Gene Therapy - Biotech, Pharma and Life Science Channel
PubMed Articles
Major aims of the 5th Central and Eastern Europe (CEE) Summit on Osteoporosis held in Bratislava, Slovakia, on 2 and 3 December 2011, were to provide participants with state-of-the-art knowledge in th...
The influence of genetic polymorphisms in MDR1 gene on breast cancer risk factors in Chinese.
Breast cancer (BC) is the most common cancer among women in the world. The human multidrug resistance 1 gene (MDR1) is potentially an important gene influencing the susceptibility to breast cancer. Th...
Epigenetics: a new mechanism of regulation of heart failure?
Heart failure is a syndrome resulting from a complex genetic predisposition and multiple environmental factors, and is a leading cause of morbidity and mortality. It is frequently accompanied by chang...
Arteries and veins show marked differences in their anatomy, physiology and genetic expression pattern. In this study, we analyzed impact of overexpression or downregulation of arterial marker gene He...
Adoptive cell therapy with tumor-infiltrating lymphocytes (TILs) represents an effective treatment for patients with metastatic melanoma. However, most of the Ag targets recognized by effective melano...
cis-regulatory DNA sequence elements, such as enhancers and silencers, function to control the spatial and temporal expression of their target genes. Although the overall levels of gene expression in...
Foxp3 is a key marker of CD4CD25 regulatory T cells and appears highly specific for regulatory T cells. Human dendritic cells transfected with foxp3 gene also exhibit immunosuppressive functions. We w...
Silver has antimicrobial properties and silver nanoparticles (Ag-NPs) have been some of the most widely used NPs. Information regarding their effects is still insufficient, in particular for soil dwel...
The importance of 5'AMP-activated protein kinase (AMPK) in regulating glucose and fatty acid metabolism is increasing. Thus, it is regarded as a new pharmacological target for treatment of obesity, in...
A multi-layer inference approach to reconstruct condition-specific genes and their regulation.
An important topic in systems biology is the reverse engineering of regulatory mechanisms through reconstruction of context-dependent gene networks. A major challenge is to identify the genes and the...
News Articles
The majority of US and European rheumatologists surveyed by health care advisory firm Decision Resources cite a therapy's induction of remission as one of the attributes that most influences their pre...
ORLANDO, Fla., June 20, 2013 /PRNewswire/ -- With more Americans searching for alternatives to using narcotics to manage pain, a group of physicians and therapists using a safe and painless FDA-c...
As many individuals now obtain physical therapy sessions, it is a necessity to organize files and documentations of the client’s visit. Marketing expert and licensed physical therapist, Nitin Chhoda...
Can Herpes Affect Fertility? polyDNA Answers Survey Questions
In its June, 2013 survey, polyDNA found that 48% of male respondents were unaware of the fact that herpes sores on the scrotum do not affect fertility, but the herpes virus can harm fertility. polyDNA...
Neuroscience: Stem cells in multiple time zones
In fruitfly larvae, neural stem cells generate different cell types at different times. It emerges that these temporal progressions are controlled by multiple cascades of gene transcription factors.
Sarepta's 84-week data show continued eteplirsen efficacy
With little new guidance on accelerated US FDA approval for the Duchenne muscular dystrophy (DMD) therapy eteplirsen, Sarepta Therapeutics investors gave the company's stock a 4.3% boost on 19 June ba...
Testosterone Replacement Improves Pain Perception And Tolerance In Men With Low Testosterone
Testosterone therapy is associated with decreased pain perception in men with low testosterone levels related to opioid (narcotic) pain relievers (analgesics), a new study finds. The results were pres...
Discovery Reveals The Secret Of DNA Methylation
Methylation refers to a chemical modification of DNA and this modification can occur in millions of positions in the DNA sequence. Until now, scientists believed that this epigenetic phenomenon active...
Does germ-line deletion of the PIP gene constitute a widespread risk for cancer?
The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis
A complex interaction of signalling events, including the Wnt pathway, regulates sprouting of blood vessels from pre-existing vasculature during angiogenesis. Here we show that two distinct mutations...
Events
The 12th annual Evolution Summit is a premium forum bringing together leaders in biopharmaceutical clinical operations with the most renowned CROs and solution providers.
Stem Cells & Cell Therapy Summit
Select Biosciences' Stem Cells & Cell Therapy Summit is focused on providing an up-to-date expansive view of the current marketplace
3rd World Congress on Cancer Science & Therapy
3rd world congress on Cancer Science & Therapy serves as a reunion land for scientists in the area of cancer research.
6TH ANNUAL RECOMBINANT ANTIBODIES Conference
An insight into novel therapeutics and future technologies
Companies
Ligand is an emerging specialty pharmaceutical company that discovers, develops and markets innovative small molecule drugs to address critical, unmet medical needs. Ligand markets four oncology and d...
A world leader in personal and public access defibrillators, HeartSine's mission is to advance the deployment of lifesaving defibrillation therapy in non-traditional areas of care through the developm...
