Falciparum malaria - Biotech, Pharma and Life Science Channel
PubMed Articles
Anti-inflammatory activity of ethyl acetate fraction of the seeds of Brucea Javanica.
The seeds of Brucea javanica (L.) Merr. (Yadanzi in Chinese) have been used for the treatment of inflammation, dysentery, malaria, and cancer in Chinese traditional medicine. However, the anti-inflamm...
Himatanthus articulatus (Apocynaceae) is a plant native to the Amazon, popularly used to treat external ulcers, tumors, inflammations, cancer, syphilis and malaria.
Tithonia diversifolia (Hemsl.) A. Gray has been commonly used in folk medicine to treat abscesses, microbiological infections, snake bites, malaria and diabetes. Both anti-inflammatory and anti-malari...
In many organisms the Y chromosome initiates sex determination and regulates male fertility and mating behaviour. However, molecular characterization of Y genes is rare outside of a few model species...
Metabolic plasticity for isoprenoid biosynthesis in bacteria.
Isoprenoids are a large family of compounds synthesized by all free-living organisms. In most bacteria, the common precursors of all isoprenoids are produced by the MEP (methylerythritol 4-phosphate)...
In 2007 Timor-Leste, a malaria endemic country, changed its Malaria Treatment Protocol for uncomplicated falciparum malaria from sulphadoxine-pyrimethamine to artemether-lumefantrine. The change in tr...
Plasmodium spp. parasites, the causative agents of malaria, survive and replicate in human hosts by modulating host protective immune responses. In a rodent model, malaria manifests as a severe spleno...
Multiple splenic infarcts in acute Plasmodium vivax malaria: A rare case report.
In tropical countries like India, malaria has been one of the most common parasitic illnesses leading to frequent hospitalization and causing major economic burden among the masses. Although Plasmodiu...
Plasmodium vivax cerebral malaria complicated with venous sinus thrombosis in Colombia.
Complicated malaria is usually due to Plasmodium falciparum. Nevertheless, Plasmodium vivax is infrequently related with life-threatening complications. Few cases have been reported of severe Plasmodi...
To evaluate microscopy, OptiMAL® and multiplex PCR for the identification of Plasmodium falciparumm (P. falciparum) and Plasmodium vivax (P. vivax) from the field isolates of Bikaner, Rajasthan (Nort...
News Articles
Biomarkers for early malaria diagnosis
Scientists in Japan have developed a technique that could be used to diagnose malaria using a blood plasma sample just one day after infection. It is vital to diagnose malaria as soon as possible to m...
Mosquito behavior may be immune response, not parasite manipulation
(Penn State) Malaria-carrying mosquitoes appear to be manipulated by the parasites they carry, but this manipulation may simply be part of the mosquitoes' immune response, according to Penn State ento...
Investigation and treatment of imported malaria in non-endemic countries
Summary pointsMalaria is a common cause of fever in people returning from the tropicsFalciparum malaria is potentially fatal unless treated early, and patients over 65 years are at particular risk In....
A new, highly sensitive blood test that quickly detects even the lowest levels of malaria parasites in the body could make a dramatic difference in efforts to tackle the disease in the UK and across t...
Infection Makes Mosquitoes Immune to Malaria Parasites
Researchers established a bacterial infection in mosquitoes that helps fight the parasites that cause malaria. These infected insects could be a significant tool for malaria control.
Equatorial Guinea To Renovate All Its Hospitals Within Four Years
MALABO, Equatorial Guinea, May 17, 2013 /PRNewswire-USNewswire/ -- The government of Equatorial Guinea is working to renovate all the hospitals in the country within the next four years, according to...
Pierre Guermonprez and colleagues have worked out how a subset of dendritic cells expands in individuals with severe malaria. Plasmodium infection causes an accumulation of xanthine in infected red bl...
New LAMP malaria test to improve diagnosis for imported UK cases
A new, highly sensitive blood test that quickly detects even the lowest levels of malaria parasites in the body could make a dramatic difference in efforts to tackle the disease in the UK and across t...
How can we control the spread of malaria caused by 'Plasmodium vivax'?
The New York Academy of Sciences, the "la Caixa" Foundation, B·Debate and ISGlobal are holding a conference with some twenty of the top global experts in malari...
[Comment] Infectious diseases in Pakistan: a clear and present danger
Many diseases are common in Pakistan, including endemic and epidemic infectious diseases, emerging infections, and an increasing burden of non-communicable diseases. An estimated 8–9 million people...
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Companies
We have a challenging and inspiring mission: to improve the quality of human life by enabling people to do more, feel better and live longer. This mission gives us the purpose to develop innovative me...
