Glucocorticoid deficiency - Biotech, Pharma and Life Science Channel
PubMed Articles
Familial glucocorticoid deficiency: New genes and mechanisms.
Familial Glucocorticoid deficiency (FGD), in which the adrenal cortex fails to produce glucocorticoids, was first shown to be caused by defects in the receptor for ACTH (MC2R) or its accessory protein...
The glucocorticoid receptor (GR) and corticotropin-releasing hormone (CRH) are important molecular regulators of an individual's ability to respond to stressful stimuli in an adaptive manner. Impaired...
Transcriptional regulation of episodic glucocorticoid secretion.
Circadian and ultradian variations of basal glucocorticoid secretion and transient elevations during stress are essential for homeostasis. Using intronic qRT-PCR to measure changes in primary transcri...
Evidence of oxidative stress in young and aged DJ-1-deficient mice.
Loss of DJ-1 function contributes to pathogenesis in Parkinson's disease. Here, we investigate the impact of aging and DJ-1 deficiency in transgenic mice. Ventral midbrain from young DJ-1-deficient mi...
Functional specific roles of FADD: comparative proteomic analyses from knockout cell lines.
Fas-associated death domain (FADD) is a classical adaptor protein involved in tumor necrosis factor receptor family-mediated apoptosis. Besides being an essential instrument in cell death, it also pla...
Rapid single cell detection of Staphylococcus aureus by aptamer-conjugated gold nanoparticles.
Staphylococcus aureus is one of the most important human pathogens, causing more than 500,000 infections in the United States each year. Traditional methods for bacterial culture and identification ta...
ALDH2 protects against stroke by clearing 4-HNE.
Aldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme that metabolizes ethanol and toxic aldehydes such as 4-hydroxy-2-nonenal (4-HNE). Using an unbiased proteomic search, we identified ALDH2 def...
TIF1γ (transcription intermediary factor 1 gamma), which belongs to transcription intermediary factor 1 family, is an inhibitor of the TGF-β/Smad signaling pathway and could inhibit the signal trans...
The deposition of β-amyloid (Aβ) in neurons and vascular cells of the brain has been characterized in Alzheimer's disease. Ginsenoside Rg1 (Rg1) is an active components in Panax ginseng, a famous tr...
The decline in testosterone levels found in men with testosterone deficiency syndrome (TDS) is associated with a decrease in bone mineral density (BMD). To study the safety profile and efficacy of tes...
News Articles
AMAG dips then recovers on Swiss Rienso recall
AMAG Pharmaceuticals closed down 10.7% on 22 May after the company said one batch of its intravenous iron deficiency anemia (IDA) drug Rienso (ferumoxytol) was recalled in Switzerland following four...
Perspective: Casting light on sleep deficiency
The use of electric lights at night is disrupting the sleep of more and more people, says Charles Czeisler.
Synageva BioPharma™ to Present at the Jefferies 2013 Global Healthcare Conference
Synageva BioPharma Corp. (“Synageva”) (NASDAQ:GEVA), a biopharmaceutical company developing therapeutic products for rare disorders, today announced that Sanj K. Patel,...
Rockwell Steadies Itself For A Phase III Run-Up
By Sam Quirke:Rockwell Medical (RMTI) is a bio-pharmaceutical company that's focused on addressing end-stage renal disease and chronic kidney disease with innovative products and services for the trea...
The nine months during a pregnancy and the months that follow during breast-feeding can place a number of physical, physiological and metabolic demands on women. With our nutritional and chemical ba...
Iodine Key for IQ; Pregnancy Deficiency Affects Kids' Brains
Even mild iodine deficiencies in pregnancy are associated with lower IQ, verbal scores, and reading ability in resulting children. Medscape Medical News
Re-emergence of moderate iodine deficiency in developed countries
A commentary accompanying research calls for greater public health policies to eradicate iodine deficiency in the U.K. and other developed countries, including the United States.
Could a mother's lack of iodine harm her child's IQ?
“Mothers’ diets may harm IQs of two babies in three,” warns The Independent. The newspaper reports on its front page that iodine deficiency is widespread among pregnant women. Iodine is recogni...
Iodine deficiency in pregnancy 'a key public health issue'
Low iodine levels during pregnancy could have an adverse impact on the mental development of the child, a new study has found.
PHILADELPHIA, May 22, 2013 /PRNewswire/ -- Grifols, a global healthcare company based in Barcelona, Spain, presented results from a study demonstrating that a higher dose of PROLASTIN©-C (Al...
Events
None
Companies
Columbia Laboratories, Inc. is focused on developing products that utilize its novel bioadhesive drug delivery technologies to optimize drug delivery in a controlled, sustained ma...
TheAmerican Association of Clinical Endocrinologists (AACE)
The American Association of Clinical Endocrinologists (AACE) represents more than 6,500 endocrinologists in the United States and abroad. AACE is the largest association of clinic...
Kamada is a public biopharmaceutical company (TASE: KMDA) developing, producing and marketing a line of specialty life-saving biopharmaceuticals. Licensed and marketed worldwide,...
Headquartered in Morrisville, North Carolina, TearScience® has pioneered devices that provide significant clinical improvement in the treatment of evaporative dry eye. Of the m...
AGTC is focused on the research and development of novel therapeutics for patients with unmet medical needs utilizing AGTCâs proprietary, non-pathogenic adeno-associat...
