Fatal Insomnia - Biotech, Pharma and Life Science Channel

16:31 EDT 30th May 2015 | BioPortfolio

PubMed Articles [849 Associated PubMed Articles listed on BioPortfolio]

Occupational Asthma and Work-Exacerbated Asthma.

Occupational asthma (OA) and work-exacerbated asthma (WEA), collectively known as work-related asthma (WRA), have been recognized as the most prevalent work-related lung diseases in the industrialized...

Fatal Bacteremia Caused by Campylobacter gracilis, United States.

Primary Pulmonary NUT Midline Carcinoma: Clinical, Radiographic, and Pathologic Characterizations.

NUT midline carcinoma (NMC) is a poorly differentiated tumor typically driven by a t(15;19) rearrangement leading to a NUT fusion event. This rare and uniformly fatal tumor arises in multiple organ si...

A rare cause of fatal pulmonary alveolar proteinosis: Niemann-Pick disease type C2 and a novel mutation.

Niemann-Pick disease type C (NPC) is a fatal autosomal recessive lipid storage disease associated with impaired trafficking of unesterified cholesterol and glycolipids in lysosomes and late endosomes....

Occupational Fatalities During the Oil and Gas Boom - United States, 2003-2013.

During 2003-2013, the U.S. oil and gas extraction industry experienced unprecedented growth, doubling the size of its workforce and increasing the number of drilling rigs by 71%. To describe fatal eve...

A Pre-clinical Animal Model of Trypanosoma brucei Infection Demonstrating Cardiac Dysfunction.

African trypanosomiasis (AT), caused by Trypanosoma brucei species, results in both neurological and cardiac dysfunction and can be fatal if untreated. Research on the pathogenesis and treatment of th...

Defective Resensitization in Human Airway Smooth Muscle Cells Evokes β-Adrenergic Receptor Dysfunction in Severe Asthma.

β2-adrenergic receptor (β2AR) agonists (β2-agonist) are the most commonly used therapy for acute relief in asthma, but chronic use of these bronchodilators paradoxically exacerbates airway hyper-re...

Development of Novel Agents for Idiopathic Pulmonary Fibrosis: progress in target selection and clinical trial design.

Idiopathic Pulmonary Fibrosis (IPF) is a progressive, fatal disease. Until recently, the standard therapy for this disease has been essentially supportive, with the exception of a minority of patients...

IRES-Containing VEEV Vaccine Protects Cynomolgus Macaques from IE Venezuelan Equine Encephalitis Virus Aerosol Challenge.

Venezuelan equine encephalitis virus (VEEV) is an arbovirus endemic to the Americas that is responsible for severe, sometimes fatal, disease in humans and horses. We previously described an IRES-based...

Disruption of miR-29 Leads to Aberrant Differentiation of Smooth Muscle Cells Selectively Associated with Distal Lung Vasculature.

Differentiation of lung vascular smooth muscle cells (vSMCs) is tightly regulated during development or in response to challenges in a vessel specific manner. Aberrant vSMCs specifically associated wi...

News Articles [483 Associated News Articles listed on BioPortfolio]

Farydak/Kyprolis ORR tops Velcade combo in MM

Data due to be presented Tuesday at the American Society of Clinical Oncology meeting in Chicago showed a combination of Farydak panobinostat from Novartis AG (NYSE:NVS; SIX:NOVN) and Kyprolis carfilz...

Lassa Fever: What You Need to Know

In light of the fatal case of Lassa fever in the U.S., the World Health Organization (WHO) offers the following information on this acute viral hemorrhagic illness.

New Orleans doctor, nurse accused of running 'pill mill'

NEW ORLEANS (AP) — Federal authorities have arrested a New Orleans doctor and nurse accused of operating a "pill mill" at a pain management clinic that accepted only cash and doled out prescription ...

Stay gas safe this summer

Stay gas safe this summerGas safety is just as important in the summer as it is in the winter. Poorly maintained appliances and boilers can cause carbon monoxide poisoning, which can be fatal. Find ou...

