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Fatal Insomnia - Biotech, Pharma and Life Science Channel

21:36 EDT 24th July 2014 | BioPortfolio

PubMed Articles [950 Associated PubMed Articles listed on BioPortfolio]

The occurrence of Naegleria fowleri in recreational waters in Arizona.

Naegleria fowleri is a free-living amoeba found in waters in warmer regions that causes primary amoebic meningoencephalitis, a rare but almost universally fatal disease. The goal of this project was t...

Fatal Outbreak of Polyclonal Candidemia in a Neonatal Intensive Care Unit.

190 Mechanism for Sudden Unexpected Death in Epilepsy: The Amygdala as a Pathway to Seizure-Induced Apnea, Respiratory Agnosia and Sudden Death.

Sudden unexpected death in epilepsy (SUDEP) is the most common cause of death in patients with chronic refractory epilepsy. Case studies suggest that the cause of SUDEP may be respiratory depression i...

Invasive management without stents in selected acute coronary syndrome patients with a large thrombus burden: a prospective study of optical coherence tomography guided treatment decisions.

Aims: To assess whether a strategy of invasive management without stents in selected acute coronary syndrome (ACS) patients with a large thrombus burden (LTB) might be feasible and safe. Methods and r...

Ogilvie's syndrome after pediatric spinal deformity surgery: successful treatment with neostigmine.

Ogilvie's syndrome is a rare and potentially fatal disease that can easily be mistaken for postoperative ileus. Also known as acute colonic pseudo-obstruction, early recognition and diagnosis of the s...

Oroya Fever and Verruga Peruana: Bartonelloses Unique to South America.

Bartonella bacilliformis is the bacterial agent of Carrión's disease and is presumed to be transmitted between humans by phlebotomine sand flies. Carrión's disease is endemic to high-altitude valley...

The control of anaplastic thyroid carcinoma cell lines by oncolytic poxviruses.

Anaplastic thyroid cancer (ATC) is rare, but its clinical presentation is often dramatic and aggressive and is nearly uniformly fatal. Oncolytic viral therapy is a potential strategy to improve outcom...

Carotid Blowout Syndrome: Endovascular Management of Acute Hemorrhage with Tapering Overlapped Covered Stents.

Carotid blowout is a rare fatal complication most commonly observed in head and neck cancer patients, especially after radiation therapy. Traditional surgical approaches carry extremely high morbidity...

Protective immunity against infectious spleen and kidney necrosis virus induced by immunization with DNA plasmid containing mcp gene in Chinese perch Siniperca chuatsi.

Infectious spleen and kidney necrosis virus (ISKNV) is the causative agent of a disease leading to high mortality and economic losses in Chinese perch, Siniperca chuatsi. There is an urgent need to de...

Phase I study of olaparib in combination with liposomal doxorubicin in patients with advanced solid tumours.

Background:Olaparib, an oral PARP inhibitor, has shown antitumour activity as monotherapy in patients with germline BRCA1/2 (gBRCA)-mutated breast and ovarian cancer. This study evaluated olaparib cap...

News Articles [742 Associated News Articles listed on BioPortfolio]

CBT for Insomnia After Primary Breast Cancer Treatment

Find out how nurse-delivered therapy impacts insomnia in women who have undergone breast cancer treatment. Oncology Nursing Forum

Finding Sleep Apnea Patients with the Help of Sleep Apnea Doctors

LOS ANGELES, July 24, 2014 /PRNewswire/ -- Sleep doctors looking to cast a wider net for sleep apnea patients can list their practice with Sleep Doctors at SleepApneaDoctors.us. No matter the sta...

Shire gains rights to ArmaGen's Hunter syndrome drug in up to $225M deal

ArmaGen granted Shire the global rights to develop and market its enzyme replacement therapy AGT-182, which is under developm -More- Study Shows Glutathione is Effective When Taken Orally G...

NYSCF and Beyond Batten Disease Foundation partner to find cure for juvenile Batten disease

The New York Stem Cell Foundation (NYSCF) and Beyond Batten Disease Foundation (BBDF) have partnered to develop stem cell resources to investigate and explore new treatments and ultimately find a cure...

