Epithelial cell adhesion molecule EpCAM CD326 - Biotech, Pharma and Life Science Channel
Epithelial cell adhesion molecule (EpCAM; CD326) is a cell surface protein that is frequently expressed at high level on most solid tumor types, including prostate, breast, colon, gastric, ovarian, pancreatic and lung cancer. Overexpression of EpCAM has been shown to promote the proliferation, migration and invasiveness of breast cancer cells. Moreover, expression of EpCAM is associated with decreased survival in a number of cancer indications, including breast, gall bladder, bile duct, ovarian and ampullary pancreatic cancer. Most of the currently ongoing projects targeting EpCAM are antibodies or antibody-based constructs with an additional payload or effector function to enhance efficacy. Among these constructs are immunotoxins, immunocytokines and T-cell recruitment via CD3 targeting. Recently, the first EpCAM targeting antibody was recommended for approval in the European Union. Further molecules are being evaluated in ovarian cancer, gastric cancer, small-cell lung cancer, breast cancer and colorectal cancer.
News Articles
Glycotope GmbH / Glycotope Has Completed Randomization of Phase II Clinical Trial with Glycooptimized and Fully Human FSH-GEX(TM) for In Vitro Fertilization . Processed and transmitted by Thomson Re...
Aurigene and Debiopharm Group™ Report Nomination of Development Candidate Debio 0617B in Oncology
LAUSANNE, Switzerland and BANGALORE, India, June 19, 2013 /PRNewswire/ -- Aurigene Discovery Technologies, a Bangalore-based biotech focusing on small molecule and peptide drug discovery and Debiopha...
Gram Scale Transient Antibody Production in CHO Cells with MaxCyte Electroporation
Dr. Hua Tu, CEO of LakePharma, and Dr. Peer Heine, Applications Scientist at MaxCyte, to Present Data Demonstrating Superior Performance and Scalability of MaxCyte Flow Electropor...
CytoDyn Inc. Appoints Anthony D. Caracciolo as Chairman of the Board of Directors
CytoDyn Inc. (“CytoDyn”) (OTC QB: CYDY), a biotechnology company focused on the development of new therapies for combating infection with immune deficiency viruses, today anno...
-- Data Presented at the 18th Congress of the European Hematology Association -- Acetylon Pharmaceuticals Inc., the leader in development of selective histone deacetyla...
Rexahn Awarded U.S. Patent for Novel Anti-Cancer Compounds
Rexahn Pharmaceuticals, Inc. (NYSE MKT: RNN), a clinical stage biopharmaceutical company developing potential best-in-class oncology therapies, today announced that it has signifi...
SOUTH SAN FRANCISCO, Calif., June 17, 2013 /PRNewswire/ -- NGM Biopharmaceuticals, Inc. and MedImmune, the global biologics research and development arm of AstraZeneca, announced today that they have...
SOUTH SAN FRANCISCO, CA -- (Marketwired) -- 06/17/13 -- VistaGen Therapeutics, Inc. (OTCQB: VSTA), a biotechnology company applying stem cell technology for drug rescue, predictive toxicology and dru...
SUNNYVALE, Calif., June 16, 2013 /PRNewswire/ -- Pharmacyclics, Inc. (the "Company") (Nasdaq: PCYC) today announced the results of two separate Phase 2 studies suggesting that ibrutinib, an investigat...
Enanta Pharmaceuticals to Present at the Wells Fargo Securities 2013 Healthcare Conference
Enanta Pharmaceuticals, Inc., (NASDAQ: ENTA), a research and development-focused biotechnology company dedicated to creating small molecule drugs in the infectious disease field,...
Events
Select Biosciences' 4th annual Single Cell Analysis Summit 2013 will build on the overwhelming success of the previous Single Cell events.
SELECTBIO CellTech2014 will feature an integrated program of tracks designed to fully describe the latest trends in analysis of cells, cell-based assays, and high-content phenotypic assays.
Cell Culture World Congress USA
North America’s commercial cell culture event
Advancing cord blood banking & therapeutics
Stem Cells & Regenerative Medicine Congress
North America’s commercial stem cells event
Stem Cells & Cell Therapy Summit
Select Biosciences' Stem Cells & Cell Therapy Summit is focused on providing an up-to-date expansive view of the current marketplace
Oxford Global is proud to present the Biopharma Asia Series taking place on 24th & 25th September 2013 in Singapore.
2nd Annual Cell Culture & Bioprocessing Congress 2013
175 delegates representing leading biotech companies, global pharma organisations and internationally renowned academic institutions
th Annual Next Generation Sequencing Congress 2013
Over 400 Next Generation Sequencing, Genomics, Epigenetics, Genetics, Metagenomics experts from UK, Europe and USA
Companies
Verastem, Inc. (NASDAQ: VSTM) is a clinical-stage biopharmaceutical company focused on discovering and developing drugs to treat cancer by the targeted killing of cancer stem cells. Cancer stem cell...
Anacor is a biopharmaceutical company focused on discovering, developing and commercializing novel small-molecule therapeutics derived from its boron chemistry platform. Anacor ha...
Dermira is a private, development-stage company focused on developing and commercializing innovative new therapies in dermatology. Dermira was founded by an experienced management...
Phyton Biotech, LLC is a global supplier of high quality paclitaxel and docetaxel API. The company has development and manufacturing facilities near Hamburg, Germany and Va...
Concert Pharmaceuticals is a clinical stage biotechnology company with a broad development pipeline targeting renal disease, CNS disorders, inflammation and hematologic disorders....
OncoMed is a clinical development-stage biopharmaceutical company focused on discovering and developing first-in-class monoclonal antibody therapeutics targeting cancer stem cells, or CSCs. Our appr...
