Genetic Diagnostic Technologies - Biotech, Pharma and Life Science Channel
PubMed Articles
The influence of genetic polymorphisms in MDR1 gene on breast cancer risk factors in Chinese.
Breast cancer (BC) is the most common cancer among women in the world. The human multidrug resistance 1 gene (MDR1) is potentially an important gene influencing the susceptibility to breast cancer. Th...
INTRODUCTION. MCT8 is a specific transporter for the T4 and T3 thyroid hormones that allows their entry in the brain and other organs. Mutations in MCT8 (Allan-Herndon-Dudley syndrome) lead to a sever...
Preferential loss of heterozygosity at the rs1042522 locus of the tumor protein 53 gene (TP53) (Arg72Pro) is observed in several tumors. Genetic association studies in oncology often use tumor tissue...
Aggrephagy: lessons from C. elegans.
Autophagy is a lysosome-mediated degradation process that involves the formation of an enclosed double-membrane autophagosome. Yeast genetic screens have laid the groundwork for a molecular understand...
Diagnostic imaging in veterinary dental practice.
Limits to sustained energy intake. XIV. Heritability of reproductive performance in mice.
Limits to sustained energy intake (SusEI) are important because they constrain many aspects of animal performance. Individual variability in SusEI may be imposed by genetic factors that are inherited...
Shimmer: detection of genetic alterations in tumors using next-generation sequence data.
Extensive DNA sequencing of tumor and matched normal samples using exome and whole-genome sequencing technologies has enabled the discovery of recurrent genetic alterations in cancer cells, but variab...
The hepatitis C virus (HCV) is an enveloped virus that is about 50-70 nm in diameter, has positive-strand RNA, and belongs to the genus Hepacivirus and the family Flaviridae. The detection and quantif...
In the developing brain neuronal differentiation is associated with permanent exit from the mitotic cycle. Neuronal nuclear antigen (NeuN) is a nuclear protein widely expressed in the mature postmitot...
News Articles
Among patients with suspected stage I/II pulmonary sarcoidosis who were undergoing confirmation of the condition via tissue sampling, the use of the procedure known as endosonographic nodal aspiration...
Lophius Wins $469K to Develop MS Diagnostic
BETHLEHEM, Pa., June 19, 2013 /PRNewswire/ -- Saladax Biomedical, Inc., a privately held company developing novel diagnostic tests that help physicians to optimize a patient's exposure to chemoth...
Renewed hope in a once-abandoned cancer drug class
Could drugs that block the body's system for repairing damage to the genetic material DNA become a boon to health? As unlikely as it may seem, those compounds are sparking optimism as potential treatm...
Lophius Biosciences GmbH Joins NEU² and Receives Substantial Grant Funding for the Diagnosis ...
Hamburg/Regensburg, Germany, June 19, 2013 / B3C newswire / - Bionamics GmbH, the coordinator of the NEU² consortium,and Lophius Biosciences GmbH announced today that Lophius Biosciences has joi...
Study finds similar genetic variations in overweight newborns, obese adults
Similar genetic variations occur in both overweight newborns and obese adults, a large study finds.
[Review] Neural tube defects: recent advances, unsolved questions, and controversies
Neural tube defects are severe congenital malformations affecting around one in every 1000 pregnancies. An innovation in clinical management has come from the finding that closure of open spina bifida...
Invivoscribe FLT3 Testing Patents Strengthened by Supreme Court Ruling
SAN DIEGO, CA -- (Marketwired) -- 06/19/13 -- In Association of Molecular Pathology v. Myriad, the U.S. Supreme Court struck down BRCA1 and BRCA2 gene patent claims. It is important for the diagnosti...
The Evolution of Type 1 Diabetes The Evolution of Type 1 Diabetes
Type 1 diabetes (T1D) occurs in individuals with a genetic predisposition to the disease, predominantly from a human leukocyte antigen (HLA)-related immunogenotype that accounts for approximately 60%...
Clinical QuestionWhat are the benefits and harms of general health checks for adult populations?Bottom LineCompared with usual care, offers of health checks were not associated with lower rates of all...
Events
The summit will address the latest developments in the biomarker arena from discovery to translation to commercialization.
Welcome to Molecular Medicine Congress and exhibition.
Welcome to AgriGenomics World Congress 2013.
Companies
NeuroMetrix, Inc. was founded in June 1996 as a spin-off from the Harvard-M.I.T. Division of Health Sciences and Technology. The Company’s mission is to: Create value for our customers by developi...
InGenuity is a young, dynamic, fast growing pre-IPO Internet start-up that is building next generation information technologies and knowledge that will revolutionize the way functional genetic data ca...
Based in Medford, Mass., AngioLight is an interventional cardiology medical device company founded to address unmet clinical needs in coronary and peripheral stenting. The company...
NeuroVision Imaging, LLC (www.neurovision.com) was formed in 2010 and is headquartered in Sacramento, California. The Company develops digital imaging, and diagnostic solutions fo...
Sequenta, Inc. is a privately held company developing and commercializing molecular diagnostic assays based on a proprietary sequencing approach to the profiling of T and B cell r...
Founded in 1987 by the current CEO Andrew Shepherd, Omega Diagnostics Group PLC is focused on selling a wide range of specialist products, primarily in the immunoassay, in-vitro diagnostics (IVD) ma...
