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Fatal Insomnia - Biotech, Pharma and Life Science Channel

06:53 EDT 26th September 2017 | BioPortfolio

PubMed Articles [865 Associated PubMed Articles listed on BioPortfolio]

Development of a quantitative approach in blood plasma for low-dosed hallucinogens and opioids using LC-high resolution mass spectrometry.

The WHO annually reports an increasing abuse of new psychoactive substances (NPS), which are a heterogeneous group of synthetic drugs and are consumed as substitute for controlled drugs of abuse. In t...

Outcomes after concomitant traumatic brain injury and hemorrhagic shock: A secondary analysis from the Pragmatic, Randomized Optimal Platelets and Plasma Ratios trial.

Often the clinician is faced with a diagnostic and therapeutic dilemma in patients with concomitant traumatic brain injury (TBI) and hemorrhagic shock (HS), as rapid deterioration from either can be f...

Catastrophic cement reaction following cementation for megaprosthesis for proximal femoral fracture.

Bone cement implantation syndrome (BCIS) is a well-described and potentially fatal complication of orthopaedic surgery involving pressurised bone cement. Although also described for certain spinal pro...

Case of methaemoglobinaemia caused by tree oils and kerosene.

We report a case of a young man who allegedly consumed 100 mL of an indigenous pesticide which is used for the killing of rats in households in India. The constituents were azadirachtin oil (40%), t...

Synthesis of 2,4-Diaminopyrimidine Core-Based Derivatives and Biological Evaluation of Their Anti-Tubercular Activities.

Tuberculosis (TB) is a chronic, potentially fatal disease caused by Mycobacterium tuberculosis (Mtb). The dihyrofolate reductase in Mtb (mt-DHFR) is believed to be an important drug target in anti-TB ...

Aspalathin Reverts Doxorubicin-Induced Cardiotoxicity through Increased Autophagy and Decreased Expression of p53/mTOR/p62 Signaling.

Doxorubicin (Dox) is an effective chemotherapeutic agent used in the treatment of various cancers. Its clinical use is often limited due to its potentially fatal cardiotoxic side effect. Increasing ev...

Humoral Response of Buffaloes to a Recombinant Vaccine against Botulism Serotypes C and D.

Botulism is a fatal intoxication caused by botulinum neurotoxins (BoNTs), which are mainly produced by Clostridium botulinum and characterized by flaccid paralysis. The BoNTs C and D are the main sero...

Dynamic daily associations between insomnia symptoms and alcohol use in adults with chronic pain.

Individuals with chronic pain are at risk for sleep disruption and heavy alcohol use, yet the daily associations between these behaviours are not well characterized. This study aimed to determine the ...

Methods for delivering the UK's multi-centre prison-based naloxone-on-release pilot randomised trial (N-ALIVE): Europe's largest prison-based randomised controlled trial.

Naloxone is an opioid antagonist used for emergency resuscitation following opioid overdose. Prisoners with a history of heroin use by injection have a high risk of drug-related death in the first wee...

Young females at risk while driving with a small child.

Previous research suggests that young mothers with little driving experience are at risk when driving with a small child passenger. In this study we examined the prevalence, characteristics and risk o...

News Articles [727 Associated News Articles listed on BioPortfolio]

Distinct Phosphate Targets Feasible, Pilot Study Shows

A randomized controlled pilot study demonstrated the feasibility and safety of performing a large clinical trial that is powered to establish whether phosphate lowering reduces fatal and nonfatal card...

Opsidio Closes Bridge Financing to Develop Monoclonal Antibodies to Treat Fibrotic Diseases

Opsidio, LLC closed today on the first tranche of a bridge financing, led by BioAdvance and private investors. Opsidio is a Bryn Mawr, PA based biotech company developing monoclon...

Ash Trees Are Dying in Philadelphia as Emerald Ash Borers Kill Trees that Have Not Been Protected with Treatment

Philadelphia, PA (PRWEB) September 25, 2017 Emerald Ash Borers kill Ash trees in as little as 1-3 years. The signs of this fatal ...

Report: Exhausted Employees Cost American Companies Millions of Dollars Annually

INDIANAPOLIS, Sept. 25, 2017 /PRNewswire-USNewswire/ -- Sleep disorders and sleep deficiency are hidden workplace issues that affect employers across America. New research from the National Safety Cou...

