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Fatal Insomnia - Biotech, Pharma and Life Science Channel

18:04 EDT 25th May 2017 | BioPortfolio

PubMed Articles [839 Associated PubMed Articles listed on BioPortfolio]

Social Risk and Protective Factors in Adolescents' Reduction and Cessation of Alcohol Use.

Adolescents' alcohol use is related to many health problems, injuries, and violent acts, some with fatal consequences. A gap exists in the literature discussing risk/protective factors in change from ...

Component Resolved Diagnosis in Hymenoptera Anaphylaxis.

Hymenoptera anaphylaxis is one of the leading causes of severe allergic reactions and can be fatal. Venom-specific immunotherapy (VIT) can prevent a life-threatening reaction; however, confirmation of...

Sleep in Children with Autism Spectrum Disorder.

The purposes of this paper are to provide an overview of the state of the science of sleep in children with autism spectrum disorder (ASD), present hypotheses for the high prevalence of insomnia in ch...

Isometric Handgrip as an Adjunct for Blood Pressure Control: a Primer for Clinicians.

Considered a global health crisis by the World Health Organization, hypertension (HTN) is the leading risk factor for death and disability. The majority of treated patients do not attain evidence-base...

Amoebicidal activity of α-bisabolol, the main sesquiterpene in chamomile (Matricaria recutita L.) essential oil against the trophozoite stage of Acanthamoeba castellani Neff.

Acanthamoeba genus includes opportunistic pathogens which are distributed worldwide and are causative agents of a fatal encephalitis and severe keratitis in humans and other animals. Until present the...

Fatal aelurostrongylosis in a kitten in Serbia.

This paper describes a case of aelurostrongylosis in a four-month old female domestic cat (Felis catus) from South Banat, Serbia. The kitten that had died suddenly without signs of illness was autopsi...

Subcellular Energetics and Metabolism: A Cross-Species Framework.

Although it is generally believed that oxidative phosphorylation and adequate oxygenation are essential for life, human development occurs in a profoundly hypoxic environment and "normal" levels of ox...

Hepatitis A Outbreaks in European Homosexual Men.

Hepatitis A virus (HAV) is a small RNA, non-enveloped agent predominantly transmitted via the fecal/oral route through person-to-person contact or contaminated food and water. The mean incubation peri...

End of life care for glioblastoma patients at a large academic cancer center.

Glioblastoma (GBM) is a universally fatal disease, complicated by significant cognitive and physical disabilities, inherent to the disease course. The purpose of this study was to retrospectively anal...

Cardiovascular toxic effects of targeted cancer therapy.

Over the past decade, there has been a major shift in chemotherapy from non-specific cytotoxic drugs to molecular targeted drug therapies. As more molecular targeted therapies are developed, new types...

News Articles [611 Associated News Articles listed on BioPortfolio]

Ominous Conclusions From The CBO Analysis Of The GOP Health Plan: ‘Fatal Flaws,’ ‘A Train Wreck’

Opinion writers use the Congressional Budget Office's recent analysis of the updated American Health Care Act to pan the House Republican's repeal-and-replace measure.

US deaths from Alzheimer's soar 55 percent since 1999

Deaths from Alzheimer's in America have soared 55 percent since 1999, as the burden of this fatal form of dementia grows and the population ages, a federal health report said Thursday.

The Hidden Epidemic of Firearm Injury

This study compared the temporal trends of national fatal and nonfatal firearm injury rates during 2001-2013, with sobering conclusions. American Journal of Epidemiology

Cannabidiol slashes seizures in children with rare epilepsy, study finds – WCVB Boston

WCVB BostonCannabidiol slashes seizures in children with rare epilepsy, study findsWCVB BostonCannabidiol, which is found in marijuana plants, reduced the number of convulsive seizures in children wit...

Blake Insomnia Therapeutics Inc. Announces Appointment of Kyle Sarwal and Ajit Johal to its Board of Directors

NEW YORK, May 25, 2017 (GLOBE NEWSWIRE) -- Blake Insomnia Therapeutics Inc. (OTCQB:BKIT) a New York based pharmaceutical company is pleased to announce the appointment of Kyle Sarwal and Ajit Joh...