The New York Stem Cell Foundation Partners With Beyond Batten Disease Foundation to Fight Juvenile Batten Disease

Batten Disease Support and Research Association collaborates to give families the opportunity to participate at its Annual Family Conference. New York, NY (PRWEB) July 23, 2014 The New York Stem Cell...

FDA Approves Malignant Hyperthermia Drug

Eagle Pharmaceuticals Inc. announced that the U.S. Food and Drug Administration (FDA) has approved Ryanodex (dantrolene sodium) for injectable suspension indicated for the treatment of malignant hyper...

FDA approves Gilead's idelalisib

FDA approved Zydelig idelalisib from Gilead Sciences Inc. (NASDAQ:GILD) on Wednesday for three blood cancers. The agency granted full approval to Zydelig in combination with rituximab to treat relapse...

FDA approves Eagle's Ryanodex for malignant hyperthermia

FDA approved an NDA from Eagle Pharmaceuticals Inc. (NASDAQ:EGRX) for Ryanodex dantrolene to treat malignant hyperthermia. The company said it plans to launch the drug next month at a wholesale acquis...

BioFire Diagnostics Initiates Clinical Study for the FilmArray™ Meningitis/Encephalitis Panel

Molecular test will quickly identify infectious causes of meningitis and encephalitis BioFire Diagnostics, LLC, bioMérieux’s molecular biology affiliate, announced t...

My Positive Perspective Airs Episode to Raise Attention to the Group Darkness to Light

My Positive Perspective broadcasts an episode that featured the group Darkness to light. The group has the purpose of recognizing and preventing childhood sexual abuse. Charleston, SC (PRWEB) July 23,...

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Companies [16 Associated Companies listed on BioPortfolio]

Akashi Therapeutics, Inc.

Akashi Therapeutics is a clinical stage biopharmaceutical company whose mission is to develop treatments for Duchenne muscular dystrophy and other rare pediatric diseases....

Ario Pharma Ltd

ario pharma ltd focusses on the development of drugs for the treatment of respiratory indications. Ario is about to evaluate the anti-tussive properties of XEN-D0501, a potential best-in-class TRPV1...

Takeda Pharmaceuticals U.S.A., Inc. and Affymax, Inc.

Based in Deerfield, Ill., Takeda Pharmaceuticals U.S.A., Inc. and Takeda Global Research & Development Center, Inc. are subsidiaries of Takeda Pharmaceutical Company Limited, the...

Takeda Pharmaceuticals U.S.A. and Affymax, Inc.

Based in Deerfield, Ill., Takeda Pharmaceuticals U.S.A., Inc. and Takeda Development Center Americas, Inc. are subsidiaries of Takeda Pharmaceutical Company Limited, the largest p...

Oxyrane UK Limited

WHO WE ARE Oxyrane UK Limited is a biopharmaceutical company dedicated to the development of novel and biosuperior enzyme replacement therapies (ERT) to treat lysosomal storage diseases, a class o...

Alpha-Stim

Alpha-Stim is an industry leader in cranial electrotherapy stimulation (CES) devices, providing treatment for anxiety, depression, insomnia and pain, without the side effects comm...

Isabel Healthcare Inc.

Isabel Healthcare Inc. was founded in 2000 by Jason Maude and is named after Maude’s daughter who almost died after a potentially fatal illness was not recognized. Isabel Hea...

Fisher Wallace Laboratories

Founded by Charles Avery Fisher, the son of stereo pioneer Avery Fisher, Fisher Wallace Laboratories manufactures the Fisher Wallace Cranial Stimulator, a cranial electrotherapy stimulation (CES) devi...

Janssen Alzheimer Immunotherapy

Alzheimer's disease (AD), the most common form of dementia, is a fatal, degenerative brain disease that gradually destroys a person's memory and ability to learn, reason, make judgments, communicate a...

