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Fatal Insomnia - Biotech, Pharma and Life Science Channel

21:38 EST 9th February 2016 | BioPortfolio

PubMed Articles [824 Associated PubMed Articles listed on BioPortfolio]

Neonatal multiorgan failure due to ACAD9 mutation and complex I deficiency with mitochondrial hyperplasia in liver, cardiac myocytes, skeletal muscle, and renal tubules.

Complex I deficiency causes Leigh syndrome, fatal infant lactic acidosis, and neonatal cardiomyopathy. Mutations in more than 100 nuclear DNA and mitochondrial DNA genes miscode for complex I subunits...

Protective Effects of Myrtol Standardized Against Radiation-Induced Lung Injury.

As a major complication after thoracic radiotherapy, radiation-induced lung injury (RILI) has great impact on long term quality of life and could result in fatal respiratory insufficiency The present ...

Rabies in the Baltic States: Decoding a Process of Control and Elimination.

Rabies is a fatal zoonosis that still causes nearly 70, 000 human deaths every year. In Europe, the oral rabies vaccination (ORV) of red foxes (Vulpes vulpes) was developed in the late 1970s and has d...

Potent Inhibition of Pseudogymnoascus destructans, the Causative Agent of White-Nose Syndrome in Bats, by Cold-Pressed, Terpeneless, Valencia Orange Oil.

The causative agent of White-nose Syndrome (WNS), Pseudogymnoascus destructans, has been shown to be fatal to several species of bats in North America. To date, no compounds or chemical control measur...

Acidic pH-Induced Conformations and LAMP1 Binding of the Lassa Virus Glycoprotein Spike.

Lassa virus is an enveloped, bi-segmented RNA virus and the most prevalent and fatal of all Old World arenaviruses. Virus entry into the host cell is mediated by a tripartite surface spike complex, wh...

Acute lymphoblastic leukemia in the context of rasopathies.

Noonan syndrome is associated with a range of malignancies including acute lymphoblastic leukemia (ALL). However, little information is available regarding the frequency, natural history, characterist...

Treatment of Subjective Total Insomnia After Suicide Attempt With Olanzapine and Electroconvulsive Therapy.

Rotigotine in Hemodialysis-Associated Restless Legs Syndrome: A Randomized Controlled Trial.

Restless legs syndrome (RLS) has been associated with insomnia, decreased quality of life, and increased morbidity and mortality in end-stage renal disease. This randomized controlled trial investigat...

Involvement of the Nervous System Following Experimental Infection with Pasteurella multocida B:2 in Buffalo (Bubalus bubalis): a Clinicopathological Study.

Haemorrhagic septicaemia (HS) is an acute, fatal, septicaemic disease of cattle and buffaloes caused by one of two specific serotypes of Pasteurella multocida B:2 and E:2 in Asian and African, respect...

OXYGEN MITIGATES THE INFLAMMATORY RESPONSE IN A MODEL OF HEMORRHAGE AND ZYMOSAN-INDUCED INFLAMMATION.

Sequential insults (hits) may change the inflammatory reaction that develops in response to separate single hits (e.g., injury, infection); however, their effects on the long-term clinical outcome are...

News Articles [439 Associated News Articles listed on BioPortfolio]

Auricular acupressure helps with postpartum insomnia

(HealthDay)—Auricular acupressure is an effective alternative complementary therapy for postpartum women with insomnia, according to a study published in the February issue of the Journal of Clinica...

Asian gudgeon bring new terror to rivers

Small in size but significant in terms of the ecological and economic damage they cause, Asian gudgeon are invading a great number of water courses across the world, particularly in Europe. These fish...

Poor REM sleep may be linked to higher risk for anxiety, depression

(HealthDay)—REM (rapid eye movement) sleep is the phase when dreams are made, and a lack of good REM sleep has long been associated with chronic insomnia.

