Genetic Evaluation - Biotech, Pharma and Life Science Channel
PubMed Articles
Total synthesis and biological evaluation of grassypeptolide a.
Herein, we describe in full our investigations into the synthesis of grassypeptolide A (1) in 17 linear steps with an overall yield of 11.3 %. In particular, this work features the late-stage intr...
Noncanonical peptides occur frequently in Nature, and often display high bioactivity. However, the lack of tractable systems for the synthesis of diverse libraries of such peptides has thus far hamper...
Chorea due to TITF1/NKX2-1 mutation: phenotypical description and therapeutic response in a family.
INTRODUCTION. Chorea due to a mutation in the TITF1 gene, which is also known as benign hereditary chorea, is an autosomal dominant disorder that usually begins before the age of 5 years. In most case...
Phenolphthalein induces centrosome amplification and tubulin depolymerization in vitro.
Aneuploidy is a major cause of human reproductive failure and plays a large role in cancer. Phenolphthalein (PHT) induces tumors in rodents but its primary mechanism does not seem to be DNA damage. In...
Most of the world's coffee production originates from Coffea arabica, an allotetraploid species with low genetic diversity and for which few genomic resources are available. Genomic libraries with lar...
Genetic Counseling: A Transnational Perspective.
Although the basic goal and components of genetic counseling appears to be the same across the globe, judged by my experiences there are significant differences in the provision of genetic counseling...
Little is known about genetic service utilization and ovarian cancer. We identified the frequency and outcome of genetic counseling referral, predictors of referral, and referral uptake for ovarian ca...
The association between cytotoxic T-lymphocyte associated antigen 4 (CTLA-4) exon-1 +49 A/G polymorphism and Hashimoto's thyroiditis (HT) has been widely studied. The results, however, are mixed. This...
Esophageal cancer is among the leading causes of cancer-related deaths worldwide. The management of patients with esophageal cancer is determined to a large extent by patient performance status, locat...
Analysis of SYCP3 encoding synaptonemal complex protein 3 in human aneuploidies.
OBJECTIVES: To test the hypothesis that mutations of SYCP3 encoding synaptonemal complex protein 3, result in increased frequency of aneuploidies in humans. METHODS: Mutation analysis of the PCR-ampli...
News Articles
Innovative X-ray method advances new treatments for genetic diseases
An international team of scientists using a new X-ray method recorded the internal structure and cell movement inside a living frog embryo in greater detail than ever before.
Safety and efficacy evaluation methods for medical devices
Medical devices are any medical items that are neither a drug nor a biological product. In light of their different mechanisms, actions and regulatory requirements, medical device trail evaluations ar...
Authors urge importance of patients' rights in genome sequencing
Informed consent is the backbone of patient care. Genetic testing has long required patient consent and patients have had a "right not to know" the results. However, as 21st century medicine now begin...
New non-transgenic GE technology platform for genetic improvement of sunflower oilseed crop
May 13, 2013 — Scientists have developed techniques for the genetic improvement of sunflowers using a non-GMO based approach. The new technology platform can harness the plant's own genes to improve...
An evaluation of the first year of a major integrated care pilot—seen as a test bed for national government policy—has found little change in emergency admissions and in the wider use of health an...
Angelina Jolie and the Power of the Informed Decision
Dr. Kathy Miller comments on the importance of genetic testing in women at high risk for breast cancer so that they can make personal, informed decisions about their care, as Angelina Jolie has done....
Fertility Centers of Illinois discusses genetic screening for breast cancer and fertility preservation during a breast cancer diagnosis. Chicago, IL (PRWEB) May 17, 2013 After learning she had an 87...
Statistical Challenges in Medical Device Trail Evaluation
SHANGHAI , May 17, 2013 /- Medical devices are any medical items that are neither a drug nor a biological product. In light of their different mechanisms, actions and regulatory requirements, medical...
Study provides new evidence that genetic risk for schizophrenia associated with lower IQ
The relationship between the heritable risk for schizophrenia and low intelligence has not been clear. Schizophrenia is commonly associated with cognitive impairments that may cause functional disabil...
Study Of Traumatic Brain Injury, Suicide Risk In Deployed Military Personnel
JAMA Psychiatry Study Highlights A study by Craig J. Bryan, Psy.D., A.B.P.P., of the National Center for Veterans Studies, Salt Lake City, Utah, suggests that suicide risk is higher among military per...
Companies
With the advent of new technologies, in the last four years, DNA sequencing has gone through a technological revolution which has completely changed the market. While in 2007 it still cost over 10 m...
Interleukin Genetics, Inc. (OTCQB: ILIU) develops and markets a line of genetic tests under the Inherent Health® brand. The products empower individuals to prevent ce...
Founded in 2010 and based in Atlanta, curavita coordinates clinical care for critically injured workers. Through early intervention, a proprietary national network of catastrophic...
Lineagen (www.lineagen.com) is a provider of diagnostic and healthcare services focused on complex diseases for which individualsâ genetic profiles contribute strongly to...
NovaSom, Inc. is a privately held diagnostic-service provider for home testing and evaluation of sleep-disordered breathing, which includes the diagnosis of obstructive sleep apne...
Cascade Technologies Corp., through its wholly-owned subsidiary Spectral Molecular Imaging, Inc. (SMI), is a development-stage medical imaging device company, applying its proprie...