Akashi Therapeutics

Akashi Therapeutics is a clinical stage biopharmaceutical company whose mission is to develop treatments for Duchenne muscular dystrophy and other rare pediatric diseases. Akashi...

Clinical Trials [348 Associated Clinical Trials listed on BioPortfolio]

Treating Sleep Problems in VA Adult Day Health Care

The Veterans Millennium Health Care and Benefits Act (Millennium Act) of 1999 mandated the Department of Veterans Affairs (VA) to provide non-institutional long-term care to veterans. Adul...

Cardiovascular Disease (CVD) in Haemophilia

Life expectancy of hemophilia patients has improved considerably during the past decades and is approaching that of the general population. Hemophilia patients are therefore likely to be c...

Systolic Hypertension in the Elderly Program (SHEP)

The primary objective was to assess whether long-term administration of antihypertensive therapy to elderly subjects with isolated systolic hypertension reduced the combined incidence of f...

A Study of Health-Related Quality of Life in HIV-Infected Patients Undergoing Structured Treatment Interruptions of Highly Active Antiretroviral Therapy

This study will examine and compare the health-related quality of life and degree of symptom discomfort in two groups of patients receiving intensive drug therapy for HIV infection. One gr...

Antihypertensive Drug/Gene Interactions and CV Events

To investigate drug-gene interactions on the incidence of non-fatal myocardial infarction and stroke for hypertensive patients.

Study of Prostate Cancer in Black and White U.S. Veterans

Prostate cancer is diagnosed in approximately 334,500 men each year and accounts for nearly 41,800 deaths in the United States. Prostate cancer is the leading cancer affecting veterans a...

Dichloroacetate Kinetics, Metabolism and Toxicology

Dichloroacetate (DCA) is a product of water chlorination and a metabolite of certain industrial solvents, thus making it a chemical of environmental concern. However, DCA is also used as a...

Combined Behavioral/Pharmacological Therapy for Insomnia

This study will determine how sleeping pills can be combined with nondrug treatments to maximize the benefits of therapy for insomnia.

Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management and Avoidance (CHARISMA)

RATIONALE: - Atherothrombosis is a progressive and generalized vascular disease resulting in events leading to myocardial infarction (heart attack), stroke, and vascular death....

Pegylated Interferon Alfa-2a Maintenance Therapy and Liver Disease Progression in People Infected With Both HIV and Hepatitis C Virus (HCV)

Infection with both HIV and hepatitis C virus (HCV) may result in serious and sometimes fatal liver disease. The purpose of this study is to test the effectiveness of long-term pegylated i...

Videos

Dying To Sleep - Documentary

This documentary deals with a very rare and unusual prion disease called Fatal Familial Insomnia or FFI for short. FFI is a prion disease that targets the th...

Medical and Biotech [MESH] Definitions

An autosomal dominant disorder characterized by degeneration of the THALAMUS and progressive insomnia. It is caused by a mutation in the prion protein (PRIONS).

An acute organic mental disorder induced by cessation or reduction in chronic alcohol consumption. Clinical characteristics include CONFUSION; DELUSIONS; vivid HALLUCINATIONS; TREMOR; agitation; insomnia; and signs of autonomic hyperactivity (e.g., elevated blood pressure and heart rate, dilated pupils, and diaphoresis). This condition may occasionally be fatal. It was formerly called delirium tremens. (From Adams et al., Principles of Neurology, 6th ed, p1175)

Small proteinaceous infectious particles which resist inactivation by procedures that modify NUCLEIC ACIDS and contain an abnormal isoform of a cellular protein which is a major and necessary component. The abnormal (scrapie) isoform is PrPSc (PRPSC PROTEINS) and the cellular isoform PrPC (PRPC PROTEINS). The primary amino acid sequence of the two isoforms is identical. Human diseases caused by prions include CREUTZFELDT-JAKOB SYNDROME; GERSTMANN-STRAUSSLER SYNDROME; and INSOMNIA, FATAL FAMILIAL.

A hypnotic and sedative used in the treatment of INSOMNIA.

A benzodiazepine used in the treatment of anxiety, alcohol withdrawal, and insomnia.

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