The American Association of Clinical Endocrinologists
The American Association of Clinical Endocrinologists (AACE) represents more than 6,500 endocrinologists in the United States and abroad. AACE is the largest association of clinic...
Mission statement: The Alpha-1 Project will work with patients, academia, pharmaceutical and biotech companies, and public health organizations in the relentless pursuit of cures...
The mission of the Alpha-1 Foundation is to provide the leadership and resources that will result in increased research, improved health, worldwide detection, and a cure for Alpha...
NormOxys is developing a novel class of small molecule drugs, oxyrens, which enhance the bodyâs ability to deliver oxygen more efficiently to diseased tissues with oxygen def...
Medical Banking Rx is a full service pharmacy benefit management (PBM) firm that uses unconventional approaches to achieve exceptional results. It has developed and administers a...
Clinical Trials
Low cobalamin (vitamin B12) levels are frequent in the elderly. Most often they reflect a mild metabolic abnormality without clinical symptoms (subclinical cobalamin deficiency). It is unc...
Trial of the Impact of Vitamin A on Maternal Mortality
Main objectives: To evaluate the impact of weekly vitamin A supplementation (VAS) to women of reproductive age (15-45 years) on maternal mortality in rural Ghana, and to compare this with...
Evaluation of the Safety of a Polyvalent Virus in Healthy Adults
This is a research study to evaluate the safety of a vaccine to protect people from HIV infection. Human Immunodeficiency Virus (HIV) is the cause of AIDS (Acquired Immune Deficiency Syndr...
Caffeine for Apnea of Prematurity (CAP)
At least 5 of every 1000 live-born babies are very premature and weigh only 500 to 1250 grams at birth. Approximately 30-40% of these high-risk infants either die or survive with lasting...
Relationship Between Folic Acid and Warfarin Metabolism and Effect
Folic acid supplementation has been shown previously to be associated with enhanced formation of p-HPPH from phenytoin, a metabolic pathway which is predominantly mediated through the acti...
Adrenal Function in Critical Illness
An appropriate hypothalamic-pituitary-adrenal (HPA) axis response is required to survive critical illness. Primary adrenal insufficiency, relative adrenal insufficiency, tissue resistance...
Odense Androgen Study: Study of Androgens, Body Composition, and Muscle Function in Danish Men
Objective: - To define a reference-population of healthy young men (20-29 years old). - To establish reference-intervals for: 1. Total, bioavailable and free serum an...
Consequence of Lifetime Isolated Growth Hormone Deficiency
Growth hormone (GH) deficiency (GHD) in adulthood has been associated with changes in body composition (e.g. increased abdominal obesity, and reduced muscle mass), in organ functions (e.g....
Bexarotene Treatment in Schizophrenia
In this proposed study, we aim to investigate the effects of Bexarotene (Targretin; LGD1069; 4-[1-{5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl} ethenyl] benzoic acid) on severi...
Endocrine Dysfunction and Growth Hormone Deficiency in Children With Optic Nerve Hypoplasia
Hypotheses: 1. The prevalence of endocrinopathies, and growth hormone (GH) deficiency in particular, among young children diagnosed with optic nerve hypoplasia (ONH) is higher than...
Videos
Dr. Antonio Carrascosa- Head of the Pediatrics Endocrinology group at VHIR
Translational (clinical, biochemical and molecular) research on paediatric endocrine diseases. Research lines: Normal growth and development patterns in chil...
Medical and Biotech [MESH] Definitions
Pulmonary Surfactant-associated Protein B
A pulmonary surfactant associated-protein that plays an essential role in alveolar stability by lowering the surface tension at the air-liquid interface. Inherited deficiency of pulmonary surfactant-associated protein B is one cause of RESPIRATORY DISTRESS SYNDROME, NEWBORN.
Cytochrome-b(5) Reductase
A FLAVOPROTEIN oxidoreductase that occurs both as a soluble enzyme and a membrane-bound enzyme due to ALTERNATIVE SPLICING of a single mRNA. The soluble form is present mainly in ERYTHROCYTES and is involved in the reduction of METHEMOGLOBIN. The membrane-bound form of the enzyme is found primarily in the ENDOPLASMIC RETICULUM and outer mitochondrial membrane, where it participates in the desaturation of FATTY ACIDS; CHOLESTEROL biosynthesis and drug metabolism. A deficiency in the enzyme can result in METHEMOGLOBINEMIA.
1-alkyl-2-acetylglycerophosphocholine Esterase
A lipoprotein-associated PHOSPHOLIPASE A2 which modulates the action of PLATELET ACTIVATING FACTOR by hydrolyzing the SN-2 ester bond to yield the biologically inactive lyso-platelet-activating factor. It has specificity for phospholipid substrates with short-chain residues at the SN-2 position, but inactive against long-chain phospholipids. Deficiency in this enzyme is associated with many diseases including ASTHMA, and HYPERCHOLESTEROLEMIA.
Biotinidase
An enzyme which catalyzes the release of BIOTIN from biocytin. In human, defects in the enzyme are the cause of the organic acidemia MULTIPLE CARBOXYLASE DEFICIENCY or BIOTINIDASE DEFICIENCY.
Mannosidase Deficiency Diseases
Diseases caused by the loss of one or more enzymes involved in the hydrolysis of mannoside linkages (MANNOSIDASES). The defects in enzyme activity are primarily associated with genetic mutation of the genes that codes for a particular mannosidase isoenzyme.
