Fulminant colitis - Biotech, Pharma and Life Science Channel
PubMed Articles
Infection of mice with Trichinella spiralis redirects the mucosal immune system from a Th1 to a protective Th2 response with a reduction in the severity of trinitrobenzesulfonic acid-induced colonic d...
Stages of pTDP-43 pathology in amyotrophic lateral sclerosis.
Objective: To see if the distribution patterns of phosphorylated 43-kDa TAR DNA-binding protein (pTDP-43) intraneuronal inclusions in amyotrophic lateral sclerosis (ALS) permit recognition of neuropat...
BACKGROUND: Inflammatory bowel disease (IBD) associated with primary sclerosing cholangitis (PSC) is reported to be mild and prone to right-side predominance with rectal sparing. However, no dedicated...
Impaired removal of Vβ8(+) lymphocytes aggravates colitis in mice deficient for BIM.
INTRODUCTION: We investigated the role of BCL-2-interacting mediator of cell death (BIM) for lymphocyte homeostasis in intestinal mucosa. Lymphocytes lacking BIM are refractory to apoptosis. MATERIALS...
Antimicrobial peptides may influence the pathogenesis and course of inflammatory bowel disease (IBD). We sought to clarify the role of the antimicrobial glycoprotein lipocalin 2 (LCN2) in the colon by...
Thymus-derived regulatory T cells contribute to tolerance to commensal microbiota.
Peripheral mechanisms preventing autoimmunity and maintaining tolerance to commensal microbiota involve CD4(+) Foxp3(+) regulatory T (Treg) cells generated in the thymus or extrathymically by inductio...
OBJECTIVE: Interleukin-17A and interleukin-17F (IL-17A and IL-17F) are candidate genes for chronic inflammatory disease. We investigated the association between IL17A/F gene polymorphisms and suscepti...
BACKGROUND: There is increasing evidence for the role of microscopic inflammation in patients with IBS. We aimed to examine the prevalence of microscopic colitis and inflammation in Malaysian IBS pati...
Multiple sclerosis (MS) is an inflammatory central nervous system (CNS) disorder which typically occurs in early adulthood and rarely in children. Here we tested whether functional maturation of innat...
Jejunal Intussusception Associated with Lymphoma in a Horse.
A 2-year-old Thoroughbred horse presented with acute onset of colitis, and the intussuscepted jejunum was surgically resected. A transmural mass protruding into the lumen was found at the leading edge...
News Articles
Salix Pharmaceuticals, Ltd. (NASDAQ:SLXP) today announced the successful completion and outcome of two pivotal Phase 3 studies to evaluate the efficacy and safety of budesonide fo...
A new European Consortium to boost our understanding of Inflammatory Bowel Diseases
The Inflammatory Bowel Disease characterization by a multi-modal integrated biomarker study (IBD-Character) Consortium is a collaborative effort to advance our understanding of the inflammatory bowel...
Risk Of Melanoma Increased By Inflammatory Bowel Disease
Patients with inflammatory bowel disease(IBD) are at higher risk of melanoma, a form of skin cancer, report researchers at Mayo Clinic. Researchers found that IBD is associated with a 37 percent great...
Impact of Mucosal Healing on Outcomes in Ulcerative Colitis
What is the best way to achieve mucosal healing in patients with ulcerative colitis treated with anti-TNF agents, and what is the long-term outcome generally like in this subset of patients? Aliment...
The s**t hits the fan - FDA, INDs, and fecal microbiota transplants
[caption id="attachment_4663" align="alignleft" width="300" caption="Bristol Stool Chart"] [/caption]This weekend, the proverbial s**t hit the fan over the FDA's decision to require an IND for stool...
Janssen Biotech’s Simponi receives FDA approval for ulcerative colitis
The FDA has approved Janssen Biotech’s Simponi (golimumab) for the treatment of moderately to severely active ulcerative colitis (UC) in adult patients who have demonstrated corticosteroid dependenc...
Roche announced today that the EUCALYPTUS phase II induction study of etrolizumab in patients with moderate-to-severely active ulcerative colitis (UC) met its primary endpoint of clinical remission at...
Janssen’s ulcerative colitis drug approved by US FDA
Janssen Biotech, one of Johnson & Johnson's pharma companies, has announced the FDA approval of its ulcerative colitis drug, Simponi for use in the US. The FDA has approved Simponi (golimumab) for...
Santarus Announces UCERIS (budesonide) Poster Presentations at Digestive Disease Week Meeting
Santarus, Inc. (NASDAQ: SNTS) today announced that additional data from two pivotal clinical studies with UCERIS® (budesonide) extended release tablets will be featured in...