Living Tree Community Foods Recalls Macadamia Nuts and Macadamia Butter Because of Possible Health Risk

Living Tree Community Foods of Berkeley, California is recalling Organic Macadamia Nuts and Organic Macadamia Butter, because it has the potential to be contaminated with Salmonella, an organism which...

Defibrotide's Promise in Rare but Fatal Syndrome Post HSCT

Phase 3 data from a trial that used historical controls to assess safety and efficacy of defibrotide show that it confers survival benefits in patients with VOD and multiorgan failure after HSCT. Me...

Oregon teen’s death linked to rare measles complication

The Oregon Health Authority reported that the 2015 death of a boy aged 14 years was the result of subacute sclerosing panencephalitis, a rare but fatal complication of measles, according to a case stu...

MERS Virus Targets Lungs (CME/CE)

(MedPage Today) -- First autopsy in fatal case increases understanding of pathogenesis

UPDATE 3-California doctor gets 30 years to life in landmark overdose case

LOS ANGELES, Feb 5 (Reuters) - A Southern California doctor was sentenced to 30 years to life in prison on Friday for over-prescribing drugs that caused the fatal overdose of three patients in a murde...

UPDATE 2-California doctor gets 30 years to life in landmark overdose case

LOS ANGELES, Feb 5 (Reuters) - A Southern California doctor was sentenced to 30 years to life in prison on Friday for over-prescribing drugs that caused the fatal overdose of three patients in a murde...

Epistem Plc Tuberculosis Diagnostic Collaboration

Epistem and Xcelris will be evaluating Epistem’s Genedrive™ molecular device as part of India’s RNTCP (Revised National Tuberculosis Control Programme) which started in 1997 and sinc...

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Companies [17 Associated Companies listed on BioPortfolio]

CurePSP

CurePSP is the leading nonprofit advocacy organization focused on prime of life neurodegenerative diseases – a spectrum of fatal brain disorders that often strike during a pe...

Voyager Therapeutics

Voyager Therapeutics is a gene therapy company developing life-changing treatments for fatal and debilitating diseases of the central nervous system (CNS). Voyager is committed to...

Ario Pharma Ltd

ario pharma ltd focusses on the development of drugs for the treatment of respiratory indications. Ario is about to evaluate the anti-tussive properties of XEN-D0501, a potential best-in-class TRPV1...

Agilis Biotherapeutics, LLC

Agilis Biotherapeutics, LLC, is a biotechnology company focused on designing and engineering first-in-class DNA-based therapeutics to improve and save the lives of patients affect...

Edge Therapeutics, Inc.

Edge Therapeutics, Inc. is a private, clinical-stage biopharmaceutical company focused on developing and commercializing life-saving hospital products that improve patient outcome...

Takeda Pharmaceuticals U.S.A., Inc. and Affymax, Inc.

Based in Deerfield, Ill., Takeda Pharmaceuticals U.S.A., Inc. and Takeda Global Research & Development Center, Inc. are subsidiaries of Takeda Pharmaceutical Company Limited, the ...

Takeda Pharmaceuticals U.S.A. and Affymax, Inc.

Based in Deerfield, Ill., Takeda Pharmaceuticals U.S.A., Inc. and Takeda Development Center Americas, Inc. are subsidiaries of Takeda Pharmaceutical Company Limited, the largest p...

Oxyrane UK Limited

WHO WE ARE Oxyrane UK Limited is a biopharmaceutical company dedicated to the development of novel and biosuperior enzyme replacement therapies (ERT) to treat lysosomal storage diseases, a class o...

Alpha-Stim

Alpha-Stim is an industry leader in cranial electrotherapy stimulation (CES) devices, providing treatment for anxiety, depression, insomnia and pain, without the side effects comm...

Janssen Alzheimer Immunotherapy

Alzheimer's disease (AD), the most common form of dementia, is a fatal, degenerative brain disease that gradually destroys a person's memory and ability to learn, reason, make judgments, communicate a...

