Eye disease - Biotech, Pharma and Life Science Channel

19:04 EDT 30th July 2015 | BioPortfolio

PubMed Articles [14880 Associated PubMed Articles listed on BioPortfolio]

Synthesis, characterization, and preclinical validation of a PET radiopharmaceutical for interrogating Aβ (β-amyloid) plaques in Alzheimer's disease.

PET radiopharmaceuticals capable of imaging β-amyloid (Aβ) plaque burden in the brain could offer highly valuable diagnostic tools for clinical studies of Alzheimer's disease. To further supplement ...

Immune Tolerance Induction against Experimental Autoimmune Encephalomyelitis (EAE) Using A New PLP-B7AP Conjugate that Simultaneously Targets B7/CD28 Costimulatory Signal and TCR/MHC-II Signal.

Most of the current therapies used in the treatment of multiple sclerosis (MS) are either ineffective or have adverse side effects. As such, there is a need to develop better therapies that specifical...

Role of indoleamine 2,3-dioxygenase in health and disease.

IDO1 (indoleamine 2,3-dioxygenase 1) is a member of a unique class of mammalian haem dioxygenases that catalyse the oxidative catabolism of the least-abundant essential amino acid, L-Trp (L-tryptophan...

Regulation of skeletal muscle mitochondrial function by nuclear receptors: implications for health and disease.

Skeletal muscle metabolism is highly dependent on mitochondrial function, with impaired mitochondrial biogenesis associated with the development of metabolic diseases such as insulin resistance and ty...

Involvement of pro-inflammatory cytokines and growth factors in the pathogenesis of Dupuytren's contracture: a novel target for a possible future therapeutic strategy?

Dupuytren's contracture (DC) is a benign fibro-proliferative disease of the hand causing fibrotic nodules and fascial cords which determine debilitating contracture and deformities of fingers and hand...

Plasma long non-coding RNA, CoroMarker, a novel biomarker for diagnosis of coronary artery disease.

Long non-coding RNAs (lncRNAs) have been reported to be involved in the pathogenesis of cardiovascular disease (CVD), but whether circulating lncRNAs can serve as a coronary artery disease (CAD), biom...

Update in primary pulmonary lymphomas.

Despite the fact that primary pulmonary lymphoma (PPL) is a rare lung tumour, significant advances addressing clinical features, histological diagnosis, prognostic criteria and therapeutic management ...

Interstitial lung disease related to smoking: imaging considerations.

To discuss the imaging of interstitial lung disease believed to be caused by smoking.

Role of Jo-1 in the Immunopathogenesis of the Anti-synthetase Syndrome.

Histidyl-tRNA synthetase (HRS = Jo-1) represents a key autoantibody target in the anti-synthetase syndrome that is marked by myositis as well as extra-muscular organ complications including inters...

Lipid and Metabolic Changes in Rheumatoid Arthritis.

While the most obvious manifestations of rheumatoid arthritis (RA) involve inflammation and damage in the synovial joints, the systemic effects of the condition are widespread and life-threatening. Of...

News Articles [6218 Associated News Articles listed on BioPortfolio]

Genetics of congenital heart disease: the contribution of the noncoding regulatory genome

HPV vaccinations for U.S. teens rise slightly: CDC

(Reuters) - The percentage of U.S. teenagers vaccinated against the human papillomavirus increased slightly in 2014, but the rate lags behind other immunizations, the Centers for Disease Control and P...

Antimalaria drugs could be an effective treatment for Parkinson’s disease

Two antimalarials were found to activate a receptor in the brain that is involved in protecting neurons that are lost in Parkinson’s disease.

Byproduct of intestinal bacteria may jeopardize heart health in kidney disease patients

In patients with chronic kidney disease (CKD), atherosclerosis is exceedingly common and contributes to the development of heart disease, which is the leading cause of death in this group. New researc...

A test for anti-TNF non-responders? Few alternative RA therapies available

Cambridge, Massachusetts-based Selventa is developing a test to identify people with RA who won't respond to anti-TNF drugs, the results of which could save a lot of time for patients with a progressi...

Combo Tx Brings Rapid Response in Early RA (CME/CE)

(MedPage Today) -- Physical activity improved along with markers of disease activity

5 drugs for the Alzheimer’s effort

Last week we reported on Eli-Lilly’s breakthrough Alzheimer’s disease drug solanezumab. This week we look back at the history behind five existing treatments on the market.

Kidney Disease Patients Use App To Test Med Adherence

(MedPage Today) -- Feasibility of mobile technology in CKD tested

What does the future hold for COPD diagnostic and monitoring technologies?

The NIHR Horizon Scanning Research & Intelligence Centre has published its latest horizon scanning review, this time on technologies in development for the diagnosis and monitoring of chronic obst...

CVS Health, IBM tap Watson for chronic disease solution

CVS Health and IBM on Thursday announced they will use predictive analytics and Watson cognitive computing for care management services for patients with chronic disease. read more

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Companies [304 Associated Companies listed on BioPortfolio]

Catabasis Pharmaceuticals, Inc.