Profectus BioSciences, Inc. is a technology based vaccine company devoted to the treatment and prevention of chronic viral diseases with a goal of reducing morbidity and mo...
Genocea Biosciences is a vaccine discovery and development company targeting major infectious diseases with high unmet medical needs, in which T cell response helps confer protect...
Genocea Biosciences is a vaccine discovery and development company targeting major infectious diseases with high unmet medical needs, in which T cell responses help confer protect...
Okairos is a clinical-stage biopharmaceutical company, developing genetic vaccines for major infectious diseases - including malaria, hepatitis C, influenza, respiratory syncytial...
Inovio is developing a new generation of vaccines, called DNA vaccines, to treat and prevent cancers and infectious diseases. The company’s SynCon™ vaccines are designed...
Exxon Mobil Corporation and ExxonMobil Foundation, the primary philanthropic arm of Exxon Mobil Corporation in the United States, engage in a range of philanthropic activit...
The Institute for OneWorld Health is engaged in a unique drug development project to ensure consistent, affordable supplies of artemisinin, a key component of Artemisinin-Based Combination Therapies (...
Pevion Biotech AG is a fully independent Swiss vaccine company that develops innovative vaccines for unmet medical needs based on its clinically and commercially validated virosome technology. Its p...
Clinical Trials
Efficacy of Fosmidomycin-Clindamycin for Treating Malaria in Gabonese Children
There is a necessity for the development of new malaria drugs. Some antibiotics are also effective against malaria parasites. Fosmidomycin is an antibiotic that has been shown to be effect...
GSK Biologicals is developing in partnership with the Malaria Vaccine Initiative at PATH a candidate malaria vaccine RTS,S/AS02 for the routine immunization of infants and children living...
Malaria is an important cause of death and serious illness among Mozambican children. Although the risk of malaria can be reduced by drugs and by impregnated bed nets, it would be helpful...
GSK Biologicals is developing in partnership with the Program for Appropriate Technology in Health (PATH) Malaria Vaccine Initiative a candidate malaria vaccine for the routine immunizatio...
Treatment of Malaria With Quinine Plus Sulfadoxine-Pyrimethamine
Quinine remains the treatment of choice of hospitalised malaria cases. The long treatment duration of 7 days, and adverse reactions often hamper its adequate use. Reducing the treatment du...
Efficacy and Effectiveness of Combined Therapy for Uncomplicated Malaria Treatment in Peru
This is a study of the efficacy and effectiveness of combination therapy for malaria due to P. falciparum in the Loreto Department, Iquitos, Peru. The investigators will enroll subjects â...
Genetics of Alpha Thalassemia in Israeli Ethnic Groups
Alpha thalassemia causes mild anemia and is found in many ethnic groups. Usually it is found in regions where malaria is endemic. We have found that alpha thalassemia is common in Ashkenaz...
To Evaluate Current Efficacy of Antimalarials Used in Timika, Papua, Indonesia
Multidrug resistant strains of P.falciparum and P.vivax are becoming increasingly prevalent in the Asia Pacific rim. To determine the efficacy of locally recommended antimalarial protocol...
A Trial of Antimalarial Drugs Used in Pregnancy in Tanzania
Pregnant women are vulnerable to malaria, with significant implications both for their health and for the pregnancy. Sulfadoxine-pyrimethamine (SP) is currently the first line drug for the...
Anti-Malarial Drug Resistance in Cameroon
The project is a three-armed study designed to evaluate the efficacy of amodiaquine(AQ), sulphadoxine-pyrimethamine(SP) and(AQ+SP) in three sites in Cameroon that differ in their baseline...
Videos
Malaria
Protein Lounge animations @ http://www.proteinlounge.com/Animation/Animation.aspx Malaria is a vector-borne infectious disease caused by a protozoan parasite...
Medical and Biotech [MESH] Definitions
Plasmodium Ovale
A species of protozoan parasite causing MALARIA. It is the rarest of the four species of PLASMODIUM infecting humans, but is common in West African countries and neighboring areas.
Anopheles Gambiae
A species of mosquito in the genus Anopheles and the principle vector of MALARIA in Africa.
Schizonts
Multinucleate cells or a stage in the development of sporozoan protozoa. It is exemplified by the life cycle of PLASMODIUM FALCIPARUM in the MALARIA infection cycle.
Proguanil
A biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.
Primaquine
An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Adverse effects include anemias and GI disturbances. (From Martindale, The Extra Pharmacopeia, 30th ed, p404)