Clinical Trials [437 Associated Clinical Trials listed on BioPortfolio]

Effects of Neuro-Stim System on Pain, Sleep, and Opioid Use

The purpose of this study is to evaluate the ability of Neuro-Stim System, a non-pharmacologic alternative for pain management, to reduce pain and treat insomnia. Neuro-Stim System uses el...

Pilot Study of a Combination Drug Product for Treatment of Short-term Insomnia

The purpose of this study is to evaluate the effect of a combination drug product containing diphenhydramine, zolpidem and lorazepam on total sleep time. Participants will be adults who so...

Preoperative Fibroscopy as a Predictor of the Difficulty of Laryngoscopy and Intubation

The aim of this study is the evaluation of preoperative transnasal fiberoscopy, as a possible predictor of difficult laryngoscopy and intubation during elective general anesthesia in an ad...

Naloxone Auto-injector as a Universal Precaution for Patients With Opioid Substance Use Disorder

The purpose of this pilot-study is to to distribute naloxone auto-injector in a "Universal Precaution" manner to patients with opioid substance use disorder. The objectives are to decrease...

A Six Week, Randomized, Double-Blind Placebo-Controlled, Suvorexant Augmentation Study of Antidepressant Treatment of Major Depressive Disorder With Residual Insomnia

Depression with ongoing insomnia is a common clinical presentation with patients. Clinical data suggests that patients with insomnia that receive concomitant treatment with a sleep aid exp...

The Exploratory Study to Investigate the Effect of Ramelteon for Insomnia Patients With Major Depressive Disorder by Using Actigraphy

This study will investigate exploratorily the effect of ramelteon 8 mg once daily for 8 weeks in treatment for insomnia participants with depression by using actigraphy.

Iatrogenic Effects of Treatment for Childhood Cancer Constitution of a Biological Samples Bank

The constitution of a biological samples bank, attached to epidemiological studies Cohort F-CCSS on iatrogenic effects of treatment of childhood cancer, will identify genetic variants that...

Impact of Sleep Workshops in College Students

The purpose of this pilot study is to assess the impact of sleep workshops on sleep, mood, anxiety and well-being measures in a sample of college students. College students have a high pre...

CBT-I for Veterans With TBI

Many Operation Enduring Freedom/Operation Iraqi Freedom/Operation New Dawn era Veterans have suffered a mild traumatic brain injury (mTBI), and now cope with multiple post-injury symptoms,...

The Effect of White Noise In High Noise Environment

Many patients complain to clinicians that they have difficulty sleeping appears to be due to environmental noise. There is a common perception that acute noises are more troublesome than c...

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Medical and Biotech [MESH] Definitions

An autosomal dominant disorder characterized by degeneration of the THALAMUS and progressive insomnia. It is caused by a mutation in the prion protein (PRIONS).

An acute organic mental disorder induced by cessation or reduction in chronic alcohol consumption. Clinical characteristics include CONFUSION; DELUSIONS; vivid HALLUCINATIONS; TREMOR; agitation; insomnia; and signs of autonomic hyperactivity (e.g., elevated blood pressure and heart rate, dilated pupils, and diaphoresis). This condition may occasionally be fatal. It was formerly called delirium tremens. (From Adams et al., Principles of Neurology, 6th ed, p1175)

Small proteinaceous infectious particles which resist inactivation by procedures that modify NUCLEIC ACIDS and contain an abnormal isoform of a cellular protein which is a major and necessary component. The abnormal (scrapie) isoform is PrPSc (PRPSC PROTEINS) and the cellular isoform PrPC (PRPC PROTEINS). The primary amino acid sequence of the two isoforms is identical. Human diseases caused by prions include CREUTZFELDT-JAKOB SYNDROME; GERSTMANN-STRAUSSLER SYNDROME; and INSOMNIA, FATAL FAMILIAL.

A hypnotic and sedative used in the treatment of INSOMNIA.

A benzodiazepine used in the treatment of anxiety, alcohol withdrawal, and insomnia.

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