Studies Show Improved IBD Diagnoses and Treatments
NEW YORK, NY--(Marketwired - May 17, 2013) - Four important findings from the Pediatric Resource Organization for Kids with Inflammatory Intestinal Digestive Diseases (PRO-KIIDS) will be presented th...
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Companies
The Trudeau Institute is an independent, not-for-profit, biomedical research organization, whose scientific mission is to make breakthrough discoveries leading to improved human h...
Helmedix is developing new therapies for autoimmune diseases. The company has identified peptides derived from helminthic worms that have immune-modulating properties. These peptides are being explo...
Santarus, Inc. is a specialty biopharmaceutical company focused on acquiring, developing and commercializing proprietary products that address the needs of patients treated by gas...
Clinical Trials
Host Immune Response to Clostridium Difficile Infection in Inflammatory Bowel Disease Patients
The inflammatory bowel diseases (IBD), ulcerative colitis (UC) and Crohn's disease (CD) are chronic conditions affecting approximately 1.4 million Americans. The burden of Clostridium dif...
Long-Term Treatment of Collagenous Colitis With Budesonide
The aim of the trial is to examine the effect of budesonide treatment on collagenous colitis. All patients is treated for 6 weeks with budesonide and thereafter randomised to 24 weeks trea...
The hypothesis underlying this study is that nasally administered calcitonin will stabilize or improve bone mineral density in young patients with ulcerative colitis or Crohn's disease. Pa...
A Trial of Rosiglitazone for Ulcerative Colitis
This is a multicenter, randomized, double-blind, placebo-controlled study evaluating rosiglitazone: 4 mg tablets or placebo tablets administered orally twice daily for 12 weeks. The purpo...
The purpose of this study is to evaluate the safety and efficacy of the drug OPC-6535 compared to a placebo in patients with active Ulcerative Colitis. Depending on their response, partic...
The purpose of this study is to evaluate the safety and efficacy of the drug OPC-6535 compared to a placebo in patients with active Ulcerative Colitis. Depending on their response, partic...
Interferon-beta Treatment of Ulcerative Colitis
This study will evaluate the safety and effectiveness of the drug interferon-beta in treating ulcerative colitis and examine the drug's effect on the immune system. People with ulcerative...
Study Evaluating rhIL-11 in Left-Sided Ulcerative Colitis
To explore the safety of orally delivered rhIL-11 in patients with mild to moderate left-sided ulcerative colitis. To explore the effects of orally administered rhIL-11 on pharmacogenomic...
Collection of Liver Tissue for Virologic Studies
This study will examine liver tissue to investigate the role of viral infections in fulminant hepatitis, liver failure, and profound bone marrow failure. All patients who are undergoing l...
Phase II Placebo-Controlled Study of 4-Aminosalicylic Acid for Ulcerative Colitis
OBJECTIVES: I. Assess the safety and efficacy of 4-aminosalicylic acid in patients with mildly to moderately severe ulcerative colitis.
Videos
A Fulminant Ulcerative Colitis
A fulminant ulcerative colitis is a serious condition, where surgery can be life saving. This video shows the endoscopic finding in a patient with a fulminan...
Medical and Biotech [MESH] Definitions
Colitis, Microscopic
A condition characterized by chronic watery DIARRHEA of unknown origin, a normal COLONOSCOPY but abnormal histopathology on BIOPSY. This syndrome was first described in 1980 by Read and associates. Subtypes include COLLAGENOUS COLITIS and LYMPHOCYTIC COLITIS. Both have similar clinical symptoms and are distinguishable only by histology.
Colitis, Collagenous
A subtype of MICROSCOPIC COLITIS, characterized by chronic watery DIARRHEA of unknown origin, a normal COLONOSCOPY but abnormal histopathology on BIOPSY. Microscopic examination of biopsy samples taken from the COLON show larger-than-normal band of subepithelial COLLAGEN.
Colitis, Lymphocytic
A subtype of MICROSCOPIC COLITIS, characterized by chronic watery DIARRHEA of unknown origin, a normal COLONOSCOPY but abnormal histopathology on BIOPSY. Microscopic examination of biopsy samples taken from the COLON show infiltration of LYMPHOCYTES in the superficial EPITHELIUM and the underlying connective tissue (lamina propria).
Enterohemorrhagic Escherichia Coli
Strains of ESCHERICHIA COLI that are a subgroup of SHIGA-TOXIGENIC ESCHERICHIA COLI. They cause non-bloody and bloody DIARRHEA; HEMOLYTIC UREMIC SYNDROME; and hemorrhagic COLITIS. An important member of this subgroup is ESCHERICHIA COLI O157-H7.
Vitamin U
A vitamin found in green vegetables. It is used in the treatment of peptic ulcers, colitis, and gastritis and has an effect on secretory, acid-forming, and enzymatic functions of the intestinal tract.
