Enzymes - news, views, reports - Biotech, Pharma and Life Science Channel
Enzymes are proteins that catalyze (i.e., increase the rates of) chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates sufficient for life. Since enzymes are selective for their substrates and speed up only a few reactions from among many possibilities, the set of enzymes made in a cell determines which metabolic pathways occur in that cell.
Source: Wikipedia
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News Articles
Acetylon Pharmaceuticals to Present at UBS Global Healthcare Conference
Acetylon Pharmaceuticals Inc., the leader in targeted epigenetic drug discovery and development for enhanced therapeutic outcomes, today announced that Walter C. Ogier, President...
Synageva BioPharma Corp. (Synageva) (NASDAQ:GEVA), a biopharmaceutical company developing therapeutic products for rare diseases, today announced that the U.S. Food and Dru...
ARAD, Israel, May 16, 2013 /PRNewswire/ -- Andain Inc. (OTCBB: ANDN) ("Andain" or the "Company"), a company engaged in commercializing novel technologies in biotech, medical and life sciences fields...
Dyadic International Reports First Quarter 2013 Financial Results
JUPITER, Fla., May 15, 2013 /PRNewswire/ -- Dyadic International, Inc. (OTC Pink: DYAI), a global biotechnology company, today announced financial results for the quarter ended March 31, 2013....
Synageva BioPharmaâ„¢ Joins the International MPS Network in Support of MPS Awareness Day 2013
Synageva BioPharma Corp. (Synageva) (NASDAQ:GEVA), a biopharmaceutical company developing therapeutic products for rare diseases, joins the International MPS Network and ot...
BASF And Dyadic International Enter Into A Research And License Agreement
LUDWIGSHAFEN, Germany and JUPITER, Fla., May 15, 2013 /PRNewswire/ -- BASF (BAS.DE) and Dyadic International, Inc. ("Dyadic") (OTC Pink: DYAI) announced today that the two Companies have entered...
Codexis to Present at 2013 UBS Global Healthcare Conference
Codexis, Inc. (NASDAQ: CDXS), a developer of engineered enzymes for pharmaceutical, biofuel and chemical production, today announced that John Nicols, President and CEO of Codexis...
Callidus Biopharma Announces $4.6 million in Series A Financing to Pursue Orphan Disease Therapies
DOYLESTOWN, Pa., May 14, 2013 /PRNewswire/ -- Callidus Biopharma, Inc., a development-stage biotechnology company focused on creating breakthrough biologic drugs for a range of orphan diseases, a...
IPSWICH, Mass., May 10, 2013 /PRNewswire/ -- New England Biolabs (NEB), a world leader in the discovery and production of reagents for the life science industry, launched a new reagent kit for site-di...
BioCryst to Present at Two Upcoming Investor Conferences
BioCryst Pharmaceuticals, Inc. (NASDAQ:BCRX) today announced that executives from BioCryst are scheduled to present and provide a corporate summary and update regarding the...
Events
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Companies
BuckPower Deer Velvet is imported from New Zealand and marketed by TCCD International, a South Florida manufacturer of natural products. Specially formulated with enzymes, 100% na...
Precision BioSciences’ mission is to continually provide, improve, and enable the world’s most powerful genome engineering technology. Precision’s proprietary Direc...
CytomX Therapeutics is an early stage biotechnology company developing Probodies™, or proteolytically-activated antibodies. Probodies combine the well-established power and s...
Ansaris is a division of Locus Pharmaceuticals, a privately held biopharmaceutical company focused on solving today’s small molecule drug discovery challenges, has been the l...
NeurAxon, Inc. (www.neuraxon.com) discovers and develops next-generation pain therapeutics focused on its first-in-class selective inhibitors of neuronal nitric oxide synthase...
Permeon Biologics is pioneering a breakthrough class of intracellular biologics that target a broad spectrum of previously undruggable targets. Leveraging its novel IntraphilinâÂ...
Maine Standards Company, LLC, is located in Windham, Maine. Maine Standards Company manufactures VALIDATE® test kits for over 80 analytes, including general chemistries, urine...
Mountain View Pharmaceuticals, Inc.
MVP is a privately-held California corporation with expertise in the application of advanced polymer-coupling technology to make protein-based drugs safer and longer acting. To da...
Genkyotex is developing first in class, small molecule therapeutics that specifically and selectively inhibit the NOX family of enzymes. Using a unique screening platform, Genkyot...
Orabrush Inc. (www.orabrush.com) is an e-commerce distribution platform that leverages social media marketing, with expertise in YouTube advertising, to commercialize in...
Clinical Trials
Vorinostat and Gemcitabine in Treating Patients With Metastatic or Unresectable Solid Tumors
This phase I trial is studying the side effects and best dose of vorinostat and gemcitabine in treating patients with metastatic or unresectable solid tumors. Drugs used in chemotherapy, s...
Tipifarnib may stop the growth of breast cancer by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. Drugs used in chemotherapy, such as paclitax...
RATIONALE: Dutasteride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. PURPOSE: This phase II trial is studying how well dutasteride works in tr...
RATIONALE: Dasatinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. PURPOSE: This phase II trial is studying how well dasatinib works in treati...
The Impact of Genotype on Plasma and Cerebral Spinal Fluid Pharmacokinetics of Celecoxib in Children
Background: Celecoxib is effective for reducing postoperative pain in adults. Children use celecoxib more rapidly than adults and require higher doses. Celecoxib is partially metabolized...
