) for long term in usual-post-marketing therapy to prevention of recurrence of gastri...
This study investigates safety and pharmacokinetic comparison of DWJ1276, a combination drug of Rosuvastatin and Olmesartan (test formulation), and co-administration of Rosuvastatin and Ol...
Drug Eluting Balloon Versus Drug Eluting Stent in PCI
Drug eluting balloons (DEB) have been developed to overcome the limitations of drug eluting stent (DES), but clinical results of different studies about DEB are not consistent. Thus, we p...
Pharmacokinetic Drug Interaction Between Pregabalin and Thioctic Acid.
A randomized, open-label, six-sequence, three-period, three-treatment, multiple dosing clinical trial to investigate the pharmacokinetic drug interaction between Pregabalin and Thioctic ac...
RATIONALE: Drugs used in chemotherapy, such as melphalan, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Chemopro...
Exhale (R) Stent for Emphysema
Current treatment for emphysema is limited to measures that include inhaled oxygen, bronchodilators, anti-inflammatory drugs and pulmonary rehabilitation. Highly invasive procedures such...
A Research Study Examining the Use of Olanzapine for the Prevention of Migraine
Olanzapine (o-lan-zah-peen) is a medication that has been approved by the Food and Drug Administration (FDA) for the treatment of patients with schizophrenia and/ or bipolar disorder. The...
Valganciclovir (VGCV) has recently been approved by the Food and Drug Administration (FDA) for the treatment and prevention of cytomegalovirus (CMV) retinitis in HIV patients. It is under...
PubMed Articles
INTRODUCTION: Nonunion of femoral neck fractures frequently occurs in elderly patients. In patients with rheumatoid arthritis, reoperation rates after internal fixation of a displaced femoral neck fra...
The aim of the study is to evaluate the efficacy and safety of a three-drug chemotherapy regimen including gemcitabine, carboplatin, and paclitaxel as induction therapy in clinical stage III non-small...
Evidence for predictive role of BRCA1 and bTUBIII in gastric cancer.
Sensitivity of gastric cancer (GC) to conventional cytotoxic therapy may be at least in part attributed to molecular features of the tumor cells. We analyzed all patients with metastatic GC treated in...
TL-118-anti-angiogenic treatment in pancreatic cancer: a case report.
Pancreatic cancer is one of the most aggressive malignant tumors. In recent years, little progress has been made in understanding and treatment of the disease. The two most commonly used chemotherapy...
Phase-change materials are the alloys at the heart of an emerging class of next-generation, non-volatile digital memory technologies. However, the widely studied Ge-Sb-Te system possesses several unde...
A multifunctional nanoplatform with four-in-one photoresponsive functionalities has been achieved through the co-encapsulation of two chromo-fluorogenic components within biocompatible polymeric nanop...
The purinosome, a multi-protein complex involved in the de novo biosynthesis of purines in humans.
Purine nucleotides are ubiquitous molecules that play vital roles in all kingdoms of life, not only as components of nucleic acids, but also participating in signaling and energy storage. Cellular poo...
Synthesis and pharmacology of proteasome inhibitors.
Shortly after the discovery of the proteasome it was proposed that inhibitors could stabilize proteins which ultimately would trigger apoptosis in tumor cells. The essential questions were whether sma...
Serious complications following gluteal injection of silicone.
Silicone has a broad range of medical applications and plays an important role, for example, in plastic reconstruction. The use of silicone, however, may result in unpredictable consequences for the p...
The association of unwanted drug effects and increased psychovegetative lability.
OBJECTIVE: Based on a history of unwanted drug effects, patients had to undergo a series of exposure tests to identify alternative non-invasive drugs. In our study we examined if psychosomatic factors...
Videos
Drug discovery and development process
Discovering and bringing one new drug to the market typically takes an average of 14 years of research and clinical development efforts. Learn about the many...
Medical and Biotech [MESH] Definitions
Nontherapeutic Human Experimentation
Human experimentation that is not intended to benefit the subjects on whom it is performed. Phase I drug studies (CLINICAL TRIALS, PHASE I AS TOPIC) and research involving healthy volunteers are examples of nontherapeutic human experimentation.
Hyperuricemia
Excessive URIC ACID or urate in blood as defined by its solubility in plasma at 37 degrees C; greater than 0.42mmol per liter (7.0mg/dL) in men or 0.36mmol per liter (6.0mg/dL) in women. This condition is caused by overproduction of uric acid or impaired renal clearance. Hyperuricemia can be acquired, drug-induced or genetically determined (LESCH-NYHAN SYNDROME). It is associated with HYPERTENSION and GOUT.
Metered Dose Inhalers
A medical device used to ensure the proper amount of medication is delivered for inhalation. Usually, it is a small aerosol canister placed in a plastic holder. When the canister is pressed, a calibrated amount of drug is released.
Histamine H1 Antagonists, Non-sedating
A class of non-sedating drugs that bind to but do not activate histamine receptors (DRUG INVERSE AGONISM), thereby blocking the actions of histamine or histamine agonists. These antihistamines represent a heterogenous group of compounds with differing chemical structures, adverse effects, distribution, and metabolism. Compared to the early (first generation) antihistamines, these non-sedating antihistamines have greater receptor specificity, lower penetration of BLOOD-BRAIN BARRIER, and are less likely to cause drowsiness or psychomotor impairment.
Structural Homology, Protein
The degree of 3-dimensional shape similarity between proteins. It can be an indication of distant AMINO ACID SEQUENCE HOMOLOGY and used for rational DRUG DESIGN.