Lassa Fever – United States of America

On 25 May, PAHO/WHO was informed that the United States Center for Disease Control and prevention (CDC) and the New Jersey Department of Health had confirmed a fatal case of Lassa fever. The case was ...

Researchers assess non-fatal suicidal behaviors in US Army administrative records

Although the U.S. Army suicide rate is known to have risen sharply over the past decade, information about medically documented, non-fatal suicidal behaviors is far more limited. According to finding...

Medicines optimisation for patients with insomnia

Keele University, with support from Flynn Pharma, has developed a guide for healthcare professionals about medicines optimisation in patients with insomnia. The guide is available for free at: www...

AAA: Teen Drivers Put Everyone at Risk

AAA Foundation Study Raises Alert as 100 Deadliest Days Begins Teen Driver Downloadable B-Roll This Smart News Release features multimedia. View the full release here: ...

Skin Cancer Awareness Month: Pennsylvania Ban of Teens from Tanning Salons Is Praised by Fresh Water Advocate Sharon Kleyne

Grants Pass, OR (PRWEB) May 26, 2015 The skin cancer melanoma develops rapidly and is nearly always fatal if not caught early. Melanoma is also easily prevented. Worldwide, according to radio host ...

[In Context] Living in the shadow of dying

Perhaps known by some as Lou Gehrig's disease, named after the Major League Baseball Yankees legend, amyotrophic lateral sclerosis (ALS), a fatal and degenerative disease causing neuron death, muscle ...

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Companies [16 Associated Companies listed on BioPortfolio]

Voyager Therapeutics

Voyager Therapeutics is a gene therapy company developing life-changing treatments for fatal and debilitating diseases of the central nervous system (CNS). Voyager is committed to...

Ario Pharma Ltd

ario pharma ltd focusses on the development of drugs for the treatment of respiratory indications. Ario is about to evaluate the anti-tussive properties of XEN-D0501, a potential best-in-class TRPV1...

Agilis Biotherapeutics, LLC

Agilis Biotherapeutics, LLC, is a biotechnology company focused on designing and engineering first-in-class DNA-based therapeutics to improve and save the lives of patients affect...

Edge Therapeutics, Inc.

Edge Therapeutics, Inc. is a private, clinical-stage biopharmaceutical company focused on developing and commercializing life-saving hospital products that improve patient outcome...

Takeda Pharmaceuticals U.S.A., Inc. and Affymax, Inc.

Based in Deerfield, Ill., Takeda Pharmaceuticals U.S.A., Inc. and Takeda Global Research & Development Center, Inc. are subsidiaries of Takeda Pharmaceutical Company Limited, the ...

Takeda Pharmaceuticals U.S.A. and Affymax, Inc.

Based in Deerfield, Ill., Takeda Pharmaceuticals U.S.A., Inc. and Takeda Development Center Americas, Inc. are subsidiaries of Takeda Pharmaceutical Company Limited, the largest p...

Oxyrane UK Limited

WHO WE ARE Oxyrane UK Limited is a biopharmaceutical company dedicated to the development of novel and biosuperior enzyme replacement therapies (ERT) to treat lysosomal storage diseases, a class o...

Alpha-Stim

Alpha-Stim is an industry leader in cranial electrotherapy stimulation (CES) devices, providing treatment for anxiety, depression, insomnia and pain, without the side effects comm...

Janssen Alzheimer Immunotherapy

Alzheimer's disease (AD), the most common form of dementia, is a fatal, degenerative brain disease that gradually destroys a person's memory and ability to learn, reason, make judgments, communicate a...

Akashi Therapeutics, Inc.

Akashi Therapeutics is a clinical stage biopharmaceutical company whose mission is to develop treatments for Duchenne muscular dystrophy and other rare pediatric diseases. ...

Clinical Trials [378 Associated Clinical Trials listed on BioPortfolio]

Circadian Phase Assessments at Home

An estimated 23 million Americans, including adolescents and the elderly, suffer from circadian rhythm sleep disorders, such as delayed sleep phase disorder, advanced sleep phase disorder ...