Catabasis Pharmaceuticals is leveraging its pathway pharmacology drug development platform to bring important medicines to patients with severe lipid disorders and rare inflammato...

Voyager Therapeutics, Inc.

Voyager Therapeutics is a clinical-stage gene therapy company developing life-changing treatments for severe diseases of the central nervous system. Voyager is committed to advanc...

Intralytix, Inc.

lntralytix was founded in 1998 to address growing problems in the control and treatment of disease-causing bacteria. These problems are presently compounded by public and governmental reluctance to em...

Seres Therapeutics, Inc.

Seres Therapeutics, Inc. is a leading microbiome therapeutics platform company developing a novel class of biological drugs that are designed to treat disease by restoring the fun...

Center for Infectious Disease Research

Center for Infectious Disease Research is the largest independent, non-profit organization in the U.S. focused solely on infectious disease research. Our mission is to make transf...

The Feinstein Institute for Medical Research

Headquartered in Manhasset, NY, The Feinstein Institute for Medical Research is home to international scientific leaders in many areas including Parkinson's disease, Alzhei...

Global Genes

Global Genes is a non-profit organization that operates as one of the leading rare disease patient advocacy groups in the world. Global Genes promotes the needs of the Rare Diseas...

EBR Systems, Inc.

EBR Systems is dedicated to superior treatment of cardiac rhythm disease by providing more physiologically effective stimulation through wireless endocardial pacing. The companyâ...

Health Recovery Solutions

Health Recovery Solutions, a New York City based telehealth provider, supplies the nation’s leading medical centers and home health agencies with disease-specific platforms f...

Kedrion Biopharma Inc.

Kedrion is an international company that collects and fractionates blood plasma to produce and distribute plasma-derived therapeutic products for use in treating and preventing se...

Clinical Trials [1422 Associated Clinical Trials listed on BioPortfolio]

Coronary Artery and Systemic Autoimmune Disease: Diagnostics and Treatment

This study evaluates in vivo intracoronary imaging using intravascular ultrasound and optical coherence tomography and safety and efficacy of new generation fully bioresorbable vascular sc...

Hereditary Parkinson s Disease Natural History Protocol

Background: - Parkinson s disease is a disease of the nervous system that affects movement. People usually get it in their 70s or 80s. Early onset Parkinson s disease (EOPD) begins be...

Relationship Between Obesity and Periodontal Disease

Obesity is an epidemic with increasing prevalence in the Asia Pacific region. The first Malaysian national estimate in 1996 of obesity was 5.8%. A systematic review reported a marked incre...

Prevalence of Chronic Kidney Disease and Its Association With Clinical Outcome in Patients With Coronary Heart Disease

This is a prospective, multi-center, hospital-based observational study. The aim of the study is to evaluate the prevalence of chronic kidney disease in patients with stable coronar heart ...

Safety and Efficacy Study of BCD-066 Compared to Aranesp® for Anemia Treatment in Chronic Kidney Disease Patients

The purpose of the study is to prove equivalence of efficacy and safety of BCD-066 and Aranesp® in treatment of anemia in chronic kidney disease patients on dialysis.

A Study to Evaluate Efficacy and Safety of Infliximab in Participant With Moderate-to-Severe Refractory Intestinal Behcet's Disease

The purpose of this study is to evaluate the efficacy of infliximab in induction regimen by assessing the mean decrease in Disease Activity Index for intestinal Behcet's disease (DAIBD) sc...

Effect of Harvoni on Proteinuria and Estimated Glomerular Filtration Rate (eGFR) in Hepatitis C (HCV) Associated Chronic Kidney Disease (CKD)

Treatment protocol to see if people with hepatitis C (HCV) and chronic kidney disease (CKD) who are treated with Harvoni for 12 weeks have improvements in their kidney disease.

Sample Collection Study to Evaluate DNA Markers in Subjects With Inflammatory Bowel Disease (IBD)

The primary objective of this study is to gather stool samples from subjects with inflammatory bowel disease (IBD) to be added to a test set of stool samples that will be utilized to help ...

A Study of an Investigational Drug, ALN-AAT, in Healthy Adult Subjects and Patients With ZZ Type Alpha-1 Antitrypsin Deficiency Liver Disease

The purpose of this study is to evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Subcutaneously Administered ALN-AAT in Healthy Adult Subjects and Patients with...

Family Meeting Study for End Stage Renal Disease

A randomized clinical trial for patients with end stage renal disease in which a family consultation condition is compared against a treatment as usual control condition on the hospital re...

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Medical and Biotech [MESH] Definitions

Animate or inanimate sources which normally harbor disease-causing organisms and thus serve as potential sources of disease outbreaks. Reservoirs are distinguished from vectors (DISEASE VECTORS) and carriers, which are agents of disease transmission rather than continuing sources of potential disease outbreaks.

Analyses for a specific enzyme activity, or of the level of a specific enzyme that is used to assess health and disease risk, for early detection of disease or disease prediction, diagnosis, and change in disease status.

The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.


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