Dermira is a private, development-stage company focused on developing and commercializing innovative new therapies in dermatology. Dermira was founded by an experienced management...
Based in Brisbane, California, XDx is a molecular diagnostics company focused on the discovery, development and commercialization of noninvasive gene expression-based tests for th...
Biodesix is a personalized medicine company focused on the development of diagnostic products that inform treatment decisions and improve patient care. In 2009, Biodesix launched VeriStrat®, a serum...
Provision Center for Proton Therapy
Opening in early 2014, the Provision Center for Proton Therapy will be the first of its kind in Tennessee and only the second in the Southeast. Proton therapy, the most advanced...
Uscom Limited is an Australian medical device company which listed on the Australian Securities Exchange in December 2003. Uscom has developed a Non Invasive Ultrasonic Cardiac Ou...
THE Surgical Hospital of Phoenix
THE Surgical Hospital of Phoenix, the first licensed surgical specialty facility of its kind in Arizona, first opened its doors in May of 2005. Specializing in spine, orthopedics,...
TRANSGENE is a leading integrated gene therapy company, dedicated to the discovery and development of gene delivery technologies and gene therapy products for the treatment of acquired and inherited d...
Acorda Therapeutics, Inc. was established in March 1995 to develop therapeutic products for spinal cord injury ("SCI") and other central nervous system disorders. Acorda is focusing its initial develo...
Clinical Trials
Background: - BRCA1 and BRCA2 gene mutations have been linked to a higher risk of developing breast cancer and other cancers, and may be associated with types of breast cancer that are mo...
This is a randomized, double-blind, placebo-controlled, parallel-group, multi-national study alirocumab (REGN727/ SAR236553) in patients with Heterozygous Familial Hypercholesterolemia (he...
Ventricular Arrhythmias in Uremic Cardiomyopathy
There is a certain gene called sarcoplasmic reticulum gene (SERCA2a), which is found in heart muscle. This gene is also found in blood vessels and skin tissue. When active this gene builds...
Family-Based Drug Services for Young Disaster Victims
This protocol seizes this rare scientific opportunity to test an integrative family based model to address youths' coexisting substance abuse and trauma in the wake of Hurricane Katrina. T...
Music Therapy in Methodist Homes: a Study Investigating the Impact of a Music Therapy Programme
The study is a cluster randomised control trial, which aims to investigate the effectiveness of music therapy in minimising Behavioural and Psychological Symptoms of Dementia (BPSD) in old...
Physical Activity and Cognitive Behavioural Therapy in Panic Disorder
Physical activity (treadmill) supports the effect of cognitive behavioural therapy in patients with panic disorder with/without agoraphobia
Gene Expression in Cumulus Cells to Predict Pregnancy
The purpose of this study is to determine the performance of a genetic assay, GemART, in cumulus cells predictive of embryo viability, and pregnancy success in women undergoing in vitro fe...
Transdiagnostic Behavioral Activation Therapy for Youth Anxiety and Depression
Psychological therapies for depression have demonstrated efficacy, but outcomes are still unsatisfactory, especially in cases with high comorbidity. Depression and anxiety co-occur in up t...
PTK787 + Trastuzumab for HER2 Overexpressing Metastatic Breast Cancer
HER2 gene amplification increases VEGF production in breast cancers; combined inhibition of HER2 and VEGF enhances response in xenograft models. The upregulation of VEGF in HER2-overexpres...
The objective of the study is to identify and validate predictive markers of infliximab responsiveness in RA patients by 2 approaches: i) measuring biochemical, immunological and bone mark...
Videos
Gene Therapy: The Time Is Now: Nick Leschly at TEDxBoston
"Forget the price. What's the value of that treatment?" What if we could fix a patient's own cells and cure their disease once and for all instead of treatin...
Medical and Biotech [MESH] Definitions
Dna Shuffling
The use of DNA recombination (RECOMBINATION, GENETIC) to prepare a large gene library of novel, chimeric genes from a population of randomly fragmented DNA from related gene sequences.
Rna Interference
A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.
Heterogeneous-nuclear Ribonucleoprotein K
A heterogeneous-nuclear ribonucleoprotein found in the CELL NUCLEUS and the CYTOPLASM. Heterogeneous-nuclear ribonucleoprotein K has been implicated in the regulation of gene expression at nearly all levels: GENETIC TRANSCRIPTION; mRNA processing (RNA PROCESSING, POST-TRANSCRIPTIONAL), mRNA transport, mRNA stability, and translation (TRANSLATION, GENETIC). The hnRNP protein has a strong affinity for polypyrimidine-rich RNA and for single-stranded polypyrimidine-rich DNA. Multiple hnRNP K protein isoforms exist due to alternative splicing and display different nucleic-acid-binding properties.
Rna, Small Interfering
Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
Transcription Factors, General
Transcription factors that form transcription initiation complexes on DNA, bind to specific DNA-DIRECTED RNA POLYMERASES and are required to initiate transcription. Although their binding may be localized to distinct sequence and structural motifs within the DNA they are considered non-specific with regard to the specific gene being transcribed.