Cascade Technologies Corporation
Cascade Technologies Corp., through its wholly owned subsidiary Spectral Molecular Imaging, Inc., is a development-stage, medical imaging device company, applying its proprietary...
âWe encourage all citizens to write Congress about the widespread, unchecked, non-stop proliferation of radiofrequency radiation in our midst and the inaction of the FCC to r...
Headquartered in Rockville, Maryland, USA, Axeq Technologies is a US-division of Korea-based Macrogen, Inc. Axeq is a global provider of next-generation sequencing, Sanger sequenc...
For more than 75 years, the American Board of Medical Specialties (ABMS) has been the medical organization overseeing physician certification in the United States. It assists its...
Clinical Trials
Screening Evaluation for Women With Postpartum Depression
This study evaluates the relationship between mood changes and hormones in women with postpartum depression (PPD). This is an observational study; volunteers who participate will not rece...
Moxifloxacin in Pediatric Subjects With Complicated Intra-abdominal Infection
The primary focus of the study is the evaluation of the safety of treatment with moxifloxacin in a pediatric population 3 months to
Marinobufagenin as a Target for DIGIBIND in Preeclampsia
Background: - Preeclampsia is a combination of high blood pressure and other potentially life-threatening symptoms. Preeclampsia occurs in up to 10% of pregnancies and is a...
Gene Expression in Cumulus Cells to Predict Pregnancy
The purpose of this study is to determine the performance of a genetic assay, GemART, in cumulus cells predictive of embryo viability, and pregnancy success in women undergoing in vitro fe...
Family Preparation Study For Withdrawal of Mechanical Ventilation From Their Family Member
Using the self-regulation theory, an intervention to prepare families for that experience was developed. This study will assess the impact of the intervention on a family’s evaluation of...
Low cobalamin (vitamin B12) levels are frequent in the elderly. Most often they reflect a mild metabolic abnormality without clinical symptoms (subclinical cobalamin deficiency). It is unc...
Pilot Study to Evaluate the Restore Orthobiologic Implant in Rotator Cuff Tear Repair
Primary Endpoints: Comparative evaluation of any differences between the two groups in change from baseline to the 3-month time point in terms of: - Functional recovery (patient...
Anti-Estrogens - A Potential Treatment for Bipolar Affective Disorder in Women?
OBJECTIVE: To test the use of two adjunctive hormonal agents in a 28 day three-arm, double-blind, placebo-controlled study in the treatment of acute mania/hypomania. HYPOTHESIS:...
Influenza Vaccine in Lung Transplant Patients
Research Question: How do antibody and T cell responses following influenza vaccine compare among lung transplant patients, patients waiting for lung transplantation and healthy individua...
Evaluation of TEACH (Training Early Achievers for Careers in Health) Research
The conceptual framework underlying the TEACH Research Program is based on a specific theoretical approach designed to influence adolescent career choice, in this case towards a career in...
Videos
Reviving IRRI's Genetic Evaluation and Utilization Program: Dave Mackill pioneer interview
See full interview at http://archive.irri.org/publications/today/Mackill.asp and Rice Today article at http://irri.org/knowledge/publications/rice-today/spec...
Medical and Biotech [MESH] Definitions
Dna Shuffling
The use of DNA recombination (RECOMBINATION, GENETIC) to prepare a large gene library of novel, chimeric genes from a population of randomly fragmented DNA from related gene sequences.
Heterogeneous-nuclear Ribonucleoprotein K
A heterogeneous-nuclear ribonucleoprotein found in the CELL NUCLEUS and the CYTOPLASM. Heterogeneous-nuclear ribonucleoprotein K has been implicated in the regulation of gene expression at nearly all levels: GENETIC TRANSCRIPTION; mRNA processing (RNA PROCESSING, POST-TRANSCRIPTIONAL), mRNA transport, mRNA stability, and translation (TRANSLATION, GENETIC). The hnRNP protein has a strong affinity for polypyrimidine-rich RNA and for single-stranded polypyrimidine-rich DNA. Multiple hnRNP K protein isoforms exist due to alternative splicing and display different nucleic-acid-binding properties.
Micrornas
Small double-stranded, non-protein coding RNAs, 21-25 nucleotides in length generated from single-stranded microRNA gene transcripts by the same RIBONUCLEASE III, Dicer, that produces small interfering RNAs (RNA, SMALL INTERFERING). They become part of the RNA-INDUCED SILENCING COMPLEX and repress the translation (TRANSLATION, GENETIC) of target RNA by binding to homologous 3'UTR region as an imperfect match. The small temporal RNAs (stRNAs), let-7 and lin-4, from C. elegans, are the first 2 miRNAs discovered, and are from a class of miRNAs involved in developmental timing.
Silencer Elements, Transcriptional
Nucleic acid sequences that are involved in the negative regulation of GENETIC TRANSCRIPTION by chromatin silencing.
Ribosomal Protein S6
A ribosomal protein that may play a role in controlling cell growth and proliferation. It is a major substrate of RIBOSOMAL PROTEIN S6 KINASES and plays a role in regulating the translation (TRANSLATION, GENETIC) of RNAs that contain an RNA 5' TERMINAL OLIGOPYRIMIDINE SEQUENCE.