Neurim Pharmaceuticals' New Paediatric Prolonged-Release Melatonin ('PedPRM') to be Marketed by Flynn Pharma in UK and Ireland

TEL AVIV, Israel, September 25, 2017 /PRNewswire/ -- Neurim Pharmaceuticals ('Neurim') and Flynn Pharma ('Flynn') announced today a license agreement in which Flynn will obtain the exclusive marke...

Sleep Training Moves Beyond Medication to Provide Lasting Treatment for 60 Million Patients Struggling with Insomnia, According to Osteopathic Physicians

CHICAGO, Sept. 25, 2017 /PRNewswire-USNewswire/ -- For the estimated 60 million people struggling with insomnia, sleep training is an underutilized treatment that can move patients away from medicatio...

Republicans make desperate bid to save health care bill

Republican opposition to the GOP health care bill swelled to near-fatal numbers Sunday as Sen. Susan Collins all but closed the door on supporting the last-ditch effort to scrap the Obama health care ...

Merck Eshmuno P anti-A and anti-B chromatography resins

Merck has launched the Eshmuno P anti-A and Eshmuno P anti-B affinity chromatography resins, specifically designed to remove anti-A and anti-B isoagglutinin antibodies during the manufacturing of plas...

Woman Bitten Several Times By Copperhead Snake At LongHorn Steakhouse

Copperhead snakes bite more people in the U.S. than any other snake species. Although their bites are typically not fatal to humans but are serious and should be treated with medical attention immedia...

St Louis protests: Journalists say they were beaten and arrested by police while covering demonstrations

Reporters say they were pepper sprayed, beaten, and arrested by St Louis police while covering protests in the midwestern city. Police arrested more than 200 people over the weekend, as protesters to...

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Companies [22 Associated Companies listed on BioPortfolio]

Happify Health

Happify Health (www.HappifyHealth.com) offers evidence-based emotional health behavioral change technology solutions for employers, health plans and enterprise organizations. ...

Agilis Biotherapeutics and GTRI

Agilis is advancing innovative gene therapies designed to provide long-term efficacy for patients with debilitating, often fatal, rare genetic diseases that affect the central ner...

Agilis Biotherapeutics, Inc.

Agilis is advancing innovative gene therapies designed to provide long-term efficacy for patients with debilitating, often fatal, rare genetic diseases that affect the central ner...

Rasna Therapeutics, Inc.

Rasna Therapeutics, Inc. is a development stage biotechnology company focused primarily on the high unmet need that exists for leukemias. Rasna’s primary indication is acute ...

Rasna Therapeutics , Inc.

Rasna Therapeutics, Inc. is a biotechnology company focused primarily on the high unmet need that exists for leukemias. Rasna’s primary indication is acute myeloid leukemia (...

CurePSP

CurePSP is the leading nonprofit advocacy organization focused on prime of life neurodegenerative diseases – a spectrum of fatal brain disorders that often strike during a pe...

Voyager Therapeutics

Voyager Therapeutics is a gene therapy company developing life-changing treatments for fatal and debilitating diseases of the central nervous system (CNS). Voyager is committed to...

Ario Pharma Ltd

ario pharma ltd focusses on the development of drugs for the treatment of respiratory indications. Ario is about to evaluate the anti-tussive properties of XEN-D0501, a potential best-in-class TRPV1...

Agilis Biotherapeutics, LLC

Agilis Biotherapeutics, LLC, is a biotechnology company focused on designing and engineering first-in-class DNA-based therapeutics to improve and save the lives of patients affect...

Edge Therapeutics, Inc.

Edge Therapeutics, Inc. is a private, clinical-stage biopharmaceutical company focused on developing and commercializing life-saving hospital products that improve patient outcome...

Clinical Trials [609 Associated Clinical Trials listed on BioPortfolio]

Autoantibody Reduction for Acute Exacerbations of Idiopathic Pulmonary Fibrosis

Acute exacerbations (AE) are a dreaded manifestation of idiopathic pulmonary fibrosis (IPF) that presents with rapidly worsening respiratory function over days to weeks. AE account for abo...