Selumetinib in Treating Young Patients With Recurrent or Refractory Low Grade Glioma
This phase I trial is studying the side effects and the best dose of selumetinib in treating young patients with recurrent or refractory low grade glioma. Selumetinib may stop the growth o...
RATIONALE: Sorafenib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the cancer. PURPOSE: This randomized phase I...
Sorafenib in Treating Patients With Advanced Soft Tissue Sarcomas
RATIONALE: Sorafenib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. PURPOSE: This phase II trial is stu...
RATIONALE: Drugs used in chemotherapy, such as vorinostat, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Vorinos...
Statins in Proteinuric Nephropathies
End stage renal disease (ESRD) is rapidly growing worldwide. Patients with ESRD have increased morbidity and mortality mostly because of a dramatic excess of cardiovascular disease. Thus,...
PubMed Articles
CYP2A6, CYP1A1, and CYP2D6 polymorphisms in lung cancer patients from Central South China.
Lung cancer is a common cause of cancer-related death. The link between risk of lung cancer susceptibility and genetic polymorphisms in metabolic enzymes is well documented. In this study, the relatio...
MiADMSA Protects Arsenic-Induced Oxidative Stress in Human Keratinocyte 'HaCaT' Cells.
Arsenic toxicity may lead to skin manifestations and arsenic accumulation in keratinised tissue. Thus human keratinocytes has been extensively used to study dermal effects of arsenic exposure. The pre...
Enzyme activity measurement via spectral evolution profiling and PARAFAC.
The recent advances in multi-way analysis provide new solutions to traditional enzyme activity assessment. In the present study enzyme activity has been determined by monitoring spectral changes of su...
Enzyme promiscuity: using a p450 enzyme as a carbene transfer catalyst.
How about this for a change: The promiscuous enzyme cytochrome P450-BM3 catalyzes the cyclopropanation of olefins, sometimes with high stereoselectivity. The highlighted paper demonstrates that it i...
An easy assay: A synthetic substrate enables a colorimetric screen for terpene synthase cyclization activity, thereby facilitating the engineering of these enzymes. By using directed evolution, the th...
Managing Cardiotoxicity of Chemotherapy.
OPINION STATEMENT: The increase in survivorship of cancer patients makes the understanding of the available options for prevention and treatment of cardiotoxicity induced by antineoplastic agents a cr...
BACKGROUND: Previous research has suggested a putative utility of pancreatic (pro)enzymes in cancer treatment. The aim of the present study was to investigate the in vitro effects of a mixture of two...
Trichoderma asperellum parasitizes a large variety of phytopathogenic fungi. The mycoparasitic activity of T. asperellum depends on the secretion of complex mixtures of hydrolytic enzymes able to degr...
Probing of Potential Luminous Bacteria in Bay of Bengal and Its Enzyme Characterization.
The present study dealt with the isolation, identification and enzyme characterization of potential luminous bacteria from water, sediment, squid, and cuttle fish samples of the Karaikal coast, Bay of...
This paper reports the production and characterization of crude xylanase from the newly isolated Humicola sp. Ly01. The highest (41.8 U/ml) production of the crude xylanase was obtained under the opti...
Videos
Enzymes: Mr. W's Enzyme Song
On iTunes: https://itunes.apple.com/us/album/enzymes-single/id596841592 On Amazon: http://www.amazon.com/Enzymes/dp/B00B6KLXEA/ Go to http://www.sciencemusic...
Medical and Biotech [MESH] Definitions
Dynamins
A family of high molecular weight GTP phosphohydrolases that play a direct role in vesicle transport. They associate with microtubule bundles (MICROTUBULES) and are believed to produce mechanical force via a process linked to GTP hydrolysis. This enzyme was formerly listed as EC 3.6.1.50.
Adp Ribose Transferases
Enzymes that transfer the ADP-RIBOSE group of NAD or NADP to proteins or other small molecules. Transfer of ADP-ribose to water (i.e., hydrolysis) is catalyzed by the NADASES. The mono(ADP-ribose)transferases transfer a single ADP-ribose. POLY(ADP-RIBOSE) POLYMERASES transfer multiple units of ADP-ribose to protein targets, building POLY ADENOSINE DIPHOSPHATE RIBOSE in linear or branched chains.
Adp-ribosyl Cyclase
A membrane-bound or cytosolic enzyme that catalyzes the synthesis of CYCLIC ADP-RIBOSE (cADPR) from nicotinamide adenine dinucleotide (NAD). This enzyme generally catalyzes the hydrolysis of cADPR to ADP-RIBOSE, as well, and sometimes the synthesis of cyclic ADP-ribose 2' phosphate (2'-P-cADPR) from NADP.
Lectins
Proteins that share the common characteristic of binding to carbohydrates. Some ANTIBODIES and carbohydrate-metabolizing proteins (ENZYMES) also bind to carbohydrates, however they are not considered lectins. PLANT LECTINS are carbohydrate-binding proteins that have been primarily identified by their hemagglutinating activity (HEMAGGLUTININS). However, a variety of lectins occur in animal species where they serve diverse array of functions through specific carbohydrate recognition.
Plant Lectins
Protein or glycoprotein substances of plant origin that bind to sugar moieties in cell walls or membranes. Some carbohydrate-metabolizing proteins (ENZYMES) from PLANTS also bind to carbohydrates, however they are not considered lectins. Many plant lectins change the physiology of the membrane of BLOOD CELLS to cause agglutination, mitosis, or other biochemical changes. They may play a role in plant defense mechanisms.