The Effect of Melatonin Upon Post-Acute Withdrawal Among Males in a Residential Treatment Program

Individuals recovering from drug and/or alcohol addiction initially experience the symptoms of acute withdrawal before experiencing the symptoms of post-acute withdrawal (PAWS). PAWS incl...

Cognitive Behavior Therapy for Insomnia Delivered by a Therapist or on the Internet

Background: Insomnia is a highly prevalent and disabling disorder where Cognitive Behavior Therapy for Insomnia (CBT-I) is established as the best available treatment. Still, only a neglig...

Safety and Efficacy Study of Apixaban to Prevent Clots in Children With Leukemia Who Have a Central Venous Catheter and Are Treated With PEG Asparaginase

To compare the effect of prophylactic oral or enteric apixaban versus no administration of systemic prophylactic anticoagulant during induction chemotherapy, on the composite endpoint of a...

Antidepressant Treatment of AIDS Related Depression.

To test the effectiveness treating AIDS related depression with imipramine hydrochloride. Depression syndromes are commonly associated with chronic, disabling, and fatal diseases. Due to ...

A Phase 2, Randomized Dose-ranging Study to Evaluate the Efficacy of Tralokinumab in Adults With Idiopathic Pulmonary Fibrosis

To study the safety and effectiveness of multiple-doses of tralokinumab on pulmonary function in adults with mild to moderate idiopathic pulmonary fibrosis (IPF). IPF is a chronic, progre...

Gabapentin for Insomnia Symptoms and Nighttime Vasomotor Symptoms in Peri- and Postmenopausal Women

The broad goal of this study is to obtain pilot data to determine the tolerability and preliminary efficacy of the non-hormonal agent gabapentin for insomnia symptoms and nighttime Vasomot...

Cardiovascular Patient Outcomes and Research Team Primary PCI Registry

The proposed study is a registry of patients treated with primary angioplasty for acute myocardial infarction. The aim of this registry is to define the outcomes of patients treated for a...

CBT Insomnia Teens: Augmenting SSRIs to Improve Youth Depression

This study is a randomized controlled trial that tests the effectiveness of cognitive behavior therapy (CBT) for insomnia with comorbid depression in youth aged 12 through 19 who have rece...

Oral Clofarabine for Relapsed/Refractory Non-Hodgkin Lymphoma

Oral clofarabine is related to two intravenous chemotherapy drugs used for this disease and works in two different ways. It affects the development of new cancer cells by blocking two enz...

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Medical and Biotech [MESH] Definitions

An autosomal dominant disorder characterized by degeneration of the THALAMUS and progressive insomnia. It is caused by a mutation in the prion protein (PRIONS).

An acute organic mental disorder induced by cessation or reduction in chronic alcohol consumption. Clinical characteristics include CONFUSION; DELUSIONS; vivid HALLUCINATIONS; TREMOR; agitation; insomnia; and signs of autonomic hyperactivity (e.g., elevated blood pressure and heart rate, dilated pupils, and diaphoresis). This condition may occasionally be fatal. It was formerly called delirium tremens. (From Adams et al., Principles of Neurology, 6th ed, p1175)

Small proteinaceous infectious particles which resist inactivation by procedures that modify NUCLEIC ACIDS and contain an abnormal isoform of a cellular protein which is a major and necessary component. The abnormal (scrapie) isoform is PrPSc (PRPSC PROTEINS) and the cellular isoform PrPC (PRPC PROTEINS). The primary amino acid sequence of the two isoforms is identical. Human diseases caused by prions include CREUTZFELDT-JAKOB SYNDROME; GERSTMANN-STRAUSSLER SYNDROME; and INSOMNIA, FATAL FAMILIAL.

A hypnotic and sedative used in the treatment of INSOMNIA.

A benzodiazepine used in the treatment of anxiety, alcohol withdrawal, and insomnia.

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