A Study to Assess the Pharmacodynamic Effects of SAGE-217 in Healthy Adults Using an Insomnia Model

This study will assess the pharmacodynamic effects of SAGE-217 in approximately 42 healthy adult subjects using an insomnia model.

Female Aneurysm Screening STudy

An abdominal aortic aneurysm (AAA) is a swelling of the main blood vessel (aorta) in the abdomen. If the swelling gets too large the aorta can burst and this is usually fatal. In order to ...

Angiography for Evaluation of the Feeder Vessel in EUS-guided Coils and Cyanoacrylate Therapy for Gastric Varices

INTRODUCTION: Bleeding from gastric varices (GV) is associated with a high mortality rate. Injection of cyanoacrylate (CYA) using standard gastroscope has demonstrated to achieve higher he...

Cross-sectional Study on Insomnia and Depression Using Home Sleep Monitors

The investigators hypothesized that depression is associated with home sleep EEG, subjective sleepiness and insomnia symptoms. To test this, the investigators plan to perform sleep examina...

Sleep Disorders in Transient Ischemic Attack and Stroke: SOMN'AIC Study

Sleep disorders in the setting of stroke are numerous, including sleep-related breathing disorders, insomnia, excessive daytime sleepiness and restless legs syndrome. Consequences of these...

Mindfulness Based Intervention for Insomnia ('Joyful Sleep') in Young and Middle-aged Patients With Insomnia

The primary objective of this proposed three-year (January 01, 2018 to December 31,2020) project is to verify the effect of 'Joyful Sleep' intervention on young and middle-aged patients wi...

Non-inferiority Study of Telemedicine Versus Conventional CBT-I in Recently Hospitalized Patients With Insomnia

Insomnia is a common medical condition that has a deleterious effect on emotional status, health-related quality of life, and has been associated with hospitalizations and all-cause mortal...

Ramelteon for Complex Insomnia in Veterans With PTSD

Obstructive sleep apnea is commonly reported in Veterans with post-traumatic stress disorder, which can potentiate symptoms of anxiety and depression, daytime symptoms and worsen nightmare...

Non-Pharmacological Treatments for Insomnia in Chronic Traumatic Brain Injury

The purpose of this clinical trial is to assess the relative efficacy of two non-pharmacological interventions for insomnia in Veterans suffering from chronic mild traumatic brain injury (...

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Medical and Biotech [MESH] Definitions

An autosomal dominant disorder characterized by degeneration of the THALAMUS and progressive insomnia. It is caused by a mutation in the prion protein (PRIONS).

An acute organic mental disorder induced by cessation or reduction in chronic alcohol consumption. Clinical characteristics include CONFUSION; DELUSIONS; vivid HALLUCINATIONS; TREMOR; agitation; insomnia; and signs of autonomic hyperactivity (e.g., elevated blood pressure and heart rate, dilated pupils, and diaphoresis). This condition may occasionally be fatal. It was formerly called delirium tremens. (From Adams et al., Principles of Neurology, 6th ed, p1175)

Membrane glycosylphosphatidylinositol-anchored glycoproteins that may aggregate into rod-like structures. The prion protein (PRNP) gene is characterized by five TANDEM REPEAT SEQUENCES that encode a highly unstable protein region of five octapeptide repeats. Mutations in the repeat region and elsewhere in this gene are associated with CREUTZFELDT-JAKOB DISEASE; FATAL FAMILIAL INSOMNIA; GERSTMANN-STRAUSSLER DISEASE; Huntington disease-like 1, and KURU.

Small proteinaceous infectious particles which resist inactivation by procedures that modify NUCLEIC ACIDS and contain an abnormal isoform of a cellular protein which is a major and necessary component. The abnormal (scrapie) isoform is PrPSc (PRPSC PROTEINS) and the cellular isoform PrPC (PRPC PROTEINS). The primary amino acid sequence of the two isoforms is identical. Human diseases caused by prions include CREUTZFELDT-JAKOB SYNDROME; GERSTMANN-STRAUSSLER SYNDROME; and INSOMNIA, FATAL FAMILIAL.

A hypnotic and sedative used in the treatment of INSOMNIA.

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