Blake Insomnia Therapeutics Announces Appointment Of And To Its Board Of Directors

  Life Sciences Jobs   ...

Charging bear attacks hunter in terrifying encounter caught on video

A Canadian hunter is lucky to be alive after being attacked by a black bear. Richard Wesley was bow hunting near Fire River, Ontario, when he noticed a large black bear roaming nearby. At first, the b...

U.S. Food and Drug Administration Accepts for Priority Review Bristol-Myers Squibb’s Application for Opdivo (nivolumab) in Previously Treated Hepatocellular Carcinoma

Application is based on results from the Phase 1/2 CheckMate -040 trial Bristol-Myers Squibb Company (NYSE:BMY) today announced that the U.S. Food and Drug Admin...

Insomnia Pipeline Review, H1 2017 [Updated: 23052017] Prices from USD $2000

Insomnia Pipeline Review, H1 2017SummaryGlobal Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Insomnia Pipeline Review, H1 2017, provides an overview of the Insomnia Ce...

Brain microenvironment makes HER2-positive breast cancer metastases resistant to treatment

While target therapies directed toward genetic mutations that drive a tumor's growth have significantly improved the outlook for many patients, they have not been as successful in controlling brain me...

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Companies [20 Associated Companies listed on BioPortfolio]

Agilis Biotherapeutics, Inc.

Agilis is advancing innovative gene therapies designed to provide long-term efficacy for patients with debilitating, often fatal, rare genetic diseases that affect the central ner...

Rasna Therapeutics, Inc.

Rasna Therapeutics, Inc. is a development stage biotechnology company focused primarily on the high unmet need that exists for leukemias. Rasna’s primary indication is acute ...

Rasna Therapeutics , Inc.

Rasna Therapeutics, Inc. is a biotechnology company focused primarily on the high unmet need that exists for leukemias. Rasna’s primary indication is acute myeloid leukemia (...

CurePSP

CurePSP is the leading nonprofit advocacy organization focused on prime of life neurodegenerative diseases – a spectrum of fatal brain disorders that often strike during a pe...

Voyager Therapeutics

Voyager Therapeutics is a gene therapy company developing life-changing treatments for fatal and debilitating diseases of the central nervous system (CNS). Voyager is committed to...

Ario Pharma Ltd

ario pharma ltd focusses on the development of drugs for the treatment of respiratory indications. Ario is about to evaluate the anti-tussive properties of XEN-D0501, a potential best-in-class TRPV1...

Agilis Biotherapeutics, LLC

Agilis Biotherapeutics, LLC, is a biotechnology company focused on designing and engineering first-in-class DNA-based therapeutics to improve and save the lives of patients affect...

Edge Therapeutics, Inc.

Edge Therapeutics, Inc. is a private, clinical-stage biopharmaceutical company focused on developing and commercializing life-saving hospital products that improve patient outcome...

Takeda Pharmaceuticals U.S.A., Inc. and Affymax, Inc.

Based in Deerfield, Ill., Takeda Pharmaceuticals U.S.A., Inc. and Takeda Global Research & Development Center, Inc. are subsidiaries of Takeda Pharmaceutical Company Limited, the ...

Takeda Pharmaceuticals U.S.A. and Affymax, Inc.

Based in Deerfield, Ill., Takeda Pharmaceuticals U.S.A., Inc. and Takeda Development Center Americas, Inc. are subsidiaries of Takeda Pharmaceutical Company Limited, the largest p...

Clinical Trials [572 Associated Clinical Trials listed on BioPortfolio]

Zolpidem, Exercise and Insomnia

Introduction: The prevalence of chronic insomnia in the general population is 10 to 15%. The therapy commonly prescribed for its treatment is pharmacological, however, there are several no...