Diaxonhit (NYSE Alternext, FR0004054427, ALEHT) is a French fully integrated leader in the in-vitro diagnostic field, involved from research to commercialization of specialty diagnostic products....
Hamilton Company is a global leader in the design and manufacture of liquid handling, process measurement, robotics and storage solutions, serving customers in academic and privat...
Atherotech is a CLIA-certified clinical reference laboratory and cardiodiagnostic company focusing on cardiometabolic tests, including the company's patented VAP Cholesterol Test, which reports the ch...
Unisyn Medical Technologies, Inc./Consensys Imaging Service, Inc.
Consensys Imaging Service, Inc. is a leading provider of services to the diagnostic imaging industry. Consensys leverages its proprietary technologies and advanced technical capab...
Clinical Trials
Comparison of the HyperQ Versus Conventional Electrocardiogram (ECG) to Detect Ischemia
The purpose of the investigation is to verify the efficiency of the HyperQ™ system in detecting exercise induced ischemia, with higher specificity and sensitivity than conventional ECG S...
Gene Expression in Cumulus Cells to Predict Pregnancy
The purpose of this study is to determine the performance of a genetic assay, GemART, in cumulus cells predictive of embryo viability, and pregnancy success in women undergoing in vitro fe...
1/2-MC4R Genotype and Pediatric Antipsychotic Drug- Induced Weight Gain
We will conduct a 12-week, randomized open label study, comparing usual care (UC) antipsychotic treatment (aripiprazole, quetiapine, risperidone) with ziprasidone (ZIP) in children and ado...
Cohort Study for Patients Using Fuzeon (Enfuvirtide)
The Radata-Fuzeon cohort is an observational cohort study to gain a better understanding of Fuzeon (Enfuvirtide) in daily clinical practice. Patients planned to take this drug in a new ant...
myoARRAY and TcLandscape Analysis for the Diagnosis of Inflammatory Myopathies
The diagnosis of the different forms of inflammatory myopathies (polymyositis, dermatomyositis, inclusion-body myositis...) remains difficult which may lead to unappropriate patient care....
Low cobalamin (vitamin B12) levels are frequent in the elderly. Most often they reflect a mild metabolic abnormality without clinical symptoms (subclinical cobalamin deficiency). It is unc...
The anticipation of pain and discomfort, a diagnosis, and other intrinsic unknowns make patients anxious both prior to and during a procedure. Therefore, the main goal of sedation with a...
Iodixanol in Multidetector-Row Computed Tomography-Coronary Angiography (MDCT-CA)
Image quality in coronary artery computed tomography is influenced by the heart rate variation during the examination. The purpose of this clinical trial is to investigate the change in he...
Influenza Vaccine in Lung Transplant Patients
Research Question: How do antibody and T cell responses following influenza vaccine compare among lung transplant patients, patients waiting for lung transplantation and healthy individua...
The overall goal of this study is to determine how FDG-PET can be incorporated into the assessment of the axilla in the staging and treatment of women with early stage breast cancer....
Videos
Pre-Implantation Genetic Diagnosis and Gender Selection New Jersey
http://www.northhudsonivf.com At North Hudson I.V.F. in New Jersey, we use technology similar to pre-implantation genetic diagnosis to perform gender selecti...
Medical and Biotech [MESH] Definitions
Dna Shuffling
The use of DNA recombination (RECOMBINATION, GENETIC) to prepare a large gene library of novel, chimeric genes from a population of randomly fragmented DNA from related gene sequences.
Duty To Recontact
The ethical and/or legal obligation of a health provider or researcher to communicate with a former patient or research subject about advances in research relevant to a treatment or to a genetic or other diagnostic test provided earlier, or about proposed new uses of blood or tissue samples taken in the past for another purpose.
Heterogeneous-nuclear Ribonucleoprotein K
A heterogeneous-nuclear ribonucleoprotein found in the CELL NUCLEUS and the CYTOPLASM. Heterogeneous-nuclear ribonucleoprotein K has been implicated in the regulation of gene expression at nearly all levels: GENETIC TRANSCRIPTION; mRNA processing (RNA PROCESSING, POST-TRANSCRIPTIONAL), mRNA transport, mRNA stability, and translation (TRANSLATION, GENETIC). The hnRNP protein has a strong affinity for polypyrimidine-rich RNA and for single-stranded polypyrimidine-rich DNA. Multiple hnRNP K protein isoforms exist due to alternative splicing and display different nucleic-acid-binding properties.
Micrornas
Small double-stranded, non-protein coding RNAs, 21-25 nucleotides in length generated from single-stranded microRNA gene transcripts by the same RIBONUCLEASE III, Dicer, that produces small interfering RNAs (RNA, SMALL INTERFERING). They become part of the RNA-INDUCED SILENCING COMPLEX and repress the translation (TRANSLATION, GENETIC) of target RNA by binding to homologous 3'UTR region as an imperfect match. The small temporal RNAs (stRNAs), let-7 and lin-4, from C. elegans, are the first 2 miRNAs discovered, and are from a class of miRNAs involved in developmental timing.
Silencer Elements, Transcriptional
Nucleic acid sequences that are involved in the negative regulation of GENETIC TRANSCRIPTION by chromatin silencing.