DiaTech Oncology is a privately held clinical pathology laboratory that offers patient-specific chemotherapy testing to help oncologists determine the best cancer treatment plans...
Sequenta, Inc. is a privately held company developing and commercializing molecular diagnostic assays based on a proprietary sequencing approach to the profiling of T and B cell r...
Founded in 1989 and with headquarters in Ann Arbor, Michigan, Aastrom Biosciences is dedicated to the development of stem cell treatments for critical cardiovascular diseases. Aastrom is currently e...
TetraLogic Pharmaceuticals is a privately held biopharmaceutical company that discovers and develops small molecule drugs that modulate programmed cell death pathways to treat deb...
Clinical Trials
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may...
This phase II trial is studying how well giving erlotinib together with celecoxib works in treating patients with recurrent stage IIIB or stage IV non-small cell lung cancer. Erlotinib and...
The purpose of this research study is to: 1) Determine the highest dose of the drug vorinostat that can be given safely in combination with carboplatin and gemcitabine and 2) determine how...
Stem Cell Collection With Ofatumumab
The goal of this clinical research study is to learn if it is possible to collect stem cells after ofatumumab and chemotherapy treatment. This study will also evaluate side-effects, number...
A Study of Pemetrexed and Gefitinib Versus Gefitinib in Non-Small Cell Lung Cancer (NSCLC)
The purpose of this study is to compare the combination of pemetrexed and gefitinib versus gefitinib alone, in terms of progression-free survival. This study is in participants who have st...
This phase I trial studies the side effects and best dose of PI3K inhibitor BKM120 when given together with carboplatin and pemetrexed disodium in treating patients with stage IV non-small...
This trial is conducted in Europe and North America. The aim of this trial is to investigate if liraglutide treatment can increase the proportion of insulin-independent subjects one year a...
IMA901 in Patients Receiving Sunitinib for Advanced/Metastatic Renal Cell Carcinoma
The primary objective of the phase III study is to investigate whether IMA901 can prolong overall survival in patients with metastatic and/or locally advanced renal cell carcinoma (RCC) wh...
Erlotinib and Sirolimus for the Treatment of Metastatic Renal Cell Carcinoma
The purpose of this study is to test the safety and efficacy of the combination of erlotinib hydrochloride (Tarceva™) and sirolimus (Rapamune™) in the treatment of patients with metast...
A Study of Prasugrel in Pediatric Participants With Sickle Cell Disease (SCD)
The main purpose of the study is to evaluate the efficacy and safety of the study drug known as prasugrel for the reduction of Vaso-Occlusive Crisis events in pediatric participants with s...
PubMed Articles
Protein tyrosine phosphatase nonreceptor type 12 (PTPN12) has been recognized as a tumor suppressor gene that may inhibit tumor growth. However, PTPN12 expression in oral squamous carcinoma (OSCC) has...
Effects of legumain as a potential prognostic factor on gastric cancers.
Although legumain has been found to be a prognostic factor in both breast cancer and colorectal cancer, its effects on gastric cancer are unknown. In this study, we investigated effects of legumain on...
It is well accepted that Ag-induced B cell differentiation often results in the generation of exceptionally long-lived plasma cells. Much of the work supporting this viewpoint stems from studies focus...
The title compound, [Cu8(C15H10N3O3S)4Cl4(C3H7NO)2]·2C3H7NO, consisting of eight Cu(II) cations, four trianionic 1-(2-oxidobenzoyl)-2-(2-oxo-2-phenylethanethioyl)hydrazine-1,2-diide ligands, four chl...
In the title complex, [Cu(C16H16Cl3N3O2P)Cl(C12H8N2)], the Cu(II) cation presents a square-pyramidal environment, where the CuO2N2 base is formed by two O atoms from carbonyl and phosphoryl groups, an...
Insulin resistance (IR) and pancreatic β-cell dysfunction lead to type 2 diabetes mellitus (DM). We tested whether risk factors would differ for DM that was preceded predominantly by IR, β-cell dysf...
CCL15, a member of the CC chemokine family, is a potent chemoattractant for leukocytes and endothelial cells (ECs). Given that chemokines play key roles in vascular inflammation, we investigated the e...
Ab-mediated rejection (AMR) of solid organ transplants is characterized by intragraft macrophages. It is incompletely understood how donor-specific Ab binding to graft endothelium promotes monocyte ad...
The Proto-Oncogene c-myc Regulates Antibody Secretion and Ig Class Switch Recombination.
The immune response involves the generation of Ab-secreting cells and memory B cells through a process called terminal B lymphocyte differentiation. This program requires the transcriptional repressor...
CD40 Mediates Downregulation of CD32B on Specific Memory B Cell Populations in Rheumatoid Arthritis.
Altered B cell function is important in the pathogenesis of rheumatoid arthritis (RA). In this report, we show that patients with active RA have an increased frequency of CD32B low/neg cells in the CD...
Videos
Medical and Biotech [MESH] Definitions
Chromosomes, Plant
Complex nucleoprotein structures which contain the genomic DNA and are part of the CELL NUCLEUS of PLANTS.
Spectral Karyotyping
The simultaneous identification of all chromosomes from a cell by fluorescence in situ hybridization (IN SITU HYBRIDIZATION, FLUORESCENCE) with chromosome-specific florescent probes that are discerned by their different emission spectra.
Chromosomes, Mammalian
Complex nucleoprotein structures which contain the genomic DNA and are part of the CELL NUCLEUS of MAMMALS.
Stem Cell Transplantation
The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.
Periplasmic Proteins
Proteins found in the PERIPLASM of organisms with cell walls.