A Study to Determine the Abuse Potential of Single Oral Doses of Lemborexant Compared to Zolpidem, Suvorexant and Placebo in Healthy, Non-Dependent, Recreational Sedative Users

The primary purpose of this study is to evaluate the abuse potential of lemborexant (E2006) in comparison to placebo and 2 controls with known abuse potential (ie, zolpidem and suvorexant)...

Transcranial Magnetic Stimulation in Nonfluent/Agrammatic Variant Primary Progressive Aphasia

Nonfluent/agrammatic variant primary progressive aphasia (nf/avPPA) is a fatal neurodegenerative disease that begins with isolated language deficits. There is currently no cure or treatmen...

Implementing and Evaluating Computer-Based Interventions for Mental Health: Testing an Implementation Strategy for VA Outpatient Care

Internet-based self-help programs are personalized, self-guided interventions delivered over a computer, mobile device, or other Internet platform and focused on improving knowledge, aware...

Intervention for Sleep and Pain in Youth

This study tests the feasibility, acceptability, and preliminary efficacy of a seven-session cognitive-behavioral therapy intervention to treat sleep and pain problems in youth ages 11-17 ...

Alcohol Consumption and Coronary Heart Disease Onset

The primary aim of this study is to examine if long-term patterns of alcohol consumption are associated with time-to-onset for incident coronary heart disease (fatal and non-fatal), using ...

High-dose Intravenous Methotrexate Versus Intrathecal Methotrexate for Central Nervous System Prophylaxis in DLBCL

The outcome of patients with central nervous system (CNS) relapse in DLBCL is poor, with median survival times of 2-5 months. This fatal prognosis necessitates CNS prevention in a subgroup...

Efficacy of EA on Depression Related Insomnia: Study Protocol for a Multicenter RCT

The investigators describe a protocol for a multicenter randomized controlled trial to find out the efficacy of electroacupuncture for depression related insomnia.

A Study of Suvorexant in Patients With Multiple Sclerosis Fatigue and Insomnia

This study assesses the safety, tolerability, and efficacy of suvorexant in multiple sclerosis patients. Enrolled subjects will receive 2 weeks of treatment during treatment period 1 with ...

i-Sleep: Internet-based Treatment for Insomnia

In this study, people who suffer from insomnia will be randomized to one of three study conditions. The first group receives a multicomponent internet-based cognitive behavioral self-help ...

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Medical and Biotech [MESH] Definitions

An autosomal dominant disorder characterized by degeneration of the THALAMUS and progressive insomnia. It is caused by a mutation in the prion protein (PRIONS).

An acute organic mental disorder induced by cessation or reduction in chronic alcohol consumption. Clinical characteristics include CONFUSION; DELUSIONS; vivid HALLUCINATIONS; TREMOR; agitation; insomnia; and signs of autonomic hyperactivity (e.g., elevated blood pressure and heart rate, dilated pupils, and diaphoresis). This condition may occasionally be fatal. It was formerly called delirium tremens. (From Adams et al., Principles of Neurology, 6th ed, p1175)

Membrane glycosylphosphatidylinositol-anchored glycoproteins that may aggregate into rod-like structures. The prion protein (PRNP) gene is characterized by five TANDEM REPEAT SEQUENCES that encode a highly unstable protein region of five octapeptide repeats. Mutations in the repeat region and elsewhere in this gene are associated with CREUTZFELDT-JAKOB DISEASE; FATAL FAMILIAL INSOMNIA; GERSTMANN-STRAUSSLER DISEASE; Huntington disease-like 1, and KURU.

Small proteinaceous infectious particles which resist inactivation by procedures that modify NUCLEIC ACIDS and contain an abnormal isoform of a cellular protein which is a major and necessary component. The abnormal (scrapie) isoform is PrPSc (PRPSC PROTEINS) and the cellular isoform PrPC (PRPC PROTEINS). The primary amino acid sequence of the two isoforms is identical. Human diseases caused by prions include CREUTZFELDT-JAKOB SYNDROME; GERSTMANN-STRAUSSLER SYNDROME; and INSOMNIA, FATAL FAMILIAL.

A hypnotic and sedative used in the treatment of INSOMNIA.

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